Mucoadhesive DL-lactide/glycolide copolymer nanospheres coated with chitosan to improve oral delivery of elcatonin

Pharmaceutical Development and Technology

Volumn 5, Issue 1, 2000, Pages 77-85

  Kawashima, Yoshiaki ^a   Yamamoto, Hiromitsu ^a   Takeuchi, Hirofumi ^a   Kuno, Yoshio ^a  

^a GIFU PHARMACEUTICAL UNIVERSITY   (Japan)

Author keywords

Chitosan; Elcatonin; Mucoadhesiveness; Nanosphere; PLGA; Solvent diffusion method

Indexed keywords

CHITIN; ELCATONIN; NANOPARTICLE; POLYGLACTIN;

ADHESION; ANIMAL EXPERIMENT; ANIMAL TISSUE; ARTICLE; CALCIUM BLOOD LEVEL; CONTROLLED STUDY; DRUG ABSORPTION; DRUG COATING; DRUG DELIVERY SYSTEM; DRUG RELEASE; EMULSION; NONHUMAN; PARTICLE SIZE; PRIORITY JOURNAL; RAT;

ACRYLIC RESINS; ADMINISTRATION, ORAL; ALGINATES; ANIMALS; BIOCOMPATIBLE MATERIALS; CALCITONIN; CALCIUM; CHELATING AGENTS; CHITIN; CHITOSAN; DELAYED-ACTION PREPARATIONS; DIGESTIVE PHYSIOLOGY; DRUG DELIVERY SYSTEMS; FLUORESCEIN-5-ISOTHIOCYANATE; GLUCURONIC ACID; HEXURONIC ACIDS; INTUBATION; LACTIC ACID; MALE; MICROSPHERES; POLYGLYCOLIC ACID; POLYMERS; RATS; RATS, WISTAR; TABLETS, ENTERIC-COATED; TIME FACTORS;

EID: 0033969945     PISSN: 10837450     EISSN: None     Source Type: Journal    
DOI: 10.1081/PDT-100100522     Document Type: Article

References (21)

1. B. Dortunc, L. Ozer, and N. Uyanik, Development and in vitro evaluation of a buccoadhesive pindolol tablet formulation, Drug Dev. Ind. Pharm., 24(3), 281-288 (1998).
2. M. A. Longer, H. S. Ch'ng, and J. R. Robinson, Bioadhesive polymers as plalforms for oral controlled drug delivery III: Oral delivery of chlorothiazide using a bioadhesive polymer, J. Pharm. Sci., 74(4), 406-411 (1985).
3. Y. Machida, Development of topical drug delivery systems utilizing polymeric materials, Yakugaku Zasshi, 113(5), 356-368 (1993).
4. H. Takeuchi, H. Yamamoto, T. Niwa, T. Hino, and Y. Kawashima, Enteral absorption of insulin in rats from mucoadhesive chitosan-coated liposomes, Pharm. Res., 13(6), 896-901 (1996).
5. J. P. Bai, L. L. Chang, and J. H. Guo, Effects of polyacrylic polymers on the degradation of insulin and peptide drugs by chymotrypsin and trypsin, J. Pharm. Pharmacol., 48(1), 17-21 (1996).
6. C. M. Lehr, J. A. Bouwstra, W. Kok, A. G. De Boer, J. J. Tukker, J. C. Verhoef, D. D. Breimer, and H. E. Junginger, Effects of the mucoadhesive polymer polycarbophil on the intestinal absorption of a peptide drug in the rat, J. Pharm. Pharmacol., 44(5), 402-407 (1992).
7. C. Damge, C. Michel, M. Aprahamian, and P. Couvreur, New approach for oral administration of insulin with polyalkylcyanoacrylate nanocapsules as drug carrier, Diabetes, 37(2), 246-251 (1988).
8. G. Ponchel, M. J. Montisci, A. Dembri, C. Durrer, and D. Duchêne, Mucoadhesion of colloidal particulate system in the gastro-intestinal tract, Eur. J. Pharm. Biopharm, 44, 25-31 (1997).
9. S. Miyazaki, A. Nakayama, M. Oda, M. Takada, and D. Attwood, Chitosan and sodium alginate based bioadhesive tablets for intraoral drug delivery, Biol. Pharm. Bull., 17(5), 745-747 (1994).
10. A. Bernkop-Schnurch and M. Pasta, Intestinal peptide and protein delivery: novel bioadhesive drug-carrier matrix shielding from enzymatic attack, J. Pharm. Sci., 87(4), 430-434 (1998).
11. E. E. Hassan and J. M. Gallo, A simple rheological method for the in vitro assessment of mucin-polymer bi-adhesive bond strength, Pharm. Res., 7(5), 491 -495 (1990).
12. P. Esposito, I. Colombo, and M. Lovrecich, Investigation of surface properties of some polymers by a thermodynamic and mechanical approach: possibility of predicting mucoadhesion and biocompatibility, Biomaterials, 15(3), 177-182 (1994).
13. C. Li, P. P. Bhatt, and T. P. Johnston, Evaluation of a mucoadhesive buccal patch for delivery of peptides: in vitro screening of bioadhesion. Drug Dev. Ind. Pharm., 24(10), 919-926 (1998).
14. E. Ilan, S. Amseleni, M. Weisspapir, J. Schwarz, A. Yogev, E. Zawoznik, and D. Friedman, Improved oral delivery of desmopressin via a novel vehicle: mucoadhesive submicron emulsion, Pharm. Res., 13(7), 1083-1087 (1996).
15. Y. Akiyama, N. Nagahara, T. Kashihara, S. Hirai, and H. Toguchi, In vitro and in vivo evaluation of mucoadhesive microspheres prepared for the gastrointestinal tract using polyglycerol esters of fatty acids and a poly(acrylic acid) derivative. Pharm. Res., 12(3), 397-405 (1995).
16. N. Hussain, P. U. Jani, A. T. Florence, Enhanced oral uptake of tomato lectin-conjugated nanoparticles in the rat, Pharm. Res., 14(5), 613-618 (1997).
17. J. M. Irache, C. Durrer, D. Duchene, and G. Ponchel, Bioadhesion of lectin-latex conjugates to rat intestinal mucosa, Pharm. Res., 13(11), 1716-1719 (1996).
18. Y. Ogawa, H. Okada, M. Yamamoto, and T. Shimamoto, In vivo release profiles of leuprolide acetate from microcapsules prepared with polylactic acids or copoly(lactic/ glycolic) acids and in vivo degradation of these polymers, Chem. Pharm. Bull., 36(4), 1095-1103 (1988).
19. Y. Kawashima, H. Yamamoto, H. Takeuchi, T. Hino, and H. Niwa, Properties of a peptide containing DL-lactide/ glycolide copolymer nanospheres prepared by novel emulsion solvent diffusion methods, Eur. J. Pharm. Biopharm., 45(1), 41-48 (1998).
20. Y. Nogata, Y. Yamamoto, T. Sakurada, T. Noda, S. Katsuragi, M. Hayashi, I. Takada, and S. Watanabe, Physicochemical properties and assay of elcatonin, Iyakuhin Kenkyu, 13(1), 334-339 (1982).
21. S. Sakuma, N. Suzuki, H. Kikuchi, K. Hiwatari, K. Arikawa, A. Kishida, and M. Akashi, Oral peptide delivery using nanoparticles composed of novel graft copolymers having hydrophobic backbone and hydrophilic branches, Int. J. Pharm., 149(1), 93-106 (1997).