Poly(ester amide) blend microspheres for oral insulin delivery

International Journal of Pharmaceutics

Volumn 455, Issue 1-2, 2013, Pages 259-266

  He, Pan ^a,d   Liu, Huaiyu ^c   Tang, Zhaohui ^a   Deng, Mingxiao ^b   Yang, Yan ^c   Pang, Xuan ^a   Chen, Xuesi ^a  

^a CHANGCHUN INSTITUTE OF APPLIED CHEMISTRY   (China)

^b NORTHEAST NORMAL UNIVERSITY   (China)

^c JILIN UNIVERSITY   (China)

^d UNIVERSITY OF CHINESE ACADEMY OF SCIENCES   (China)

Author keywords

Blend microspheres; Oral insulin delivery; pH sensitivity; Poly(ester amide)

Indexed keywords

AMIDE; DRUG CARRIER; GLUCOSE; INSULIN; MICROSPHERE; POLY(ESTER AMIDE); UNCLASSIFIED DRUG;

ANIMAL EXPERIMENT; ANIMAL MODEL; AREA UNDER THE CURVE; ARTICLE; CONTROLLED DRUG RELEASE; CONTROLLED STUDY; DRUG ABSORPTION; DRUG BIOAVAILABILITY; DRUG DISTRIBUTION; DRUG SCREENING; GLUCOSE BLOOD LEVEL; HYDROPHOBICITY; INSULIN BLOOD LEVEL; INSULIN RELEASE; INTESTINE ABSORPTION; MALE; NONHUMAN; PH; PRIORITY JOURNAL; RAT; STOMACH JUICE; STREPTOZOCIN DIABETES;

ARG-PEA; ARGININE-BASED POLY(ESTER AMIDE); BLEND MICROSPHERES; BLEND MICROSPHERES CONTAINING 30% ARG-PEA AND 70% L0.2 BY WEIGHT; CLSM; DIMETHYL ACETAMIDE; DIMETHYL SULFOXIDE; DMA; DMF; DMSO; EE; ENCAPSULATION EFFICIENCY; ENVIRONMENTAL SCANNING ELECTRON MICROSCOPY; ESEM; FITC; FLUORESCEIN ISOTHIOCYANATE; GASTROINTESTINAL; GI; L0.2; L0.2-30A; LASER SCANNING CONFOCAL MICROSCOPY; N,N-DIMETHYLFORMAMIDE; ORAL INSULIN DELIVERY; P(MAA-G-EG); PEA; PEA-COOH; PEA-COOH WITH 20% (MOLAR CONTENT) OF LEUCINE-BASED MONOMER; PH SENSITIVITY; POLY(ESTER AMIDE); POLY(ESTER AMIDE) WITH PENDANT COOH GROUPS; POLY(METHACRYLIC-G-ETHYLENE GLYCOL); S/O/O; SC; SCANNING ELECTRON MICROSCOPY; SDS; SEM; SODIUM DODECYL SULPHATE; SOLID-IN-OIL-IN-OIL; SORBITAN SESQUIOLEATE; SPAN83; STREPTOZOTOCIN; STZ; SUBCUTANEOUS;

ADMINISTRATION, ORAL; ANIMALS; ARGININE; BIOLOGICAL AVAILABILITY; DIABETES MELLITUS, EXPERIMENTAL; HYPOGLYCEMIC AGENTS; INSULIN; LEUCINE; LYSINE; MALE; MICROSPHERES; NYLONS; POLYESTERS; RATS; RATS, WISTAR;

EID: 84883877039     PISSN: 03785173     EISSN: 18733476     Source Type: Journal    
DOI: 10.1016/j.ijpharm.2013.07.022     Document Type: Article

References (41)

1. Babu, V.R., Patel, P., Mundargi, R.C., Rangaswamy, V., Aminabhavi, T.M., 2008. Developments in polymeric devices for oral insulin delivery. Expert Opin. Drug Deliv. 5, 403-415. (Pubitemid 351721720)
2. Blanchette, J., Kavimandan, N., Peppas, N.A., 2004. Principles of transmucosal delivery of therapeutic agents. Biomed. Pharmacother. 58, 142-151. (Pubitemid 38479918)
3. Chaturvedi, K., Ganguly, K., Nadagouda, M.N., Aminabhavi, T.M., 2013. Polymeric hydrogels for oral insulin delivery. J. Control. Release 165, 129-138.
4. Chen, M.-C., Sonaje, K., Chen, K.-J., Sung, H.-W., 2011. A review of the prospects for polymeric nanoparticle platforms in oral insulin delivery. Biomaterials 32, 9826-9838.
5. Cheng, J., Teply, B.A., Jeong, S.Y., Yim, C.H., Ho, D., Sherifi, I., Jon, S., Farokhzad, O.C., Khademhosseini, A., Langer, R.S., 2006. Magnetically responsive polymeric microparticles for oral delivery of protein drugs. Pharm. Res. 23, 557-564.
6. Cui, F.D., Tao, A.J., Cun, D.M., Zhang, L.Q., Shi, K., 2007. Preparation of insulin loaded PLGA-Hp55 nanoparticles for oral delivery. J. Pharm. Sci. 96, 421-427. (Pubitemid 46363571)
7. Deng, M., Wu, J., Reinhart-King, C.A., Chu, C.C., 2009. Synthesis and characterization of biodegradable poly(ester amide)s with pendant amine functional groups and in vitro cellular response. Biomacromolecules 10, 3037-3047.
8. Deng, M., Wu, J., Reinhart-King, C.A., Chu, C.C., 2011. Biodegradable functional poly(ester amide)s with pendant hydroxyl functional groups: synthesis, characterization, fabrication and in vitro cellular response. Acta Biomater. 7, 1504-1515.
9. Goldberg, M., Gomez-Orellana, I., 2003. Challenges for the oral delivery of macromolecules. Nat. Rev. Drug Discov. 2, 289-295. (Pubitemid 37361687)
10. Gordon Still, J., 2002. Development of oral insulin: progress and current status. Diabetes Metab. Res. Rev. 18, S29L 37.
11. Guo, K., Chu, C.C., 2009. Biodegradable and injectable paclitaxel-loaded poly(ester amide)s microspheres: fabrication and characterization. J. Biomed. Mater. Res. B: Appl. Biomater. 89, 491-500.
12. Han, Y., Tian, H., He, P., Chen, X., Jing, X., 2009. Insulin nanoparticle preparation and encapsulation into poly(lactic-co-glycolic acid) microspheres by using an anhydrous system. Int. J. Pharm. 378, 159-166.
13. He, P., Tang, Z., Lin, L., Deng, M., Pang, X., Zhuang, X., Chen, X., 2012. Novel biodegradable and pH-sensitive poly(ester amide) microspheres for oral insulin delivery. Macromol. Biosci. 12, 547-556.
14. Hoffman, A., Ziv, E., 1997. Pharmacokinetic considerations of new insulin formulations and routes of administration. Clin. Pharmacokinet. 33, 285-301. (Pubitemid 27429895)
15. Holowka, E.P., Sun, V.Z., Kamei, D.T., Deming, T.J., 2007. Polyarginine segments in block copolypeptides drive both vesicular assembly and intracellular delivery. Nat. Mater. 6, 52-57. (Pubitemid 46041477)
16. Jose, S., Fangueiro, J.F., Smitha, J., Cinu, T.A., Chacko, A.J., Premaletha, K., Souto, E.B., 2012. Cross-linked chitosan microspheres for oral delivery of insulin: Taguchi design and in vivo testing. Colloids Surf. B: Biointerfaces 92, 175-179.
17. Khafagy, E.-S., Morishita, M., Ida, N., Nishio, R., Isowa, K., Takayama, K., 2010. Structural requirements of penetratin absorption enhancement efficiency for insulin delivery. J. Control. Release 143, 302-310.
18. Khafagy el, S., Morishita, M., Onuki, Y., Takayama, K., 2007. Current challenges in non-invasive insulin delivery systems: a comparative review. Adv. Drug Deliv. Rev. 59, 1521-1546.
19. Lowman, A.M., Morishita, M., Kajita, M., Nagai, T., Peppas, N.A., 1999. Oral delivery of insulin using pH-responsive complexation gels. J. Pharm. Sci. 88, 933-937. (Pubitemid 29438959)
20. Morishita, M., Goto, T., Nakamura, K., Lowman, A.M., Takayama, K., Peppas, N.A., 2006. Novel oral insulin delivery systems based on complexation polymer hydrogels: single and multiple administration studies in type 1 and 2 diabetic rats. J. Control. Release 110, 587-594.
21. Morishita, M., Kamei, N., Ehara, J., Isowa, K., Takayama, K., 2007. A novel approach using functional peptides for efficient intestinal absorption of insulin. J. Control. Release 118, 177-184. (Pubitemid 46329737)
22. Muller, G., 2011. Oral delivery of protein drugs: driver for personalized medicine. Curr. Issues Mol. Biol. 13, 13-24.
23. Mundargi, R.C., Rangaswamy, V., Aminabhavi, T.M., 2011a. pH-sensitive oral insulin delivery systems using Eudragit microspheres. Drug Dev. Ind. Pharm. 37, 977-985.
24. Mundargi, R.C., Rangaswamy, V., Aminabhavi, T.M., 2011b. Poly(N-vinylcaprolactam-co-methacrylic acid) hydrogel microparticles for oral insulin delivery. J. Microencapsul. 28, 384-394.
25. Nishihata, T., Rytting, J.H., Kamada, A., Higuchi, T., 1981. Enhanced intestinal absorption of insulin in rats in the presence of sodium 5-methoxysalicylate. Diabetes 30, 1065-1067.
26. Pang, X., Chu, C.C., 2010. Synthesis, characterization and biodegradation of functionalized amino acid-based poly(ester amide)s. Biomaterials 31, 3745-3754.
27. Radwant, M.A., Aboul-Enein, H.Y., 2002. The effect of oral absorption enhancers on the in vivo performance of insulin-loaded poly(ethylcyanoacrylate) nanospheres in diabetic rats. J. Microencapsul. 19, 225-235. (Pubitemid 34100615)
28. Renukuntla, J., Vadlapudi, A.D., Patel, A., Boddu, S.H., Mitra, A.K., 2013. Approaches for enhancing oral bioavailability of peptides and proteins. Int. J. Pharm. 447, 75-93.
29. Rojas, E.C., Papadopoulos, K.D., 2007. Induction of instability in water-in-oil-in-water double emulsions by freeze-thaw cycling. Langmuir 23, 6911-6917. (Pubitemid 47143208)
30. Sah, H., 1997. A new strategy to determine the actual protein content of poly(lactide-co-glycolide) microspheres. J. Pharm. Sci. 86, 1315-1318. (Pubitemid 27486108)
31. Sarmento, B., Martins, S., Ferreira, D., Souto, E.B., 2007. Oral insulin delivery by means of solid lipid nanoparticles. Int. J. Nanomed. 2, 743-749.
32. Sonia, T.A., Sharma, C.P., 2012. An overview of natural polymers for oral insulin delivery. Drug Discov. Today 17, 784-792.
33. Su, F.Y., Lin, K.J., Sonaje, K., Wey, S.P., Yen, T.C., Ho, Y.C., Panda, N., Chuang, E.Y., Maiti, B., Sung, H.W., 2012. Protease inhibition and absorption enhancement by functional nanoparticles for effective oral insulin delivery. Biomaterials 33, 2801-2811.
34. Sung, H.W., Sonaje, K., Liao, Z.X., Hsu, L.W., Chuang, E.Y., 2012. pH-responsive nanoparticles shelled with chitosan for oral delivery of insulin: from mechanism to therapeutic applications. Acc. Chem. Res. 45, 619-629.
35. Teply, B.A., Tong, R., Jeong, S.Y., Luther, G., Sherifi, I., Yim, C.H., Khademhosseini, A., Farokhzad, O.C., Langer, R.S., Cheng, J., 2008. The use of charge-coupled polymeric microparticles and micromagnets for modulating the bioavailability of orally delivered macromolecules. Biomaterials 29, 1216-1223.
36. Thompson, C.J., Tetley, L., Cheng, W.P., 2010. The influence of polymer architecture on the protective effect of novel comb shaped amphiphilic poly(allylamine) against in vitro enzymatic degradation of insulin-towards oral insulin delivery. Int. J. Pharm. 383, 216-227.
37. Whiting, D.R., Guariguata, L., Weil, C., Shaw, J., 2011. IDF diabetes atlas: global estimates of the prevalence of diabetes for 2011 and 2030. Diabetes Res. Clin. Pract. 94, 311-321.
38. Wu, J., Mutschler, M.A., Chu, C.C., 2011. Synthesis and characterization of ionic charged water soluble arginine-based poly(ester amide). J. Mater. Sci. Mater. Med. 22, 469-479.
39. Wu, Z.M., Zhou, L., Guo, X.D., Jiang, W., Ling, L., Qian, Y., Luo, K.Q., Zhang, L.J., 2012. HP55-coated capsule containing PLGA/RS nanoparticles for oral delivery of insulin. Int. J. Pharm. 425, 1-8.
40. Yamanouchi, D., Wu, J., Lazar, A.N., Kent, K.C., Chu, C.C., Liu, B., 2008. Biodegradable arginine-based poly(ester-amide)s as non-viral gene delivery reagents. Biomaterials 29, 3269-3277.
41. Zhao, L., Ding, J., He, P., Xiao, C., Tang, Z., Zhuang, X., Chen, X., 2011. An efficient pH sensitive oral insulin delivery system enhanced by deoxycholic acid. J. Control. Release 152, e184L 186.