PH-responsive nanoparticles shelled with chitosan for oral delivery of insulin: From mechanism to therapeutic applications

Accounts of Chemical Research

Volumn 45, Issue 4, 2012, Pages 619-629

  Sung, Hsing Wen ^a   Sonaje, Kiran ^a   Liao, Zi Xian ^a   Hsu, Li Wen ^a   Chuang, Er Yuan ^a  

^a NATIONAL TSING HUA UNIVERSITY   (Taiwan)

Author keywords

[No Author keywords available]

Indexed keywords

CHITOSAN; DRUG CARRIER; INSULIN; NANOPARTICLE;

ANIMAL; ARTICLE; CHEMISTRY; HUMAN; METABOLISM; ORAL DRUG ADMINISTRATION; PH;

ADMINISTRATION, ORAL; ANIMALS; CHITOSAN; DRUG CARRIERS; HUMANS; HYDROGEN-ION CONCENTRATION; INSULIN; NANOPARTICLES;

EID: 84859891864     PISSN: 00014842     EISSN: 15204898     Source Type: Journal    
DOI: 10.1021/ar200234q     Document Type: Article

References (47)

1. Owens, D. R.; Zinman, B.; Bolli, G. Alternative Routes of Insulin Delivery Diabetic Med. 2003, 20, 886-898 (Pubitemid 41701487)
2. Sood, A.; Panchagnula, R. Peroral Route: An Opportunity for Protein and Peptide Drug Delivery Chem. Rev. 2001, 101, 3275-3303 (Pubitemid 35373038)
3. Goldberg, M.; Gomez-Orellana, I. Challenges for the Oral Delivery of Macromolecules Nat. Rev. Drug Discovery 2003, 2, 289-295 (Pubitemid 37361687)
4. Morishita, M.; Goto, T.; Peppas, N. A.; Joseph, J. I.; Torjman, M. C.; Munsick, C.; Nakamura, K.; Yamagata, T.; Takayama, K.; Lowman, A. M. Mucosal Insulin Delivery Systems Based on Complexation Polymer Hydrogels: Effect of Particle Size on Insulin Enteral Absorption J. Controlled Release 2004, 97, 115-124 (Pubitemid 38624514)
5. Gong, R.; Li, C.; Zhu, S.; Zhang, Y.; Du, Y.; Jiang, J. A Novel pH-Sensitive Hydrogel Based on Dual Crosslinked Alginate/N-α-Glutaric Acid Chitosan for Oral Delivery Of Protein Carbohydr. Polym. 2011, 85, 869-874
6. Ng, K. K.; Lovell, J. F.; Zheng, G. Lipoprotein-Inspired Nanoparticles for Cancer Theranostics Acc. Chem. Res. 2011, 44, 1105-1113
7. Xie, J.; Liu, G.; Eden, H. S.; Ai, H.; Chen, X. Surface-Engineered Magnetic Nanoparticle Platforms for Cancer Imaging and Therapy Acc. Chem. Res. 2011, 44, 883-892
8. Makhlof, A.; Tozuka, Y.; Takeuchi, H. Design and Evaluation of Novel pH-Sensitive Chitosan Nanoparticles for Oral Insulin Delivery Eur. J. Pharm. Sci. 2011, 42, 445-451
9. Nellans, H. N. Mechanisms of Peptide and Protein-Absorption: (1) Paracellular Intestinal Transport-Modulation of Absorption Adv. Drug Delivery Rev. 1991, 7, 339-364
10. Sonaje, K.; Lin, K. J.; Wang, J. J.; Mi, F. L.; Chen, C. T.; Juang, J. H.; Sung, H. W. Self-Assembled pH-Sensitive Nanoparticles: A Platform for Oral Delivery of Protein Drugs Adv. Funct. Mater. 2010, 20, 3695-3700
11. Wedmore, I.; McManus, J. G.; Pusateri, A. E.; Holcomb, J. B. A Special Report on the Chitosan-Based Hemostatic Dressing: Experience in Current Combat Operations J. Trauma 2006, 60, 655-658
12. Kumar, M. N. V. R.; Muzzarelli, R. A. A.; Muzzarelli, C.; Sashiwa, H.; Domb, A. J. Chitosan Chemistry and Pharmaceutical Perspectives Chem. Rev. 2004, 104, 6017-6084 (Pubitemid 40025733)
13. Thanou, M.; Verhoef, J. C.; Junginger, H. E. Oral Drug Absorption Enhancement by Chitosan and its Derivatives Adv. Drug Delivery Rev. 2001, 52, 117-126 (Pubitemid 33079167)
14. Smith, J.; Wood, E.; Dornish, M. Effect of Chitosan on Epithelial Cell Tight Junctions Pharm. Res. 2004, 21, 43-49 (Pubitemid 38122290)
15. de la Fuente, M.; Raviña, M.; Paolicelli, P.; Sanchez, A.; Seijo, B.; Alonso, M. J. Chitosan-Based Nanostructures: A Delivery Platform for Ocular Therapeutics Adv. Drug Delivery Rev. 2010, 62, 100-117
16. Peniche, H.; Peniche, C. Chitosan nanoparticles: A Contribution to Nanomedicine Polym. Int. 2011, 60, 883-889
17. Chaudhury, A.; Das, S. Recent Advancement of Chitosan-Based Nanoparticles for Oral Controlled Delivery of Insulin and Other Therapeutic Agents AAPS PharmSciTech 2011, 12, 10-20
18. Fan, L.; Wu, H.; Zhang, H.; Li, F.; Yang, T. h.; Gu, C.h.; Yang, Q. Novel super pH-Sensitive Nanoparticles Responsive to Tumor Extracellular pH Carbohydr. Polym. 2008, 73, 390-400
19. Kean, T.; Thanou, M. Biodegradation, Biodistribution and Toxicity of Chitosan Adv. Drug Delivery Rev. 2010, 62, 3-11
20. Kiang, T.; Wen, J.; Lim, H. W.; Leong, K. W. The Effect of the Degree of Chitosan Deacetylation on the Efficiency of Gene Transfection Biomaterials 2004, 25, 5293-5301 (Pubitemid 38523332)
21. Ma, Z.; Lim, T. M.; Lim, L. Y. Pharmacological Activity of Peroral Chitosan-Insulin Nanoparticles in Diabetic Rats Int. J. Pharm. 2005, 293, 271-280 (Pubitemid 40381099)
22. Hu, Y.; Jiang, X.; Ding, Y.; Ge, H.; Yuan, Y.; Yang, C. Synthesis and Characterization of Chitosan-Poly(Acrylic Acid) Nanoparticles Biomaterials 2002, 23, 3193-3201 (Pubitemid 34525103)
23. Lin, Y. H.; Chung, C. K.; Chen, C. T.; Liang, H. F.; Chen, S. C.; Sung, H. W. Preparation of Nanoparticles Composed of Chitosan/Poly-γ-Glutamic Acid and Evaluation of Their Permeability Through Caco-2 Cells Biomacromolecules 2005, 6, 1104-1112
24. Lin, Y. H.; Mi, F. L.; Chen, C. T.; Chang, W. C.; Peng, S. F.; Liang, H. F.; Sung, H. W. Preparation and Characterization of Nanoparticles Shelled with Chitosan for Oral Insulin Delivery Biomacromolecules 2007, 8, 146-152
25. Lin, Y. H.; Chen, C. T.; Liang, H. F.; Kulkarni, A. R.; Lee, P. W.; Chen, C. H.; Sung, H. W. Novel Nanoparticles for Oral Insulin Delivery via the Paracellular Pathway Nanotechnology 2007, 18, 105102
26. Lin, Y. H.; Sonaje, K.; Lin, K. M.; Juang, J. H.; Mi, F. L.; Yang, H. W.; Sung, H. W. Multi-Ion-Crosslinked Nanoparticles with pH-Responsive Characteristics for Oral Delivery of Protein Drugs J. Controlled Release 2008, 132, 141-149
27. Mi, F. L.; Wu, Y. Y.; Lin, Y. H.; Sonaje, K.; Ho, Y. C.; Chen, C. T.; Juang, J. H.; Sung, H. W. Oral Delivery of Peptide Drugs Using Nanoparticles Self-Assembled by Poly(γ-Glutamic Acid) and a Chitosan Derivative Functionalized by Trimethylation Bioconjugate Chem. 2008, 19, 1248-1255 (Pubitemid 351874948)
28. Sonaje, K.; Lin, Y. H.; Juang, J. H.; Wey, S. P.; Chen, C. T.; Sung, H. W. In vivo Evaluation of Safety and Efficacy of Self-Assembled Nanoparticles for Oral Insulin Delivery Biomaterials 2009, 30, 2329-2339
29. Sonaje, K.; Lin, K. J.; Wey, S. P.; Lin, C. K.; Yeh, T. H.; Nguyen, H. N.; Hsu, C. W.; Yen, T. C.; Juang, J. H.; Sung, H. W. Biodistribution, Pharmacodynamics and Pharmacokinetics of Insulin Analogues in a Rat Model: Oral Delivery Using pH-Responsive Nanoparticles vs. Subcutaneous Injection Biomaterials 2010, 31, 6849-6858
30. Sonaje, K.; Chen, Y. J.; Chen, H. L.; Wey, S. P.; Juang, J. H.; Nguyen, H. N.; Hsu, C. W.; Lin, K. J.; Sung, H. W. Enteric-Coated Capsules Filled with Freeze-Dried Chitosan/Poly(γ-Glutamic Acid) Nanoparticles for Oral Insulin Delivery Biomaterials 2010, 31, 3384-3394
31. Yeh, T. H.; Hsu, L. W.; Tseng, M. T.; Lee, P. L.; Sonjae, K.; Ho, Y. C.; Sung, H. W. Mechanism and Consequence of Chitosan-Mediated Reversible Epithelial Tight Junction Opening Biomaterials 2011, 32, 6164-6173
32. Tsukita, S.; Furuse, M.; Itoh, M. Multifunctional Strands in Tight Junctions Nat. Rev. Mol. Cell. Biol. 2001, 2, 285-293 (Pubitemid 33676971)
33. Emdin, S. O.; Dodson, G. G.; Cutfield, J. M.; Cutfield, S. M. Role of Zinc in Insulin Biosynthesis. Some Possible Zinc-Insulin Interactions in the Pancreatic B-Cell Diabetologia 1980, 19, 174-182 (Pubitemid 10003175)
34. Ashiuchi, M.; Kamei, T.; Misono, H. Poly-γ-Glutamate Synthetase of Bacillus Subtilis J. Mol. Catal. B: Enzym. 2003, 23, 101-106
35. Sonaje, K.; Lin, K. J.; Tseng, M. T.; Wey, S. P.; Su, F. Y.; Chuang, E. Y.; Hsu, C. W.; Chen, C. T.; Sung, H. W. Effects of Chitosan-Nanoparticle- Mediated Tight Junction Opening on the Oral Absorption of Endotoxins Biomaterials 2011, 32, 8712-8721
36. Deacon, M. P.; McGurk, S.; Roberts, C. J.; Williams, P. M.; Tendler, S. J.; Davies, M. C.; Davis, S. S.; Harding, S. E. Atomic Force Microscopy of Gastric Mucin and Chitosan Mucoadhesive Systems Biochem. J. 2000, 348 (Pt 3) 557-563 (Pubitemid 30410244)
37. Flynn, A. N.; Itani, O. A.; Moninger, T. O.; Welsh, M. J. Acute Regulation of Tight Junction Ion Selectivity in Human Airway Epithelia Proc. Natl. Acad. Sci. U.S.A. 2009, 106, 3591-3596
38. Lus Basic Toxicology: Fundamentals, Target Organs, and Risk Assessment, 5 th ed.; Lu, F. C.; Kacew, S., Eds.; Informa Healthcare, New York, NY, 2009; pp 15-28.
39. Li, G.; Liu, Y.; Tzeng, N.; Cui, G.; Block, M. L.; Wilson, B.; Qin, L.; Wang, T.; Liu, B.; Liu, J.; Hong, J. S. Protective Effect of Dextromethorphan Against Endotoxic Shock in Mice Biochem. Pharmacol. 2005, 69, 233-240 (Pubitemid 41556569)
40. Slieker, L. J.; Roberts, E. F.; Shaw, W. N.; Johnson, W. T. Effect of Streptozocin-Induced Diabetes on Insulin-Receptor Tyrosine Kinase Activity in Obese Zucker Rats Diabetes 1990, 39, 619-625 (Pubitemid 20223790)
41. Khan, M. Z. I.; Prebeg, Z.; Kurjakovic, N. A pH-dependent colon targeted oral drug delivery system using methacrylic acid copolymers. I. Manipulation of drug release using Eudragit® L100-55 and Eudragit® S100 combinations J. Controlled Release 1999, 58, 215-222 (Pubitemid 29112892)
42. Nguyen, H. N.; Wey, S. P.; Juang, J. H.; Sonaje, K.; Ho, Y. C.; Chuang, E. Y.; Hsu, C. W.; Yen, T. C.; Lin, K. J.; Sung, H. W. The Glucose-Lowering Potential of Exendin-4 Orally Delivered via a pH-Sensitive Nanoparticle Vehicle and Effects on Subsequent Insulin Secretion in vivo Biomaterials 2011, 32, 2673-2682
43. Chen, M. C.; Wong, H. S.; Lin, K. J.; Chen, H. L.; Wey, S. P.; Sonaje, K.; Lin, Y. H.; Chu, C. Y.; Sung, H. W. The Characteristics, Biodistribution and Bioavailability of a Chitosan-Based Nanoparticulate System for the Oral Delivery of Heparin Biomaterials 2009, 30, 6629-6637
44. Ding, X.; Saxena, N. K.; Lin, S.; Gupta, N. A.; Anania, F. A. Exendin-4, a Glucagon-Like Protein-1 (GLP-1) Receptor Agonist, Reverses Hepatic Steatosis in ob/ob Mice Hepatology 2006, 43, 173-181 (Pubitemid 43733604)
45. Norris, S. L.; Lee, N.; Thakurta, S.; Chan, B. K. Exenatide Efficacy and Safety: A Systematic Review Diabetic Med. 2009, 26, 837-846
46. Gedulin, B. R.; Smith, P. A.; Jodka, C. M.; Chen, K.; Bhavsar, S.; Nielsen, L. L.; Parkes, D. G.; Young, A. A. Pharmacokinetics and Pharmacodynamics of Exenatide Following Alternate Routes of Administration Int. J. Pharm. 2008, 356, 231-238
47. Hirsh, J. Low-Molecular-Weight Heparin: A Review of the Results of Recent Studies of the Treatment of Venous Thromboembolism and Unstable Angina Circulation 1998, 98, 1575-1582 (Pubitemid 28481675)