Permeation enhancement of octreotide by specific bile salts in rats and human subjects: In vitro, in vivo correlations

British Journal of Pharmacology

Volumn 117, Issue 1, 1996, Pages 217-223

  Fricker, G ^a,c   Fahr, A ^a   Beglinger, C ^b   Kissel, T ^a,d   Reiter, G ^a   Drewe, J ^b  

^a Sandoz Pharma Ltd   (Switzerland)

^b UNIVERSITY OF BASEL   (Switzerland)

^c UNIVERSITY OF HEIDELBERG   (Germany)

^d PHILIPPS UNIVERSITY MARBURG   (Germany)

Author keywords

Chenodeoxycholic acid; Intestinal absorption; Octreotide; Ursodeoxycholic acid

Indexed keywords

BILE SALT; CHENODEOXYCHOLIC ACID; LIPOSOME; OCTREOTIDE; RUBIDIUM ION; SOMATOSTATIN DERIVATIVE; URSODEOXYCHOLIC ACID;

ADULT; AREA UNDER THE CURVE; ARTICLE; CELL CULTURE; CLINICAL TRIAL; CONTROLLED CLINICAL TRIAL; CONTROLLED STUDY; DRUG ABSORPTION; DRUG BIOAVAILABILITY; DRUG BLOOD LEVEL; GASTROINTESTINAL TRACT; HUMAN; HUMAN EXPERIMENT; INTESTINE ABSORPTION; INTRAVENOUS DRUG ADMINISTRATION; LIPID MEMBRANE; LIPID MONOLAYER; MALE; MEMBRANE PERMEABILITY; NONHUMAN; NORMAL HUMAN; ORAL DRUG ADMINISTRATION; PRIORITY JOURNAL; RANDOMIZED CONTROLLED TRIAL; RAT; VOLUNTEER;

EID: 0030048289     PISSN: 00071188     EISSN: None     Source Type: Journal    
DOI: 10.1111/j.1476-5381.1996.tb15177.x     Document Type: Article

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