메뉴 건너뛰기




Volumn 588, Issue 16, 2014, Pages 2590-2599

TP63 and TP73 in cancer, an unresolved "family" puzzle of complexity, redundancy and hierarchy

Author keywords

Development; TP53; TP63; TP73; Tumor suppressors

Indexed keywords

F BOX PROTEIN; FBXO45 PROTEIN; NAD(P)H QUINONE OXIDOREDUCTASE 1; NEDL2 PROTEIN; PEPTIDYLPROLYL ISOMERASE PIN1; PROTEIN MDM2; PROTEIN P53; PROTEIN P63; PROTEIN P73; REDUCED NICOTINAMIDE ADENINE DINUCLEOTIDE (PHOSPHATE) DEHYDROGENASE (QUINONE); TRANSCRIPTION FACTOR; UBIQUITIN PROTEIN LIGASE E3; UBIQUITIN PROTEIN LIGASE NEDD4; UNCLASSIFIED DRUG; YES ASSOCIATED PROTEIN 1;

EID: 84905085953     PISSN: 00145793     EISSN: 18733468     Source Type: Journal    
DOI: 10.1016/j.febslet.2014.06.047     Document Type: Review
Times cited : (39)

References (179)
  • 1
    • 0030812331 scopus 로고    scopus 로고
    • Monoallelically expressed gene related to p53 at 1p36, a region frequently deleted in neuroblastoma and other human cancers
    • M. Kaghad, H. Bonnet, and A. Yang et al. Monoallelically expressed gene related to p53 at 1p36, a region frequently deleted in neuroblastoma and other human cancers Cell 90 1997 809 819
    • (1997) Cell , vol.90 , pp. 809-819
    • Kaghad, M.1    Bonnet, H.2    Yang, A.3
  • 2
    • 0032161624 scopus 로고    scopus 로고
    • P63, a p53 homolog at 3q27-29, encodes multiple products with transactivating, death-inducing and dominant-negative activities
    • A. Yang, M. Kaghad, and Y. Wang et al. p63, a p53 homolog at 3q27-29, encodes multiple products with transactivating, death-inducing and dominant-negative activities Mol. Cell 2 1998 305 316
    • (1998) Mol. Cell , vol.2 , pp. 305-316
    • Yang, A.1    Kaghad, M.2    Wang, Y.3
  • 3
    • 0033594485 scopus 로고    scopus 로고
    • P63 is essential for regenerative proliferation in limb, craniofacial and epithelial development
    • A. Yang, R. Schweitzer, and D. Sun et al. p63 is essential for regenerative proliferation in limb, craniofacial and epithelial development Nature 398 1999 714 718
    • (1999) Nature , vol.398 , pp. 714-718
    • Yang, A.1    Schweitzer, R.2    Sun, D.3
  • 4
    • 0033594491 scopus 로고    scopus 로고
    • P63 is a p53 homologue required for limb and epidermal morphogenesis
    • A.A. Mills, B. Zheng, X.J. Wang, and H. Vogel et al. p63 is a p53 homologue required for limb and epidermal morphogenesis Nature 398 1999 708 713
    • (1999) Nature , vol.398 , pp. 708-713
    • Mills, A.A.1    Zheng, B.2    Wang, X.J.3    Vogel, H.4
  • 5
    • 17544363909 scopus 로고    scopus 로고
    • P73-deficient mice have neurological, pheromonal and inflammatory defects but lack spontaneous tumours
    • A. Yang, N. Walker, and R. Bronson et al. p73-deficient mice have neurological, pheromonal and inflammatory defects but lack spontaneous tumours Nature 404 2000 99 103
    • (2000) Nature , vol.404 , pp. 99-103
    • Yang, A.1    Walker, N.2    Bronson, R.3
  • 6
    • 0034079520 scopus 로고    scopus 로고
    • The p53/p63/p73 family of transcription factors: Overlapping and distinct functions
    • M. Levrero, V. De Laurenzi, and A. Costanzo et al. The p53/p63/p73 family of transcription factors: overlapping and distinct functions J. Cell Sci. 113 2000 1661 1670
    • (2000) J. Cell Sci. , vol.113 , pp. 1661-1670
    • Levrero, M.1    De Laurenzi, V.2    Costanzo, A.3
  • 7
    • 33646798450 scopus 로고    scopus 로고
    • P53/p63/p73 isoforms: An orchestra of isoforms to harmonise cell differentiation and response to stress
    • F. Murray-Zmijewski, D.P. Lane, and J.C. Bourdon p53/p63/p73 isoforms: an orchestra of isoforms to harmonise cell differentiation and response to stress Cell Death Differ. 3 2006 962 972
    • (2006) Cell Death Differ. , vol.3 , pp. 962-972
    • Murray-Zmijewski, F.1    Lane, D.P.2    Bourdon, J.C.3
  • 8
    • 70350707752 scopus 로고    scopus 로고
    • The p53 family protein p73 provides new insights into cancer chemosensitivity and targeting
    • P. Lunghi, A. Costanzo, and L. Mazzera et al. The p53 family protein p73 provides new insights into cancer chemosensitivity and targeting Clin. Cancer Res. 15 2009 6495 6502
    • (2009) Clin. Cancer Res. , vol.15 , pp. 6495-6502
    • Lunghi, P.1    Costanzo, A.2    Mazzera, L.3
  • 9
    • 33847230852 scopus 로고    scopus 로고
    • The p53 family in differentiation and tumorigenesis
    • T. Stiewe The p53 family in differentiation and tumorigenesis Nat. Rev. Cancer 7 2007 165 168
    • (2007) Nat. Rev. Cancer , vol.7 , pp. 165-168
    • Stiewe, T.1
  • 10
    • 17444390129 scopus 로고    scopus 로고
    • Tumor predisposition in mice mutant for p63 and p73: Evidence for broader tumor suppressor functions for the p53 family
    • E.R. Flores, S. Sengupta, and J.B. Miller et al. Tumor predisposition in mice mutant for p63 and p73: evidence for broader tumor suppressor functions for the p53 family Cancer Cell 7 2005 363 373
    • (2005) Cancer Cell , vol.7 , pp. 363-373
    • Flores, E.R.1    Sengupta, S.2    Miller, J.B.3
  • 11
    • 73349088166 scopus 로고    scopus 로고
    • TAp63 induces senescence and suppresses tumorigenesis in vivo
    • X. Guo, W.M. Keyes, and C. Papazoglu et al. TAp63 induces senescence and suppresses tumorigenesis in vivo Nat. Cell Biol. 11 2009 1451 1457
    • (2009) Nat. Cell Biol. , vol.11 , pp. 1451-1457
    • Guo, X.1    Keyes, W.M.2    Papazoglu, C.3
  • 12
    • 53549134949 scopus 로고    scopus 로고
    • TAp73 knockout shows genomic instability with infertility and tumor suppressor functions
    • R. Tomasini, K. Tsuchihara, and M. Wilhelm et al. TAp73 knockout shows genomic instability with infertility and tumor suppressor functions Genes Dev. 22 2008 2677 2691
    • (2008) Genes Dev. , vol.22 , pp. 2677-2691
    • Tomasini, R.1    Tsuchihara, K.2    Wilhelm, M.3
  • 13
    • 2442494895 scopus 로고    scopus 로고
    • The common and distinct target genes of the p53 family transcription factors
    • K. Harms, S. Nozell, and X. Chen The common and distinct target genes of the p53 family transcription factors Cell. Mol. Life Sci. 61 2004 822 842
    • (2004) Cell. Mol. Life Sci. , vol.61 , pp. 822-842
    • Harms, K.1    Nozell, S.2    Chen, X.3
  • 14
    • 0033603494 scopus 로고    scopus 로고
    • P73 and p63 are homotetramers capable of weak heterotypic interactions with each other but not with p53
    • T.S. Davison, C. Vagner, M. Kaghad, and A. Ayed et al. p73 and p63 are homotetramers capable of weak heterotypic interactions with each other but not with p53 J. Biol. Chem. 274 1999 18709 18714
    • (1999) J. Biol. Chem. , vol.274 , pp. 18709-18714
    • Davison, T.S.1    Vagner, C.2    Kaghad, M.3    Ayed, A.4
  • 15
    • 80054938836 scopus 로고    scopus 로고
    • IASPP/p63 autoregulatory feedback loop is required for the homeostasis of stratified epithelia
    • A. Chikh, R.N. Matin, and V. Senatore et al. IASPP/p63 autoregulatory feedback loop is required for the homeostasis of stratified epithelia EMBO J. 30 2011 4261 4273
    • (2011) EMBO J. , vol.30 , pp. 4261-4273
    • Chikh, A.1    Matin, R.N.2    Senatore, V.3
  • 16
    • 84890942102 scopus 로고    scopus 로고
    • Uncovering the role of p53 splice variants in human malignancy: A clinical perspective
    • S. Surget, M.P. Khoury, and J.C. Bourdon Uncovering the role of p53 splice variants in human malignancy: a clinical perspective Onco Targets Ther. 7 2013 57 68
    • (2013) Onco Targets Ther. , vol.7 , pp. 57-68
    • Surget, S.1    Khoury, M.P.2    Bourdon, J.C.3
  • 17
    • 41849146852 scopus 로고    scopus 로고
    • C-terminal diversity within the p53 family accounts for differences in DNA binding and transcriptional activity
    • M. Sauer, A.C. Bretz, and R. Beinoraviciute-Kellner et al. C-terminal diversity within the p53 family accounts for differences in DNA binding and transcriptional activity Nucleic Acids Res. 36 2008 1900 1912
    • (2008) Nucleic Acids Res. , vol.36 , pp. 1900-1912
    • Sauer, M.1    Bretz, A.C.2    Beinoraviciute-Kellner, R.3
  • 18
    • 0032476743 scopus 로고    scopus 로고
    • Two new p73 splice variants, gamma and delta, with different transcriptional activity
    • V. De Laurenzi, A. Costanzo, and D. Barcaroli et al. Two new p73 splice variants, gamma and delta, with different transcriptional activity J. Exp. Med. 188 1998 1763 1768
    • (1998) J. Exp. Med. , vol.188 , pp. 1763-1768
    • De Laurenzi, V.1    Costanzo, A.2    Barcaroli, D.3
  • 19
    • 0032990811 scopus 로고    scopus 로고
    • Additional complexity in p73: Induction by mitogens in lymphoid cells and identification of two new splicing variants epsilon and zeta
    • V.D. De Laurenzi, M.V. Catani, and A. Terrinoni et al. Additional complexity in p73: induction by mitogens in lymphoid cells and identification of two new splicing variants epsilon and zeta Cell Death Differ. 6 1999 389 390
    • (1999) Cell Death Differ. , vol.6 , pp. 389-390
    • De Laurenzi, V.D.1    Catani, M.V.2    Terrinoni, A.3
  • 20
    • 0034609798 scopus 로고    scopus 로고
    • Role for the p53 homologue p73 in E2F-1-induced apoptosis
    • M. Irwin, M.C. Marin, and A.C. Phillips et al. Role for the p53 homologue p73 in E2F-1-induced apoptosis Nature 407 2000 645 648
    • (2000) Nature , vol.407 , pp. 645-648
    • Irwin, M.1    Marin, M.C.2    Phillips, A.C.3
  • 21
    • 0033666776 scopus 로고    scopus 로고
    • Role of the p53-homologue p73 in E2F1-induced apoptosis
    • T. Stiewe, and B.M. Putzer Role of the p53-homologue p73 in E2F1-induced apoptosis Nat. Genet. 26 2000 464 469
    • (2000) Nat. Genet. , vol.26 , pp. 464-469
    • Stiewe, T.1    Putzer, B.M.2
  • 22
    • 0036094734 scopus 로고    scopus 로고
    • The human p73 promoter: Characterization and identification of functional E2F binding sites
    • R.S. Seelan, M. Irwin, and P. van der Stoop et al. The human p73 promoter: characterization and identification of functional E2F binding sites Neoplasia 4 2002 195 203
    • (2002) Neoplasia , vol.4 , pp. 195-203
    • Seelan, R.S.1    Irwin, M.2    Van Der Stoop, P.3
  • 23
    • 0345099612 scopus 로고    scopus 로고
    • DNA damage induces transcriptional activation of p73 by removing C-EBPalpha repression on E2F1
    • M. Marabese, F. Vikhanskaya, and C. Rainelli et al. DNA damage induces transcriptional activation of p73 by removing C-EBPalpha repression on E2F1 Nucleic Acids Res. 31 2003 6624 6632
    • (2003) Nucleic Acids Res. , vol.31 , pp. 6624-6632
    • Marabese, M.1    Vikhanskaya, F.2    Rainelli, C.3
  • 24
    • 0035193044 scopus 로고    scopus 로고
    • The transcriptional repressor ZEB regulates p73 expression at the crossroad between proliferation and differentiation
    • G. Fontemaggi, A. Gurtner, and S. Strano et al. The transcriptional repressor ZEB regulates p73 expression at the crossroad between proliferation and differentiation Mol. Cell. Biol. 21 2001 8461 8470
    • (2001) Mol. Cell. Biol. , vol.21 , pp. 8461-8470
    • Fontemaggi, G.1    Gurtner, A.2    Strano, S.3
  • 25
    • 36048942316 scopus 로고    scopus 로고
    • Yin Yang 1 induces transcriptional activity of p73 through cooperation with E2F1
    • S. Wu, S. Murai, and K. Kataoka et al. Yin Yang 1 induces transcriptional activity of p73 through cooperation with E2F1 Biochem. Biophys. Res. Commun. 365 2008 75 81
    • (2008) Biochem. Biophys. Res. Commun. , vol.365 , pp. 75-81
    • Wu, S.1    Murai, S.2    Kataoka, K.3
  • 26
    • 18244402691 scopus 로고    scopus 로고
    • Human delta Np73 regulates a dominant negative feedback loop for TAp73 and p53
    • T.J. Grob, U. Novak, and C. Maisse et al. Human delta Np73 regulates a dominant negative feedback loop for TAp73 and p53 Cell Death Differ. 8 2001 1213 1223
    • (2001) Cell Death Differ. , vol.8 , pp. 1213-1223
    • Grob, T.J.1    Novak, U.2    Maisse, C.3
  • 27
    • 0037161921 scopus 로고    scopus 로고
    • DN-p73 is activated after DNA damage in a p53-dependent manner to regulate p53-induced cell cycle arrest
    • S. Vossio, E. Palescandolo, and N. Pediconi et al. DN-p73 is activated after DNA damage in a p53-dependent manner to regulate p53-induced cell cycle arrest Oncogene 21 2002 3796 3803
    • (2002) Oncogene , vol.21 , pp. 3796-3803
    • Vossio, S.1    Palescandolo, E.2    Pediconi, N.3
  • 28
    • 0037130473 scopus 로고    scopus 로고
    • P53 induces the expression of its antagonist p73 Delta N, establishing an autoregulatory feedback loop
    • N.N. Kartasheva, A. Contente, and C. Lenz-Stoppler et al. P53 induces the expression of its antagonist p73 Delta N, establishing an autoregulatory feedback loop Oncogene 21 2002 4715 4727
    • (2002) Oncogene , vol.21 , pp. 4715-4727
    • Kartasheva, N.N.1    Contente, A.2    Lenz-Stoppler, C.3
  • 29
    • 0036203514 scopus 로고    scopus 로고
    • Autoinhibitory regulation of p73 by Delta Np73 to modulate cell survival and death through a p73-specific target element within the Delta Np73 promoter
    • T. Nakagawa, M. Takahashi, and T. Ozaki et al. Autoinhibitory regulation of p73 by Delta Np73 to modulate cell survival and death through a p73-specific target element within the Delta Np73 promoter Mol. Cell. Biol. 22 2002 2575 2585
    • (2002) Mol. Cell. Biol. , vol.22 , pp. 2575-2585
    • Nakagawa, T.1    Takahashi, M.2    Ozaki, T.3
  • 30
    • 70350122931 scopus 로고    scopus 로고
    • Amphiregulin induces the alternative splicing of p73 into its oncogenic isoform DeltaEx2p73 in human hepatocellular tumors
    • (e1-4)
    • J. Castillo, S. Goñi, and M.U. Latasa et al. Amphiregulin induces the alternative splicing of p73 into its oncogenic isoform DeltaEx2p73 in human hepatocellular tumors Gastroenterology 137 2009 1805 1815 (e1-4)
    • (2009) Gastroenterology , vol.137 , pp. 1805-1815
    • Castillo, J.1    Goñi, S.2    Latasa, M.U.3
  • 31
    • 15444367709 scopus 로고    scopus 로고
    • The ubiquitin-protein ligase Itch regulates p73 stability
    • M. Rossi, V. De Laurenzi, and E. Munarriz et al. The ubiquitin-protein ligase Itch regulates p73 stability EMBO J. 24 2005 836 848
    • (2005) EMBO J. , vol.24 , pp. 836-848
    • Rossi, M.1    De Laurenzi, V.2    Munarriz, E.3
  • 32
    • 33748065322 scopus 로고    scopus 로고
    • The E3 ubiquitin ligase Itch controls the protein stability of p63
    • M. Rossi, R.I. Aqeilan, and M. Neale et al. The E3 ubiquitin ligase Itch controls the protein stability of p63 Proc. Natl. Acad. Sci. USA 103 2006 12753 12758
    • (2006) Proc. Natl. Acad. Sci. USA , vol.103 , pp. 12753-12758
    • Rossi, M.1    Aqeilan, R.I.2    Neale, M.3
  • 33
    • 33947382284 scopus 로고    scopus 로고
    • The Yes-associated protein 1 stabilizes p73 by preventing Itch-mediated ubiquitination of p73
    • D. Levy, Y. Adamovich, and N. Reuven et al. The Yes-associated protein 1 stabilizes p73 by preventing Itch-mediated ubiquitination of p73 Cell Death Differ. 14 2007 743 751
    • (2007) Cell Death Differ. , vol.14 , pp. 743-751
    • Levy, D.1    Adamovich, Y.2    Reuven, N.3
  • 34
    • 0033602462 scopus 로고    scopus 로고
    • Inactivation of the p53-homologue p73 by the mdm2-oncoprotein
    • M. Dobbelstein, S. Wienzek, and C. Konig et al. Inactivation of the p53-homologue p73 by the mdm2-oncoprotein Oncogene 18 1999 2101 2106
    • (1999) Oncogene , vol.18 , pp. 2101-2106
    • Dobbelstein, M.1    Wienzek, S.2    Konig, C.3
  • 35
    • 0032961828 scopus 로고    scopus 로고
    • MDM2 suppresses p73 function without promoting p73 degradation
    • X. Zeng, L. Chen, and C.A. Jost et al. MDM2 suppresses p73 function without promoting p73 degradation Mol. Cell. Biol. 19 1999 3257 3266
    • (1999) Mol. Cell. Biol. , vol.19 , pp. 3257-3266
    • Zeng, X.1    Chen, L.2    Jost, C.A.3
  • 36
    • 33845920314 scopus 로고    scopus 로고
    • Mdm2-mediated NEDD8 modification of TAp73 regulates its transactivation function
    • I.R. Watson, A. Blanch, and D.C. Lin et al. Mdm2-mediated NEDD8 modification of TAp73 regulates its transactivation function J. Biol. Chem. 281 2006 34096 34103
    • (2006) J. Biol. Chem. , vol.281 , pp. 34096-34103
    • Watson, I.R.1    Blanch, A.2    Lin, D.C.3
  • 37
    • 77954894921 scopus 로고    scopus 로고
    • MDM2 and Fbw7 cooperate to induce p63 protein degradation following DNA damage and cell differentiation
    • F. Galli, M. Rossi, and Y. D'Alessandra et al. MDM2 and Fbw7 cooperate to induce p63 protein degradation following DNA damage and cell differentiation J. Cell Sci. 123 2010 2423 2433
    • (2010) J. Cell Sci. , vol.123 , pp. 2423-2433
    • Galli, F.1    Rossi, M.2    D'Alessandra, Y.3
  • 38
    • 69849083542 scopus 로고    scopus 로고
    • The F-box protein FBXO45 promotes the proteasome-dependent degradation of p73
    • A. Peschiaroli, F. Scialpi, and F. Bernassola et al. The F-box protein FBXO45 promotes the proteasome-dependent degradation of p73 Oncogene 28 2009 3157 3166
    • (2009) Oncogene , vol.28 , pp. 3157-3166
    • Peschiaroli, A.1    Scialpi, F.2    Bernassola, F.3
  • 39
    • 27944506944 scopus 로고    scopus 로고
    • UFD2a mediates the proteasomal turnover of p73 without promoting p73 ubiquitination
    • M. Hosoda, T. Ozaki, and K. Miyazaki et al. UFD2a mediates the proteasomal turnover of p73 without promoting p73 ubiquitination Oncogene 24 2005 7156 7169
    • (2005) Oncogene , vol.24 , pp. 7156-7169
    • Hosoda, M.1    Ozaki, T.2    Miyazaki, K.3
  • 40
    • 0042349285 scopus 로고    scopus 로고
    • A novel HECT-type E3 ubiquitin ligase, NEDL2, stabilizes p73 and enhances its transcriptional activity
    • K. Miyazaki, T. Ozaki, and C. Kato et al. A novel HECT-type E3 ubiquitin ligase, NEDL2, stabilizes p73 and enhances its transcriptional activity Biochem. Biophys. Res. Commun. 308 2003 106 113
    • (2003) Biochem. Biophys. Res. Commun. , vol.308 , pp. 106-113
    • Miyazaki, K.1    Ozaki, T.2    Kato, C.3
  • 41
    • 0036791010 scopus 로고    scopus 로고
    • Mdm-2 and ubiquitin-independent p53 proteasomal degradation regulated by NQO1
    • G. Asher, J. Lotem, and L. Sachs et al. Mdm-2 and ubiquitin-independent p53 proteasomal degradation regulated by NQO1 Proc. Natl. Acad. Sci. USA 99 2002 13125 13130
    • (2002) Proc. Natl. Acad. Sci. USA , vol.99 , pp. 13125-13130
    • Asher, G.1    Lotem, J.2    Sachs, L.3
  • 42
    • 84891768461 scopus 로고    scopus 로고
    • Pin1 modulates p63α protein stability in regulation of cell survival, proliferation and tumor formation
    • (Dec 5)
    • C. Li, D.L. Chang, Z. Yang, and J. Qi et al. Pin1 modulates p63α protein stability in regulation of cell survival, proliferation and tumor formation Cell Death Dis. 4 2013 e943 (Dec 5)
    • (2013) Cell Death Dis. , vol.4 , pp. 943
    • Li, C.1    Chang, D.L.2    Yang, Z.3    Qi, J.4
  • 43
    • 84902993110 scopus 로고    scopus 로고
    • DLX5, FGF8 and the Pin1 isomerase control Δnp63α protein stability during limb development: A regulatory loop at the basis of the SHFM and EEC congenital malformations
    • (Feb 25, Epub ahead of print)
    • M. Restelli, T. Lopardo, and N. Lo Iacono et al. DLX5, FGF8 and the Pin1 isomerase control ΔNp63α protein stability during limb development: a regulatory loop at the basis of the SHFM and EEC congenital malformations Hum. Mol. Genet. 2014 (Feb 25, Epub ahead of print)
    • (2014) Hum. Mol. Genet.
    • Restelli, M.1    Lopardo, T.2    Lo Iacono, N.3
  • 44
    • 7244240783 scopus 로고    scopus 로고
    • C-Jun regulates the stability and activity of the p53 homologue, p73
    • W.H. Toh, M.M. Siddique, and L. Boominathan et al. C-Jun regulates the stability and activity of the p53 homologue, p73 J. Biol. Chem. 279 2004 44713 44722
    • (2004) J. Biol. Chem. , vol.279 , pp. 44713-44722
    • Toh, W.H.1    Siddique, M.M.2    Boominathan, L.3
  • 45
    • 77950430911 scopus 로고    scopus 로고
    • The antiapoptotic DeltaNp73 is degraded in a c-Jun-dependent manner upon genotoxic stress through the antizyme-mediated pathway
    • I. Dulloo, G. Gopalan, and G. Melino et al. The antiapoptotic DeltaNp73 is degraded in a c-Jun-dependent manner upon genotoxic stress through the antizyme-mediated pathway Proc. Natl. Acad. Sci. USA 107 2010 4902 4907
    • (2010) Proc. Natl. Acad. Sci. USA , vol.107 , pp. 4902-4907
    • Dulloo, I.1    Gopalan, G.2    Melino, G.3
  • 46
    • 77955648341 scopus 로고    scopus 로고
    • Differential control of TAp73 and DeltaNp73 protein stability by the ring finger ubiquitin ligase PIR2
    • B.S. Sayan, A.L. Yang, and F. Conforti et al. Differential control of TAp73 and DeltaNp73 protein stability by the ring finger ubiquitin ligase PIR2 Proc. Natl. Acad. Sci. USA 107 2010 12877 12882
    • (2010) Proc. Natl. Acad. Sci. USA , vol.107 , pp. 12877-12882
    • Sayan, B.S.1    Yang, A.L.2    Conforti, F.3
  • 47
    • 84876679235 scopus 로고    scopus 로고
    • Pirh2 E3 ubiquitin ligase modulates keratinocyte differentiation through p63
    • Y.S. Jung, Y. Qian, and W. Yan et al. Pirh2 E3 ubiquitin ligase modulates keratinocyte differentiation through p63 J. Invest. Dermatol. 133 2013 1178 1187
    • (2013) J. Invest. Dermatol. , vol.133 , pp. 1178-1187
    • Jung, Y.S.1    Qian, Y.2    Yan, W.3
  • 48
    • 38949123716 scopus 로고    scopus 로고
    • Biochemical and structural studies of ASPP proteins reveal differential binding to p53, p63, and p73
    • R.A. Robinson, X. Lu, E.Y. Jones, and C. Siebold Biochemical and structural studies of ASPP proteins reveal differential binding to p53, p63, and p73 Structure 16 2008 259 268
    • (2008) Structure , vol.16 , pp. 259-268
    • Robinson, R.A.1    Lu, X.2    Jones, E.Y.3    Siebold, C.4
  • 49
    • 33749118677 scopus 로고    scopus 로고
    • IASPP preferentially binds p53 proline-rich region and modulates apoptotic function of codon 72-polymorphic p53
    • D. Bergamaschi, Y. Samuels, and A. Sullivan et al. IASPP preferentially binds p53 proline-rich region and modulates apoptotic function of codon 72-polymorphic p53 Nat. Genet. 38 2006 1133 1141
    • (2006) Nat. Genet. , vol.38 , pp. 1133-1141
    • Bergamaschi, D.1    Samuels, Y.2    Sullivan, A.3
  • 50
    • 1642499353 scopus 로고    scopus 로고
    • ASPP1 and ASPP2: Common activators of p53 family members
    • D. Bergamaschi, Y. Samuels, and B. Jin et al. ASPP1 and ASPP2: common activators of p53 family members Mol. Cell. Biol. 24 2004 1341 1350
    • (2004) Mol. Cell. Biol. , vol.24 , pp. 1341-1350
    • Bergamaschi, D.1    Samuels, Y.2    Jin, B.3
  • 51
    • 33745631827 scopus 로고    scopus 로고
    • Pattern of p63 mutations and their phenotypes-update
    • T. Rinne, B. Hamel, and H. van Bokhoven et al. Pattern of p63 mutations and their phenotypes-update Am. J. Med. Genet. A 140 2006 1396 1406
    • (2006) Am. J. Med. Genet. A , vol.140 , pp. 1396-1406
    • Rinne, T.1    Hamel, B.2    Van Bokhoven, H.3
  • 52
    • 80052657539 scopus 로고    scopus 로고
    • A symphony of regulations centered on p63 to control development of ectoderm-derived structures
    • L. Guerrini, A. Costanzo, and G.R. Merlo A symphony of regulations centered on p63 to control development of ectoderm-derived structures J. Biomed. Biotechnol. 2011 2011 864904
    • (2011) J. Biomed. Biotechnol. , vol.2011 , pp. 864904
    • Guerrini, L.1    Costanzo, A.2    Merlo, G.R.3
  • 54
    • 0035253507 scopus 로고    scopus 로고
    • Hay-Wells syndrome is caused by heterozygous missense mutations in the SAM domain of p63
    • J.A. McGrath, P.H. Duijf, and V. Doetsch et al. Hay-Wells syndrome is caused by heterozygous missense mutations in the SAM domain of p63 Hum. Mol. Genet. 10 2001 221 229
    • (2001) Hum. Mol. Genet. , vol.10 , pp. 221-229
    • McGrath, J.A.1    Duijf, P.H.2    Doetsch, V.3
  • 55
    • 34247511981 scopus 로고    scopus 로고
    • P63 Is essential for the proliferative potential of stem cells in stratified epithelia
    • M. Senoo, F. Pinto, and C.P. Crum et al. P63 Is essential for the proliferative potential of stem cells in stratified epithelia Cell 129 2007 523 536
    • (2007) Cell , vol.129 , pp. 523-536
    • Senoo, M.1    Pinto, F.2    Crum, C.P.3
  • 56
    • 24344447780 scopus 로고    scopus 로고
    • P63 deficiency activates a program of cellular senescence and leads to accelerated aging
    • W.M. Keyes, Y. Wu, and H. Vogel et al. P63 deficiency activates a program of cellular senescence and leads to accelerated aging Genes Dev. 19 2005 1986 1999
    • (2005) Genes Dev. , vol.19 , pp. 1986-1999
    • Keyes, W.M.1    Wu, Y.2    Vogel, H.3
  • 57
    • 67649159970 scopus 로고    scopus 로고
    • TAp63 prevents premature aging by promoting adult stem cell maintenance
    • X. Su, M. Paris, and Y.J. Gi et al. TAp63 prevents premature aging by promoting adult stem cell maintenance Cell Stem Cell 5 2009 64 75
    • (2009) Cell Stem Cell , vol.5 , pp. 64-75
    • Su, X.1    Paris, M.2    Gi, Y.J.3
  • 58
    • 55349124977 scopus 로고    scopus 로고
    • DeltaNp63 is essential for epidermal commitment of embryonic stem cells
    • A. Medawar, T. Virolle, and P. Rostagno et al. DeltaNp63 is essential for epidermal commitment of embryonic stem cells PLoS One 3 2008 e3441
    • (2008) PLoS One , vol.3 , pp. 3441
    • Medawar, A.1    Virolle, T.2    Rostagno, P.3
  • 59
    • 33646711244 scopus 로고    scopus 로고
    • P63 regulates multiple signalling pathways required for ectodermal organogenesis and differentiation
    • J. Laurikkala, M.L. Mikkola, and M. James et al. P63 regulates multiple signalling pathways required for ectodermal organogenesis and differentiation Development 133 2006 1553 1563
    • (2006) Development , vol.133 , pp. 1553-1563
    • Laurikkala, J.1    Mikkola, M.L.2    James, M.3
  • 60
    • 33845244180 scopus 로고    scopus 로고
    • P63 protects the female germ line during meiotic arrest
    • E.K. Suh, A. Yang, and A. Kettenbach et al. P63 protects the female germ line during meiotic arrest Nature 444 2006 624 628
    • (2006) Nature , vol.444 , pp. 624-628
    • Suh, E.K.1    Yang, A.2    Kettenbach, A.3
  • 61
    • 0942301281 scopus 로고    scopus 로고
    • P63 is the molecular switch for initiation of an epithelial stratification program
    • M.I. Koster, S. Kim, and A.A. Mills et al. P63 is the molecular switch for initiation of an epithelial stratification program Genes Dev. 18 2004 126 131
    • (2004) Genes Dev. , vol.18 , pp. 126-131
    • Koster, M.I.1    Kim, S.2    Mills, A.A.3
  • 62
    • 33847623675 scopus 로고    scopus 로고
    • P63 induces key target genes required for epidermal morphogenesis
    • M.I. Koster, D. Dai, and B. Marinari et al. p63 induces key target genes required for epidermal morphogenesis Proc. Natl. Acad. Sci. USA 104 2007 3255 3260
    • (2007) Proc. Natl. Acad. Sci. USA , vol.104 , pp. 3255-3260
    • Koster, M.I.1    Dai, D.2    Marinari, B.3
  • 63
    • 0037804687 scopus 로고    scopus 로고
    • DNp63alpha functions as both a positive and a negative transcriptional regulator and blocks in vitro differentiation of murine keratinocytes
    • K.E. King, R.M. Ponnamperuma, and T. Yamashita et al. DNp63alpha functions as both a positive and a negative transcriptional regulator and blocks in vitro differentiation of murine keratinocytes Oncogene 22 2003 3635 3644
    • (2003) Oncogene , vol.22 , pp. 3635-3644
    • King, K.E.1    Ponnamperuma, R.M.2    Yamashita, T.3
  • 64
    • 33645894992 scopus 로고    scopus 로고
    • Cross-regulation between Notch and p63 in keratinocyte commitment to differentiation
    • B.C. Nguyen, K. Lefort, and A. Mandinova et al. Cross-regulation between Notch and p63 in keratinocyte commitment to differentiation Genes Dev. 20 2006 1028 1042
    • (2006) Genes Dev. , vol.20 , pp. 1028-1042
    • Nguyen, B.C.1    Lefort, K.2    Mandinova, A.3
  • 65
    • 77951865156 scopus 로고    scopus 로고
    • A regulatory feedback loop involving p63 and IRF6 links the pathogenesis of 2 genetically different human ectodermal dysplasias
    • F. Moretti, B. Marinari, and N. Lo Iacono et al. A regulatory feedback loop involving p63 and IRF6 links the pathogenesis of 2 genetically different human ectodermal dysplasias J. Clin. Invest. 120 2010 1570 1577
    • (2010) J. Clin. Invest. , vol.120 , pp. 1570-1577
    • Moretti, F.1    Marinari, B.2    Lo Iacono, N.3
  • 66
    • 65949100595 scopus 로고    scopus 로고
    • Homeodomain protein Dlx3 induces phosphorylation-dependent p63 degradation
    • A. Di Costanzo, L. Festa, and O. Duverger et al. Homeodomain protein Dlx3 induces phosphorylation-dependent p63 degradation Cell Cycle 8 2009 1185 1195
    • (2009) Cell Cycle , vol.8 , pp. 1185-1195
    • Di Costanzo, A.1    Festa, L.2    Duverger, O.3
  • 67
    • 65949090056 scopus 로고    scopus 로고
    • A feedback regulatory loop between p63 and Dlx3: Implications for epidermal differentiation
    • F. Moretti, and A. Costanzo A feedback regulatory loop between p63 and Dlx3: implications for epidermal differentiation Cell Cycle 8 2009 1113
    • (2009) Cell Cycle , vol.8 , pp. 1113
    • Moretti, F.1    Costanzo, A.2
  • 68
    • 40749111551 scopus 로고    scopus 로고
    • A skin microRNA promotes differentiation by repressing 'stemness'
    • R. Yi, M.N. Poy, M. Stoffel, and E. Fuchs A skin microRNA promotes differentiation by repressing 'stemness' Nature 452 2008 225 229
    • (2008) Nature , vol.452 , pp. 225-229
    • Yi, R.1    Poy, M.N.2    Stoffel, M.3    Fuchs, E.4
  • 69
    • 27644547419 scopus 로고    scopus 로고
    • Chromatin immunoprecipitation-based screen to identify functional genomic binding sites for sequence-specific transactivators
    • J.M. Hearnes, D.J. Mays, and K.L. Schavolt et al. Chromatin immunoprecipitation-based screen to identify functional genomic binding sites for sequence-specific transactivators Mol. Cell. Biol. 25 2005 10148 10158
    • (2005) Mol. Cell. Biol. , vol.25 , pp. 10148-10158
    • Hearnes, J.M.1    Mays, D.J.2    Schavolt, K.L.3
  • 70
    • 27144448738 scopus 로고    scopus 로고
    • A p38-dependent pathway regulates DeltaNp63 DNA binding to p53-dependent promoters in UV-induced apoptosis of keratinocytes
    • M. Papoutsaki, F. Moretti, and M. Lanza et al. A p38-dependent pathway regulates DeltaNp63 DNA binding to p53-dependent promoters in UV-induced apoptosis of keratinocytes Oncogene 24 2005 6970 6975
    • (2005) Oncogene , vol.24 , pp. 6970-6975
    • Papoutsaki, M.1    Moretti, F.2    Lanza, M.3
  • 71
    • 84886242972 scopus 로고    scopus 로고
    • Phospho-ΔNp63α regulates AQP3, ALOX12B, CASP14 and CLDN1 expression through transcription and microRNA modulation
    • E.A. Ratovitski Phospho-ΔNp63α regulates AQP3, ALOX12B, CASP14 and CLDN1 expression through transcription and microRNA modulation FEBS Lett. 587 2013 3581 3586
    • (2013) FEBS Lett. , vol.587 , pp. 3581-3586
    • Ratovitski, E.A.1
  • 72
    • 58149360788 scopus 로고    scopus 로고
    • IKKalpha is a p63 transcriptional target involved in the pathogenesis of ectodermal dysplasias
    • B. Marinari, C. Ballaro, and M.I. Koster et al. IKKalpha is a p63 transcriptional target involved in the pathogenesis of ectodermal dysplasias J. Invest. Dermatol. 129 2009 60 69
    • (2009) J. Invest. Dermatol. , vol.129 , pp. 60-69
    • Marinari, B.1    Ballaro, C.2    Koster, M.I.3
  • 73
    • 69249131771 scopus 로고    scopus 로고
    • Differential PERP regulation by TP63 mutants provides insight into AEC pathogenesis
    • V.G. Beaudry, N. Pathak, M.I. Koster, and L.D. Attardi Differential PERP regulation by TP63 mutants provides insight into AEC pathogenesis Am. J. Med. Genet. A 149A 2009 1952 1957
    • (2009) Am. J. Med. Genet. A , vol.149 A , pp. 1952-1957
    • Beaudry, V.G.1    Pathak, N.2    Koster, M.I.3    Attardi, L.D.4
  • 74
    • 78650334266 scopus 로고    scopus 로고
    • Regulation of Δnp63α by NF-κB
    • T. Sen, X. Chang, and D. Sidransky et al. Regulation of ΔNp63α by NF-κB Cell Cycle 9 2010 24
    • (2010) Cell Cycle , vol.9 , pp. 24
    • Sen, T.1    Chang, X.2    Sidransky, D.3
  • 75
    • 1942484963 scopus 로고    scopus 로고
    • IkappaB kinase-alpha acts in the epidermis to control skeletal and craniofacial morphogenesis
    • A.K. Sil, S. Maeda, Y. Sano, and D.R. Roop et al. IkappaB kinase-alpha acts in the epidermis to control skeletal and craniofacial morphogenesis Nature 428 2004 660 664
    • (2004) Nature , vol.428 , pp. 660-664
    • Sil, A.K.1    Maeda, S.2    Sano, Y.3    Roop, D.R.4
  • 76
    • 40649097065 scopus 로고    scopus 로고
    • IKKalpha is a critical coregulator of a Smad4-independent TGFbeta-Smad2/3 signaling pathway that controls keratinocyte differentiation
    • P. Descargues, A.K. Sil, and Y. Sano et al. IKKalpha is a critical coregulator of a Smad4-independent TGFbeta-Smad2/3 signaling pathway that controls keratinocyte differentiation Proc. Natl. Acad. Sci. USA 105 2008 2487 2492
    • (2008) Proc. Natl. Acad. Sci. USA , vol.105 , pp. 2487-2492
    • Descargues, P.1    Sil, A.K.2    Sano, Y.3
  • 77
    • 55949089769 scopus 로고    scopus 로고
    • The tumor suppressor activity of IKKalpha in stratified epithelia is exerted in part via the TGF-beta antiproliferative pathway
    • B. Marinari, F. Moretti, and E. Botti et al. The tumor suppressor activity of IKKalpha in stratified epithelia is exerted in part via the TGF-beta antiproliferative pathway Proc. Natl. Acad. Sci. USA 105 2008 17091 17096
    • (2008) Proc. Natl. Acad. Sci. USA , vol.105 , pp. 17091-17096
    • Marinari, B.1    Moretti, F.2    Botti, E.3
  • 78
    • 77951849894 scopus 로고    scopus 로고
    • Cooperation between the transcription factors p63 and IRF6 is essential to prevent cleft palate in mice
    • H.A. Thomason, H. Zhou, and E.N. Kouwenhoven et al. Cooperation between the transcription factors p63 and IRF6 is essential to prevent cleft palate in mice J. Clin. Invest. 120 2010 1561 1569
    • (2010) J. Clin. Invest. , vol.120 , pp. 1561-1569
    • Thomason, H.A.1    Zhou, H.2    Kouwenhoven, E.N.3
  • 79
    • 49049120287 scopus 로고    scopus 로고
    • Facial clefting in Tp63 deficient mice results from altered Bmp4, Fgf8 and Shh signaling
    • H.A. Thomason, M.J. Dixon, and J. Dixon Facial clefting in Tp63 deficient mice results from altered Bmp4, Fgf8 and Shh signaling Dev. Biol. 321 2008 273 282
    • (2008) Dev. Biol. , vol.321 , pp. 273-282
    • Thomason, H.A.1    Dixon, M.J.2    Dixon, J.3
  • 80
    • 42349098965 scopus 로고    scopus 로고
    • The quest for the 1p36 tumor suppressor
    • A. Bagchi, and A.A. Mills The quest for the 1p36 tumor suppressor Cancer Res. 68 2008 2551 2556
    • (2008) Cancer Res. , vol.68 , pp. 2551-2556
    • Bagchi, A.1    Mills, A.A.2
  • 81
    • 0035082243 scopus 로고    scopus 로고
    • Role of the newer p53 family proteins in malignancy
    • M.S. Irwin, and W.G. Kaelin Jr. Role of the newer p53 family proteins in malignancy Apoptosis 6 2001 17 29
    • (2001) Apoptosis , vol.6 , pp. 17-29
    • Irwin, M.S.1    Kaelin, Jr.W.G.2
  • 83
    • 0037044799 scopus 로고    scopus 로고
    • Identification of direct p73 target genes combining DNA microarray and chromatin immunoprecipitation analyses
    • G. Fontemaggi, I. Kela, and N. Amariglio et al. Identification of direct p73 target genes combining DNA microarray and chromatin immunoprecipitation analyses J. Biol. Chem. 277 2002 43359 43368
    • (2002) J. Biol. Chem. , vol.277 , pp. 43359-43368
    • Fontemaggi, G.1    Kela, I.2    Amariglio, N.3
  • 84
    • 0042977668 scopus 로고    scopus 로고
    • DeltaNp73 facilitates cell immortalization and cooperates with oncogenic Ras in cellular transformation in vivo
    • O. Petrenko, A. Zaika, and U.M. Moll DeltaNp73 facilitates cell immortalization and cooperates with oncogenic Ras in cellular transformation in vivo Mol. Cell. Biol. 23 2003 5540 5555
    • (2003) Mol. Cell. Biol. , vol.23 , pp. 5540-5555
    • Petrenko, O.1    Zaika, A.2    Moll, U.M.3
  • 85
    • 0033565514 scopus 로고    scopus 로고
    • Transcriptional silencing of the p73 gene in acute lymphoblastic leukemia and Burkitt's lymphoma is associated with 5′ CpG island methylation
    • P.G. Corn, S.J. Kuerbitz, and M.M. van Noesel et al. Transcriptional silencing of the p73 gene in acute lymphoblastic leukemia and Burkitt's lymphoma is associated with 5′ CpG island methylation Cancer Res. 59 1999 3352 3356
    • (1999) Cancer Res. , vol.59 , pp. 3352-3356
    • Corn, P.G.1    Kuerbitz, S.J.2    Van Noesel, M.M.3
  • 86
    • 0033179665 scopus 로고    scopus 로고
    • Loss of p73 gene expression in leukemias/lymphomas due to hypermethylation
    • S. Kawano, C.W. Miller, and A.F. Gombart et al. Loss of p73 gene expression in leukemias/lymphomas due to hypermethylation Blood 94 1999 1113 1120
    • (1999) Blood , vol.94 , pp. 1113-1120
    • Kawano, S.1    Miller, C.W.2    Gombart, A.F.3
  • 87
    • 33744830912 scopus 로고    scopus 로고
    • P63 heterozygous mutant mice are not prone to spontaneous or chemically induced tumors
    • W.M. Keyes, H. Vogel, and M.I. Koster et al. P63 heterozygous mutant mice are not prone to spontaneous or chemically induced tumors Proc. Natl. Acad. Sci. USA 103 2006 8435 8440
    • (2006) Proc. Natl. Acad. Sci. USA , vol.103 , pp. 8435-8440
    • Keyes, W.M.1    Vogel, H.2    Koster, M.I.3
  • 88
    • 84856188471 scopus 로고    scopus 로고
    • Δnp63 knockout mice reveal its indispensable role as a master regulator of epithelial development and differentiation
    • R.A. Romano, K. Smalley, and C. Magraw et al. ΔNp63 knockout mice reveal its indispensable role as a master regulator of epithelial development and differentiation Development 4 2012 772 782
    • (2012) Development , vol.4 , pp. 772-782
    • Romano, R.A.1    Smalley, K.2    Magraw, C.3
  • 90
    • 84872295543 scopus 로고    scopus 로고
    • TAp73 is required for macrophage-mediated innate immunity and the resolution of inflammatory responses
    • R. Tomasini, V. Secq, and L. Pouyet et al. TAp73 is required for macrophage-mediated innate immunity and the resolution of inflammatory responses Cell Death Differ. 20 2013 293 301
    • (2013) Cell Death Differ. , vol.20 , pp. 293-301
    • Tomasini, R.1    Secq, V.2    Pouyet, L.3
  • 91
    • 84897491377 scopus 로고    scopus 로고
    • TAp73 is essential for germ cell adhesion and maturation in testis
    • L. Holembowski, D. Kramer, and D. Riedel et al. TAp73 is essential for germ cell adhesion and maturation in testis J. Cell Biol. 204 2014 1173 1190
    • (2014) J. Cell Biol. , vol.204 , pp. 1173-1190
    • Holembowski, L.1    Kramer, D.2    Riedel, D.3
  • 92
    • 84893467658 scopus 로고    scopus 로고
    • TAp73 is required for spermatogenesis and the maintenance of male fertility
    • S. Inoue, R. Tomasini, and A. Rufini et al. TAp73 is required for spermatogenesis and the maintenance of male fertility Proc. Natl. Acad. Sci. USA 111 2014 1843 1848
    • (2014) Proc. Natl. Acad. Sci. USA , vol.111 , pp. 1843-1848
    • Inoue, S.1    Tomasini, R.2    Rufini, A.3
  • 93
    • 58849134327 scopus 로고    scopus 로고
    • TAp73 regulates the spindle assembly checkpoint by modulating BubR1 activity
    • R. Tomasini, K. Tsuchihara, and C. Tsuda et al. TAp73 regulates the spindle assembly checkpoint by modulating BubR1 activity Proc. Natl. Acad. Sci. USA 106 2009 797 802
    • (2009) Proc. Natl. Acad. Sci. USA , vol.106 , pp. 797-802
    • Tomasini, R.1    Tsuchihara, K.2    Tsuda, C.3
  • 94
    • 1542572304 scopus 로고    scopus 로고
    • P73 is regulated by phosphorylation at the G2/M transition
    • M. Fulco, A. Costanzo, and P. Merlo et al. P73 is regulated by phosphorylation at the G2/M transition J. Biol. Chem. 278 2003 49196 49202
    • (2003) J. Biol. Chem. , vol.278 , pp. 49196-49202
    • Fulco, M.1    Costanzo, A.2    Merlo, P.3
  • 95
    • 24044476212 scopus 로고    scopus 로고
    • A role of p73 in mitotic exit
    • P. Merlo, M. Fulco, and A. Costanzo et al. A role of p73 in mitotic exit J. Biol. Chem. 80 2005 30354 30360
    • (2005) J. Biol. Chem. , vol.80 , pp. 30354-30360
    • Merlo, P.1    Fulco, M.2    Costanzo, A.3
  • 96
    • 34547737480 scopus 로고    scopus 로고
    • P73 suppresses polyploidy and aneuploidy in the absence of functional p53
    • F. Talos, A. Nemajerova, and E.R. Flores et al. P73 suppresses polyploidy and aneuploidy in the absence of functional p53 Mol. Cell 27 2007 647 659
    • (2007) Mol. Cell , vol.27 , pp. 647-659
    • Talos, F.1    Nemajerova, A.2    Flores, E.R.3
  • 97
    • 58249089039 scopus 로고    scopus 로고
    • P53 and p73 in suppression of Myc-driven lymphomagenesis
    • H. Griesmann, K. Schlereth, and M. Krause et al. P53 and p73 in suppression of Myc-driven lymphomagenesis Int. J. Cancer 124 2009 502 506
    • (2009) Int. J. Cancer , vol.124 , pp. 502-506
    • Griesmann, H.1    Schlereth, K.2    Krause, M.3
  • 98
    • 77953228868 scopus 로고    scopus 로고
    • Loss of p73 promotes dissemination of Myc-induced B cell lymphomas in mice
    • A. Nemajerova, O. Petrenko, and L. Trumper et al. Loss of p73 promotes dissemination of Myc-induced B cell lymphomas in mice J. Clin. Invest. 120 2010 2070 2080
    • (2010) J. Clin. Invest. , vol.120 , pp. 2070-2080
    • Nemajerova, A.1    Petrenko, O.2    Trumper, L.3
  • 99
    • 84877311822 scopus 로고    scopus 로고
    • Global genomic profiling reveals an extensive p53-regulated autophagy program contributing to key p53 responses
    • D. Kenzelmann Broz, and S. Spano Mello et al. Global genomic profiling reveals an extensive p53-regulated autophagy program contributing to key p53 responses Genes Dev. 27 2013 1016 1031
    • (2013) Genes Dev. , vol.27 , pp. 1016-1031
    • Kenzelmann Broz, D.1    Spano Mello, S.2
  • 100
    • 0037041392 scopus 로고    scopus 로고
    • P63 and p73 are required for p53-dependent apoptosis in response to DNA damage
    • E.R. Flores, K.Y. Tsai, and D. Crowley et al. P63 and p73 are required for p53-dependent apoptosis in response to DNA damage Nature 416 2002 560 564
    • (2002) Nature , vol.416 , pp. 560-564
    • Flores, E.R.1    Tsai, K.Y.2    Crowley, D.3
  • 101
    • 79955751752 scopus 로고    scopus 로고
    • Metabolic regulation by p53
    • O.D. Maddocks, and K.H. Vousden Metabolic regulation by p53 J. Mol. Med. 89 2011 237 245
    • (2011) J. Mol. Med. , vol.89 , pp. 237-245
    • Maddocks, O.D.1    Vousden, K.H.2
  • 102
    • 84867094874 scopus 로고    scopus 로고
    • TAp63 is a master transcriptional regulator of lipid and glucose metabolism
    • X. Su, Y.J. Gi, and D. Chakravarti et al. TAp63 is a master transcriptional regulator of lipid and glucose metabolism Cell Metab. 16 2012 511 525
    • (2012) Cell Metab. , vol.16 , pp. 511-525
    • Su, X.1    Gi, Y.J.2    Chakravarti, D.3
  • 103
    • 84883776970 scopus 로고    scopus 로고
    • P73 regulates autophagy and hepatocellular lipid metabolism through a transcriptional activation of the ATG5 gene
    • Z. He, H. Liu, and M. Agostini et al. p73 regulates autophagy and hepatocellular lipid metabolism through a transcriptional activation of the ATG5 gene Cell Death Differ. 20 2013 1415 1424
    • (2013) Cell Death Differ. , vol.20 , pp. 1415-1424
    • He, Z.1    Liu, H.2    Agostini, M.3
  • 104
    • 84868019043 scopus 로고    scopus 로고
    • Cancer cell metabolism: One hallmark, many faces
    • J.R. Cantor, and D.M. Sabatini Cancer cell metabolism: one hallmark, many faces Cancer Discov. 10 2012 881 898
    • (2012) Cancer Discov. , vol.10 , pp. 881-898
    • Cantor, J.R.1    Sabatini, D.M.2
  • 105
    • 84881453767 scopus 로고    scopus 로고
    • TAp73 enhances the pentose phosphate pathway and supports cell proliferation
    • W. Du, P. Jiang, and A. Mancuso et al. TAp73 enhances the pentose phosphate pathway and supports cell proliferation Nat. Cell Biol. 15 2013 991 1000
    • (2013) Nat. Cell Biol. , vol.15 , pp. 991-1000
    • Du, W.1    Jiang, P.2    Mancuso, A.3
  • 106
    • 84866497949 scopus 로고    scopus 로고
    • TAp73 depletion accelerates aging through metabolic dysregulation
    • A. Rufini, M.V. Niklison-Chirou, and S. Inoue et al. TAp73 depletion accelerates aging through metabolic dysregulation Genes Dev. 26 2012 2009 2014
    • (2012) Genes Dev. , vol.26 , pp. 2009-2014
    • Rufini, A.1    Niklison-Chirou, M.V.2    Inoue, S.3
  • 107
    • 79952280229 scopus 로고    scopus 로고
    • P53 regulates biosynthesis through direct inactivation of glucose-6-phosphate dehydrogenase
    • P. Jiang, W. Du, and X. Wang et al. p53 regulates biosynthesis through direct inactivation of glucose-6-phosphate dehydrogenase Nat. Cell Biol. 13 2011 310 316
    • (2011) Nat. Cell Biol. , vol.13 , pp. 310-316
    • Jiang, P.1    Du, W.2    Wang, X.3
  • 108
    • 33745918951 scopus 로고    scopus 로고
    • TIGAR, a p53-inducible regulator of glycolysis and apoptosis
    • K. Bensaad, A. Tsuruta, and M.A. Selak et al. TIGAR, a p53-inducible regulator of glycolysis and apoptosis Cell 126 1 2006 107 120
    • (2006) Cell , vol.126 , Issue.1 , pp. 107-120
    • Bensaad, K.1    Tsuruta, A.2    Selak, M.A.3
  • 109
    • 84878981053 scopus 로고    scopus 로고
    • TIGAR is required for efficient intestinal regeneration and tumorigenesis
    • E.C. Cheung, D. Athineos, and P. Lee et al. TIGAR is required for efficient intestinal regeneration and tumorigenesis Dev. Cell 25 2013 463 477
    • (2013) Dev. Cell , vol.25 , pp. 463-477
    • Cheung, E.C.1    Athineos, D.2    Lee, P.3
  • 110
    • 84890403623 scopus 로고    scopus 로고
    • GLS2 is transcriptionally regulated by p73 and contributes to neuronal differentiation
    • T. Velletri, F. Romeo, and P. Tucci et al. GLS2 is transcriptionally regulated by p73 and contributes to neuronal differentiation Cell Cycle 12 2013 3564 3573
    • (2013) Cell Cycle , vol.12 , pp. 3564-3573
    • Velletri, T.1    Romeo, F.2    Tucci, P.3
  • 111
    • 84961390534 scopus 로고    scopus 로고
    • P73 regulates serine biosynthesis in cancer
    • 10.1038/onc.2013.456 (Nov 4, Epub ahead of print)
    • I. Amelio, E.K. Markert, and A. Rufini et al. p73 regulates serine biosynthesis in cancer Oncogene 2013 10.1038/onc.2013.456 (Nov 4, Epub ahead of print)
    • (2013) Oncogene
    • Amelio, I.1    Markert, E.K.2    Rufini, A.3
  • 113
    • 77952227625 scopus 로고    scopus 로고
    • Phosphate-activated glutaminase (GLS2), a p53-inducible regulator of glutamine metabolism and reactive oxygen species
    • S. Suzuki, T. Tanaka, and M.V. Poyurovsky et al. Phosphate-activated glutaminase (GLS2), a p53-inducible regulator of glutamine metabolism and reactive oxygen species Proc. Natl. Acad. Sci. USA 107 2010 7461 7466
    • (2010) Proc. Natl. Acad. Sci. USA , vol.107 , pp. 7461-7466
    • Suzuki, S.1    Tanaka, T.2    Poyurovsky, M.V.3
  • 114
    • 77952212178 scopus 로고    scopus 로고
    • Glutaminase 2, a novel p53 target gene regulating energy metabolism and antioxidant function
    • W. Hu, C. Zhang, and R. Wu et al. Glutaminase 2, a novel p53 target gene regulating energy metabolism and antioxidant function Proc. Natl. Acad. Sci. USA 107 2010 7455 7460
    • (2010) Proc. Natl. Acad. Sci. USA , vol.107 , pp. 7455-7460
    • Hu, W.1    Zhang, C.2    Wu, R.3
  • 115
    • 79955751752 scopus 로고    scopus 로고
    • Metabolic regulation by p53
    • O.D. Maddocks, and K.H. Vousden Metabolic regulation by p53 J. Mol. Med. 2011 89 2011 237 245
    • (2011) J. Mol. Med. , vol.2011 , Issue.89 , pp. 237-245
    • Maddocks, O.D.1    Vousden, K.H.2
  • 116
    • 84875894714 scopus 로고    scopus 로고
    • Glutamine supports pancreatic cancer growth through a KRAS-regulated metabolic pathway
    • J. Son, C.A. Lyssiotis, and H. Ying et al. Glutamine supports pancreatic cancer growth through a KRAS-regulated metabolic pathway Nature 496 2013 101 105
    • (2013) Nature , vol.496 , pp. 101-105
    • Son, J.1    Lyssiotis, C.A.2    Ying, H.3
  • 117
    • 84873678601 scopus 로고    scopus 로고
    • Reciprocal regulation of p53 and malic enzymes modulates metabolism and senescence
    • P. Jiang, W. Du, A. Mancuso, K.E. Wellen, and X. Yang Reciprocal regulation of p53 and malic enzymes modulates metabolism and senescence Nature 493 2013 689 693
    • (2013) Nature , vol.493 , pp. 689-693
    • Jiang, P.1    Du, W.2    Mancuso, A.3    Wellen, K.E.4    Yang, X.5
  • 118
    • 84891886652 scopus 로고    scopus 로고
    • A critical role of glucose-6-phosphate dehydrogenase in TAp73-mediated cell proliferation
    • P. Jiang, W. Du, and X. Yang A critical role of glucose-6-phosphate dehydrogenase in TAp73-mediated cell proliferation Cell Cycle 12 2013 3720 3726
    • (2013) Cell Cycle , vol.12 , pp. 3720-3726
    • Jiang, P.1    Du, W.2    Yang, X.3
  • 119
    • 72249108928 scopus 로고    scopus 로고
    • P73 and p63 sustain cellular growth by transcriptional activation of cell cycle progression genes
    • K. Lefkimmiatis, M.F. Caratozzolo, and P. Merlo et al. p73 and p63 sustain cellular growth by transcriptional activation of cell cycle progression genes Cancer Res. 69 2009 8563 8571
    • (2009) Cancer Res. , vol.69 , pp. 8563-8571
    • Lefkimmiatis, K.1    Caratozzolo, M.F.2    Merlo, P.3
  • 120
    • 31144431726 scopus 로고    scopus 로고
    • Connecting p63 to cellular proliferation: The example of the adenosine deaminase target gene
    • E. Sbisà, G. Mastropasqua, and K. Lefkimmiatis et al. Connecting p63 to cellular proliferation: the example of the adenosine deaminase target gene Cell Cycle 2 2006 205 212
    • (2006) Cell Cycle , vol.2 , pp. 205-212
    • Sbisà, E.1    Mastropasqua, G.2    Lefkimmiatis, K.3
  • 121
    • 84873638664 scopus 로고    scopus 로고
    • P63 regulates cell proliferation and cell cycle progression-associated genes in stromal cells of giant cell tumor of the bone
    • C.P. Lau, P.K. Ng, and M.S. Li et al. p63 regulates cell proliferation and cell cycle progression-associated genes in stromal cells of giant cell tumor of the bone Int. J. Oncol. 42 2013 437 443
    • (2013) Int. J. Oncol. , vol.42 , pp. 437-443
    • Lau, C.P.1    Ng, P.K.2    Li, M.S.3
  • 122
    • 0041997348 scopus 로고    scopus 로고
    • Chemosensitivity linked to p73 function
    • M.S. Irwin, K. Kondo, and M. Marin Jr. et al. Chemosensitivity linked to p73 function Cancer Cell 3 2003 403 410
    • (2003) Cancer Cell , vol.3 , pp. 403-410
    • Irwin, M.S.1    Kondo, K.2    Marin, Jr.M.3
  • 123
    • 0038142184 scopus 로고    scopus 로고
    • Differential regulation of E2F1 apoptotic target genes in response to DNA damage
    • N. Pediconi, A. Ianari, and A. Costanzo et al. Differential regulation of E2F1 apoptotic target genes in response to DNA damage Nat. Cell Biol. 5 2003 552 558
    • (2003) Nat. Cell Biol. , vol.5 , pp. 552-558
    • Pediconi, N.1    Ianari, A.2    Costanzo, A.3
  • 124
    • 67649213878 scopus 로고    scopus 로고
    • Acetylation status of E2F-1 has an important role in the regulation of E2F-1-mediated transactivation of tumor suppressor p73
    • T. Ozaki, R. Okoshi, and M. Sang et al. Acetylation status of E2F-1 has an important role in the regulation of E2F-1-mediated transactivation of tumor suppressor p73 Biochem. Biophys. Res. Commun. 386 2009 207 211
    • (2009) Biochem. Biophys. Res. Commun. , vol.386 , pp. 207-211
    • Ozaki, T.1    Okoshi, R.2    Sang, M.3
  • 125
    • 10644270921 scopus 로고    scopus 로고
    • P73 induction after DNA damage is regulated by checkpoint kinases Chk1 and Chk2
    • M. Urist, T. Tanaka, and M.V. Poyurovsky et al. P73 induction after DNA damage is regulated by checkpoint kinases Chk1 and Chk2 Genes Dev. 18 2004 3041 3054
    • (2004) Genes Dev. , vol.18 , pp. 3041-3054
    • Urist, M.1    Tanaka, T.2    Poyurovsky, M.V.3
  • 126
    • 64649092913 scopus 로고    scopus 로고
    • HSirT1-dependent regulation of the PCAF-E2F1-p73 apoptotic pathway in response to DNA damage
    • N. Pediconi, F. Guerrieri, and S. Vossio et al. HSirT1-dependent regulation of the PCAF-E2F1-p73 apoptotic pathway in response to DNA damage Mol. Cell. Biol. 29 2009 1989 1998
    • (2009) Mol. Cell. Biol. , vol.29 , pp. 1989-1998
    • Pediconi, N.1    Guerrieri, F.2    Vossio, S.3
  • 127
    • 77954274181 scopus 로고    scopus 로고
    • Lysine methylation regulates E2F1-induced cell death
    • H. Kontaki, and I. Talianidis Lysine methylation regulates E2F1-induced cell death Mol. Cell 39 2010 152 160
    • (2010) Mol. Cell , vol.39 , pp. 152-160
    • Kontaki, H.1    Talianidis, I.2
  • 128
    • 0033600240 scopus 로고    scopus 로고
    • Interaction of c-Abl and p73alpha and their collaboration to induce apoptosis
    • R. Agami, G. Blandino, and M. Oren et al. Interaction of c-Abl and p73alpha and their collaboration to induce apoptosis Nature 399 1999 809 813
    • (1999) Nature , vol.399 , pp. 809-813
    • Agami, R.1    Blandino, G.2    Oren, M.3
  • 129
    • 0033600234 scopus 로고    scopus 로고
    • The tyrosine kinase c-Abl regulates p73 in apoptotic response to cisplatin-induced DNA damage
    • J.G. Gong, A. Costanzo, and H.Q. Yang et al. The tyrosine kinase c-Abl regulates p73 in apoptotic response to cisplatin-induced DNA damage Nature 399 1999 806 809
    • (1999) Nature , vol.399 , pp. 806-809
    • Gong, J.G.1    Costanzo, A.2    Yang, H.Q.3
  • 130
    • 0033600235 scopus 로고    scopus 로고
    • P73 is regulated by tyrosine kinase c-Abl in the apoptotic response to DNA damage
    • Z.M. Yuan, H. Shioya, and T. Ishiko et al. p73 is regulated by tyrosine kinase c-Abl in the apoptotic response to DNA damage Nature 399 1999 814 817
    • (1999) Nature , vol.399 , pp. 814-817
    • Yuan, Z.M.1    Shioya, H.2    Ishiko, T.3
  • 131
    • 0242664079 scopus 로고    scopus 로고
    • P73alpha regulation by Chk1 in response to DNA damage
    • S. Gonzalez, C. Prives, and C. Cordon-Cardo p73alpha regulation by Chk1 in response to DNA damage Mol. Cell. Biol. 23 2003 8161 8171
    • (2003) Mol. Cell. Biol. , vol.23 , pp. 8161-8171
    • Gonzalez, S.1    Prives, C.2    Cordon-Cardo, C.3
  • 132
    • 0037072483 scopus 로고    scopus 로고
    • P73beta is regulated by protein kinase Cdelta catalytic fragment generated in the apoptotic response to DNA damage
    • J. Ren, R. Datta, and H. Shioya et al. p73beta is regulated by protein kinase Cdelta catalytic fragment generated in the apoptotic response to DNA damage J. Biol. Chem. 277 2002 33758 33765
    • (2002) J. Biol. Chem. , vol.277 , pp. 33758-33765
    • Ren, J.1    Datta, R.2    Shioya, H.3
  • 133
    • 34547453816 scopus 로고    scopus 로고
    • Regulation of p73-mediated apoptosis by c-Jun N-terminal kinase
    • E.V. Jones, M.J. Dickman, and A.J. Whitmarsh Regulation of p73-mediated apoptosis by c-Jun N-terminal kinase Biochem. J. 05 2007 617 623
    • (2007) Biochem. J. , vol.5 , pp. 617-623
    • Jones, E.V.1    Dickman, M.J.2    Whitmarsh, A.J.3
  • 134
    • 85047696046 scopus 로고    scopus 로고
    • Regulation of p73 by c-Abl through the p38 MAP kinase pathway
    • R. Sanchez-Prieto, V.J. Sanchez-Arevalo, and J.M. Servitja et al. Regulation of p73 by c-Abl through the p38 MAP kinase pathway Oncogene 21 2002 974 979
    • (2002) Oncogene , vol.21 , pp. 974-979
    • Sanchez-Prieto, R.1    Sanchez-Arevalo, V.J.2    Servitja, J.M.3
  • 135
    • 0030925565 scopus 로고    scopus 로고
    • Ataxia telangiectasia mutant protein activates c-Abl tyrosine kinase in response to ionizing radiation
    • R. Baskaran, L.D. Wood, and L.L. Whitaker et al. Ataxia telangiectasia mutant protein activates c-Abl tyrosine kinase in response to ionizing radiation Nature 387 1997 516 519
    • (1997) Nature , vol.387 , pp. 516-519
    • Baskaran, R.1    Wood, L.D.2    Whitaker, L.L.3
  • 136
    • 39149136475 scopus 로고    scopus 로고
    • ATM-dependent nuclear accumulation of IKK-alpha plays an important role in the regulation of p73-mediated apoptosis in response to cisplatin
    • K. Yoshida, T. Ozaki, and K. Furuya et al. ATM-dependent nuclear accumulation of IKK-alpha plays an important role in the regulation of p73-mediated apoptosis in response to cisplatin Oncogene 27 2008 1183 1188
    • (2008) Oncogene , vol.27 , pp. 1183-1188
    • Yoshida, K.1    Ozaki, T.2    Furuya, K.3
  • 137
    • 34547094374 scopus 로고    scopus 로고
    • Stabilization of p73 by nuclear IkappaB kinase-alpha mediates cisplatin-induced apoptosis
    • K. Furuya, T. Ozaki, and T. Hanamoto et al. Stabilization of p73 by nuclear IkappaB kinase-alpha mediates cisplatin-induced apoptosis J. Biol. Chem. 282 2007 18365 18378
    • (2007) J. Biol. Chem. , vol.282 , pp. 18365-18378
    • Furuya, K.1    Ozaki, T.2    Hanamoto, T.3
  • 138
    • 21044442524 scopus 로고    scopus 로고
    • The transcriptional coactivator Yes-associated protein drives p73 gene-target specificity in response to DNA Damage
    • S. Strano, O. Monti, and N. Pediconi et al. The transcriptional coactivator Yes-associated protein drives p73 gene-target specificity in response to DNA Damage Mol. Cell 18 2005 447 459
    • (2005) Mol. Cell , vol.18 , pp. 447-459
    • Strano, S.1    Monti, O.2    Pediconi, N.3
  • 139
    • 0035805487 scopus 로고    scopus 로고
    • Physical interaction with Yes-associated protein enhances p73 transcriptional activity
    • S. Strano, E. Munarriz, and M. Rossi et al. Physical interaction with Yes-associated protein enhances p73 transcriptional activity J. Biol. Chem. 276 2001 15164 15173
    • (2001) J. Biol. Chem. , vol.276 , pp. 15164-15173
    • Strano, S.1    Munarriz, E.2    Rossi, M.3
  • 140
    • 0037249343 scopus 로고    scopus 로고
    • Akt phosphorylates the Yes-associated protein, YAP, to induce interaction with 14-3-3 and attenuation of p73-mediated apoptosis
    • S. Basu, N.F. Totty, and M.S. Irwin et al. Akt phosphorylates the Yes-associated protein, YAP, to induce interaction with 14-3-3 and attenuation of p73-mediated apoptosis Mol. Cell 11 2003 11 23
    • (2003) Mol. Cell , vol.11 , pp. 11-23
    • Basu, S.1    Totty, N.F.2    Irwin, M.S.3
  • 141
    • 18244408596 scopus 로고    scopus 로고
    • DNA damage-dependent acetylation of p73 dictates the selective activation of apoptotic target genes
    • A. Costanzo, P. Merlo, and N. Pediconi et al. DNA damage-dependent acetylation of p73 dictates the selective activation of apoptotic target genes Mol. Cell 9 2002 175 186
    • (2002) Mol. Cell , vol.9 , pp. 175-186
    • Costanzo, A.1    Merlo, P.2    Pediconi, N.3
  • 142
    • 2942547565 scopus 로고    scopus 로고
    • Pin1 links the activities of c-Abl and p300 in regulating p73 function
    • F. Mantovani, S. Piazza, and M. Gostissa et al. Pin1 links the activities of c-Abl and p300 in regulating p73 function Mol. Cell 14 2004 625 636
    • (2004) Mol. Cell , vol.14 , pp. 625-636
    • Mantovani, F.1    Piazza, S.2    Gostissa, M.3
  • 143
    • 30344450404 scopus 로고    scopus 로고
    • P63 mediates survival in squamous cell carcinoma by suppression of p73-dependent apoptosis
    • J.W. Rocco, C.O. Leong, and N. Kuperwasser et al. p63 mediates survival in squamous cell carcinoma by suppression of p73-dependent apoptosis Cancer Cell 9 2006 45 56
    • (2006) Cancer Cell , vol.9 , pp. 45-56
    • Rocco, J.W.1    Leong, C.O.2    Kuperwasser, N.3
  • 144
    • 34248166978 scopus 로고    scopus 로고
    • The p63/p73 network mediates chemosensitivity to cisplatin in a biologically defined subset of primary breast cancers
    • C.O. Leong, N. Vidnovic, M.P. DeYoung, D. Sgroi, and L.W. Ellisen The p63/p73 network mediates chemosensitivity to cisplatin in a biologically defined subset of primary breast cancers J. Clin. Invest. 117 2007 1370 1380
    • (2007) J. Clin. Invest. , vol.117 , pp. 1370-1380
    • Leong, C.O.1    Vidnovic, N.2    Deyoung, M.P.3    Sgroi, D.4    Ellisen, L.W.5
  • 145
    • 0034063604 scopus 로고    scopus 로고
    • A common polymorphism acts as an intragenic modifier of mutant p53 behaviour
    • M.C. Marin, C.A. Jost, and L.A. Brooks et al. A common polymorphism acts as an intragenic modifier of mutant p53 behaviour Nat. Genet. 25 2000 47 54
    • (2000) Nat. Genet. , vol.25 , pp. 47-54
    • Marin, M.C.1    Jost, C.A.2    Brooks, L.A.3
  • 146
    • 10744230945 scopus 로고    scopus 로고
    • P53 polymorphism influences response in cancer chemotherapy via modulation of p73-dependent apoptosis
    • D. Bergamaschi, M. Gasco, and L. Hiller et al. p53 polymorphism influences response in cancer chemotherapy via modulation of p73-dependent apoptosis Cancer Cell 3 2003 387 402
    • (2003) Cancer Cell , vol.3 , pp. 387-402
    • Bergamaschi, D.1    Gasco, M.2    Hiller, L.3
  • 147
    • 0037372005 scopus 로고    scopus 로고
    • The codon 72 polymorphic variants of p53 have markedly different apoptotic potential
    • P. Dumont, J.I. Leu, and A.C. Della Pietra et al. The codon 72 polymorphic variants of p53 have markedly different apoptotic potential Nat. Genet. 33 2003 357 365
    • (2003) Nat. Genet. , vol.33 , pp. 357-365
    • Dumont, P.1    Leu, J.I.2    Della Pietra, A.C.3
  • 148
    • 0035096488 scopus 로고    scopus 로고
    • Inactivate the remaining p53 allele or the alternate p73? Preferential selection of the Arg72 polymorphism in cancers with recessive p53 mutants but not transdominant mutants
    • M. Tada, K. Furuuchi, and M. Kaneda et al. Inactivate the remaining p53 allele or the alternate p73? Preferential selection of the Arg72 polymorphism in cancers with recessive p53 mutants but not transdominant mutants Carcinogenesis 22 2001 515 517
    • (2001) Carcinogenesis , vol.22 , pp. 515-517
    • Tada, M.1    Furuuchi, K.2    Kaneda, M.3
  • 149
    • 0036468249 scopus 로고    scopus 로고
    • Possible oncogenic potential of DeltaNp73: A newly identified isoform of human p73
    • O. Ishimoto, C. Kawahara, and K. Enjo et al. Possible oncogenic potential of DeltaNp73: a newly identified isoform of human p73 Cancer Res. 62 2002 636 641
    • (2002) Cancer Res. , vol.62 , pp. 636-641
    • Ishimoto, O.1    Kawahara, C.2    Enjo, K.3
  • 150
    • 0036628511 scopus 로고    scopus 로고
    • Transactivation-deficient DeltaTA-p73 acts as an oncogene
    • T. Stiewe, S. Zimmermann, and A. Frilling et al. Transactivation- deficient DeltaTA-p73 acts as an oncogene Cancer Res. 62 2002 3598 3602
    • (2002) Cancer Res. , vol.62 , pp. 3598-3602
    • Stiewe, T.1    Zimmermann, S.2    Frilling, A.3
  • 151
    • 38849116924 scopus 로고    scopus 로고
    • Autonomous growth and hepatocarcinogenesis in transgenic mice expressing the p53 family inhibitor DNp73
    • A. Tannapfel, K. John, and N. Mise et al. Autonomous growth and hepatocarcinogenesis in transgenic mice expressing the p53 family inhibitor DNp73 Carcinogenesis 29 2008 211 218
    • (2008) Carcinogenesis , vol.29 , pp. 211-218
    • Tannapfel, A.1    John, K.2    Mise, N.3
  • 152
    • 0037119631 scopus 로고    scopus 로고
    • DeltaNp73, a dominant-negative inhibitor of wild-type p53 and TAp73, is up-regulated in human tumors
    • A.I. Zaika, N. Slade, and S.H. Erster et al. DeltaNp73, a dominant-negative inhibitor of wild-type p53 and TAp73, is up-regulated in human tumors J. Exp. Med. 196 2002 765 780
    • (2002) J. Exp. Med. , vol.196 , pp. 765-780
    • Zaika, A.I.1    Slade, N.2    Erster, S.H.3
  • 153
    • 0038190875 scopus 로고    scopus 로고
    • Inactivation of retinoblastoma (RB) tumor suppressor by oncogenic isoforms of the p53 family member p73
    • T. Stiewe, J. Stanelle, and C.C. Theseling et al. Inactivation of retinoblastoma (RB) tumor suppressor by oncogenic isoforms of the p53 family member p73 J. Biol. Chem. 278 2003 14230 14236
    • (2003) J. Biol. Chem. , vol.278 , pp. 14230-14236
    • Stiewe, T.1    Stanelle, J.2    Theseling, C.C.3
  • 154
    • 33749433216 scopus 로고    scopus 로고
    • P53 family members in myogenic differentiation and rhabdomyosarcoma development
    • H. Cam, H. Griesmann, and M. Beitzinger et al. p53 family members in myogenic differentiation and rhabdomyosarcoma development Cancer Cell 10 2006 281 293
    • (2006) Cancer Cell , vol.10 , pp. 281-293
    • Cam, H.1    Griesmann, H.2    Beitzinger, M.3
  • 155
    • 48349083376 scopus 로고    scopus 로고
    • TAp73beta and DNp73beta activate the expression of the pro-survival caspase-2S
    • W.H. Toh, E. Logette, and L. Corcos et al. TAp73beta and DNp73beta activate the expression of the pro-survival caspase-2S Nucleic Acids Res. 36 2008 4498 4509
    • (2008) Nucleic Acids Res. , vol.36 , pp. 4498-4509
    • Toh, W.H.1    Logette, E.2    Corcos, L.3
  • 156
    • 33748923639 scopus 로고    scopus 로고
    • Cross-talks in the p53 family: DeltaNp63 is an anti-apoptotic target for deltaNp73alpha and p53 gain-of-function mutants
    • M. Lanza, B. Marinari, and M. Papoutsaki et al. Cross-talks in the p53 family: deltaNp63 is an anti-apoptotic target for deltaNp73alpha and p53 gain-of-function mutants Cell Cycle 5 2006 1996 2004
    • (2006) Cell Cycle , vol.5 , pp. 1996-2004
    • Lanza, M.1    Marinari, B.2    Papoutsaki, M.3
  • 157
    • 0344441928 scopus 로고    scopus 로고
    • DeltaNp73 can modulate the expression of various genes in a p53-independent fashion
    • N.N. Kartasheva, C. Lenz-Bauer, and O. Hartmann et al. DeltaNp73 can modulate the expression of various genes in a p53-independent fashion Oncogene 22 2003 8246 8254
    • (2003) Oncogene , vol.22 , pp. 8246-8254
    • Kartasheva, N.N.1    Lenz-Bauer, C.2    Hartmann, O.3
  • 158
    • 38849166061 scopus 로고    scopus 로고
    • Patterns of p73 N-terminal isoform expression and p53 status have prognostic value in gynecological cancers
    • K. Becker, P. Pancoska, and N. Concin et al. Patterns of p73 N-terminal isoform expression and p53 status have prognostic value in gynecological cancers Int. J. Oncol. 29 2006 889 902
    • (2006) Int. J. Oncol. , vol.29 , pp. 889-902
    • Becker, K.1    Pancoska, P.2    Concin, N.3
  • 159
    • 11144357549 scopus 로고    scopus 로고
    • Transdominant DeltaTAp73 isoforms are frequently up-regulated in ovarian cancer Evidence for their role as epigenetic p53 inhibitors in vivo
    • N. Concin, K. Becker, and N. Slade et al. Transdominant DeltaTAp73 isoforms are frequently up-regulated in ovarian cancer Evidence for their role as epigenetic p53 inhibitors in vivo Cancer Res. 64 2004 2449 2460
    • (2004) Cancer Res. , vol.64 , pp. 2449-2460
    • Concin, N.1    Becker, K.2    Slade, N.3
  • 160
    • 27644458185 scopus 로고    scopus 로고
    • Aberrant expression of DeltaNp73 in benign and malignant tumours of the prostate: Correlation with Gleason score
    • M. Guan, and Y. Chen Aberrant expression of DeltaNp73 in benign and malignant tumours of the prostate: correlation with Gleason score J. Clin. Pathol. 58 2005 1175 1179
    • (2005) J. Clin. Pathol. , vol.58 , pp. 1175-1179
    • Guan, M.1    Chen, Y.2
  • 161
    • 0345256343 scopus 로고    scopus 로고
    • Alterations of DeltaTA-p 73 splice transcripts during melanoma development and progression
    • S. Tuve, S.N. Wagner, and B. Schittek et al. Alterations of DeltaTA-p 73 splice transcripts during melanoma development and progression Int. J. Cancer 108 2004 162 166
    • (2004) Int. J. Cancer , vol.108 , pp. 162-166
    • Tuve, S.1    Wagner, S.N.2    Schittek, B.3
  • 162
    • 0036005908 scopus 로고    scopus 로고
    • Expression of DeltaNp73 is a molecular marker for adverse outcome in neuroblastoma patients
    • I. Casciano, K. Mazzocco, and L. Boni et al. Expression of DeltaNp73 is a molecular marker for adverse outcome in neuroblastoma patients Cell Death Differ. 9 2002 246 251
    • (2002) Cell Death Differ. , vol.9 , pp. 246-251
    • Casciano, I.1    Mazzocco, K.2    Boni, L.3
  • 163
    • 0842311606 scopus 로고    scopus 로고
    • Quantitative TP73 transcript analysis in hepatocellular carcinomas
    • T. Stiewe, S. Tuve, and M. Peter et al. Quantitative TP73 transcript analysis in hepatocellular carcinomas Clin. Cancer Res. 10 2004 626 633
    • (2004) Clin. Cancer Res. , vol.10 , pp. 626-633
    • Stiewe, T.1    Tuve, S.2    Peter, M.3
  • 164
    • 27944476397 scopus 로고    scopus 로고
    • TAp73/Delta Np73 influences apoptotic response, chemosensitivity and prognosis in hepatocellular carcinoma
    • M. Muller, T. Schilling, and A.E. Sayan et al. TAp73/Delta Np73 influences apoptotic response, chemosensitivity and prognosis in hepatocellular carcinoma Cell Death Differ. 12 2005 1564 1577
    • (2005) Cell Death Differ. , vol.12 , pp. 1564-1577
    • Muller, M.1    Schilling, T.2    Sayan, A.E.3
  • 165
    • 41949088521 scopus 로고    scopus 로고
    • DNp73 a matter of cancer: Mechanisms and clinical implications
    • S. Buhlmann, and B.M. Putzer DNp73 a matter of cancer: mechanisms and clinical implications Biochim. Biophys. Acta 1785 2008 207 216
    • (2008) Biochim. Biophys. Acta , vol.1785 , pp. 207-216
    • Buhlmann, S.1    Putzer, B.M.2
  • 166
    • 40949101720 scopus 로고    scopus 로고
    • P73 poses a barrier to malignant transformation by limiting anchorage-independent growth
    • M. Beitzinger, L. Hofmann, and C. Oswald et al. P73 poses a barrier to malignant transformation by limiting anchorage-independent growth EMBO J. 27 2008 792 803
    • (2008) EMBO J. , vol.27 , pp. 792-803
    • Beitzinger, M.1    Hofmann, L.2    Oswald, C.3
  • 167
    • 84885344813 scopus 로고    scopus 로고
    • DNp73 exerts function in metastasis initiation by disconnecting the inhibitory role of EPLIN on IGF1R-AKT/STAT3 signaling
    • M. Steder, V. Alla, and C. Meier et al. DNp73 exerts function in metastasis initiation by disconnecting the inhibitory role of EPLIN on IGF1R-AKT/STAT3 signaling Cancer Cell 24 2013 512 527
    • (2013) Cancer Cell , vol.24 , pp. 512-527
    • Steder, M.1    Alla, V.2    Meier, C.3
  • 168
    • 3042813412 scopus 로고    scopus 로고
    • P63: Molecular complexity in development and cancer
    • M.D. Westfall, and J.A. Pietenpol p63: molecular complexity in development and cancer Carcinogenesis 25 2004 857 864
    • (2004) Carcinogenesis , vol.25 , pp. 857-864
    • Westfall, M.D.1    Pietenpol, J.A.2
  • 169
    • 13444250890 scopus 로고    scopus 로고
    • DNp63a up-regulates the Hsp70 gene in human cancer
    • G. Wu, M. Osada, and Z.F. Guo et al. DNp63a up-regulates the Hsp70 gene in human cancer Cancer Res. 65 2005 758 766
    • (2005) Cancer Res. , vol.65 , pp. 758-766
    • Wu, G.1    Osada, M.2    Guo, Z.F.3
  • 170
    • 52649151797 scopus 로고    scopus 로고
    • Molecular interactions of ASPP1 and ASPP2 with the p53 protein family and the apoptotic promoters PUMA and Bax
    • S. Patel, R. George, and F. Autore et al. Molecular interactions of ASPP1 and ASPP2 with the p53 protein family and the apoptotic promoters PUMA and Bax Nucleic Acids Res. 36 2008 5139 5151
    • (2008) Nucleic Acids Res. , vol.36 , pp. 5139-5151
    • Patel, S.1    George, R.2    Autore, F.3
  • 171
    • 82455209036 scopus 로고    scopus 로고
    • HIPK2 phosphorylates Δnp63α and promotes its degradation in response to DNA damage
    • C. Lazzari, A. Prodosmo, and F. Siepi et al. HIPK2 phosphorylates ΔNp63α and promotes its degradation in response to DNA damage Oncogene 30 2011 4802 4813
    • (2011) Oncogene , vol.30 , pp. 4802-4813
    • Lazzari, C.1    Prodosmo, A.2    Siepi, F.3
  • 172
    • 80051983047 scopus 로고    scopus 로고
    • Developmental factor IRF6 exhibits tumor suppressor activity in squamous cell carcinomas
    • E. Botti, G. Spallone, and F. Moretti et al. Developmental factor IRF6 exhibits tumor suppressor activity in squamous cell carcinomas Proc. Natl. Acad. Sci. 108 2011 13710 13715
    • (2011) Proc. Natl. Acad. Sci. , vol.108 , pp. 13710-13715
    • Botti, E.1    Spallone, G.2    Moretti, F.3
  • 173
    • 55949089769 scopus 로고    scopus 로고
    • The tumor suppressor activity of IKKalpha in stratified epithelia is exerted in part via the TGF-beta antiproliferative pathway
    • B. Marinari, F. Moretti, and E. Botti et al. The tumor suppressor activity of IKKalpha in stratified epithelia is exerted in part via the TGF-beta antiproliferative pathway Proc. Natl. Acad. Sci. USA 105 2008 17091 17096
    • (2008) Proc. Natl. Acad. Sci. USA , vol.105 , pp. 17091-17096
    • Marinari, B.1    Moretti, F.2    Botti, E.3
  • 174
    • 84880875969 scopus 로고    scopus 로고
    • FGFR2 signaling underlies p63 oncogenic function in squamous cell carcinoma
    • M.R. Ramsey, C. Wilson, and B. Ory et al. FGFR2 signaling underlies p63 oncogenic function in squamous cell carcinoma J. Clin. Invest. 123 2013 3525 3538
    • (2013) J. Clin. Invest. , vol.123 , pp. 3525-3538
    • Ramsey, M.R.1    Wilson, C.2    Ory, B.3
  • 175
    • 54349102235 scopus 로고    scopus 로고
    • IKKalpha, a critical regulator of epidermal differentiation and a suppressor of skin cancer
    • P. Descargues, A.K. Sil, and M. Karin IKKalpha, a critical regulator of epidermal differentiation and a suppressor of skin cancer EMBO J. 27 2008 2639 2647
    • (2008) EMBO J. , vol.27 , pp. 2639-2647
    • Descargues, P.1    Sil, A.K.2    Karin, M.3
  • 176
    • 33751217161 scopus 로고    scopus 로고
    • A critical role for i kappaB kinase alpha in the development of human and mouse squamous cell carcinomas
    • B. Liu, E. Park, and F. Zhu et al. A critical role for I kappaB kinase alpha in the development of human and mouse squamous cell carcinomas Proc. Natl. Acad. Sci. USA 103 2006 17202 17207
    • (2006) Proc. Natl. Acad. Sci. USA , vol.103 , pp. 17202-17207
    • Liu, B.1    Park, E.2    Zhu, F.3
  • 177
    • 0035809983 scopus 로고    scopus 로고
    • IKKalpha controls formation of the epidermis independently of NF-kappaB
    • Y. Hu, V. Baud, and T. Oga et al. IKKalpha controls formation of the epidermis independently of NF-kappaB Nature 410 2001 710 714
    • (2001) Nature , vol.410 , pp. 710-714
    • Hu, Y.1    Baud, V.2    Oga, T.3
  • 178
    • 81255210846 scopus 로고    scopus 로고
    • IRF6 is a mediator of Notch pro-differentiation and tumour suppressive function in keratinocytes
    • G. Restivo, B.C. Nguyen, and P. Dziunycz et al. IRF6 is a mediator of Notch pro-differentiation and tumour suppressive function in keratinocytes EMBO J. 30 2011 4571 4585
    • (2011) EMBO J. , vol.30 , pp. 4571-4585
    • Restivo, G.1    Nguyen, B.C.2    Dziunycz, P.3
  • 179
    • 77949362925 scopus 로고    scopus 로고
    • Isoform-specific p73 knockout mice reveal a novel role for delta Np73 in the DNA damage response pathway
    • M.T. Wilhelm, A. Rufini, and M.K. Wetzel et al. Isoform-specific p73 knockout mice reveal a novel role for delta Np73 in the DNA damage response pathway Genes Dev. 24 2010 549 560
    • (2010) Genes Dev. , vol.24 , pp. 549-560
    • Wilhelm, M.T.1    Rufini, A.2    Wetzel, M.K.3


* 이 정보는 Elsevier사의 SCOPUS DB에서 KISTI가 분석하여 추출한 것입니다.