Oral peptide drug delivery: Polymer-inhibitor conjugates protecting insulin from enzymatic degradation in vitro

Biomaterials

Volumn 21, Issue 14, 2000, Pages 1499-1507

  Marschütz, Michaela K ^a   Bernkop Schnürch, Andreas ^a  

^a UNIVERSITY OF VIENNA   (Austria)

Author keywords

Enzymatic degradation; Insulin delivery; Protective effect; Sodium carboxymethylcellulose derivatives

Indexed keywords

BIODEGRADATION; CELLULOSE DERIVATIVES; CONTROLLED DRUG DELIVERY; ENZYME INHIBITION; INSULIN; METABOLISM; PHYSIOLOGICAL MODELS; PLASTIC ADHESIVES; POLYPEPTIDES;

ENZYMATIC DEGRADATION; INSULIN DELIVERY; ORAL PEPTIDE DRUG DELIVERY; SODIUM CARBOXYMETHYLCELLULOSE DERIVATIVES;

BIOMATERIALS;

BOWMAN BIRK INHIBITOR; CARBOXYMETHYLCELLULOSE; CHYMOTRYPSIN; DRUG CARRIER; ELASTASE; ELASTATINAL; ENZYME INHIBITOR; INSULIN; PEPTIDE; POLYMER; SERINE PROTEINASE; TISSUE ADHESIVE; TRYPSIN;

ARTICLE; CONJUGATE; CONTROLLED STUDY; COVALENT BOND; DEGRADATION; DRUG DELIVERY SYSTEM; DRUG STABILITY; ENZYME INHIBITION; IN VITRO STUDY; MATRIX TABLET; ORAL DRUG ADMINISTRATION; PRIORITY JOURNAL; PROTECTION;

ADMINISTRATION, ORAL; AMINO ACID SEQUENCE; BIOCOMPATIBLE MATERIALS; CARBOXYMETHYLCELLULOSE; CHYMOTRYPSIN; DRUG CARRIERS; INDICATORS AND REAGENTS; INSULIN; KINETICS; MODELS, MOLECULAR; MOLECULAR SEQUENCE DATA; OLIGOPEPTIDES; PANCREATIC ELASTASE; PEPTIDES; PROTEIN BINDING; PROTEIN CONFORMATION; SERINE PROTEINASE INHIBITORS; TRYPSIN; TRYPSIN INHIBITOR, BOWMAN-BIRK SOYBEAN;

EID: 0342748396     PISSN: 01429612     EISSN: None     Source Type: Journal    
DOI: 10.1016/S0142-9612(00)00039-9     Document Type: Article

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