A carrier-mediated prodrug approach to improve the oral absorption of antileukemic drug decitabine

Molecular Pharmaceutics

Volumn 10, Issue 8, 2013, Pages 3195-3202

  Zhang, Youxi ^a   Sun, Jin ^a   Gao, Yikun ^a   Jin, Ling ^a   Xu, Youjun ^a   Lian, He ^a   Sun, Yongbing ^b   Sun, Yinghua ^a   Liu, Jianyu ^a   Fan, Rui ^a   Zhang, Tianhong ^a   He, Zhonggui ^a  

^a SHENYANG PHARMACEUTICAL UNIVERSITY   (China)

^b JIANGXI UNIVERSITY OF TRADITIONAL CHINESE MEDICINE   (China)

Author keywords

decitabine; oral bioavailability; peptide transporter; permeability; prodrug

Indexed keywords

5 AZA 2' DEOXYCYTIDINE; DRUG CARRIER; LEPTIN; PHOSPHATE BUFFERED SALINE; PRODRUG;

ANIMAL EXPERIMENT; ARTICLE; CELL STRAIN CACO 2; CONTROLLED STUDY; DRUG ABSORPTION; DRUG BIOAVAILABILITY; DRUG PENETRATION; INTESTINE FLUID; MALE; NONHUMAN; PLASMA; PRIORITY JOURNAL; RAT; STOMACH JUICE; TISSUE HOMOGENATE;

ANIMALS; ANTIMETABOLITES, ANTINEOPLASTIC; AZACITIDINE; CACO-2 CELLS; CHROMATOGRAPHY, HIGH PRESSURE LIQUID; HUMANS; MALE; MODELS, BIOLOGICAL; PRODRUGS; RATS; RATS, SPRAGUE-DAWLEY; TANDEM MASS SPECTROMETRY;

EID: 84881322895     PISSN: 15438384     EISSN: 15438392     Source Type: Journal    
DOI: 10.1021/mp400233x     Document Type: Article

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