N-octyl-N-Arginine chitosan micelles as an oral delivery system of insulin

Journal of Biomedical Nanotechnology

Volumn 9, Issue 4, 2013, Pages 601-609

  Zhang, Zhen Hai ^a,b   Abbad, Sarra ^b   Pan, Rui Rui ^b   Waddad, Ayman Y ^b   Hou, Lu Lu ^b   Lv, Hui Xia ^b   Zhou, Jian Ping ^b  

^a Jiangsu Provincial Academy of Chinese Medicine   (China)

^b CHINA PHARMACEUTICAL UNIVERSITY   (China)

Author keywords

Arginine Rich Polymeric Micelles; Cell Penetration Peptides; Chitosan; Insulin; N Octyl N Arginine Chitosan; Oral Administration

Indexed keywords

CELL PENETRATION; DRUG LOADING CAPACITY; HYPOGLYCEMIC EFFECT; ORAL ADMINISTRATION; ORAL INSULIN DELIVERY; ORAL PEPTIDE DELIVERY; PHARMACOLOGICAL ACTIVITY; POLYMERIC MICELLE;

ARGININE; CELLS; CHITOSAN; DIFFERENTIAL SCANNING CALORIMETRY; LOADING; MICELLES; PEPTIDES; POLYMERS; TRANSMISSION ELECTRON MICROSCOPY;

INSULIN;

ARGININE; CHITOSAN; INSULIN;

ANIMAL EXPERIMENT; ANTIDIABETIC ACTIVITY; ARTICLE; CELL STRAIN CACO 2; CELL VIABILITY; COMPLEX FORMATION; DRUG BIOAVAILABILITY; DRUG CYTOTOXICITY; DRUG DEGRADATION; DRUG DELIVERY SYSTEM; ENZYMATIC DEGRADATION; ENZYME DEGRADATION; ENZYME STABILITY; GLUCOSE BLOOD LEVEL; HYDROGEN BOND; IN VITRO STUDY; IN VIVO STUDY; INTERNALIZATION; INTESTINE FLUID; MICELLE; MOLECULAR DOCKING; NONHUMAN; PARTICLE SIZE; PH; RAT; STOMACH JUICE; TIGHT JUNCTION; TRANSPORT MEDIUM; ZETA POTENTIAL;

ADMINISTRATION, ORAL; ANIMALS; ARGININE; BIOLOGICAL TRANSPORT; BLOOD GLUCOSE; CACO-2 CELLS; CALORIMETRY, DIFFERENTIAL SCANNING; CELL DEATH; CELL SURVIVAL; CHITOSAN; DRUG DELIVERY SYSTEMS; ELECTRIC IMPEDANCE; EPITHELIAL CELLS; HUMANS; HYPOGLYCEMIC AGENTS; INSULIN; MICELLES; MICROSCOPY, ELECTRON, TRANSMISSION; MODELS, MOLECULAR; PEPSIN A; RATS; TRYPSIN;

EID: 84876583613     PISSN: 15507033     EISSN: 15507041     Source Type: Journal    
DOI: 10.1166/jbn.2013.1572     Document Type: Article

References (32)

1. C. J. Thompson, L. Tetley, and W. P. Cheng, The influence of polymer architecture on the protective effect of novel comb shaped amphiphilic poly (allylamine) against in vitro enzymatic degradation of insulin - towards oral insulin delivery. Int. J. Pharm. 383, 216 (2010).
2. M. W. Kristy, M. S. Gregory, and, A. P. Nicholas, Wheat germ agglutinin functionalized complexation hydrogels for oral insulin delivery. Biomacromolecules 9, 1293 (2008).
3. J. M. Randall, Perspective: Oral drug delivery research in Europe. J. Control Release 161, 247 (2012).
4. W. Zhiming, Z. Liying, G. Xindong, W. Jianga, L. Linga, Y. Qiana, Q. L. Kathy, and Z. Lijuan, HP55-coated capsule containing PLGA/RS nanoparticles for oral delivery of insulin. Int. J. Pharm. 425, 1 (2012).
5. Y. Lichen, D. Jieying, Z. Jing, and H. Chunbai, Polymer integrity related absorption mechanism of superporous hydrogel containing interpenetrating polymer networks for oral delivery of insulin. Biomaterials 31, 3347 (2010).
6. A. Mukerjee and V. Pruthi, Oral insulin delivery by polymeric nanospheres. J. Biomed. Nanotechnol. 3, 68 (2007).
7. F. D. Cui, K. Shi, L. Q. Zhang, A. J. Tao, and Y. Kawashima, Biodegradable nanoparticles loaded with insulin-phospholipid complex for oral delivery: Preparation, in vitro characterization and in vivo evaluation. J. Control Release 114, 242 (2006).
8. E. Amani, A. R. Mayyas, Q. Nidal, F. Asim, and B. Adnan, Formulation and characterization of an oily-based system for oral delivery of insulin. Eur. J. Pharm. Biopharm. 73, 69 (2009).
9. R. Kavitha and L. Vinod, Trans-activating transcriptional activator (TAT) peptide-mediated brain drug delivery. J. Biomed. Nanotechnol. 2, 173 (2006).
10. F. Camilla and N. H. Moerck, Cell-penetrating peptides for drug delivery across membrane barriers. J. Biomed. Nanotechnol. 13, 105 (2008).
11. C. Sung-Kee, K. M. Kaustabh, and S. L. Woo, Recent advances in cell-penetrating, non-peptide molecular carriers. Inter. J. Pharm. 354, 16 (2008).
12. M. Dongxu, S. Nianqiu, and Q. Xianrong, Distinct transduction modes of arginine-rich cell-penetrating peptides for cargo delivery into tumor cells. Int. J. Pharm. 419, 200 (2011).
13. T. Rachel and P. M. Hans, Chances and pitfalls of cell penetrating peptides for cellular drug delivery. Eur. J. Pharm. Biopharm. 58, 209 (2004).
14. T. Sara, L. C. Ana, M. Miguel, and C. P. L. Maria, Cell-penetrating peptides - Mechanisms of cellular uptake and generation of delivery systems. Pharmaceuticals 3, 961 (2010).
15. S. M. Fuchs and R. T. Raines, Pathway for polyarginine entry into mammalian cells. Biochemistry 43, 2438 (2004).
16. S. Nimesh and R. Chandra, Guanidinium-grafted polyethylenimine: An efficient transfecting agent for mammalian cells. Eur. J. Pharm. Biopharm. 68, 647 (2008).
17. N. Kamei, M. Mariko, Y. Eda, N. Ida, N. Reiji, and K. Takayama, Usefulness of cellpenetrating peptides to improve intestinal insulin absorption. J. Control Release 132, 21 (2008).
18. R. Raphael, R. Heloise, R. Anne, D. Nicolas, J. Christine, and P. Veronique, Chitosan and chitosan derivatives in drug delivery and tissue engineering. Adv. Polym. Sci. 244, 19 (2011).
19. W. Juan, T. Haining, Y. Aihua, L. Peixue, L. Hongxiang, Z. Guangxi, and W. Jun, Preparation of chitosan-based nanoparticles for delivery of low molecular weight heparin. J. Biomed. Nanotechnol. 7, 696 (2011).
20. S. Srivastava, A. Verma, B. L. Frankamp, and V. M. Rotello, Controlled assembly of protein-nanoparticle composites through protein surface recognition. Adv. Mat. 17, 617 (2005).
21. N. Joung-Pyo, C. Changyong, J. Mi-Kyeong, J. Young, N. Jae-Woon, K. Sung-Hyun, and P. Yoonkyung, Insulin-incorporated chitosan nanoparticles based on polyelectrolyte complex formation. J. Macromol. Res. 18, 630 (2010).
22. L. Huixia, Z. Zhenhai, W. Xiaopan, C. Qingqing, H. Xuhui, Z. Jianping, Z. Qiang, H. Lulu, and H. Wei, A biomimetic chitosan derivates: Preparation, characterization and transdermal enhancement studies of N-arginine chitosan. Molecules 16, 6778 (2011).
23. C. Y. Liu, R. R. Pan, T. Y. Jiang, J. P. Zhou, and H. X. Lv, Synthesis and characterization of N-octyl-N-arginine chitosan - A chitosan derivant with a mimetic structure of cell-penetrating peptides. Acta Pharm. Sin. 47, 797 (2012).
24. M. R. Huo, Y. Zhang, J. P. Zhou, A. F. Zhang, D. Yu, Y. P. Wu, J. Li, and H. Li, Synthesis and characterization of low-toxic amphiphilic chitosan derivatives and their application as micelle carrier for antitumor drug. Inter. J. Pharm. 394, 162 (2010).
25. G. Rosa, R. Iommelli, M. I. Rotonda, A. Miro, and F. Quaglia, Influence of the co-encapsulation of different non-ionic surfactants on the properties of PLGA insulin-loaded microspheres. J. Control Release 69, 283 (2000).
26. S. Mao, O. Germershaus, D. Fischer, T. Linn, R. Schnepf, and T. Kissel, Uptake and transport of PEG-graft-trimethyl-chitosan copolymer - Insulin nanocomplexes by epithelial cells. Pharm Res. 22, 2058 (2005).
27. R. J. Nakamura, J. I. Murray, N. A. Joseph M, Peppas, Morishita, and A. M. Lowman, Oral insulin delivery using P(MAA-g-EG) hydrogels: Effects of network morphology on insulin delivery characteristics. J. Control Release 95, 589 (2004).
28. H. Jianyan, Z. Lingmin, C. Peng, C. Shitao, and T. S. Qing, Transportation efficiency of insulin loaded in agarose-grafting-hyaluronan microparticle crossing Coca-2 cell monolayer. Curr. Appl. Phys. 11, 794 (2011).
29. S. Michael, B. Isabel, A. D. Lea, W. Matthias, and K. Thomas, Nanosized insulin-complexes based on biodegradable amine-modified graft polyesters poly[vinyl-3-(diethylamino)- propylcarbamate-co- (vinyl acetate)-co-(vinyl alcohol)]-graft-poly-(L-lactic acid): Protection against enzymatic degradation, interaction with Caco-2 cell monolayers, peptide transport and cytotoxicity. Eur. J. Pharm. Biopharm. 66, 165 (2007).
30. Y. Lichen, D. Jieying, F. Likun, H. Miao, C. Fuying, T. Cui, and Y. Chunhua, Beneficial properties for insulin absorption using superporous hydrogel containing interpenetrating polymer network as oral delivery vehicles. Int. J. Pharm. 350, 220 (2008).
31. M. Abdallah, T. Yuichi, and T. Hirofumi, Design and evaluation of novel pH-sensitive chitosan nanoparticles for oral insulin delivery. Eur. J. Pharm. Sci. 42, 445 (2011).
32. S. Zili, S. Nikoletta, T. Dimitris, T. Leto-Aikaterini, T. Angelos, A. Nounesis, and G. Paleos, Arginine end-functionalized poly(Llysine) dendrigrafts for the stabilization and controlled release of insulin. J. Colloid Interf. Sci. 351, 433 (2010).