Role for the p53 homologue p73 in E2F-1-induced apoptosis

Nature

Volumn 407, Issue 6804, 2000, Pages 645-648

  Irwin, Meredith ^a   Marin, Maria Carmen ^a   Phillips, Andrew C ^b   Seelan, Ratnam S ^c   Smith, David I ^c   Liu, Wanguo ^c   Flores, Elsa R ^d,e   Tsai, Kenneth Y ^d   Jacks, Tyler ^d,e   Vousden, Karen H ^b   Kaelin Jr , William G ^a,e  

^a BRIGHAM AND WOMEN S HOSPITAL   (United States)

^b NATIONAL CANCER INSTITUTE   (United States)

^c MAYO CLINIC COLLEGE OF MEDICINE   (United States)

^d MASSACHUSETTS INSTITUTE OF TECHNOLOGY   (United States)

^e HOWARD HUGHES MEDICAL INSTITUTE   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

PROTEIN P53; PROTEIN P73; TRANSCRIPTION FACTOR E2F;

ANIMAL CELL; APOPTOSIS; ARTICLE; CELL CYCLE; CONTROLLED STUDY; DNA BINDING; FIBROBLAST; MOUSE; NONHUMAN; PRIORITY JOURNAL; PROTEIN STABILITY; SEQUENCE HOMOLOGY; TRANSCRIPTION REGULATION;

ANIMAL; APOPTOSIS; CELL LINE; DNA; DNA-BINDING PROTEINS; GENE EXPRESSION REGULATION; MICE; MUTATION; NUCLEAR PROTEINS; PROTEIN BINDING; PROTEIN P53; SUPPORT, NON-U.S. GOV'T; TRANSCRIPTION FACTORS; TRANSCRIPTION, GENETIC;

EID: 0034609798     PISSN: 00280836     EISSN: None     Source Type: Journal    
DOI: 10.1038/35036614     Document Type: Article

References (29)

1. Phillips, A., Bates, S., Ryan, K., Helin, K. & Vousden, K. Induction of DNA synthesis and apoptosis are separable functions of E2F-1. Genes Dev. 11, 1853-1863 (1997).
2. Hsieh, J., Fredersdorf, S., Kouzarides, T., Martin, K. & Lu, X. E2F1-induced apoptosis requires DNA binding but not transactivation and is inhibited by the retinoblastoma protein through direct interaction. Genes Dev. 11, 1840-1852 (1997).
3. Wu, X. & Levine, A. J. p53 and E2F1 Cooperate to mediate apoptosis. Proc. Natl Acad. Sci. USA 91, 3602-3606 (1994).
4. Qin, X.Q., Livingston, D. M., Kaelin, W. G. & Adams, P. Deregulated E2F1 expression leads to S-phase entry and p53-mediated apoptosis. Proc. Natl Acad Sci. USA 91, 10918-10922 (1994).
5. Holmberg, C., Helin, K., Sehested, M. & Karlstrom, O. E2F-1-Induced p53-independent apoptosis in transgenic mice. Oncogene 17, 143-155 (1998).
6. Nip, J. et al. E2F-1 cooperates with topoisomerase II inhibition and DNA damage to selectively augment p53-independent apoptosis. Mol. Cell. Biol. 17, 1049-1056 (1997).
7. Agah, R. et al. Adenoviral delivery of E2F-1 directs cell cycle reentry and p53-independent apoptosis in postmitotic adult myocardium in vivo. J. Clin. Invest. 100, 2722-2728 (1997).
8. Hunt, K. et al. Adenovirus-mediated overexpression of the transcription factor E2F-1 induces apoptosis in human breast and ovarian carcinoma cell lines and does not require p53. Cancer Res. 57, 4722-4726 (1997).
9. Sherr, C. Tumor surveillance via the ARF-p53 pathway. Genes Dev. 12, 2984-2991 (1998).
10. Bates, S. et al. p14ARF links the tumour suppressors RB and p53. Nature 395, 124-125 (1998).
11. Kaelin, W. G. The emerging p53 gene family. J. Natl Cancer Institute 91, 594-598 (1999).
12. Dyson, N. The regulation of E2F by pRB-family proteins. Genes Dev. 12, 2245-2262 (1998).
13. Shaulian, E., Zauberman, A., Ginsberg, D. & Oren, M. Identification of a minimal transforming domain of p53: negative dominance through abrogation of sequence-specific DNA binding. Mol. Cell. Biol. 12, 5581-5592 (1992).
14. Davison, T. et al. p73 and p63 are homotetramers capable of weak heterotypic interactions with each other but not with p53. J. Biol. Chem. 274, 18709-10814 (1999).
15. Lomax, M., Barnes, D., Hupp, T., Picksley, S. & Camplejohn, R. Characterization of p53 oligomerization domain mutations isolated ffrom Li-Fraumeni and Li-Fraumeni like family members. Oncogene 17, 643-649 (1998).
16. Davison, T., Yin, P., Nie, E., Kay, C. & Arrowsmith, C. Characterization of the oligomerization defects of two p53 mutants found in families with LI-Fraumeni and Li-Fraumeni syndrome. Oncogene 17, 651-656 (1998).
17. Marin, M. C. et al. Viral oncoproteins discriminate between p53 and the p53 homologue p73. Mol. Cell Biol. 18, 6316-24 (1998).
18. Phillips, A., Ernst, M., Bates, S., Rice, N. & Vousden, K. E2F-1 potentiates cell death by blocking antiapoptotic signaling pathways. Mol. Cell 4, 771-781 (1999).
19. Lissy, N. A., Davis, P. K., Irwin, M., Kaelin, W. G. & Dowdy, S. F. A common E2F-1 and p73 pathway mediates cell death induced by TCR activation. Nature 407, 642-645 (2000).
20. Fueyo, J. et al. Overexpression of E2F-1 in glioma triggers apoptosis and suppresses tumour growth in vitro and in vivo. Nature Med. 4, 685-690 (1998).
21. Chen, Y. et al. Selective killing of transformed cells by cyclin/cyclin-dependent kinase 2 antagonists. Proc. Natl Acad. Sci. USA 96, 4325-4329 (1999).
22. Jost, C., Marin, M. & Kaelin, W. G. p73 is a human p53-related protein thai can induce apoptosis. Nature 389, 191-194 (1997).
23. Brugarolas, J., Bronson, R. & Jacks, T. p21 is a critical CDK2 regulator essential for proliferation control in Rb-deficient cells. J. Cell Biol 141, 503-514 (1998).
24. Yang, A. et al. p73-deficient mice have neurological, pheromonal and inflammatory defects but lack spontaneous tumors. Nature 404, 99-103 (2000).
25. De Laurenzi, V. et al. Two new p73 splice variants, γ and δ, with different transcriptional activity. J. Exp. Med. 188, 1763-1768 (1998).
26. Krek, W. et al. Negative regulation of the growth-promoting transcription factor E2F-1 by a stably bound cyclin A-dependent protein kinase. Cell 78, 1-20 (1994).
27. Kaghad, M. et al. Monoallelically Expressed Gene Related to p53 at Ip36, a region frequently deleted in neuroblastoma and other human cancers. Cell 90, 809-819 (1997).
28. Weber, K. L., Bolander, M. E. & Sarkar, G. Rapid acquisition of unknown DNA sequence adjacent to a known segment by multiplex restriction site PCR. BioTechniques 25, 415-419 (1998).
29. Yang, A. et al. p63, a p53 homologue at 3q27-29, encodes multiple products with transactivating, death Inducing, and dominant negative activities. Mol. Cell 2, 305-316 (1998).