The effect of backbone cyclization on PK/PD properties of bioactive peptide-peptoid hybrids: The melanocortin agonist paradigm

Bioorganic and Medicinal Chemistry

Volumn 18, Issue 2, 2010, Pages 580-589

  Ovadia, Oded ^a   Linde, Yaniv ^a   Haskell Luevano, Carrie ^b   Dirain, Marvin L ^b   Sheynis, Tanya ^c   Jelinek, Raz ^c   Gilon, Chaim ^a   Hoffman, Amnon ^a  

^a HEBREW UNIVERSITY OF JERUSALEM   (Israel)

^b UNIVERSITY OF FLORIDA   (United States)

^c BEN GURION UNIVERSITY OF THE NEGEV   (Israel)

Author keywords

Backbone cyclization; Melanocortin; Peptomers

Indexed keywords

HYBRID PROTEIN; MELANOCORTIN 4 RECEPTOR; MELANOCORTIN RECEPTOR AGONIST; PEPTIDE; PEPTIDOMIMETIC AGENT; PEPTOID; PEPTOMER; UNCLASSIFIED DRUG;

ANIMAL EXPERIMENT; ANIMAL TISSUE; ARTICLE; BIOLOGICAL ACTIVITY; CELL STRAIN CACO 2; CHEMICAL MODIFICATION; CONFORMATIONAL TRANSITION; CONTROLLED STUDY; CYCLIZATION; DRUG EFFECT; DRUG SCREENING; DRUG STRUCTURE; EMBRYO; HUMAN; HUMAN CELL; INTESTINE MUCOSA PERMEABILITY; MALE; NONHUMAN; PHARMACODYNAMICS; RAT;

BIOLOGICAL TRANSPORT; CACO-2 CELLS; CELL LINE; CELL MEMBRANE PERMEABILITY; CYCLIZATION; HUMANS; MOLECULAR CONFORMATION; PEPTIDE LIBRARY; PEPTIDES, CYCLIC; RECEPTOR, MELANOCORTIN, TYPE 4;

EID: 76449116488     PISSN: 09680896     EISSN: None     Source Type: Journal    
DOI: 10.1016/j.bmc.2009.12.010     Document Type: Article

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