Intestinal mucosa permeability following oral insulin delivery using core shell corona nanolipoparticles

Biomaterials

Volumn 34, Issue 37, 2013, Pages 9678-9687

  Li, Xiuying ^a,b   Guo, Shiyan ^a   Zhu, Chunliu ^a   Zhu, Quanlei ^a   Gan, Yong ^a   Rantanen, Jukka ^b   Rahbek, Ulrik Lytt ^c   Hovgaard, Lars ^c   Yang, Mingshi ^b  

^a SHANGHAI INSTITUTE OF MATERIA MEDICA   (China)

^b UNIVERSITY OF COPENHAGEN   (Denmark)

^c NOVO NORDISK A S   (Denmark)

Author keywords

Cellular uptake; Core shell corona; Insulin; Mucus penetrating particles; Oral protein delivery

Indexed keywords

CELLULAR INTERNALIZATION; CELLULAR UPTAKE; CHITOSAN NANOPARTICLES; CORE SHELL; ENZYMATIC DEGRADATION; EPITHELIAL PERMEABILITY; MUCUS-PENETRATING PARTICLES; ORAL PROTEIN DELIVERY;

BODY FLUIDS; CHITOSAN; DRUG PRODUCTS; NANOPARTICLES; POLYETHYLENE OXIDES; SHELLS (STRUCTURES); SUSPENSIONS (FLUIDS);

INSULIN;

CHITOSAN; CORE SHELL CORONA NANOLIPOPARTICLE; GLUCOSE; INSULIN; MACROGOL; NANOPARTICLE; POLOXAMER; PROTEIN; UNCLASSIFIED DRUG;

ANIMAL EXPERIMENT; ANIMAL MODEL; ANIMAL TISSUE; ANTIDIABETIC ACTIVITY; ARTICLE; CONTROLLED STUDY; DIABETES MELLITUS; DRUG ABSORPTION; DRUG ACCUMULATION; DRUG STABILITY; ENZYMATIC DEGRADATION; EX VIVO STUDY; GLUCOSE BLOOD LEVEL; HYDRATION; HYDROPHILICITY; ILEUM; IN VIVO STUDY; INTERNALIZATION; INTESTINE ABSORPTION; INTESTINE MUCOSA PERMEABILITY; MALE; MUCUS; NONHUMAN; PARTICLE SIZE; PRIORITY JOURNAL; RAT; ZETA POTENTIAL;

RATTUS;

CELLULAR UPTAKE; CORE SHELL CORONA; INSULIN; MUCUS PENETRATING PARTICLES; ORAL PROTEIN DELIVERY;

ADMINISTRATION, ORAL; ANIMALS; CACO-2 CELLS; CHITOSAN; DIABETES MELLITUS, EXPERIMENTAL; DRUG DELIVERY SYSTEMS; HUMANS; HYPOGLYCEMIC AGENTS; INSULIN; INTESTINAL ABSORPTION; INTESTINAL MUCOSA; MALE; NANOPARTICLES; PERMEABILITY; POLOXAMER; POLYETHYLENE GLYCOLS; RATS; RATS, SPRAGUE-DAWLEY;

EID: 84884815498     PISSN: 01429612     EISSN: 18785905     Source Type: Journal    
DOI: 10.1016/j.biomaterials.2013.08.048     Document Type: Article

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