Role of the p53-homologue p73 in E2F1-induced apoptosis

Nature Genetics

Volumn 26, Issue 4, 2000, Pages 464-469

  Stiewe, T ^a   Putzer, B M ^a  

^a UNIVERSITY OF DUISBURG ESSEN   (Germany)

Author keywords

[No Author keywords available]

Indexed keywords

PROTEIN P53; PROTEIN P73; TRANSCRIPTION FACTOR E2F;

AMINO ACID SEQUENCE; ANIMAL CELL; APOPTOSIS; ARTICLE; CONTROLLED STUDY; GENE ACTIVATION; HUMAN; HUMAN CELL; NONHUMAN; NUCLEOTIDE SEQUENCE; PRIORITY JOURNAL; SEQUENCE HOMOLOGY; SIGNAL TRANSDUCTION; TRANSCRIPTION REGULATION; TUMOR SUPPRESSOR GENE;

ANIMALS; APOPTOSIS; BASE SEQUENCE; BINDING SITES; CARRIER PROTEINS; CELL CYCLE PROTEINS; CELL LINE; COS CELLS; DNA PRIMERS; DNA-BINDING PROTEINS; E2F TRANSCRIPTION FACTORS; E2F1 TRANSCRIPTION FACTOR; GENE EXPRESSION REGULATION; GENES, TUMOR SUPPRESSOR; HUMANS; MICE; MOLECULAR SEQUENCE DATA; MUTATION; NUCLEAR PROTEINS; PROMOTER REGIONS (GENETICS); TRANS-ACTIVATION (GENETICS); TRANSCRIPTION FACTOR DP1; TRANSCRIPTION FACTORS; TRANSFECTION; TUMOR SUPPRESSOR PROTEIN P53; TUMOR SUPPRESSOR PROTEINS; U937 CELLS;

ANIMALIA;

EID: 0033666776     PISSN: 10614036     EISSN: None     Source Type: Journal    
DOI: 10.1038/82617     Document Type: Article

References (28)

1. Tumor surveillance via the ARF-p53 pathway
2. Induction of DNA synthesis and apoptosis are separable functions of E2F-1
3. p14ARF links the tumor suppressors RB and p53
4. Myc signaling via the ARF tumor suppressor regulates p53-dependent apoptosis and immortalization
5. Monoallelically expressed gene related to p53 at 1p36, a region frequently deleted in neuroblastoma and other human cancers
6. p73 is a human pS3-related protein that can induce apoptosis
7. The potential tumor suppressor p73 differentially regulates cellular p53 target genes
8. CDC25A phosphatase is a target of E2F and is required for efficient E2F-induced S phase
9. The N-terminal domain of p73 interacts with the CH1 domain of p300/CREB binding protein and mediates transcriptional activation and a poptosis
10. p73 function is inhibited by tumor-derived p53 mutants in mammalian cells
11. A common polymorphism acts as an intragenic modifier of mutant p53 behaviour
12. E2F-1 potentiates cell death by blocking anti-apoptotic signaling pathways
13. Expression level, allelic origin, and mutation analysis of the p73 gene in neuroblastoma tumors and cell lines
14. Overexpression of the wild type p73 gene in human bladder cancer
15. Analysis of p73 in human borderline and invasive ovarian tumor
16. Inhibition of E2F-1 transactivation by direct binding of the retinoblastoma protein
17. A genetic analysis of the E2F1 gene distinguishes regulation by Rb, p107, and adenovirus E4
18. Exogenous E2F expression is growth inhibitory before, during, and after cellular transformation
19. Suppression of human colorectal carcinoma cell growth by wild-type p53
20. Two new p73 splice variants, γ and δ, with different transcriptional activity
21. Improved safety through tamoxifen-regulated induction of cytotoxic genes delivered by Ad vectors for cancer gene therapy
22. Use of a membrane-localized green fluorescent protein allows simultaneous identification of transfected cells and cell cycle analysis by flow cytometry
23. E1A signaling to p53 involves the p19ARF tumor suppressor
24. Electroporation intracellular buffer increases cell survival
25. A comparison of DNA-binding drugs as inhibitors of E2F1- and Sp1-DNA complexes and associated gene expression
26. Direct activation of TERT transcription by c-MYC
27. Viral oncoproteins discriminate between p53 and the p53 homolog p73
28. Quantification of apoptosis and necrosis by flow cytometry