-
1
-
-
53549135850
-
-
eds. Goodman, M., Felix, A., Moroder, L. & Tonolio, C.Georg Thieme Verlag
-
Gilon, C., Dechantsreiter, M.A., Burkhart, F., Friedler, A. & Kessler, H. in Houben-Weyl Methods of Organic Chemistry, Vol. E22c (eds. Goodman, M., Felix, A., Moroder, L. & Tonolio, C.) 215-291 (Georg Thieme Verlag, 2002).
-
(2002)
Houben-Weyl Methods of Organic Chemistry
, vol.E22C
, pp. 215-291
-
-
Gilon, C.1
Dechantsreiter, M.A.2
Burkhart, F.3
Friedler, A.4
Kessler, H.5
-
2
-
-
22244488749
-
Oral delivery of peptide drugs: Barriers and developments
-
DOI 10.2165/00063030-200519030-00003
-
Hamman, J.H., Enslin, G.M. & Kotze, A.F. Oral delivery of peptide drugs: barriers and developments. Biodrugs 19, 165-177 (2005). (Pubitemid 40994232)
-
(2005)
BioDrugs
, vol.19
, Issue.3
, pp. 165-177
-
-
Hamman, J.H.1
Enslin, G.M.2
Kotze, A.F.3
-
3
-
-
0020163940
-
Peptide Conformations 19 conformation and biological activity of cyclic-peptides
-
Kessler, H. Peptide Conformations. 19. Conformation and biological activity of cyclic-peptides. Angew. Chem. Int. Ed. 21, 512-523 (1982).
-
(1982)
Angew. Chem. Int. Ed.
, vol.21
, pp. 512-523
-
-
Kessler, H.1
-
4
-
-
39749193898
-
Backbone cyclic peptidomimetic melanocortin-4 receptor agonist as a novel orally administrated drug lead for treating obesity
-
DOI 10.1021/jm701093y
-
Hess, S. et al. Backbone cyclic peptidomimetic melanocortin-4 receptor agonist as a novel orally administrated drug lead for treating obesity. J. Med. Chem. 51, 1026-1034 (2008). (Pubitemid 351304710)
-
(2008)
Journal of Medicinal Chemistry
, vol.51
, Issue.4
, pp. 1026-1034
-
-
Hess, S.1
Linde, Y.2
Ovadia, O.3
Safrai, E.4
Shalev, D.E.5
Swed, A.6
Halbfinger, E.7
Lapidot, T.8
Winkler, I.9
Gabinet, Y.10
Faier, A.11
Yarden, D.12
Xiang, Z.13
Portillo, F.P.14
Haskell-Luevano, C.15
Gilon, C.16
Hoffman, A.17
-
5
-
-
0014543875
-
Topochemical investigation of peptide systems
-
Shemyakin, M.M., Ovchinnikov, Y.A. & Ivanov, V.T. Topochemical investigation of peptide systems. Angew. Chem. Int. Ed. Engl. 8, 492-499 (1969).
-
(1969)
Angew. Chem. Int. Ed. Engl.
, vol.8
, pp. 492-499
-
-
Shemyakin, M.M.1
Ovchinnikov, Y.A.2
Ivanov, V.T.3
-
6
-
-
33845560283
-
Concept of linear modified retro-peptide structures
-
Goodman, M. & Chorev, M. Concept of linear modified retro-peptide structures. Acc. Chem. Res. 12, 1-7 (1979).
-
(1979)
Acc. Chem. Res.
, Issue.12
, pp. 1-7
-
-
Goodman, M.1
Chorev, M.2
-
7
-
-
33745502124
-
Peptidomimetics for receptor ligands-discovery development and medical perspectives
-
Giannis, A. Peptidomimetics for receptor ligands-discovery, development, and medical perspectives. Angew. Chem. Int. Ed. 32, 1244-1267 (1993).
-
(1993)
Angew. Chem. Int. Ed.
, vol.32
, pp. 1244-1267
-
-
Giannis, A.1
-
8
-
-
69249136291
-
Anticonvulsant Met-enkephalin analogues containing backbone spacers reveal alternative non-opioid signaling in the brain
-
Lee, H.K. et al. Anticonvulsant Met-enkephalin analogues containing backbone spacers reveal alternative non-opioid signaling in the brain. ACS Chem. Biol. 4, 659-671 (2009).
-
(2009)
ACS Chem. Biol.
, vol.4
, pp. 659-671
-
-
Lee, H.K.1
-
9
-
-
0026726041
-
Peptoids-a modular approach to drug discovery
-
USA
-
Simon, R.J. et al. Peptoids-a modular approach to drug discovery. Proc. Natl. Acad. Sci. USA 89, 9367-9371 (1992).
-
(1992)
Proc. Natl. Acad. Sci.
, vol.89
, pp. 9367-9371
-
-
Simon, R.J.1
-
10
-
-
33749271351
-
Peptoids-a new approach to the development of pharmaceuticals
-
Kessler, H. Peptoids-a new approach to the development of pharmaceuticals. Angew. Chem. Int. Ed. Engl. 32, 543-544 (1993).
-
(1993)
Angew. Chem. Int. Ed. Engl.
, vol.32
, pp. 543-544
-
-
Kessler, H.1
-
11
-
-
79959580534
-
Contemporary strategies for peptide macrocyclization
-
White, C.J. & Yudin, A.K. Contemporary strategies for peptide macrocyclization. Nat. Chem. 3, 509-524 (2011).
-
(2011)
Nat. Chem.
, vol.3
, pp. 509-524
-
-
White, C.J.1
Yudin, A.K.2
-
12
-
-
0033678653
-
Conjugation of arginine oligomers to cyclosporin A facilitates topical delivery and inhibition of inflammation
-
Rothbard, J.B. et al. Conjugation of arginine oligomers to cyclosporin A facilitates topical delivery and inhibition of inflammation. Nat. Med. 6, 1253-1257 (2000).
-
(2000)
Nat. Med.
, vol.6
, pp. 1253-1257
-
-
Rothbard, J.B.1
-
13
-
-
0034700141
-
The design synthesis and evaluation of molecules that enable or enhance cellular uptake: Peptoid molecular transporters
-
USA
-
Wender, P.A. et al. The design, synthesis, and evaluation of molecules that enable or enhance cellular uptake: peptoid molecular transporters. Proc. Natl. Acad. Sci. USA 97, 13003-13008 (2000).
-
(2000)
Proc. Natl. Acad. Sci.
, vol.97
, pp. 13003-13008
-
-
Wender, P.A.1
-
14
-
-
0346460957
-
Cell-penetrating peptides: A reevaluation of the mechanism of cellular uptake
-
DOI 10.1074/jbc.M209548200
-
Richard, J.P. et al. Cell-penetrating peptides-a re-evaluation of the mechanism of cellular uptake. J. Biol. Chem. 278, 585-590 (2003). (Pubitemid 36043612)
-
(2003)
Journal of Biological Chemistry
, vol.278
, Issue.1
, pp. 585-590
-
-
Richard, J.P.1
Melikov, K.2
Vives, E.3
Ramos, C.4
Verbeure, B.5
Gait, M.J.6
Chernomordik, L.V.7
Lebleu, B.8
-
15
-
-
27644561216
-
Characterisation of cell-penetrating peptide-mediated peptide delivery
-
Jones, S.W. et al. Characterisation of cell-penetrating peptide-mediated peptide delivery. Br. J. Pharmacol. 145, 1093-1102 (2005).
-
(2005)
Br. J. Pharmacol.
, vol.145
, pp. 1093-1102
-
-
Jones, S.W.1
-
16
-
-
0017157814
-
Biological effects of Cyclosporin-a-new antilymphocytic agent
-
Borel, J.F., Feurer, C., Gubler, H.U. & Stahelin, H. Biological effects of Cyclosporin-a-new antilymphocytic agent. Agents Actions 6, 468-475 (1976).
-
(1976)
Agents Actions
, vol.6
, pp. 468-475
-
-
Borel, J.F.1
Feurer, C.2
Gubler, H.U.3
Stahelin, H.4
-
17
-
-
0027444847
-
Isolation of Dolastatins 10-15 from the marine mollusk Dolabella auricularia
-
Pettit, G.R. et al. Isolation of Dolastatins 10-15 from the marine mollusk Dolabella auricularia. Tetrahedron 49, 9151-9170 (1993).
-
(1993)
Tetrahedron
, vol.49
, pp. 9151-9170
-
-
Pettit, G.R.1
-
18
-
-
33646264575
-
IB-01212 a new cytotoxic cyclodepsipeptide isolated from the marine fungus Clonostachys sp. ESNA-A009
-
Cruz, L.J. et al. IB-01212, a new cytotoxic cyclodepsipeptide isolated from the marine fungus Clonostachys sp. ESNA-A009. J. Org. Chem. 71, 3335-3338 (2006).
-
(2006)
J. Org. Chem.
, vol.71
, pp. 3335-3338
-
-
Cruz, L.J.1
-
19
-
-
77954121578
-
Mutremdamide A and koshikamides C-H peptide inhibitors of hiv-1 entry from different theonella species
-
Plaza, A. et al. Mutremdamide A and koshikamides C-H, peptide inhibitors of HIV-1 entry from different Theonella species. J. Org. Chem. 75, 4344-4355 (2010).
-
(2010)
J. Org. Chem.
, vol.75
, pp. 4344-4355
-
-
Plaza, A.1
-
20
-
-
0035289779
-
Experimental and computational approaches to estimate solubility and permeability in drug discovery and development settings
-
Lipinski, C.A., Lombardo, F., Dominy, B.W. & Feeney, P.J. Experimental and computational approaches to estimate solubility and permeability in drug discovery and development settings. Adv. Drug Deliv. Rev. 46, 3-26 (2001).
-
(2001)
Adv. Drug Deliv. Rev.
, vol.46
, pp. 3-26
-
-
Lipinski, C.A.1
Lombardo, F.2
Dominy, B.W.3
Feeney, P.J.4
-
21
-
-
50349089332
-
Synthesis and biological-activity of peptides related to eledoisin 1 hexapeptide amides containing alpha-hydroxy acids
-
Japan
-
Sugano, H., Higaki, K. & Miyoshi, M. Synthesis and biological-activity of peptides related to eledoisin. 1. Hexapeptide amides containing alpha-hydroxy acids. Bull. Chem. Soc. Japan 46, 226-230 (1973).
-
(1973)
Bull. Chem. Soc.
, vol.46
, pp. 226-230
-
-
Sugano, H.1
Higaki, K.2
Miyoshi, M.3
-
22
-
-
0033549864
-
3 integrin antagonists
-
DOI 10.1021/jm970832g
-
Dechantsreiter, M.A. et al. N-methylated cyclic RGD peptides as highly active and selectivea(v)β(3) integrin antagonists. J. Med. Chem. 42, 3033-3040 (1999). (Pubitemid 29384038)
-
(1999)
Journal of Medicinal Chemistry
, vol.42
, Issue.16
, pp. 3033-3040
-
-
Dechantsreiter, M.A.1
Planker, E.2
Matha, B.3
Lohof, E.4
Holzemann, G.5
Jonczyk, A.6
Goodman, S.L.7
Kessler, H.8
-
23
-
-
79952741178
-
Cilengitide: The first anti-angiogenic small molecule drug candidate design synthesis and clinical evaluation
-
Mas-Moruno, C., Rechenmacher, F. & Kessler, H. Cilengitide: the first anti-angiogenic small molecule drug candidate design, synthesis and clinical evaluation. Anticancer Agents Med. Chem. 10, 753-768 (2011).
-
(2011)
Anticancer Agents Med. Chem.
, vol.10
, pp. 753-768
-
-
Mas-Moruno, C.1
Rechenmacher, F.2
Kessler, H.3
-
24
-
-
0030768536
-
Stereoisomeric peptide libraries and peptidomimetics for designing selective inhibitors of the avβ3 integrin for a new cancer therapy
-
Haubner, R., Finsinger, D. & Kessler, H. Stereoisomeric peptide libraries and peptidomimetics for designing selective inhibitors of the avβ3 integrin for a new cancer therapy. Angew. Chem. Int. Ed. Engl. 36, 1374-1389 (1997).
-
(1997)
Angew. Chem. Int. Ed. Engl.
, vol.36
, pp. 1374-1389
-
-
Haubner, R.1
Finsinger, D.2
Kessler, H.3
-
25
-
-
0036095659
-
1-40 fibrillogenesis
-
DOI 10.1034/j.1399-3011.2002.11002.x
-
Gordon, D.J., Tappe, R. & Meredith, S.C. Design and characterization of a membrane permeable N-methyl amino acid-containing peptide that inhibits A β(1-40) fibrillogenesis. J. Pept. Res. 60, 37-55 (2002). (Pubitemid 34680830)
-
(2002)
Journal of Peptide Research
, vol.60
, Issue.1
, pp. 37-55
-
-
Gordon, D.J.1
Tappe, R.2
Meredith, S.C.3
-
26
-
-
84981904438
-
Detection of intramolecular mobility by NMR spectroscopy 13 detection of hindered rotation and inversion by NMR spectroscopy
-
Kessler, H. Detection of intramolecular mobility by NMR spectroscopy. 13. Detection of hindered rotation and inversion by NMR spectroscopy. Angew. Chem. Int. Ed. 9, 219-235 (1970).
-
(1970)
Angew. Chem. Int. Ed.
, Issue.9
, pp. 219-235
-
-
Kessler, H.1
-
27
-
-
57349171593
-
N-methylation of peptides: A new perspective in medicinal chemistry
-
Chatterjee, J., Gilon, C., Hoffman, A. & Kessler, H. N-methylation of peptides: a new perspective in medicinal chemistry. Acc. Chem. Res. 41, 1331-1342 (2008).
-
(2008)
Acc. Chem. Res.
, vol.41
, pp. 1331-1342
-
-
Chatterjee, J.1
Gilon, C.2
Hoffman, A.3
Kessler, H.4
-
28
-
-
77953717986
-
Improvement of drug-like properties of peptides: The somatostatin paradigm
-
Ovadia, O. et al. Improvement of drug-like properties of peptides: the somatostatin paradigm. Expert Opin. Drug Discov. 5, 655-671 (2010).
-
(2010)
Expert Opin. Drug Discov.
, vol.5
, pp. 655-671
-
-
Ovadia, O.1
-
29
-
-
53849131695
-
Conformational preference and potential templates of N-methylated cyclic pentaalanine peptides
-
Chatterjee, J., Mierke, D.F. & Kessler, H. Conformational preference and potential templates of N-methylated cyclic pentaalanine peptides. Chem. Eur. J. 14, 1508-1517 (2008).
-
(2008)
Chem. Eur. J.
, vol.14
, pp. 1508-1517
-
-
Chatterjee, J.1
Mierke, D.F.2
Kessler, H.3
-
30
-
-
63449088626
-
Can N-methylated amino acids serve as substitutes for prolines in conformational design of cyclic pentapeptides
-
Laufer, B., Chatterjee, J., Frank, A.O. & Kessler, H. Can N-methylated amino acids serve as substitutes for prolines in conformational design of cyclic pentapeptides? J. Pept. Sci. 15, 141-146 (2009).
-
(2009)
J. Pept. Sci.
, vol.15
, pp. 141-146
-
-
Laufer, B.1
Chatterjee, J.2
Frank, A.O.3
Kessler, H.4
-
31
-
-
37849035729
-
Multiple N-methylation by a designed approach enhances receptor selectivity
-
Chatterjee, J. et al. Multiple N-methylation by a designed approach enhances receptor selectivity. J. Med. Chem. 50, 5878-5881 (2007).
-
(2007)
J. Med. Chem.
, vol.50
, pp. 5878-5881
-
-
Chatterjee, J.1
-
32
-
-
79960385479
-
N-Methylated sst2 selective somatostatin cyclic peptide analogue as potent candidate for treating neurogenic inflammation
-
Chatterjee, J. et al. N-Methylated sst2 selective somatostatin cyclic peptide analogue as potent candidate for treating neurogenic inflammation. ACS Med. Chem. Lett. 2, 509-514 (2011).
-
(2011)
ACS Med. Chem. Lett.
, vol.2
, pp. 509-514
-
-
Chatterjee, J.1
-
33
-
-
77953304018
-
Multiple N-methylation of MT-II backbone amide bonds leads to melanocortin receptor subtype hMC1R selectivity: Pharmacological and conformational studies
-
Doedens, L. et al. Multiple N-methylation of MT-II backbone amide bonds leads to melanocortin receptor subtype hMC1R selectivity: pharmacological and conformational studies. J. Am. Chem. Soc. 132, 8115-8128 (2010).
-
(2010)
J. Am. Chem. Soc.
, vol.132
, pp. 8115-8128
-
-
Doedens, L.1
-
34
-
-
41949086504
-
Improving oral bioavailability of peptides by multiple N-methylation: Somatostatin analogues
-
Biron, E. et al. Improving oral bioavailability of peptides by multiple N-methylation: somatostatin analogues. Angew. Chem. Int. Ed. 47, 2595-2599 (2008).
-
(2008)
Angew. Chem. Int. Ed.
, vol.47
, pp. 2595-2599
-
-
Biron, E.1
-
35
-
-
79953811147
-
The effect of multiple N-methylation on intestinal permeability of peptides
-
Ovadia, O. et al. The effect of multiple N-methylation on intestinal permeability of peptides. Mol. Pharmaceutics 8, 479-487 (2011).
-
(2011)
Mol. Pharmaceutics
, vol.8
, pp. 479-487
-
-
Ovadia, O.1
-
36
-
-
33644799946
-
Optimized selective N-methylation of peptides on solid support
-
DOI 10.1002/psc.711
-
Biron, E., Chatterjee, J. & Kessler, H. Optimized selective N-methylation of peptides on solid support. J. Pept. Sci. 12, 213-219 (2006). (Pubitemid 43349362)
-
(2006)
Journal of Peptide Science
, vol.12
, Issue.3
, pp. 213-219
-
-
Biron, E.1
Chatterjee, J.2
Kessler, H.3
-
37
-
-
39149116365
-
Solid-phase peptide synthesis: From standard procedures to the synthesis of difficult sequences
-
Coin, I., Beyermann, M. & Bienert, M. Solid-phase peptide synthesis: from standard procedures to the synthesis of difficult sequences. Nat. Protoc. 2, 3247-3256 (2007).
-
(2007)
Nat. Protoc.
, Issue.2
, pp. 3247-3256
-
-
Coin, I.1
Beyermann, M.2
Bienert, M.3
-
38
-
-
0029119899
-
2- and 4-Nitrobenzenesulfonamides: Exceptionally versatile means for preparation of secondary amines and protection of amines
-
Fukuyama, T., Jow, C.-K. & Cheung, M. 2- and 4- Nitrobenzenesulfonamides: exceptionally versatile means for preparation of secondary amines and protection of amines. Tetrahedron Lett. 36, 6373-6374 (1995).
-
(1995)
Tetrahedron Lett.
, Issue.36
, pp. 6373-6374
-
-
Fukuyama, T.1
Jow, C.-K.2
Cheung, M.3
-
39
-
-
78049371456
-
Solid-phase synthesis of short a-helices stabilized by the hydrogen bond surrogate approach
-
Patgiri, A., Menzenski, M.Z., Mahon, A.B. & Arora, P.S. Solid-phase synthesis of short a-helices stabilized by the hydrogen bond surrogate approach. Nat. Protoc. 5, 1857-1865 (2010).
-
(2010)
Nat. Protoc.
, vol.5
, pp. 1857-1865
-
-
Patgiri, A.1
Menzenski, M.Z.2
Mahon, A.B.3
Arora, P.S.4
-
40
-
-
79958086652
-
Synthesis of all-hydrocarbon stapled a-helical peptides by ring-closing olefin metathesis
-
Kim, Y.W., Grossmann, T.N. & Verdine, G.L. Synthesis of all-hydrocarbon stapled a-helical peptides by ring-closing olefin metathesis. Nat. Protoc. 6, 761-771 (2011).
-
(2011)
Nat. Protoc.
, vol.6
, pp. 761-771
-
-
Kim, Y.W.1
Grossmann, T.N.2
Verdine, G.L.3
-
41
-
-
3843049165
-
An improved method for the solution cyclization of peptides under pseudo-high dilution conditions
-
DOI 10.1016/j.jbiotec.2004.03.015, PII S0168165604002317
-
Malesevic, M., Strijowski, U., Bächle, D. & Sewald, N. An improved method for the solution cyclization of peptides under pseudo-high dilution conditions. J. Biotechnol. 112, 73-77 (2004). (Pubitemid 39037388)
-
(2004)
Journal of Biotechnology
, vol.112
, Issue.1-2
, pp. 73-77
-
-
Malesevic, M.1
Strijowski, U.2
Bachle, D.3
Sewald, N.4
-
42
-
-
33845309676
-
N-methylated cyclic pentaalanine peptides as template structures
-
DOI 10.1021/ja063123d
-
Chatterjee, J., Mierke, D. & Kessler, H. N-methylated cyclic pentaalanine peptides as template structures. J. Am. Chem. Soc. 128, 15164-15172 (2006). (Pubitemid 44868074)
-
(2006)
Journal of the American Chemical Society
, vol.128
, Issue.47
, pp. 15164-15172
-
-
Chatterjee, J.1
Mierke, D.2
Kessler, H.3
|