Drug permeation enhancement via buccal route: Possibilities and limitations

Journal of Controlled Release

Volumn 72, Issue 1-3, 2001, Pages 133-144

  Şenel, Sevda ^a   Hincal, A Atilla ^a  

^a HACETTEPE UNIVERSITY   (Turkey)

Author keywords

Bile salts; Buccal; Chitosan; Hydrocortisone; Morphine; Penetration enhancement; TGF

Indexed keywords

ACETIC ACID; ALPHA INTERFERON; ANTIINFLAMMATORY AGENT; BILE SALT; BUSERELIN; CHELATING AGENT; CHITOSAN; CYCLODEXTRIN; FATTY ACID; FATTY ACID DERIVATIVE; FLUORESCEIN ISOTHIOCYANATE; GLUCAGON LIKE PEPTIDE 1; GONADORELIN; HYDROCORTISONE; INSULIN; LAUROCAPRAM; MORPHINE; MORPHINE SULFATE; OCTREOTIDE; PENETRATION ENHANCING AGENT; PEPTIDE; SURFACTANT; TRANSFORMING GROWTH FACTOR BETA;

ARTICLE; CHEEK MUCOSA; DRUG ABSORPTION; DRUG BIOAVAILABILITY; DRUG DEGRADATION; DRUG DELIVERY SYSTEM; DRUG EFFECT; DRUG PENETRATION; DRUG SAFETY; FIRST PASS EFFECT; GASTROINTESTINAL TRACT; HUMAN; MOUTH MUCOSA; NONHUMAN; PRIORITY JOURNAL; SYSTEMIC CIRCULATION;

ADMINISTRATION, BUCCAL; ANIMALS; EXCIPIENTS; HUMANS; PERMEABILITY; PHARMACEUTICAL PREPARATIONS; PHARMACOKINETICS;

EID: 0035858298     PISSN: 01683659     EISSN: None     Source Type: Journal    
DOI: 10.1016/S0168-3659(01)00269-3     Document Type: Article

References (42)

1. In vivo evaluation of a bioadhesive buccal tablet formulation of naproxen sodium in post-operative complications of impacted third molars
2. Penetration enhancer classification
3. Permeability and metabolism as barriers to transmucosal delivery of peptides and proteins
4. Continuous flow mucosal cells for measuring in vitro permeability of small tissue samples
5. In vitro methods for measuring permeability of the oral mucosa
6. The in vitro penetration of β-blocking agents through porcine buccal epithelium
7. Buccal epithelial cell cultures as a model to study oral mucosal drug transport and metabolism
8. Oral (buccal) mucosal drug delivery - Promises and possibilities
9. New mucosal dosage form of insulin
10. Biopharmaceutic aspects of buccal absorption of insulin
11. Buccal administration of human insulin in streptozocin-diabetic rats
12. An in vivo dog model for studying recovery kinetics of the buccal mucosa permeation barrier after exposure to permeation enhancers: Apparent evidence of effective evidence enhancement without tissue damage
13. Buccal delivery for peptide drugs
14. The transmucosal absorption of recombinant human interferon-alpha B/D hybrid in the rat and rabbit
15. Oral mucosa enhanced delivery of gonadotropin-releasing hormone: (II) in vivo evaluations of GnRH-mucoadhesive devices
16. In vivo buccal delivery of the peptide drug buserelin with glycodeoxycholate as an absorption enhancer in pigs
17. Oramucosal delivery of LHRH: Pharmacokinetic studies of controlled and enhanced transmucosal permeation
18. GLP-I tablet in type 2 diabetes in fasting and postprandial conditions
19. Cellular and molecular basis of barrier function in oral epithelium
20. Structure and function of the oral mucosa and implications for drug delivery
21. Absorption barriers
22. Existence of specialized absorption mechanism for cephadroxyl, an aminocephalosporin antibiotic, in the human oral cavity
23. Effect of bile salts on the rectal absorption of sodium ampicillin in rats
24. Absorption of peptides and proteins from the respiratory tract and the potential for development of locally administered vaccine
25. The ocular route for systemic insulin delivery in the albino rabbit
26. Protease inhibitors and penetration enhancers as approaches to modify peptide absorption
27. Insulin and proinsulin proteolysis in mucosal homogenates of the albino rabbits: Implications in peptide delivery from nonoral routes
28. The effect of additives on the oral mucosal absorption of human calcitonin in rats
29. Enhancement of in vitro permeability of porcine buccal mucosa by bile salts: Kinetic and histological studies
30. Enhancement of transbuccal permeation of morphine sulfate by sodium glycodeoxycholate in vitro
31. Effects of bile salts on transport rates and routes of FIT-labelled compounds across porcine buccal epithelium in vitro
32. Examination of stratum corneum barrier function in vivo by infrared spectroscopy
33. In vitro studies on enhancing effect of sodium glycocholate on transbuccal permeation of morphine hydrochloride
34. Histological and bioadhesion studies on buccal bioadhesive tablets containing a penetration enhancer sodium glycocholate
35. In vitro/in vivo studies on buccal bioadhesive tablet formulation of carbamazepine
36. Chitosan as a novel nasal delivery system for peptide drugs
37. Chitosans and N-trimethyl chitosan chloride as absorption enhancers for nasal and rectal delivery of insulin
38. Chitosans for enhanced delivery of therapeutic peptides across intestinal epithelia: In vitro evaluation in Caco-2 cell monolayers
39. Chitosans as absorption enhancers for poorly absorbable drugs 2: Mechanism of absorption enhancement
40. Effect of chitosan in enhancing drug delivery across buccal mucosa
41. Oral mucosal drug delivery: Chitosan as vehicle and permeabilizer
42. Enhancing effect of chitosan on peptide drug delivery across buccal mucosa