Maximizing gene delivery efficiencies of cationic helical polypeptides via balanced membrane penetration and cellular targeting

Biomaterials

Volumn 35, Issue 4, 2014, Pages 1302-1314

  Zheng, Nan ^a   Yin, Lichen ^a   Song, Ziyuan ^a   Ma, Liang ^a   Tang, Haoyu ^a   Gabrielson, Nathan P ^a   Lu, Hua ^a   Cheng, Jianjun ^a  

^a University of Illinois at Urbana Champaign   (United States)

Author keywords

Helical polypeptide; Cytotoxicity; Mannose targeting; Membrane penetration; Non viral gene delivery; Self assembly

Indexed keywords

HELICAL POLYPEPTIDES; MANNOSE TARGETING; MEMBRANE PENETRATION; MEMBRANE PERMEABILITY; NON-VIRAL GENE DELIVERY; OPTIMAL FORMULATION; TARGETING CAPABILITY; TRANSFECTION EFFICIENCY;

CYTOTOXICITY; DNA; EFFICIENCY; GENE TRANSFER; LIPOSOMES; MEMBRANES; OPTIMIZATION; POLYPEPTIDES; SELF ASSEMBLY; TOXICITY; VECTORS;

MOLECULAR BIOLOGY;

CATIONIC HELICAL POLYPEPTIDE; CELL PENETRATING PEPTIDE; DNA; LIPOFECTAMINE; MANNOSE RECEPTOR; POLYPEPTIDE; UNCLASSIFIED DRUG;

ANIMAL CELL; ARTICLE; CELL MEMBRANE PERMEABILITY; CELL STRAIN COS7; CELL TYPE; CONTROLLED STUDY; CYTOTOXICITY; DNA PROTEIN COMPLEX; DRUG PENETRATION; DRUG TARGETING; DRUG UPTAKE; GENETIC TRANSFECTION; HELA CELL; HUMAN; HUMAN CELL; MACROPHAGE; MOUSE; NONHUMAN; NONVIRAL GENE DELIVERY SYSTEM; PEPTIDE SYNTHESIS; PRIORITY JOURNAL; PROTEIN ASSEMBLY;

CYTOTOXICITY; MANNOSE TARGETING; MEMBRANE PENETRATION; NON-VIRAL GENE DELIVERY; SELF-ASSEMBLY; Α-HELICAL POLYPEPTIDE;

ANIMALS; CATIONS; CELL MEMBRANE PERMEABILITY; CERCOPITHECUS AETHIOPS; COS CELLS; DNA; HELA CELLS; HUMANS; LECTINS, C-TYPE; MANNOSE-BINDING LECTINS; PEPTIDES; RECEPTORS, CELL SURFACE; TRANSFECTION;

EID: 84888436693     PISSN: 01429612     EISSN: 18785905     Source Type: Journal    
DOI: 10.1016/j.biomaterials.2013.09.090     Document Type: Article

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