메뉴 건너뛰기




Volumn 196, Issue , 2014, Pages 168-183

Targeting of gastrointestinal tract for amended delivery of protein/peptide therapeutics: Strategies and industrial perspectives

Author keywords

Gastrointestinal barriers; Oral delivery; Peptide; Proteins; Targeted delivery; Transport pathways

Indexed keywords

EMULSIONS; INDUSTRIAL RESEARCH; LIPOSOMES; PEPTIDES;

EID: 84908221805     PISSN: 01683659     EISSN: 18734995     Source Type: Journal    
DOI: 10.1016/j.jconrel.2014.09.031     Document Type: Review
Times cited : (125)

References (187)
  • 1
    • 84949134262 scopus 로고    scopus 로고
    • Biotechnologies: Current achievements and prospects social acceptance of biotechnology-derived products
    • A. Sasson Biotechnologies: current achievements and prospects social acceptance of biotechnology-derived products CHAPTER 14 2004 1 157
    • (2004) CHAPTER , vol.14 , pp. 1-157
    • Sasson, A.1
  • 3
    • 0033120652 scopus 로고    scopus 로고
    • Large-scale production of pharmaceutical-grade plasmid DNA for gene therapy: Problems and bottlenecks
    • D.M. Prazeres, G.N. Ferreira, G.A. Monteiro, C.L. Cooney, and J. Cabral Large-scale production of pharmaceutical-grade plasmid DNA for gene therapy: problems and bottlenecks Trends Biotechnol. 17 1999 169 174
    • (1999) Trends Biotechnol. , vol.17 , pp. 169-174
    • Prazeres, D.M.1    Ferreira, G.N.2    Monteiro, G.A.3    Cooney, C.L.4    Cabral, J.5
  • 4
    • 0141706699 scopus 로고    scopus 로고
    • The production of recombinant pharmaceutical proteins in plants
    • J.K. Ma, P.M. Drake, and P. Christou The production of recombinant pharmaceutical proteins in plants Nat. Rev. Genet. 4 2003 794 805
    • (2003) Nat. Rev. Genet. , vol.4 , pp. 794-805
    • Ma, J.K.1    Drake, P.M.2    Christou, P.3
  • 5
    • 0030722164 scopus 로고    scopus 로고
    • Applications of DNA shuffling to pharmaceuticals and vaccines
    • P.A. Patten, R.J. Howard, and W.P. Stemmer Applications of DNA shuffling to pharmaceuticals and vaccines Curr. Opin. Biotechnol. 8 1997 724 733
    • (1997) Curr. Opin. Biotechnol. , vol.8 , pp. 724-733
    • Patten, P.A.1    Howard, R.J.2    Stemmer, W.P.3
  • 7
    • 15544379805 scopus 로고    scopus 로고
    • Watching peptide drugs grow up
    • V. Marx Watching peptide drugs grow up Chem. Eng. News 83 2005 17 24
    • (2005) Chem. Eng. News , vol.83 , pp. 17-24
    • Marx, V.1
  • 9
    • 0031943571 scopus 로고    scopus 로고
    • Regulation of the movement of solutes across tight junctions
    • J.L. Madara Regulation of the movement of solutes across tight junctions Annu. Rev. Physiol. 60 1998 143 159
    • (1998) Annu. Rev. Physiol. , vol.60 , pp. 143-159
    • Madara, J.L.1
  • 10
    • 0024853950 scopus 로고
    • Transcytosis of macromolecules through the blood-brain barrier: A cell biological perspective and critical appraisal
    • R.D. Broadwell Transcytosis of macromolecules through the blood-brain barrier: a cell biological perspective and critical appraisal Acta Neuropathol. 79 1989 117 128
    • (1989) Acta Neuropathol. , vol.79 , pp. 117-128
    • Broadwell, R.D.1
  • 11
    • 68949208465 scopus 로고    scopus 로고
    • Nanocarriers' entry into the cell: Relevance to drug delivery
    • H. Hillaireau, and P. Couvreur Nanocarriers' entry into the cell: relevance to drug delivery Cell. Mol. Life Sci. 66 2009 2873 2896
    • (2009) Cell. Mol. Life Sci. , vol.66 , pp. 2873-2896
    • Hillaireau, H.1    Couvreur, P.2
  • 12
    • 21744458087 scopus 로고    scopus 로고
    • Nanoparticle uptake by the oral route: Fulfilling its potential?
    • A.T. Florence Nanoparticle uptake by the oral route: fulfilling its potential? Drug Discov. Today Technol. 2 2005 75 81
    • (2005) Drug Discov. Today Technol. , vol.2 , pp. 75-81
    • Florence, A.T.1
  • 13
    • 80054061227 scopus 로고    scopus 로고
    • A review of the prospects for polymeric nanoparticle platforms in oral insulin delivery
    • M.-C. Chen, K. Sonaje, K.-J. Chen, and H.-W. Sung A review of the prospects for polymeric nanoparticle platforms in oral insulin delivery Biomaterials 32 2011 9826 9838
    • (2011) Biomaterials , vol.32 , pp. 9826-9838
    • Chen, M.-C.1    Sonaje, K.2    Chen, K.-J.3    Sung, H.-W.4
  • 15
    • 0021149894 scopus 로고
    • Intestinal absorption mechanism of amino-beta-lactam antibiotics. III. Kinetics of carrier-mediated transport across the rat small intestine in situ
    • E. Nakashima, A. Tsuji, S. Kagatani, and T. Yamana Intestinal absorption mechanism of amino-beta-lactam antibiotics. III. Kinetics of carrier-mediated transport across the rat small intestine in situ J. Pharmacobiodyn 7 1984 452 464
    • (1984) J. Pharmacobiodyn , vol.7 , pp. 452-464
    • Nakashima, E.1    Tsuji, A.2    Kagatani, S.3    Yamana, T.4
  • 16
    • 0014624187 scopus 로고
    • The utilization of exogenous pyrimidines and the recycling of uridine-5′-phosphate derivatives in Saccharomyces cerevisiae, as studied by means of mutants affected in pyrimidine uptake and metabolism
    • M. Grenson The utilization of exogenous pyrimidines and the recycling of uridine-5′-phosphate derivatives in Saccharomyces cerevisiae, as studied by means of mutants affected in pyrimidine uptake and metabolism Eur. J. Biochem. 11 1969 249 260
    • (1969) Eur. J. Biochem. , vol.11 , pp. 249-260
    • Grenson, M.1
  • 17
    • 0035286685 scopus 로고    scopus 로고
    • The potential use of receptor-mediated endocytosis for oral drug delivery
    • G.J. Russell-Jones The potential use of receptor-mediated endocytosis for oral drug delivery Adv. Drug Deliv. Rev. 46 2001 59 73
    • (2001) Adv. Drug Deliv. Rev. , vol.46 , pp. 59-73
    • Russell-Jones, G.J.1
  • 18
    • 0343408485 scopus 로고    scopus 로고
    • Lipophilic prodrugs designed for intestinal lymphatic transport
    • W.N. Charman, and C.J.H. Porter Lipophilic prodrugs designed for intestinal lymphatic transport Adv. Drug Deliv. Rev. 19 1996 149 169
    • (1996) Adv. Drug Deliv. Rev. , vol.19 , pp. 149-169
    • Charman, W.N.1    Porter, C.J.H.2
  • 19
    • 0037422066 scopus 로고    scopus 로고
    • Regulated portals of entry into the cell
    • S.D. Conner, and S.L. Schmid Regulated portals of entry into the cell Nature 422 2003 37 44
    • (2003) Nature , vol.422 , pp. 37-44
    • Conner, S.D.1    Schmid, S.L.2
  • 20
    • 84863615479 scopus 로고    scopus 로고
    • Lehninger principles of biochemistry
    • D. Nelson, M. Cox, 4th ed.
    • J. Boyle Lehninger principles of biochemistry D. Nelson, M. Cox, 4th ed. Biochem Mol Biol Edu 33 2005 74 75
    • (2005) Biochem Mol Biol Edu , vol.33 , pp. 74-75
    • Boyle, J.1
  • 21
    • 84887897897 scopus 로고    scopus 로고
    • Therapeutic proteins: A to z
    • A. Ozgur, and Y. Tutar Therapeutic proteins: a to z Protein Pept. Lett. 20 2013 1365 1372
    • (2013) Protein Pept. Lett. , vol.20 , pp. 1365-1372
    • Ozgur, A.1    Tutar, Y.2
  • 22
    • 0031671475 scopus 로고    scopus 로고
    • Novel oral drug delivery gateways for biotechnology products: Polypeptides and vaccines
    • D.J. Brayden, and D.J. O'Mahony Novel oral drug delivery gateways for biotechnology products: polypeptides and vaccines Pharm. Sci. Technol. Today 1 1998 291 299
    • (1998) Pharm. Sci. Technol. Today , vol.1 , pp. 291-299
    • Brayden, D.J.1    O'Mahony, D.J.2
  • 23
    • 84878855642 scopus 로고    scopus 로고
    • Nanoparticles for oral delivery: Targeted nanoparticles with peptidic ligands for oral protein delivery
    • Y. Yun, Y.W. Cho, and K. Park Nanoparticles for oral delivery: targeted nanoparticles with peptidic ligands for oral protein delivery Adv. Drug Deliv. Rev. 65 2013 822 832
    • (2013) Adv. Drug Deliv. Rev. , vol.65 , pp. 822-832
    • Yun, Y.1    Cho, Y.W.2    Park, K.3
  • 24
    • 84859719708 scopus 로고    scopus 로고
    • Oral drug delivery with polymeric nanoparticles: The gastrointestinal mucus barriers
    • L.M. Ensign, R. Cone, and J. Hanes Oral drug delivery with polymeric nanoparticles: the gastrointestinal mucus barriers Adv. Drug Deliv. Rev. 64 2012 557 570
    • (2012) Adv. Drug Deliv. Rev. , vol.64 , pp. 557-570
    • Ensign, L.M.1    Cone, R.2    Hanes, J.3
  • 25
    • 2642550862 scopus 로고    scopus 로고
    • Challenges in the development of high protein concentration formulations
    • S.J. Shire, Z. Shahrokh, and J. Liu Challenges in the development of high protein concentration formulations J. Pharm. Sci. 93 2004 1390 1402
    • (2004) J. Pharm. Sci. , vol.93 , pp. 1390-1402
    • Shire, S.J.1    Shahrokh, Z.2    Liu, J.3
  • 26
    • 0032782071 scopus 로고    scopus 로고
    • Instability, stabilization, and formulation of liquid protein pharmaceuticals
    • W. Wang Instability, stabilization, and formulation of liquid protein pharmaceuticals Int. J. Pharm. 185 1999 129 188
    • (1999) Int. J. Pharm. , vol.185 , pp. 129-188
    • Wang, W.1
  • 27
    • 0032945323 scopus 로고    scopus 로고
    • Solid-state chemical stability of proteins and peptides
    • M. Lai, and E. Topp Solid-state chemical stability of proteins and peptides J. Pharm. Sci. 88 1999 489 500
    • (1999) J. Pharm. Sci. , vol.88 , pp. 489-500
    • Lai, M.1    Topp, E.2
  • 28
    • 0141567459 scopus 로고    scopus 로고
    • Physical stability of proteins in aqueous solution: Mechanism and driving forces in nonnative protein aggregation
    • E.Y. Chi, S. Krishnan, T.W. Randolph, and J.F. Carpenter Physical stability of proteins in aqueous solution: mechanism and driving forces in nonnative protein aggregation Pharm. Res. 20 2003 1325 1336
    • (2003) Pharm. Res. , vol.20 , pp. 1325-1336
    • Chi, E.Y.1    Krishnan, S.2    Randolph, T.W.3    Carpenter, J.F.4
  • 29
    • 18244365849 scopus 로고    scopus 로고
    • Protein drug stability: A formulation challenge
    • S. Frokjaer, and D.E. Otzen Protein drug stability: a formulation challenge Nat. Rev. Drug Discov. 4 2005 298 306
    • (2005) Nat. Rev. Drug Discov. , vol.4 , pp. 298-306
    • Frokjaer, S.1    Otzen, D.E.2
  • 30
    • 0022378366 scopus 로고
    • The design of metabolically-stable peptide analogs
    • D.F. Veber, and R.M. Freidinger The design of metabolically-stable peptide analogs Trends Neurosci. 8 1985 392 396
    • (1985) Trends Neurosci. , vol.8 , pp. 392-396
    • Veber, D.F.1    Freidinger, R.M.2
  • 31
    • 0018757398 scopus 로고
    • Structure activity relationship of orally active enkephalin analogues as analgesics
    • D. Roemer, and J. Pless Structure activity relationship of orally active enkephalin analogues as analgesics Life Sci. 24 1979 621 624
    • (1979) Life Sci. , vol.24 , pp. 621-624
    • Roemer, D.1    Pless, J.2
  • 32
    • 0033067843 scopus 로고    scopus 로고
    • The effect of conformation on the membrane permeation of coumarinic acid- and phenylpropionic acid-based cyclic prodrugs of opioid peptides
    • O.S. Gudmundsson, S.D.S. Jois, D.G.V. Velde, T.J. Siahaan, R.T. Borchardt, and B. Wang The effect of conformation on the membrane permeation of coumarinic acid- and phenylpropionic acid-based cyclic prodrugs of opioid peptides J. Pept. Res. 53 1999 383 392
    • (1999) J. Pept. Res. , vol.53 , pp. 383-392
    • Gudmundsson, O.S.1    Jois, S.D.S.2    Velde, D.G.V.3    Siahaan, T.J.4    Borchardt, R.T.5    Wang, B.6
  • 34
    • 84856924428 scopus 로고    scopus 로고
    • Synthesis of N-methylated cyclic peptides
    • J. Chatterjee, B. Laufer, and H. Kessler Synthesis of N-methylated cyclic peptides Nat. Protoc. 7 2012 432 444
    • (2012) Nat. Protoc. , vol.7 , pp. 432-444
    • Chatterjee, J.1    Laufer, B.2    Kessler, H.3
  • 35
    • 0007193238 scopus 로고    scopus 로고
    • Chemical synthesis of natural product peptides: Coupling methods for the incorporation of noncoded amino acids into peptides
    • J.M. Humphrey, and A.R. Chamberlin Chemical synthesis of natural product peptides: coupling methods for the incorporation of noncoded amino acids into peptides Chem. Rev. 97 1997 2243 2266
    • (1997) Chem. Rev. , vol.97 , pp. 2243-2266
    • Humphrey, J.M.1    Chamberlin, A.R.2
  • 36
    • 0036897824 scopus 로고    scopus 로고
    • Mimicry of bioactive peptides via non-natural, sequence-specific peptidomimetic oligomers
    • J.A. Patch, and A.E. Barron Mimicry of bioactive peptides via non-natural, sequence-specific peptidomimetic oligomers Curr. Opin. Chem. Biol. 6 2002 872 877
    • (2002) Curr. Opin. Chem. Biol. , vol.6 , pp. 872-877
    • Patch, J.A.1    Barron, A.E.2
  • 38
    • 0035717847 scopus 로고    scopus 로고
    • Evaluation of the conformational propensities of peptide isosteres as a basis for selecting bioactive pseudopeptides
    • S. Gupta, and J.W. Payne Evaluation of the conformational propensities of peptide isosteres as a basis for selecting bioactive pseudopeptides J. Pept. Res. 58 2001 546 561
    • (2001) J. Pept. Res. , vol.58 , pp. 546-561
    • Gupta, S.1    Payne, J.W.2
  • 42
    • 76449116488 scopus 로고    scopus 로고
    • The effect of backbone cyclization on PK/PD properties of bioactive peptide-peptoid hybrids: The melanocortin agonist paradigm
    • O. Ovadia, Y. Linde, C. Haskell-Luevano, M.L. Dirain, T. Sheynis, R. Jelinek, C. Gilon, and A. Hoffman The effect of backbone cyclization on PK/PD properties of bioactive peptide-peptoid hybrids: the melanocortin agonist paradigm Bioorg. Med. Chem. 18 2010 580 589
    • (2010) Bioorg. Med. Chem. , vol.18 , pp. 580-589
    • Ovadia, O.1    Linde, Y.2    Haskell-Luevano, C.3    Dirain, M.L.4    Sheynis, T.5    Jelinek, R.6    Gilon, C.7    Hoffman, A.8
  • 45
    • 0031944490 scopus 로고    scopus 로고
    • Improvement of intestinal absorption of peptide drugs by glycosylation: Transport of tetrapeptide by the sodium ion-dependent d-glucose transporter
    • M. Nomoto, K. Yamada, M. Haga, and M. Hayashi Improvement of intestinal absorption of peptide drugs by glycosylation: transport of tetrapeptide by the sodium ion-dependent d-glucose transporter J. Pharm. Sci. 87 1998 326 332
    • (1998) J. Pharm. Sci. , vol.87 , pp. 326-332
    • Nomoto, M.1    Yamada, K.2    Haga, M.3    Hayashi, M.4
  • 46
    • 2942560767 scopus 로고    scopus 로고
    • Phage display-derived peptides as therapeutic alternatives to antibodies
    • R.C. Ladner, A.K. Sato, J. Gorzelany, and M. de Souza Phage display-derived peptides as therapeutic alternatives to antibodies Drug Discov. Today 9 2004 525 529
    • (2004) Drug Discov. Today , vol.9 , pp. 525-529
    • Ladner, R.C.1    Sato, A.K.2    Gorzelany, J.3    De Souza, M.4
  • 48
    • 84862828651 scopus 로고    scopus 로고
    • The effect of polyethylene glycol recombinant human growth hormone on growth and glucose metabolism in hypophysectomized rats
    • Z.X. Zhang, Y.K. Liu, H. Pan, L. Pan, Q. Zhang, H.M. Su, Q.L. Zhao, H. Li, and C. He The effect of polyethylene glycol recombinant human growth hormone on growth and glucose metabolism in hypophysectomized rats Growth Hormon. IGF Res. 22 2012 30 35
    • (2012) Growth Hormon. IGF Res. , vol.22 , pp. 30-35
    • Zhang, Z.X.1    Liu, Y.K.2    Pan, H.3    Pan, L.4    Zhang, Q.5    Su, H.M.6    Zhao, Q.L.7    Li, H.8    He, C.9
  • 49
    • 33748151944 scopus 로고    scopus 로고
    • Improved intestinal delivery of salmon calcitonin by Lys18-amine specific PEGylation: Stability, permeability, pharmacokinetic behavior and in vivo hypocalcemic efficacy
    • Y.S. Youn, J.Y. Jung, S.H. Oh, S.D. Yoo, and K.C. Lee Improved intestinal delivery of salmon calcitonin by Lys18-amine specific PEGylation: stability, permeability, pharmacokinetic behavior and in vivo hypocalcemic efficacy J. Control. Release 114 2006 334 342
    • (2006) J. Control. Release , vol.114 , pp. 334-342
    • Youn, Y.S.1    Jung, J.Y.2    Oh, S.H.3    Yoo, S.D.4    Lee, K.C.5
  • 50
    • 33846874991 scopus 로고    scopus 로고
    • High-yield production of biologically active mono-PEGylated salmon calcitonin by site-specific PEGylation
    • Y.S. Youn, D.H. Na, and K.C. Lee High-yield production of biologically active mono-PEGylated salmon calcitonin by site-specific PEGylation J. Control. Release 117 2007 371 379
    • (2007) J. Control. Release , vol.117 , pp. 371-379
    • Youn, Y.S.1    Na, D.H.2    Lee, K.C.3
  • 51
  • 55
    • 42949174825 scopus 로고    scopus 로고
    • Prodrugs of nucleoside analogues for improved oral absorption and tissue targeting
    • F. Li, H. Maag, and T. Alfredson Prodrugs of nucleoside analogues for improved oral absorption and tissue targeting J. Pharm. Sci. 97 2008 1109 1134
    • (2008) J. Pharm. Sci. , vol.97 , pp. 1109-1134
    • Li, F.1    Maag, H.2    Alfredson, T.3
  • 56
    • 84873325984 scopus 로고    scopus 로고
    • Increasing oral absorption of polar neuraminidase inhibitors: A prodrug transporter approach applied to oseltamivir analogue
    • D. Gupta, S. Varghese Gupta, A. Dahan, Y. Tsume, J. Hilfinger, K.-D. Lee, and G.L. Amidon Increasing oral absorption of polar neuraminidase inhibitors: a prodrug transporter approach applied to oseltamivir analogue Mol. Pharm. 10 2012 512 522
    • (2012) Mol. Pharm. , vol.10 , pp. 512-522
    • Gupta, D.1    Varghese Gupta, S.2    Dahan, A.3    Tsume, Y.4    Hilfinger, J.5    Lee, K.-D.6    Amidon, G.L.7
  • 57
    • 47949131000 scopus 로고    scopus 로고
    • Synthesis, metabolism and cellular permeability of enzymatically stable dipeptide prodrugs of acyclovir
    • R.S. Talluri, S.K. Samanta, R. Gaudana, and A.K. Mitra Synthesis, metabolism and cellular permeability of enzymatically stable dipeptide prodrugs of acyclovir Int. J. Pharm. 361 2008 118 124
    • (2008) Int. J. Pharm. , vol.361 , pp. 118-124
    • Talluri, R.S.1    Samanta, S.K.2    Gaudana, R.3    Mitra, A.K.4
  • 59
    • 58149263071 scopus 로고    scopus 로고
    • Factors that restrict the intestinal cell permeation of cyclic prodrugs of an opioid peptide (DADLE): Part I. Role of efflux transporters in the intestinal mucosa
    • H. Ouyang, W. Chen, T.E. Andersen, B. Steffansen, and R.T. Borchardt Factors that restrict the intestinal cell permeation of cyclic prodrugs of an opioid peptide (DADLE): part I. Role of efflux transporters in the intestinal mucosa J. Pharm. Sci. 98 2009 337 348
    • (2009) J. Pharm. Sci. , vol.98 , pp. 337-348
    • Ouyang, H.1    Chen, W.2    Andersen, T.E.3    Steffansen, B.4    Borchardt, R.T.5
  • 60
    • 58149231151 scopus 로고    scopus 로고
    • Factors that restrict intestinal cell permeation of cyclic prodrugs of an opioid peptide (DADLE): Part II. Role of metabolic enzymes in the intestinal mucosa
    • H. Ouyang, W. Chen, T.E. Andersen, B. Steffansen, and R.T. Borchardt Factors that restrict intestinal cell permeation of cyclic prodrugs of an opioid peptide (DADLE): part II. Role of metabolic enzymes in the intestinal mucosa J. Pharm. Sci. 98 2009 349 361
    • (2009) J. Pharm. Sci. , vol.98 , pp. 349-361
    • Ouyang, H.1    Chen, W.2    Andersen, T.E.3    Steffansen, B.4    Borchardt, R.T.5
  • 61
    • 84864037655 scopus 로고    scopus 로고
    • Factors that restrict the cell permeation of cyclic prodrugs of an opioid peptide, part 3: Synthesis of analogs designed to have improved stability to oxidative metabolism
    • R. Nofsinger, T. Fuchs-Knotts, and R.T. Borchardt Factors that restrict the cell permeation of cyclic prodrugs of an opioid peptide, part 3: synthesis of analogs designed to have improved stability to oxidative metabolism J. Pharm. Sci. 101 2012 3486 3499
    • (2012) J. Pharm. Sci. , vol.101 , pp. 3486-3499
    • Nofsinger, R.1    Fuchs-Knotts, T.2    Borchardt, R.T.3
  • 62
    • 84864052734 scopus 로고    scopus 로고
    • Factors that restrict the cell permeation of cyclic prodrugs of an opioid peptide, part 4: Characterization of the biopharmaceutical and physicochemical properties of two new cyclic prodrugs designed to be stable to oxidative metabolism by cytochrome P-450 enzymes in the intestinal mucosa
    • R. Nofsinger, and R.T. Borchardt Factors that restrict the cell permeation of cyclic prodrugs of an opioid peptide, part 4: characterization of the biopharmaceutical and physicochemical properties of two new cyclic prodrugs designed to be stable to oxidative metabolism by cytochrome P-450 enzymes in the intestinal mucosa J. Pharm. Sci. 101 2012 3500 3510
    • (2012) J. Pharm. Sci. , vol.101 , pp. 3500-3510
    • Nofsinger, R.1    Borchardt, R.T.2
  • 64
    • 84862015361 scopus 로고    scopus 로고
    • A prodrug nanoparticle approach for the oral delivery of a hydrophilic peptide, leucine5-enkephalin, to the brain
    • A. Lalatsa, V. Lee, J.P. Malkinson, M. Zloh, A.G. Schätzlein, and I.F. Uchegbu A prodrug nanoparticle approach for the oral delivery of a hydrophilic peptide, leucine5-enkephalin, to the brain Mol. Pharm. 9 2012 1665 1680
    • (2012) Mol. Pharm. , vol.9 , pp. 1665-1680
    • Lalatsa, A.1    Lee, V.2    Malkinson, J.P.3    Zloh, M.4    Schätzlein, A.G.5    Uchegbu, I.F.6
  • 65
    • 0036805820 scopus 로고    scopus 로고
    • Improvement of the enzymatic stability of a cytotoxic T-lymphocyte-epitope model peptide for its oral administration
    • M.K. Marschütz, W. Zauner, F. Mattner, A. Otava, M. Buschle, and A. Bernkop-Schnürch Improvement of the enzymatic stability of a cytotoxic T-lymphocyte-epitope model peptide for its oral administration Peptides 23 2002 1727 1733
    • (2002) Peptides , vol.23 , pp. 1727-1733
    • Marschütz, M.K.1    Zauner, W.2    Mattner, F.3    Otava, A.4    Buschle, M.5    Bernkop-Schnürch, A.6
  • 68
    • 79954469776 scopus 로고    scopus 로고
    • Site-specific PEGylation of exenatide analogues markedly improved their glucoregulatory activity
    • N. Gong, A.-N. Ma, L.-J. Zhang, X.-S. Luo, Y.-H. Zhang, M. Xu, and Y.-X. Wang Site-specific PEGylation of exenatide analogues markedly improved their glucoregulatory activity Br. J. Pharmacol. 163 2011 399 412
    • (2011) Br. J. Pharmacol. , vol.163 , pp. 399-412
    • Gong, N.1    Ma, A.-N.2    Zhang, L.-J.3    Luo, X.-S.4    Zhang, Y.-H.5    Xu, M.6    Wang, Y.-X.7
  • 69
    • 84861304602 scopus 로고    scopus 로고
    • Polymer-based oral peptide nanomedicines
    • E.P. Herrero, M.J. Alonso, and N. Csaba Polymer-based oral peptide nanomedicines Ther. Deliv. 3 2012 657 668
    • (2012) Ther. Deliv. , vol.3 , pp. 657-668
    • Herrero, E.P.1    Alonso, M.J.2    Csaba, N.3
  • 70
    • 0026571249 scopus 로고
    • (C) Means to enhance penetration: (2) intestinal permeability enhancement for proteins, peptides and other polar drugs: Mechanisms and potential toxicity
    • E. Scott Swenson, and W.J. Curatolo (C) Means to enhance penetration: (2) intestinal permeability enhancement for proteins, peptides and other polar drugs: mechanisms and potential toxicity Adv. Drug Deliv. Rev. 8 1992 39 92
    • (1992) Adv. Drug Deliv. Rev. , vol.8 , pp. 39-92
    • Scott Swenson, E.1    Curatolo, W.J.2
  • 71
    • 46749122375 scopus 로고    scopus 로고
    • Safe and effective permeation enhancers for oral drug delivery
    • K. Whitehead, N. Karr, and S. Mitragotri Safe and effective permeation enhancers for oral drug delivery Pharm. Res. 25 2008 1782 1788
    • (2008) Pharm. Res. , vol.25 , pp. 1782-1788
    • Whitehead, K.1    Karr, N.2    Mitragotri, S.3
  • 72
    • 0028033391 scopus 로고
    • Intestinal permeability enhancement: Efficacy, acute local toxicity, and reversibility
    • E.S. Swenson, W. Milisen, and W. Curatolo Intestinal permeability enhancement: efficacy, acute local toxicity, and reversibility Pharm. Res. 11 1994 1132 1142
    • (1994) Pharm. Res. , vol.11 , pp. 1132-1142
    • Swenson, E.S.1    Milisen, W.2    Curatolo, W.3
  • 73
    • 0141551200 scopus 로고    scopus 로고
    • Permeation enhancing polymers in oral delivery of hydrophilic macromolecules: Thiomer/GSH systems
    • A. Bernkop-Schnurch, C.E. Kast, and D. Guggi Permeation enhancing polymers in oral delivery of hydrophilic macromolecules: thiomer/GSH systems J. Control. Release 93 2003 95 103
    • (2003) J. Control. Release , vol.93 , pp. 95-103
    • Bernkop-Schnurch, A.1    Kast, C.E.2    Guggi, D.3
  • 74
    • 0023520885 scopus 로고
    • Physiological regulation of transepithelial impedance in the intestinal mucosa of rats and hamsters
    • J.R. Pappenheimer Physiological regulation of transepithelial impedance in the intestinal mucosa of rats and hamsters J. Membr. Biol. 100 1987 137 148
    • (1987) J. Membr. Biol. , vol.100 , pp. 137-148
    • Pappenheimer, J.R.1
  • 75
    • 0030048289 scopus 로고    scopus 로고
    • Permeation enhancement of octreotide by specific bile salts in rats and human subjects: In vitro, in vivo correlations
    • G. Fricker, A. Fahr, C. Beglinger, T. Kissel, G. Reiter, and J. Drewe Permeation enhancement of octreotide by specific bile salts in rats and human subjects: in vitro, in vivo correlations Br. J. Pharmacol. 117 1996 217 223
    • (1996) Br. J. Pharmacol. , vol.117 , pp. 217-223
    • Fricker, G.1    Fahr, A.2    Beglinger, C.3    Kissel, T.4    Reiter, G.5    Drewe, J.6
  • 76
    • 12344312013 scopus 로고    scopus 로고
    • Quantitative estimation of the effects of bile salt surfactant systems on insulin stability and permeability in the rat intestine using a mass balance model
    • M.E. Lane, C.M. O'Driscoll, and O.I. Corrigan Quantitative estimation of the effects of bile salt surfactant systems on insulin stability and permeability in the rat intestine using a mass balance model J. Pharm. Pharmacol. 57 2005 169 175
    • (2005) J. Pharm. Pharmacol. , vol.57 , pp. 169-175
    • Lane, M.E.1    O'Driscoll, C.M.2    Corrigan, O.I.3
  • 77
    • 27744448891 scopus 로고    scopus 로고
    • Absorption enhancement, mechanistic and toxicity studies of medium chain fatty acids, cyclodextrins and bile salts as peroral absorption enhancers
    • P. Sharma, M.V.S. Varma, H.P.S. Chawla, and R. Panchagnula Absorption enhancement, mechanistic and toxicity studies of medium chain fatty acids, cyclodextrins and bile salts as peroral absorption enhancers Farmaco 60 2005 884 893
    • (2005) Farmaco , vol.60 , pp. 884-893
    • Sharma, P.1    Varma, M.V.S.2    Chawla, H.P.S.3    Panchagnula, R.4
  • 79
    • 84866723704 scopus 로고    scopus 로고
    • Overcoming poor permeability: Translating permeation enhancers for oral peptide delivery
    • S. Maher, and D.J. Brayden Overcoming poor permeability: translating permeation enhancers for oral peptide delivery Drug Discov. Today Technol. 9 2012 e113 e119
    • (2012) Drug Discov. Today Technol. , vol.9 , pp. 113-e119
    • Maher, S.1    Brayden, D.J.2
  • 80
    • 0033520487 scopus 로고    scopus 로고
    • In vivo protein transduction: Delivery of a biologically active protein into the mouse
    • S.R. Schwarze, A. Ho, A. Vocero-Akbani, and S.F. Dowdy In vivo protein transduction: delivery of a biologically active protein into the mouse Science 285 1999 1569 1572
    • (1999) Science , vol.285 , pp. 1569-1572
    • Schwarze, S.R.1    Ho, A.2    Vocero-Akbani, A.3    Dowdy, S.F.4
  • 81
    • 70349395917 scopus 로고    scopus 로고
    • Oligoarginine-PEG-lipid particles for gene delivery
    • Y. Maitani, and Y. Hattori Oligoarginine-PEG-lipid particles for gene delivery Expert Opin. Drug Deliv. 6 2009 1065 1077
    • (2009) Expert Opin. Drug Deliv. , vol.6 , pp. 1065-1077
    • Maitani, Y.1    Hattori, Y.2
  • 82
    • 0036784335 scopus 로고    scopus 로고
    • Translocation of liposomes into cancer cells by cell-penetrating peptides penetratin and Tat: A kinetic and efficacy study
    • Y.-L. Tseng, J.-J. Liu, and R.-L. Hong Translocation of liposomes into cancer cells by cell-penetrating peptides penetratin and Tat: a kinetic and efficacy study Mol. Pharmacol. 62 2002 864 872
    • (2002) Mol. Pharmacol. , vol.62 , pp. 864-872
    • Tseng, Y.-L.1    Liu, J.-J.2    Hong, R.-L.3
  • 86
    • 53049085052 scopus 로고    scopus 로고
    • Permeation characteristics of oligoarginine through intestinal epithelium and its usefulness for intestinal peptide drug delivery
    • N. Kamei, M. Morishita, J. Ehara, and K. Takayama Permeation characteristics of oligoarginine through intestinal epithelium and its usefulness for intestinal peptide drug delivery J. Control. Release 131 2008 94 99
    • (2008) J. Control. Release , vol.131 , pp. 94-99
    • Kamei, N.1    Morishita, M.2    Ehara, J.3    Takayama, K.4
  • 87
    • 67349268446 scopus 로고    scopus 로고
    • Importance of intermolecular interaction on the improvement of intestinal therapeutic peptide/protein absorption using cell-penetrating peptides
    • N. Kamei, M. Morishita, and K. Takayama Importance of intermolecular interaction on the improvement of intestinal therapeutic peptide/protein absorption using cell-penetrating peptides J. Control. Release 136 2009 179 186
    • (2009) J. Control. Release , vol.136 , pp. 179-186
    • Kamei, N.1    Morishita, M.2    Takayama, K.3
  • 88
    • 33847281527 scopus 로고    scopus 로고
    • A novel approach using functional peptides for efficient intestinal absorption of insulin
    • M. Morishita, N. Kamei, J. Ehara, K. Isowa, and K. Takayama A novel approach using functional peptides for efficient intestinal absorption of insulin J. Control. Release 118 2007 177 184
    • (2007) J. Control. Release , vol.118 , pp. 177-184
    • Morishita, M.1    Kamei, N.2    Ehara, J.3    Isowa, K.4    Takayama, K.5
  • 89
    • 35048856889 scopus 로고    scopus 로고
    • Cargo-dependent cytotoxicity and delivery efficacy of cell-penetrating peptides: A comparative study
    • S. El- Andaloussi, P. Jarver, H.J. Johansson, and U. Langel Cargo-dependent cytotoxicity and delivery efficacy of cell-penetrating peptides: a comparative study Biochem. J. 407 2007 285 292
    • (2007) Biochem. J. , vol.407 , pp. 285-292
    • El- Andaloussi, S.1    Jarver, P.2    Johansson, H.J.3    Langel, U.4
  • 91
    • 71749110589 scopus 로고    scopus 로고
    • Analysis of in vitro toxicity of five cell-penetrating peptides by metabolic profiling
    • K. Kilk, R. Mahlapuu, U. Soomets, and Ü. Langel Analysis of in vitro toxicity of five cell-penetrating peptides by metabolic profiling Toxicology 265 2009 87 95
    • (2009) Toxicology , vol.265 , pp. 87-95
    • Kilk, K.1    Mahlapuu, R.2    Soomets, U.3    Langel Ü.4
  • 92
    • 84871617217 scopus 로고    scopus 로고
    • Oral delivery of therapeutic protein/peptide for diabetes - Future perspectives
    • M.R. Rekha, and C.P. Sharma Oral delivery of therapeutic protein/peptide for diabetes - future perspectives Int. J. Pharm. 440 2013 48 62
    • (2013) Int. J. Pharm. , vol.440 , pp. 48-62
    • Rekha, M.R.1    Sharma, C.P.2
  • 94
    • 0032473473 scopus 로고    scopus 로고
    • The use of inhibitory agents to overcome the enzymatic barrier to perorally administered therapeutic peptides and proteins
    • A. Bernkop-Schnürch The use of inhibitory agents to overcome the enzymatic barrier to perorally administered therapeutic peptides and proteins J. Control. Release 52 1998 1 16
    • (1998) J. Control. Release , vol.52 , pp. 1-16
    • Bernkop-Schnürch, A.1
  • 95
    • 0026557582 scopus 로고
    • A phosphinic acid dipeptide analogue to stabilize peptide drugs during their intranasal absorption
    • M. Hussain, M.L. Lim, K. Raghavan, N. Rogers, R. Hidalgo, and C. Kettner A phosphinic acid dipeptide analogue to stabilize peptide drugs during their intranasal absorption Pharm. Res. 9 1992 626 628
    • (1992) Pharm. Res. , vol.9 , pp. 626-628
    • Hussain, M.1    Lim, M.L.2    Raghavan, K.3    Rogers, N.4    Hidalgo, R.5    Kettner, C.6
  • 97
    • 0029784753 scopus 로고    scopus 로고
    • Bioavailability of 1-deamino-8-d-arginine vasopressin with an enzyme inhibitor (aprotinin) from the small intestine in healthy volunteers
    • A. Fjellestad-Paulsen, L. d'Agay-Abensour, P. Höglund, and J.C. Rambaud Bioavailability of 1-deamino-8-d-arginine vasopressin with an enzyme inhibitor (aprotinin) from the small intestine in healthy volunteers Eur. J. Clin. Pharmacol. 50 1996 491 495
    • (1996) Eur. J. Clin. Pharmacol. , vol.50 , pp. 491-495
    • Fjellestad-Paulsen, A.1    D'Agay-Abensour, L.2    Höglund, P.3    Rambaud, J.C.4
  • 98
    • 0342748396 scopus 로고    scopus 로고
    • Oral peptide drug delivery: Polymer-inhibitor conjugates protecting insulin from enzymatic degradation in vitro
    • M.K. Marschütz, and A. Bernkop-Schnürch Oral peptide drug delivery: polymer-inhibitor conjugates protecting insulin from enzymatic degradation in vitro Biomaterials 21 2000 1499 1507
    • (2000) Biomaterials , vol.21 , pp. 1499-1507
    • Marschütz, M.K.1    Bernkop-Schnürch, A.2
  • 100
    • 0025966310 scopus 로고
    • Oral absorption of peptides: Influence of pH and inhibitors on the intestinal hydrolysis of Leu-enkephalin and analogues
    • D. Friedman, and G. Amidon Oral absorption of peptides: influence of pH and inhibitors on the intestinal hydrolysis of Leu-enkephalin and analogues Pharm. Res. 8 1991 93 96
    • (1991) Pharm. Res. , vol.8 , pp. 93-96
    • Friedman, D.1    Amidon, G.2
  • 101
    • 0035858298 scopus 로고    scopus 로고
    • Drug permeation enhancement via buccal route: Possibilities and limitations
    • S. Şenel, and A.A. HIncal Drug permeation enhancement via buccal route: possibilities and limitations J. Control. Release 72 2001 133 144
    • (2001) J. Control. Release , vol.72 , pp. 133-144
    • Şenel, S.1    Hincal, A.A.2
  • 102
    • 80055005118 scopus 로고    scopus 로고
    • Enhanced transbuccal salmon calcitonin (sCT) delivery: Effect of chemical enhancers and electrical assistance on in vitro sCT buccal permeation
    • D.H. Oh, K.H. Chun, S.O. Jeon, J.W. Kang, and S. Lee Enhanced transbuccal salmon calcitonin (sCT) delivery: effect of chemical enhancers and electrical assistance on in vitro sCT buccal permeation Eur. J. Pharm. Biopharm. 79 2011 357 363
    • (2011) Eur. J. Pharm. Biopharm. , vol.79 , pp. 357-363
    • Oh, D.H.1    Chun, K.H.2    Jeon, S.O.3    Kang, J.W.4    Lee, S.5
  • 103
    • 28744457833 scopus 로고    scopus 로고
    • Sublingual delivery of insulin: Effects of enhancers on the mucosal lipid fluidity and protein conformation, transport, and in vivo hypoglycemic activity
    • C.Y. Cui, W.L. Lu, L. Xiao, S.Q. Zhang, Y.B. Huang, S.L. Li, R.J. Zhang, G.L. Wang, X. Zhang, and Q. Zhang Sublingual delivery of insulin: effects of enhancers on the mucosal lipid fluidity and protein conformation, transport, and in vivo hypoglycemic activity Biol. Pharm. Bull. 28 2005 2279 2288
    • (2005) Biol. Pharm. Bull. , vol.28 , pp. 2279-2288
    • Cui, C.Y.1    Lu, W.L.2    Xiao, L.3    Zhang, S.Q.4    Huang, Y.B.5    Li, S.L.6    Zhang, R.J.7    Wang, G.L.8    Zhang, X.9    Zhang, Q.10
  • 104
    • 70349208449 scopus 로고    scopus 로고
    • Cyclodextrins and chitosan derivatives in sublingual delivery of low solubility peptides: A study using cyclosporin A, α-cyclodextrin and quaternary chitosan N-betainate
    • J. Mannila, K. Jarvinenb, J. Holappaa, L. Matilainena, S. Auriolaa, and P. Jarhoa Cyclodextrins and chitosan derivatives in sublingual delivery of low solubility peptides: a study using cyclosporin A, α-cyclodextrin and quaternary chitosan N-betainate Int. J. Pharm. 381 2009 19 24
    • (2009) Int. J. Pharm. , vol.381 , pp. 19-24
    • Mannila, J.1    Jarvinenb, K.2    Holappaa, J.3    Matilainena, L.4    Auriolaa, S.5    Jarhoa, P.6
  • 105
    • 0036103168 scopus 로고    scopus 로고
    • The evolving role of oral insulin in the treatment of diabetes using a novel RapidMist System
    • P. Modi, M. Mihic, and A. Lewin The evolving role of oral insulin in the treatment of diabetes using a novel RapidMist System Diabetes Metab. Res. 18 Suppl. 1 2002 S38 S42
    • (2002) Diabetes Metab. Res. , vol.18 , Issue.Supplement 1 , pp. 38-S42
    • Modi, P.1    Mihic, M.2    Lewin, A.3
  • 106
    • 54049114336 scopus 로고    scopus 로고
    • Delivery of insulin to the buccal mucosa utilizing the RapidMist system
    • G. Bernstein Delivery of insulin to the buccal mucosa utilizing the RapidMist system Expert Opin. Drug Deliv. 5 2008 1047 1055
    • (2008) Expert Opin. Drug Deliv. , vol.5 , pp. 1047-1055
    • Bernstein, G.1
  • 107
    • 0141518595 scopus 로고    scopus 로고
    • Systemic peptide delivery via the stomach: In vivo evaluation of an oral dosage form for salmon calcitonin
    • D. Guggi, A.H. Krauland, and A.B. Schnurch Systemic peptide delivery via the stomach: in vivo evaluation of an oral dosage form for salmon calcitonin J. Control. Release 92 2003 125 135
    • (2003) J. Control. Release , vol.92 , pp. 125-135
    • Guggi, D.1    Krauland, A.H.2    Schnurch, A.B.3
  • 108
    • 0343150936 scopus 로고    scopus 로고
    • The potential of mucoadhesive polymers in enhancing intestinal peptide drug absorption. III: Effects of chitosan-glutamate and carbomer on epithelial tight junctions in vitro
    • G. Borchard, H.L. Lueβen, A.G. de Boer, J.C. Verhoef, C.-M. Lehr, and H.E. Junginger The potential of mucoadhesive polymers in enhancing intestinal peptide drug absorption. III: effects of chitosan-glutamate and carbomer on epithelial tight junctions in vitro J. Control. Release 39 1996 131 138
    • (1996) J. Control. Release , vol.39 , pp. 131-138
    • Borchard, G.1    Lueen, H.L.2    De Boer, A.G.3    Verhoef, J.C.4    Lehr, C.-M.5    Junginger, H.E.6
  • 109
    • 0036692366 scopus 로고    scopus 로고
    • Comparative uptake studies of bioadhesive and non-bioadhesive nanoparticles in human intestinal cell lines and rats: The effect of mucus on particle adsorption and transport
    • I. Behrens, A.I. Pena, M.J. Alonso, and T. Kissel Comparative uptake studies of bioadhesive and non-bioadhesive nanoparticles in human intestinal cell lines and rats: the effect of mucus on particle adsorption and transport Pharm. Res. 19 2002 1185 1193
    • (2002) Pharm. Res. , vol.19 , pp. 1185-1193
    • Behrens, I.1    Pena, A.I.2    Alonso, M.J.3    Kissel, T.4
  • 110
    • 0036572276 scopus 로고    scopus 로고
    • The effect of enzyme inhibitor and absorption site following [D-ala2, D-leu5]enkephalin oral administration in rats
    • H.J. Lee, and G.L. Amidon The effect of enzyme inhibitor and absorption site following [D-ala2, D-leu5]enkephalin oral administration in rats Biopharm. Drug Dispos. 23 2002 131 141
    • (2002) Biopharm. Drug Dispos. , vol.23 , pp. 131-141
    • Lee, H.J.1    Amidon, G.L.2
  • 111
    • 0343962248 scopus 로고    scopus 로고
    • The role of PEG on the stability in digestive fluids and in vivo fate of PEG-PLA nanoparticles following oral administration
    • M. Tobio, A. Sanchez, A. Vila, I.I. Soriano, C. Evora, J.L. Vila-Jato, and M.J. Alonso The role of PEG on the stability in digestive fluids and in vivo fate of PEG-PLA nanoparticles following oral administration Colloids Surf. B: Biointerfaces 18 2000 315 323
    • (2000) Colloids Surf. B: Biointerfaces , vol.18 , pp. 315-323
    • Tobio, M.1    Sanchez, A.2    Vila, A.3    Soriano, I.I.4    Evora, C.5    Vila-Jato, J.L.6    Alonso, M.J.7
  • 112
    • 84884815498 scopus 로고    scopus 로고
    • Intestinal mucosa permeability following oral insulin delivery using core shell corona nanolipoparticles
    • X. Li, S. Guo, C. Zhu, Q. Zhu, Y. Gan, J. Rantanen, U.L. Rahbek, L. Hovgaard, and M. Yang Intestinal mucosa permeability following oral insulin delivery using core shell corona nanolipoparticles Biomaterials 34 2013 9678 9687
    • (2013) Biomaterials , vol.34 , pp. 9678-9687
    • Li, X.1    Guo, S.2    Zhu, C.3    Zhu, Q.4    Gan, Y.5    Rantanen, J.6    Rahbek, U.L.7    Hovgaard, L.8    Yang, M.9
  • 113
    • 84883877039 scopus 로고    scopus 로고
    • Poly(ester amide) blend microspheres for oral insulin delivery
    • P. He, H. Liu, Z. Tang, M. Deng, Y. Yang, X. Pang, and X. Chen Poly(ester amide) blend microspheres for oral insulin delivery Int. J. Pharm. 455 2013 259 266
    • (2013) Int. J. Pharm. , vol.455 , pp. 259-266
    • He, P.1    Liu, H.2    Tang, Z.3    Deng, M.4    Yang, Y.5    Pang, X.6    Chen, X.7
  • 115
    • 0033969945 scopus 로고    scopus 로고
    • Mucoadhesive dl-lactide/glycolide copolymer nanospheres coated with chitosan to improve oral delivery of elcatonin
    • Y. Kawashima, H. Yamamoto, H. Takeuchi, and Y. Kuno Mucoadhesive dl-lactide/glycolide copolymer nanospheres coated with chitosan to improve oral delivery of elcatonin Pharm. Dev. Technol. 5 2000 77 85
    • (2000) Pharm. Dev. Technol. , vol.5 , pp. 77-85
    • Kawashima, Y.1    Yamamoto, H.2    Takeuchi, H.3    Kuno, Y.4
  • 118
    • 0343488673 scopus 로고    scopus 로고
    • Intestinal secretion of drugs. the role of P-glycoprotein and related drug efflux systems in limiting oral drug absorption
    • J. Hunter, and B.H. Hirst Intestinal secretion of drugs. The role of P-glycoprotein and related drug efflux systems in limiting oral drug absorption Adv. Drug Deliv. Rev. 25 1997 129 157
    • (1997) Adv. Drug Deliv. Rev. , vol.25 , pp. 129-157
    • Hunter, J.1    Hirst, B.H.2
  • 119
    • 33845798299 scopus 로고    scopus 로고
    • Nanoemulsions as versatile formulations for paclitaxel delivery: Peroral and dermal delivery studies in rats
    • S. Khandavilli, and R. Panchagnula Nanoemulsions as versatile formulations for paclitaxel delivery: peroral and dermal delivery studies in rats J. Invest. Dermatol. 127 2006 154 162
    • (2006) J. Invest. Dermatol. , vol.127 , pp. 154-162
    • Khandavilli, S.1    Panchagnula, R.2
  • 120
    • 10044225776 scopus 로고    scopus 로고
    • Effects of particle size and surface coating on cellular uptake of polymeric nanoparticles for oral delivery of anticancer drugs
    • K. Yin Win, and S.-S. Feng Effects of particle size and surface coating on cellular uptake of polymeric nanoparticles for oral delivery of anticancer drugs Biomaterials 26 2005 2713 2722
    • (2005) Biomaterials , vol.26 , pp. 2713-2722
    • Yin Win, K.1    Feng, S.-S.2
  • 121
    • 84888436693 scopus 로고    scopus 로고
    • Maximizing gene delivery efficiencies of cationic helical polypeptides via balanced membrane penetration and cellular targeting
    • N. Zheng, L. Yin, Z. Song, L. Ma, H. Tang, N.P. Gabrielson, H. Lu, and J. Cheng Maximizing gene delivery efficiencies of cationic helical polypeptides via balanced membrane penetration and cellular targeting Biomaterials 35 2013 1302 1314
    • (2013) Biomaterials , vol.35 , pp. 1302-1314
    • Zheng, N.1    Yin, L.2    Song, Z.3    Ma, L.4    Tang, H.5    Gabrielson, N.P.6    Lu, H.7    Cheng, J.8
  • 123
    • 0035158172 scopus 로고    scopus 로고
    • Enhanced absorption of insulin and (Asu(1,7))eel-calcitonin using novel azopolymer-coated pellets for colon-specific drug delivery
    • H. Tozaki, J. Nishioka, J. Komoike, N. Okada, T. Fujita, S. Muranishi, S.I. Kim, H. Terashima, and A. Yamamoto Enhanced absorption of insulin and (Asu(1,7))eel-calcitonin using novel azopolymer-coated pellets for colon-specific drug delivery J. Pharm. Sci. 90 2001 89 97
    • (2001) J. Pharm. Sci. , vol.90 , pp. 89-97
    • Tozaki, H.1    Nishioka, J.2    Komoike, J.3    Okada, N.4    Fujita, T.5    Muranishi, S.6    Kim, S.I.7    Terashima, H.8    Yamamoto, A.9
  • 124
    • 0037139415 scopus 로고    scopus 로고
    • Colon-specific drug delivery: New approaches and in vitro/in vivo evaluation
    • L. Yang, J.S. Chu, and J.A. Fix Colon-specific drug delivery: new approaches and in vitro/in vivo evaluation Int. J. Pharm. 235 2002 1 15
    • (2002) Int. J. Pharm. , vol.235 , pp. 1-15
    • Yang, L.1    Chu, J.S.2    Fix, J.A.3
  • 125
    • 0027387020 scopus 로고
    • Vancomycin and insulin used as models for oral delivery of peptides
    • R.S. Geary, and H. Wade Schlameus Vancomycin and insulin used as models for oral delivery of peptides J. Control. Release 23 1993 65 74
    • (1993) J. Control. Release , vol.23 , pp. 65-74
    • Geary, R.S.1    Wade Schlameus, H.2
  • 126
    • 39749177298 scopus 로고    scopus 로고
    • Tricalcium phosphate delayed release formulation for oral delivery of insulin: A proof-of-concept study
    • W. Paul, and C.P. Sharma Tricalcium phosphate delayed release formulation for oral delivery of insulin: a proof-of-concept study J. Pharm. Sci. 97 2008 875 882
    • (2008) J. Pharm. Sci. , vol.97 , pp. 875-882
    • Paul, W.1    Sharma, C.P.2
  • 127
    • 84859891864 scopus 로고    scopus 로고
    • PH-responsive nanoparticles shelled with chitosan for oral delivery of insulin: From mechanism to therapeutic applications
    • H.-W. Sung, K. Sonaje, Z.-X. Liao, L.-W. Hsu, and E.-Y. Chuang pH-responsive nanoparticles shelled with chitosan for oral delivery of insulin: from mechanism to therapeutic applications Acc. Chem. Res. 45 2012 619 629
    • (2012) Acc. Chem. Res. , vol.45 , pp. 619-629
    • Sung, H.-W.1    Sonaje, K.2    Liao, Z.-X.3    Hsu, L.-W.4    Chuang, E.-Y.5
  • 128
    • 84862015268 scopus 로고    scopus 로고
    • Delivery of peptides to the blood and brain after oral uptake of quaternary ammonium palmitoyl glycol chitosan nanoparticles
    • A. Lalatsa, N.L. Garrett, T. Ferrarelli, J. Moger, A.G. Schätzlein, and I.F. Uchegbu Delivery of peptides to the blood and brain after oral uptake of quaternary ammonium palmitoyl glycol chitosan nanoparticles Mol. Pharm. 9 2012 1764 1774
    • (2012) Mol. Pharm. , vol.9 , pp. 1764-1774
    • Lalatsa, A.1    Garrett, N.L.2    Ferrarelli, T.3    Moger, J.4    Schätzlein, A.G.5    Uchegbu, I.F.6
  • 129
    • 79960595466 scopus 로고    scopus 로고
    • Physicochemical conjugation with deoxycholic acid and dimethylsulfoxide for heparin oral delivery
    • S.K. Kim, J. Huh, S.Y. Kim, Y. Byun, D.Y. Lee, and H.T. Moon Physicochemical conjugation with deoxycholic acid and dimethylsulfoxide for heparin oral delivery Bioconjug. Chem. 22 2011 1451 1458
    • (2011) Bioconjug. Chem. , vol.22 , pp. 1451-1458
    • Kim, S.K.1    Huh, J.2    Kim, S.Y.3    Byun, Y.4    Lee, D.Y.5    Moon, H.T.6
  • 130
    • 35549012407 scopus 로고    scopus 로고
    • Oral bioavailability of insulin contained in polysaccharide nanoparticles
    • B. Sarmento, A. Ribeiro, F. Veiga, D. Ferreira, and R. Neufeld Oral bioavailability of insulin contained in polysaccharide nanoparticles Biomacromolecules 8 2007 3054 3060
    • (2007) Biomacromolecules , vol.8 , pp. 3054-3060
    • Sarmento, B.1    Ribeiro, A.2    Veiga, F.3    Ferreira, D.4    Neufeld, R.5
  • 131
    • 84860720700 scopus 로고    scopus 로고
    • Colon-targeted cell-permeable NFκB inhibitory peptide is orally active against experimental colitis
    • S. Hong, S. Yum, H.-J. Yoo, S. Kang, J.-H. Yoon, D. Min, Y.M. Kim, and Y. Jung Colon-targeted cell-permeable NFκB inhibitory peptide is orally active against experimental colitis Mol. Pharm. 9 2012 1310 1319
    • (2012) Mol. Pharm. , vol.9 , pp. 1310-1319
    • Hong, S.1    Yum, S.2    Yoo, H.-J.3    Kang, S.4    Yoon, J.-H.5    Min, D.6    Kim, Y.M.7    Jung, Y.8
  • 132
    • 84899556743 scopus 로고    scopus 로고
    • Resistant starch film-coated microparticles for an oral colon-specific polypeptide delivery system and its release behaviors
    • W. Situ, L. Chen, X. Wang, and X. Li Resistant starch film-coated microparticles for an oral colon-specific polypeptide delivery system and its release behaviors J. Agric. Food Chem. 62 2014 3599 3609
    • (2014) J. Agric. Food Chem. , vol.62 , pp. 3599-3609
    • Situ, W.1    Chen, L.2    Wang, X.3    Li, X.4
  • 133
    • 84893693861 scopus 로고    scopus 로고
    • Dual-controlled oral colon-targeted delivery of bovine insulin based on mesoporous phosphonate
    • Y. Ren, X. Shi, Q. Sun, and L. Sun Dual-controlled oral colon-targeted delivery of bovine insulin based on mesoporous phosphonate Mater. Res. Bull. 48 2013 4850 4855
    • (2013) Mater. Res. Bull. , vol.48 , pp. 4850-4855
    • Ren, Y.1    Shi, X.2    Sun, Q.3    Sun, L.4
  • 136
    • 0022592643 scopus 로고
    • Aminopeptidase activity in homogenates of various absorptive mucosae m the albino rabbit: Implications in peptide delivery
    • R.E. Stratford Jr., and V.H.L. Lee Aminopeptidase activity in homogenates of various absorptive mucosae m the albino rabbit: implications in peptide delivery Int. J. Pharm. 30 1986 73 82
    • (1986) Int. J. Pharm. , vol.30 , pp. 73-82
    • Stratford, R.E.1    Lee, V.H.L.2
  • 137
    • 0026735742 scopus 로고
    • Buccal delivery for peptide drugs
    • H.P. Merkle, and G. Wolany Buccal delivery for peptide drugs J. Control. Release 21 1992 155 164
    • (1992) J. Control. Release , vol.21 , pp. 155-164
    • Merkle, H.P.1    Wolany, G.2
  • 138
    • 0037225060 scopus 로고    scopus 로고
    • Microencapsulated lipid cores for site-specific delivery of corticosteroid and peptide drugs to the colonic region
    • D. Torres, M. Rodriguez, and M. CUNA Microencapsulated lipid cores for site-specific delivery of corticosteroid and peptide drugs to the colonic region STP Pharma. Sci. 13 2003 49 56
    • (2003) STP Pharma. Sci. , vol.13 , pp. 49-56
    • Torres, D.1    Rodriguez, M.2    Cuna, M.3
  • 139
    • 0033816196 scopus 로고    scopus 로고
    • Intestinal permeation enhancers
    • B.J. Aungst Intestinal permeation enhancers J. Pharm. Sci. 89 2000 429 442
    • (2000) J. Pharm. Sci. , vol.89 , pp. 429-442
    • Aungst, B.J.1
  • 140
    • 33745096846 scopus 로고    scopus 로고
    • Colon-specific delivery and enhanced colonic absorption of [Asu(1,7)]-eel calcitonin using chitosan capsules containing various additives in rats
    • G. Fetih, H. Fausia, N. Okada, T. Fujita, M. Attia, and A. Yamamoto Colon-specific delivery and enhanced colonic absorption of [Asu(1,7)]-eel calcitonin using chitosan capsules containing various additives in rats J. Drug Target. 14 2006 165 172
    • (2006) J. Drug Target. , vol.14 , pp. 165-172
    • Fetih, G.1    Fausia, H.2    Okada, N.3    Fujita, T.4    Attia, M.5    Yamamoto, A.6
  • 142
    • 78549254833 scopus 로고    scopus 로고
    • Oral nuclear factor-kappaB decoy oligonucleotides delivery system with chitosan modified poly(d, l-lactide-co-glycolide) nanospheres for inflammatory bowel disease
    • K. Tahara, S. Samura, K. Tsuji, H. Yamamoto, Y. Tsukada, Y. Bando, H. Tsujimoto, R. Morishita, and Y. Kawashima Oral nuclear factor-kappaB decoy oligonucleotides delivery system with chitosan modified poly(d, l-lactide-co-glycolide) nanospheres for inflammatory bowel disease Biomaterials 32 2011 870 878
    • (2011) Biomaterials , vol.32 , pp. 870-878
    • Tahara, K.1    Samura, S.2    Tsuji, K.3    Yamamoto, H.4    Tsukada, Y.5    Bando, Y.6    Tsujimoto, H.7    Morishita, R.8    Kawashima, Y.9
  • 145
    • 0030457349 scopus 로고    scopus 로고
    • Transcellular delivery of an insulin-transferrin conjugate in enterocyte-like Caco-2 cells
    • D. Shah, and W.C. Shen Transcellular delivery of an insulin-transferrin conjugate in enterocyte-like Caco-2 cells J. Pharm. Sci. 85 1996 1306 1311
    • (1996) J. Pharm. Sci. , vol.85 , pp. 1306-1311
    • Shah, D.1    Shen, W.C.2
  • 146
    • 0034601281 scopus 로고    scopus 로고
    • Biodegradable nanoparticles for oral delivery of peptides: Is there a role for polymers to affect mucosal uptake?
    • T. Jung, W. Kamm, A. Breitenbach, E. Kaiserling, J.X. Xiao, and T. Kissel Biodegradable nanoparticles for oral delivery of peptides: is there a role for polymers to affect mucosal uptake? Eur. J. Pharm. Biopharm. 50 2000 147 160
    • (2000) Eur. J. Pharm. Biopharm. , vol.50 , pp. 147-160
    • Jung, T.1    Kamm, W.2    Breitenbach, A.3    Kaiserling, E.4    Xiao, J.X.5    Kissel, T.6
  • 148
    • 0036239115 scopus 로고    scopus 로고
    • Endocytosis via caveolae
    • L. Pelkmans, and A. Helenius Endocytosis via caveolae Traffic 3 2002 311 320
    • (2002) Traffic , vol.3 , pp. 311-320
    • Pelkmans, L.1    Helenius, A.2
  • 150
    • 84866688083 scopus 로고    scopus 로고
    • Folate-decorated PLGA nanoparticles as a rationally designed vehicle for the oral delivery of insulin
    • S. Jain, V.V. Rathi, A.K. Jain, M. Das, and C. Godugu Folate-decorated PLGA nanoparticles as a rationally designed vehicle for the oral delivery of insulin Nanomedicine 7 2012 1311 1337
    • (2012) Nanomedicine , vol.7 , pp. 1311-1337
    • Jain, S.1    Rathi, V.V.2    Jain, A.K.3    Das, M.4    Godugu, C.5
  • 152
    • 34447577190 scopus 로고    scopus 로고
    • Effective oral delivery of insulin in animal models using vitamin B12-coated dextran nanoparticles
    • K.B. Chalasani, G.J. Russell-Jones, A.K. Jain, P.V. Diwan, and S.K. Jain Effective oral delivery of insulin in animal models using vitamin B12-coated dextran nanoparticles J. Control. Release 122 2007 141 150
    • (2007) J. Control. Release , vol.122 , pp. 141-150
    • Chalasani, K.B.1    Russell-Jones, G.J.2    Jain, A.K.3    Diwan, P.V.4    Jain, S.K.5
  • 153
    • 33750501785 scopus 로고    scopus 로고
    • Lectin-modified solid lipid nanoparticles as carriers for oral administration of insulin
    • N. Zhang, Q. Ping, G. Huang, W. Xu, Y. Cheng, and X. Han Lectin-modified solid lipid nanoparticles as carriers for oral administration of insulin Int. J. Pharm. 327 2006 153 159
    • (2006) Int. J. Pharm. , vol.327 , pp. 153-159
    • Zhang, N.1    Ping, Q.2    Huang, G.3    Xu, W.4    Cheng, Y.5    Han, X.6
  • 154
    • 0032711921 scopus 로고    scopus 로고
    • Lectin-mediated transport of nanoparticles across Caco-2 and OK cells
    • G.J. Russell-Jones, H. Veitch, and L. Arthur Lectin-mediated transport of nanoparticles across Caco-2 and OK cells Int. J. Pharm. 190 1999 165 174
    • (1999) Int. J. Pharm. , vol.190 , pp. 165-174
    • Russell-Jones, G.J.1    Veitch, H.2    Arthur, L.3
  • 156
    • 34548828056 scopus 로고    scopus 로고
    • Preparation and evaluation of lectin-conjugated PLGA nanoparticles for oral delivery of thymopentin
    • Y. Yin, D. Chen, M. Qiao, Z. Lu, and H. Hu Preparation and evaluation of lectin-conjugated PLGA nanoparticles for oral delivery of thymopentin J. Control. Release 116 2006 337 345
    • (2006) J. Control. Release , vol.116 , pp. 337-345
    • Yin, Y.1    Chen, D.2    Qiao, M.3    Lu, Z.4    Hu, H.5
  • 157
    • 67650224017 scopus 로고    scopus 로고
    • Immunoadjuvant capacity of flagellin and mannosamine-coated poly(anhydride) nanoparticles in oral vaccination
    • H.H. Salman, J.M. Irache, and C. Gamazo Immunoadjuvant capacity of flagellin and mannosamine-coated poly(anhydride) nanoparticles in oral vaccination Vaccine 27 2009 4784 4790
    • (2009) Vaccine , vol.27 , pp. 4784-4790
    • Salman, H.H.1    Irache, J.M.2    Gamazo, C.3
  • 159
    • 0036016088 scopus 로고    scopus 로고
    • Anti-epidermal growth factor receptor drugs in cancer therapy
    • G. Tortora, and F. Ciardiello Anti-epidermal growth factor receptor drugs in cancer therapy Expert Opin. Investig. Drugs 11 2002 755 768
    • (2002) Expert Opin. Investig. Drugs , vol.11 , pp. 755-768
    • Tortora, G.1    Ciardiello, F.2
  • 161
    • 19944401541 scopus 로고    scopus 로고
    • Surface plasmon resonance scattering and absorption of anti-EGFR antibody conjugated gold nanoparticles in cancer diagnostics: Applications in oral cancer
    • I.H. El-Sayed, X. Huang, and M.A. El-Sayed Surface plasmon resonance scattering and absorption of anti-EGFR antibody conjugated gold nanoparticles in cancer diagnostics: applications in oral cancer Nano Lett. 5 2005 829 834
    • (2005) Nano Lett. , vol.5 , pp. 829-834
    • El-Sayed, I.H.1    Huang, X.2    El-Sayed, M.A.3
  • 162
    • 77956394256 scopus 로고    scopus 로고
    • Dendrimer-triglycine-EGF nanoparticles for tumor imaging and targeted nucleic acid and drug delivery
    • Q. Yuan, E. Lee, W.A. Yeudall, and H. Yang Dendrimer-triglycine-EGF nanoparticles for tumor imaging and targeted nucleic acid and drug delivery Oral Oncol. 46 2010 698 704
    • (2010) Oral Oncol. , vol.46 , pp. 698-704
    • Yuan, Q.1    Lee, E.2    Yeudall, W.A.3    Yang, H.4
  • 163
    • 65549143860 scopus 로고    scopus 로고
    • Epidermal growth factor receptor-targeted gelatin-based engineered nanocarriers for DNA delivery and transfection in human pancreatic cancer cells
    • P. Magadala, and M. Amiji Epidermal growth factor receptor-targeted gelatin-based engineered nanocarriers for DNA delivery and transfection in human pancreatic cancer cells AAPS J. 10 2008 565 576
    • (2008) AAPS J. , vol.10 , pp. 565-576
    • Magadala, P.1    Amiji, M.2
  • 164
    • 70349217470 scopus 로고    scopus 로고
    • Preparation and characterization of folate conjugated N-trimethyl chitosan nanoparticles as protein carrier targeting folate receptor: In vitro studies
    • Y. Zheng, Z. Cai, X. Song, Q. Chen, Y. Bi, Y. Li, and S. Hou Preparation and characterization of folate conjugated N-trimethyl chitosan nanoparticles as protein carrier targeting folate receptor: in vitro studies J. Drug Target. 17 2009 294 303
    • (2009) J. Drug Target. , vol.17 , pp. 294-303
    • Zheng, Y.1    Cai, Z.2    Song, X.3    Chen, Q.4    Bi, Y.5    Li, Y.6    Hou, S.7
  • 165
    • 84880362705 scopus 로고    scopus 로고
    • Biocompatible multi-walled carbon nanotube-chitosan-folic acid nanoparticle hybrids as GFP gene delivery materials
    • X. Liu, Y. Zhang, D. Ma, H. Tang, L. Tan, Q. Xie, and S. Yao Biocompatible multi-walled carbon nanotube-chitosan-folic acid nanoparticle hybrids as GFP gene delivery materials Colloids Surf. B: Biointerfaces 111 2013 224 231
    • (2013) Colloids Surf. B: Biointerfaces , vol.111 , pp. 224-231
    • Liu, X.1    Zhang, Y.2    Ma, D.3    Tang, H.4    Tan, L.5    Xie, Q.6    Yao, S.7
  • 166
    • 84867077999 scopus 로고    scopus 로고
    • Concanavalin A conjugated biodegradable nanoparticles for oral insulin delivery
    • P. Hurkat, A. Jain, A. Jain, S. Shilpi, A. Gulbake, and S. Jain Concanavalin A conjugated biodegradable nanoparticles for oral insulin delivery J. Nanopart. Res. 14 2012 1 14
    • (2012) J. Nanopart. Res. , vol.14 , pp. 1-14
    • Hurkat, P.1    Jain, A.2    Jain, A.3    Shilpi, S.4    Gulbake, A.5    Jain, S.6
  • 168
    • 38349076002 scopus 로고    scopus 로고
    • Efficient intracellular delivery of functional proteins using cationic polymer core/shell nanoparticles
    • A.L.Z. Lee, Y. Wang, W.-H. Ye, H.S. Yoon, S.Y. Chan, and Y.-Y. Yang Efficient intracellular delivery of functional proteins using cationic polymer core/shell nanoparticles Biomaterials 29 2008 1224 1232
    • (2008) Biomaterials , vol.29 , pp. 1224-1232
    • Lee, A.L.Z.1    Wang, Y.2    Ye, W.-H.3    Yoon, H.S.4    Chan, S.Y.5    Yang, Y.-Y.6
  • 169
    • 83355173904 scopus 로고    scopus 로고
    • Goblet cell-targeting nanoparticles for oral insulin delivery and the influence of mucus on insulin transport
    • Y. Jin, Y. Song, X. Zhu, D. Zhou, C. Chen, Z. Zhang, and Y. Huang Goblet cell-targeting nanoparticles for oral insulin delivery and the influence of mucus on insulin transport Biomaterials 33 2012 1573 1582
    • (2012) Biomaterials , vol.33 , pp. 1573-1582
    • Jin, Y.1    Song, Y.2    Zhu, X.3    Zhou, D.4    Chen, C.5    Zhang, Z.6    Huang, Y.7
  • 170
    • 57249094358 scopus 로고    scopus 로고
    • Evaluation of bioadhesive capacity and immunoadjuvant properties of vitamin B12-gantrez nanoparticles
    • H. Salman, C. Gamazo, P.C. Smidt, G. Russell-Jones, and J. Irache Evaluation of bioadhesive capacity and immunoadjuvant properties of vitamin B12-gantrez nanoparticles Pharm. Res. 25 2008 2859 2868
    • (2008) Pharm. Res. , vol.25 , pp. 2859-2868
    • Salman, H.1    Gamazo, C.2    Smidt, P.C.3    Russell-Jones, G.4    Irache, J.5
  • 171
    • 0035668767 scopus 로고    scopus 로고
    • Sugar-installed block copolymer micelles: Their preparation and specific interaction with lectin molecules
    • Y. Nagasaki, K. Yasugi, Y. Yamamoto, A. Harada, and K. Kataoka Sugar-installed block copolymer micelles: their preparation and specific interaction with lectin molecules Biomacromolecules 2 2001 1067 1070
    • (2001) Biomacromolecules , vol.2 , pp. 1067-1070
    • Nagasaki, Y.1    Yasugi, K.2    Yamamoto, Y.3    Harada, A.4    Kataoka, K.5
  • 172
    • 80054754759 scopus 로고    scopus 로고
    • Activation of antigen-specific T cell-responses by mannan-decorated PLGA nanoparticles
    • S. Hamdy, A. Haddadi, A. Shayeganpour, J. Samuel, and A. Lavasanifar Activation of antigen-specific T cell-responses by mannan-decorated PLGA nanoparticles Pharm. Res. 28 2011 2288 2301
    • (2011) Pharm. Res. , vol.28 , pp. 2288-2301
    • Hamdy, S.1    Haddadi, A.2    Shayeganpour, A.3    Samuel, J.4    Lavasanifar, A.5
  • 173
    • 36749076604 scopus 로고    scopus 로고
    • M-cell targeted biodegradable PLGA nanoparticles for oral immunization against hepatitis B
    • P.N. Gupta, K. Khatri, A.K. Goyal, N. Mishra, and S.P. Vyas M-cell targeted biodegradable PLGA nanoparticles for oral immunization against hepatitis B J. Drug Target. 15 2007 701 713
    • (2007) J. Drug Target. , vol.15 , pp. 701-713
    • Gupta, P.N.1    Khatri, K.2    Goyal, A.K.3    Mishra, N.4    Vyas, S.P.5
  • 174
    • 76749130541 scopus 로고    scopus 로고
    • Claudin 4-targeted protein incorporated into PLGA nanoparticles can mediate M cell targeted delivery
    • T.E. Rajapaksa, M. Stover-Hamer, X. Fernandez, H.A. Eckelhoefer, and D.D. Lo Claudin 4-targeted protein incorporated into PLGA nanoparticles can mediate M cell targeted delivery J. Control. Release 142 2010 196 205
    • (2010) J. Control. Release , vol.142 , pp. 196-205
    • Rajapaksa, T.E.1    Stover-Hamer, M.2    Fernandez, X.3    Eckelhoefer, H.A.4    Lo, D.D.5
  • 175
    • 84908200278 scopus 로고    scopus 로고
    • Development of stabilized glucomannosylated chitosan nanoparticles using tandem crosslinking method for oral vaccine delivery
    • H. Harde, A.K. Agrawal, and S. Jain Development of stabilized glucomannosylated chitosan nanoparticles using tandem crosslinking method for oral vaccine delivery Nanomedicine 2014 10.2217/nnm.13.225
    • (2014) Nanomedicine
    • Harde, H.1    Agrawal, A.K.2    Jain, S.3
  • 177
    • 84879655628 scopus 로고    scopus 로고
    • Orally delivered salmon calcitonin-loaded solid lipid nanoparticles prepared by micelle-double emulsion method via the combined use of different solid lipids
    • C. Chen, T. Fan, Y. Jin, Z. Zhou, Y. Yang, X. Zhu, Z.R. Zhang, Q. Zhang, and Y. Huang Orally delivered salmon calcitonin-loaded solid lipid nanoparticles prepared by micelle-double emulsion method via the combined use of different solid lipids Nanomedicine 8 2013 1085 1100
    • (2013) Nanomedicine , vol.8 , pp. 1085-1100
    • Chen, C.1    Fan, T.2    Jin, Y.3    Zhou, Z.4    Yang, Y.5    Zhu, X.6    Zhang, Z.R.7    Zhang, Q.8    Huang, Y.9
  • 178
    • 73549102655 scopus 로고    scopus 로고
    • Optimization of physicochemical parameters influencing the fabrication of protein-loaded chitosan nanoparticles
    • M. Vandana, and S.K. Sahoo Optimization of physicochemical parameters influencing the fabrication of protein-loaded chitosan nanoparticles Nanomedicine 4 2009 773 785
    • (2009) Nanomedicine , vol.4 , pp. 773-785
    • Vandana, M.1    Sahoo, S.K.2
  • 179
    • 79957738021 scopus 로고    scopus 로고
    • Preparation of tetanus toxoid and ovalbumin loaded gliadin nanoparticles for oral immunization
    • H. Kajal, and A. Mishra Preparation of tetanus toxoid and ovalbumin loaded gliadin nanoparticles for oral immunization J. Biomed. Nanotechnol. 7 2011 211 212
    • (2011) J. Biomed. Nanotechnol. , vol.7 , pp. 211-212
    • Kajal, H.1    Mishra, A.2
  • 180
    • 34249782272 scopus 로고    scopus 로고
    • Oral administration of peptides and proteins: Nanoparticles and cyclodextrins as biocompatible delivery systems
    • A.F. Soares, R.A. Carvalho, and F. Veiga Oral administration of peptides and proteins: nanoparticles and cyclodextrins as biocompatible delivery systems J. Biomed. Nanotechnol. 2 2007 183 202
    • (2007) J. Biomed. Nanotechnol. , vol.2 , pp. 183-202
    • Soares, A.F.1    Carvalho, R.A.2    Veiga, F.3
  • 181
    • 67649798317 scopus 로고    scopus 로고
    • Improving oral absorption of salmon calcitonin by trimyristin lipid nanoparticles
    • S. Martins, A.C. Silva, D.C. Ferreira, and E.B. Souto Improving oral absorption of salmon calcitonin by trimyristin lipid nanoparticles J. Biomed. Nanotechnol. 5 2009 76 83
    • (2009) J. Biomed. Nanotechnol. , vol.5 , pp. 76-83
    • Martins, S.1    Silva, A.C.2    Ferreira, D.C.3    Souto, E.B.4
  • 182
    • 84861469900 scopus 로고    scopus 로고
    • The in vitro and in vivo study on self-nanoemulsifying drug delivery system (SNEDDS) based on insulin-phospholipid complex
    • Q. Zhang, N. He, L. Zhang, F. Zhu, Q. Chen, Y. Qin, Z. Zhang, Q. Zhang, S. Wang, and Q. He The in vitro and in vivo study on self-nanoemulsifying drug delivery system (SNEDDS) based on insulin-phospholipid complex J. Biomed. Nanotechnol. 8 2012 90 97
    • (2012) J. Biomed. Nanotechnol. , vol.8 , pp. 90-97
    • Zhang, Q.1    He, N.2    Zhang, L.3    Zhu, F.4    Chen, Q.5    Qin, Y.6    Zhang, Z.7    Zhang, Q.8    Wang, S.9    He, Q.10
  • 184
    • 84896786646 scopus 로고    scopus 로고
    • PH sensitive thiolated cationic hydrogel for oral insulin delivery
    • T.A. Sonia, and C.P. Sharma pH sensitive thiolated cationic hydrogel for oral insulin delivery J. Biomed. Nanotechnol. 10 2014 642 650
    • (2014) J. Biomed. Nanotechnol. , vol.10 , pp. 642-650
    • Sonia, T.A.1    Sharma, C.P.2
  • 185
    • 84949141732 scopus 로고    scopus 로고
    • Available from: (Date of access: 4 August 2014)
    • Available from: http://www.accesspharma.com/product-programs/cobalamin-mediated-oral-drug-delivery/ (Date of access: 4 August 2014)
  • 186
    • 84949141733 scopus 로고    scopus 로고
    • Available from: (Date of access: 4 August 2014)
    • Available from: http://www.aphios.com/ (Date of access: 4 August 2014)
  • 187
    • 2942554010 scopus 로고    scopus 로고
    • The oral delivery of protein and peptide drugs
    • (December)
    • R. Soltero, and E. Nnochiri The oral delivery of protein and peptide drugs Innov. Pharm. Technol. 2001 106 110 (December)
    • (2001) Innov. Pharm. Technol. , pp. 106-110
    • Soltero, R.1    Nnochiri, E.2


* 이 정보는 Elsevier사의 SCOPUS DB에서 KISTI가 분석하여 추출한 것입니다.