Delivery of peptides to the blood and brain after oral uptake of quaternary ammonium palmitoyl glycol chitosan nanoparticles

Molecular Pharmaceutics

Volumn 9, Issue 6, 2012, Pages 1764-1774

  Lalatsa, A ^a   Garrett, N L ^b   Ferrarelli, T ^a,d   Moger, J ^b   Schatzlein A G ^a,c   Uchegbu, I F ^a,c  

^a UNIVERSITY OF LONDON   (United Kingdom)

^b UNIVERSITY OF EXETER   (United Kingdom)

^c NANOMERICS LTD   (United Kingdom)

^d UNIVERSITY OF CALABRIA   (Italy)

Author keywords

biodistribution; CARS microscopy; chitosan amphiphiles; chitosan nanoparticles; GCPQ; leucine5 enkephalin; molecular weight; nanoparticle oral uptake; oral peptide delivery; quaternary ammonium palmitoyl glycol chitosan

Indexed keywords

CHITOSAN DERIVATIVE; LEUCINE ENKEPHALIN; NANOPARTICLE; QUATERNARY AMMONIUM PALMITOYL GLYCOL CHITOSAN NANOPARTICLE 10; QUATERNARY AMMONIUM PALMITOYL GLYCOL CHITOSAN NANOPARTICLE 14; QUATERNARY AMMONIUM PALMITOYL GLYCOL CHITOSAN NANOPARTICLE 50; QUATERNARY AMMONIUM PALMITOYL GLYCOL CHITOSAN NANOPARTICLE 6; UNCLASSIFIED DRUG;

ANIMAL CELL; ANIMAL EXPERIMENT; ANIMAL MODEL; ANIMAL TISSUE; ARTICLE; BIODEGRADATION; BLOOD BRAIN BARRIER; CONTROLLED STUDY; DRUG DELIVERY SYSTEM; DRUG DISTRIBUTION; GALLBLADDER; GASTROINTESTINAL ABSORPTION; IMAGING SYSTEM; INTESTINE CELL; MALE; MOLECULAR WEIGHT; MOUSE; NONHUMAN; PRIORITY JOURNAL; RAMAN SPECTROMETRY;

ADMINISTRATION, ORAL; ANIMALS; BRAIN; CHITOSAN; MALE; MICE; MICE, INBRED BALB C; MOLECULAR WEIGHT; NANOPARTICLES; PEPTIDES; QUATERNARY AMMONIUM COMPOUNDS;

EID: 84862015268     PISSN: 15438384     EISSN: 15438392     Source Type: Journal    
DOI: 10.1021/mp300068j     Document Type: Article

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