The effect of enzyme inhibitor and absorption site following [D-ala2, D-leu5]enkephalin oral administration in rats

Biopharmaceutics and Drug Disposition

Volumn 23, Issue 4, 2002, Pages 131-141

  Lee, Hye J ^a   Amidon, Gordon L ^b  

^a Seoul National University   (South Korea)

^b UNIVERSITY OF MICHIGAN   (United States)

Author keywords

Enzyme inhibitor; Oral delivery; Pharmacokinetics; Site specific; YdAGdL

Indexed keywords

ACS; AMASTATIN; ENKEPHALIN[2 DEXTRO ALANINE 5 DEXTRO LEUCINE]; ENZYME INHIBITOR;

ANIMAL EXPERIMENT; ARTICLE; CONTROLLED STUDY; DOSE RESPONSE; DRUG ABSORPTION; DRUG BIOAVAILABILITY; DRUG BLOOD LEVEL; DRUG CLEARANCE; DRUG DISTRIBUTION; DRUG ELIMINATION; DRUG HALF LIFE; DRUG INHIBITION; HEART OUTPUT; MALE; NONHUMAN; RADIOMETRY; RAT; THIN LAYER CHROMATOGRAPHY;

NON-PROGRAMMATIC;

ADMINISTRATION, ORAL; ANIMALS; ANTI-BACTERIAL AGENTS; CHROMATOGRAPHY, THIN LAYER; DOSE-RESPONSE RELATIONSHIP, DRUG; ENKEPHALIN, LEUCINE-2-ALANINE; ENZYME INHIBITORS; ILEUM; INJECTIONS, INTRAVENOUS; INTESTINAL ABSORPTION; JEJUNUM; MALE; PEPTIDES; RATS; RATS, SPRAGUE-DAWLEY; TRITIUM;

EID: 0036572276     PISSN: 01422782     EISSN: None     Source Type: Journal    
DOI: 10.1002/bdd.302     Document Type: Article

References (36)

1. A month-long effect from a single injection of microencapsulated human growth hormone
2. Absorption of peptide and peptido-mimetic drugs
3. First-pass metabolism of peptide drugs in rat perfused liver
4. Estimating human oral fraction dose absorbed: A correlation using rat intestinal membrane permeability for passive and carrier-mediated compounds
5. Absorption of difficult drug molecules: Carrier-mediated transport of peptides and peptide analogues
6. Design of prodrugs for oral drug delivery
7. Biopharmaceutical properties and pharmacokinetics of peptide and protein drugs
8. Factors and strategies for improving buccal absorption of peptides
9. Transmucosal delivery systems for calcitonin: A review
10. Percutaneous absorption and dermal delivery of cyclosporin A
11. Cyclosporin A eyedrops: Manufacturing, toxicity, pharmacokinetics and indications in 2000
12. Intranasal drug delivery
13. Oral peptide delivery: Improving the systemic availability of small peptides and enkephalin analogs
14. An in vitro evaluation of metabolism and poor membrane permeation impeding intestinal absorption of leucine enkephalin, and methods to increase absorption
15. Absorption of insulin from the human small intestine
16. Release and breakdown: Postsecretory metabolism of peptides
17. Kinetic analysis of the metabolism of leucine enkephalin and analogues by rabbit intestinal brush-border enzymes: Assessment of the potential for effective oral delivery
18. The effect of carbidopa on the pharmacokinetics of intravenously administered levodopa: The mechanism of action in the treatment of parkinsonism
19. The absorption of insulin from various regions of the rat intestine
20. Gamma-glutamyl transpeptidase of rat intestine: Localization and possible role in amino acid transport
21. Distribution and biosynthesis of aminopeptidase. N and dipeptidyl aminopeptidase IV in rat small intestine
22. Peptide hydrolases of the human intestinal mucosa: Distribution of activities between brush-border and cytosol
23. Oral absorption of peptides: Influence of pH and inhibitors on the intestinal hydrolysis of leu-enkephalin and analogues
24. Evaluation of a chronically isolated intestinal loop in the rat for the study of drug absorption kinetics
25. Effective delivery of salmon calcitonin employing a surfactant, liposome and a specific absorption site in rats
26. A systemic bioavailability study of cholescystokinin octapeptide in rats: Characterization targeted delivery
27. Reversed phase thin-layer chromatography for the separation of β-lipotropin and enkephalins
28. Noncompartmental analysis based on statistical moment theory
29. Manual of microsurgery on the laboratory rat
30. Amino acid and peptide absorption in bypassed jejunum following jejunoileal bypass in rats
31. Intestinal/hepatic transport and metabolism issues for enkephalin analogues: Model pentapeptide compound with potential for oral delivery
32. Transport approaches to the biopharmaceutical design of oral drug delivery systems: Prediction of intestinal absorption
33. Plasma uptake and in vivo metabolism of [leu]enkephalin following its intraperitoneal administration to rats
34. 3H] leucine enkephalin
35. Characterization of hydrolysis of [leu]enkephalin and D-ala2-[L-leu]enkephalin in rat plasma
36. Systemic absorption of ocularly administered enkephalinamide and inulin in the albino rabbit: Extent, pathways, and vehicle effects