hSirT1-Dependent regulation of the PCAF-E2F1-p73 apoptotic pathway in response to DNA damage

Molecular and Cellular Biology

Volumn 29, Issue 8, 2009, Pages 1989-1998

  Pediconi, Natalia ^a,b   Guerrieri, Francesca ^c   Vossio, Stefania ^a,c   Bruno, Tiziana ^b   Belloni, Laura ^a,c   Schinzari, Valeria ^c   Scisciani, Cecilia ^a,b   Fanciulli, Maurizio ^b   Levrero, Massimo ^a,b,c  

^a FONDAZIONE POLICLINICO UNIVERSITARIO A GEMELLI IRCCS   (Italy)

^b REGINA ELENA NATIONAL CANCER INSTITUTE   (Italy)

^c SAPIENZA UNIVERSITY OF ROME   (Italy)

Author keywords

[No Author keywords available]

Indexed keywords

DOXORUBICIN; HISTONE ACETYLTRANSFERASE PCAF; IMMUNOGLOBULIN ENHANCER BINDING PROTEIN; NICOTINAMIDE; PROTEIN P53; VALPROIC ACID;

ANIMAL CELL; APOPTOSIS; ARTICLE; CELL STRESS; CONTROLLED STUDY; DNA DAMAGE; DNA REPAIR; DNA REPLICATION; GENE TARGETING; HUMAN; HUMAN CELL; IN VITRO STUDY; MICROARRAY ANALYSIS; MOUSE; NONHUMAN; PRIORITY JOURNAL; PROTEIN EXPRESSION; PROTEIN INTERACTION; REVERSE TRANSCRIPTION POLYMERASE CHAIN REACTION; TUMOR CELL LINE;

ACETYLATION; APOPTOSIS; DNA DAMAGE; DNA-BINDING PROTEINS; E2F1 TRANSCRIPTION FACTOR; GENE EXPRESSION REGULATION; HUMANS; NUCLEAR PROTEINS; P300-CBP TRANSCRIPTION FACTORS; PROMOTER REGIONS, GENETIC; SIRTUINS; TRANSCRIPTION, GENETIC; TUMOR SUPPRESSOR PROTEINS;

EID: 64649092913     PISSN: 02707306     EISSN: None     Source Type: Journal    
DOI: 10.1128/MCB.00552-08     Document Type: Article

References (35)

1. Bieda, M., X. Xu, M. A. Singer, R. Green, and P. J. Farnham. 2006. Unbiased location analysis of E2F1-binding sites suggests a widespread role for E2F1 in the human genome. Genome Res. 16:595-605.
2. Brunet, A., L. B. Sweeney, J. F. Sturgill, K. F. Chua, P. L. Greer, Y. Lin, H. Tran, S. E. Ross, R. Mostoslavsky, H. Y. Cohen, L. S. Hu, H. L. Cheng, M. P. Jedrychowski, S. P. Gygi, D. A. Sinclair, F. W. Alt, and M. E. Greenberg. 2004. Stress-dependent regulation of FOXO transcription factors by the SIRT1 deacetylase. Science 303:2011-2015.
3. Chen, W. Y., D. H. Wang, R. C. Yen, J. Luo, W. Gu, and S. B. Baylin. 2005. Tumor suppressor HIC1 directly regulates SIRT1 to modulate p53-depen-dent DNA-damage responses. Cell 123:437-448.
4. Cheng, H. L., R. Mostoslavsky, S. Saito, J. P. Manis, Y. Gu, P. Patel, R. Bronson, E. Appella, F. W. Alt, and K. F. Chua. 2003. Developmental defects and p53 hyperacetylation in Sir2 homolog (SIRTl)-deficient mice. Proc. Natl. Acad. Sci. USA 100:10794-10799.
5. Cohen, H. Y., C. Miller, K. J. Bitterman, N. R. Wall, B. Hekking, B. Kessler, K. T. Howitz, M. Gorospe, R. de Cabo, and D. A, Sinclair. 2004. Calorie restriction promotes mammalian cell survival by inducing the SIRT1 deacetylase. Science 305:390-392.
6. Costanzo, A., P. Merlo, N. Pediconi, M. Fulco, V. Sartorelli, P. A, Cole, G. Fontemaggi, M. Fanciulli, L. Schiltz, G. Blandino, C. Balsano, and M. Levrero. 2002. DNA damage-dependent acetylation of p73 dictates the selective activation of apoptotic target genes. Mol. Cell 9:175-186.
7. DeGregori, J., and D. G. Johnson. 2006. Distinct and overlapping roles for E2F family members in transcription, proliferation and apoptosis. Curr. Mol. Med. 6:739-748.
8. Flores, E. R., S. Sengupta, J. B. Miller, J. J. Newman, R. Bronson, D. Crowley, A. Yang, F. McKeon, and T. Jacks. 2005. Tumor predisposition in mice mutant for p63 and p73: evidence for broader tumor suppressor functions for the p53 family. Cancer Cell 7:363-373.
9. Flores, E. R., K. Y. Tsai, D. Crowley, S. Sengupta, A. Yang, F. McKeon, and T. Jacks. 2002. p63 and p73 are required for p53-dependent apoptosis in response to DNA damage. Nature 416:560-564
10. Ford, J., M. Jiang, and J. Milner. 2005. Cancer-specific functions of SIRT1 enable human epithelial cancer cell growth and survival. Cancer Res. 65: 10457-10463.
11. 2/M transition. J. Biol. Chem. 278:49196-9202.
12. Fulco, M, R. L. Schiltz, S. Iezzi, M. T. King, P. Zhao, Y. Kashiwaya, E. Hoffman, R. L. Veech, and V. Sartorelli. 2003. Sir2 regulates skeletal muscle differentiation as a potential sensor of the redox state. Mol. Cell 12:51-62.
13. Gong, J. G., A. Costanzo, H. Q. Yang, G. Melino, W. G. Kaelin, Jr., M. Levrero, and J. Y. Wang. 1999. The tyrosine kinase c-Abl regulates p73 in apoptotic response to cisplatin-induced DNA damage. Nature 399:806-809.
14. Herrera, J. E., K. Sakaguchi, M. Bergel, L. Trieschmann, Y. Nakatani, and M. Bustin. 1999. Specific acetylation of chromosomal protein HMG-17 by PCAF alters its interaction with nucleosomes. Mol. Cell. Biol. 19:3466-3473.
15. Imai, S., C. M. Armstrong, M. Kaeberlein, and L. Guarente. 2000. Tran-scriptional silencing and longevity protein Sir2 is an NAD-dependent histone deacetylase. Nature 403:795-800.
16. Irwin, M., M. C. Marin, A. C. Phillips, R. S. Seedan, D. I. Smith, W. Liu, E. R. Flores, K. Y. Tsai, T. Jacks, K. H. Vousden, and W. G. Kaelin, Jr. 2000. Role for the p53 homologue p73 in E2F-1-induced apoptosis. Nature 407:645-648.
17. Irwin, M. S., K. Kondo, M. C. Marin, L. S. Cheng, W. C. Hahn, and W. G. Kaelin, Jr. 2003. Chemosensitivity linked to p73 function. Cancer Cell 3:403-410.
18. Langley, E., M. Pearson, M. Faretta, U. M. Bauer, R. A. Frye, S. Minucci, P. G. Pelicci, and T. Kouzarides. 2002. Human SIR2 deacetylates p53 and antagonizes PML/p53-induced cellular senescence. EMBO J. 21:2383-2396.
19. Luo, J., A. Y. Nikolaev, S. Imai, D. Chen, F. Su, A. Shiloh, L. Guarente, and W. Gu. 2001. Negative control of p53 by Sir2alpha promotes cell survival under stress. Cell 107:137-148.
20. Matsushita, N., Y. Takami, M. Kimura, S. Tachiiri, M. Ishiai, T. Nakayama, and M. Takata. 2005. Role of NAD-dependent deacetylases SIRT1 and SIRT2 in radiation and cisplatin-induced cell death in vertebrate cells. Genes Cells 10:321-332.
21. Muller, H., A. P. Bracken, R. Vernell, M. C. Moroni, F. Christians, E. Grassilli, E. Prosperini, E. Vigo, J. D. Oliner, and K. Helin. 2001. E2Fs regulate the expression of genes involved in differentiation, development, proliferation, and apoptosis. Genes Dev. 15:267-285.
22. Nahle, Z., J. Polakoff, R. V. Davuluri, M. E. McCurrach, M. D. Jacobson, M. Narita, M. Q. Zhang, Y. Lazebnik, D. Bar-Sagi, and S. W. Lowe. 2002. Direct coupling of the cell cycle and cell death machinery by E2F. Nat. Cell Biol. 4:859-864.
23. Pediconi, N, A. Ianari, A. Costanzo, L. Belloni, R. Gallo, L. Cimino, A, Porcellini, I. Screpanti, C. Balsano, E. Alesse, A. Gulino, and M. Levrero. 2003. Differential regulation of E2F1 apoptotic target genes in response to DNA damage. Nat. Cell Biol. 5:552-558.
24. Ren, B., H. Cam, Y. Takahashi, T. Volkert, J. Terragni, R. A, Young, and B. D. Dynlacht. 2002. E2F integrates cell cycle progression with DNA repair, replication, and G(2)/M checkpoints. Genes Dev. 16:245-256.
25. Santos-Rosa, H., E. Valls, T. Kouzarides, and M. Martinez-Balbas. 2003. Mechanisms of P/CAF auto-acetylation. Nucleic Acids Res. 31:4285-4292.
26. Stevens, C., L. Smith, and N. B. La Thangue. 2003. Chk2 activates E2F-1 in response to DNA damage. Nat. Cell Biol. 5:401-409.
27. Strano, S., O. Monti, N. Pediconi, A. Baccarini, G. Fontemaggi, E. Lapi, F. Mantovani, A. Damalas, G. Citro, A. Sacchi, G. Del Sal, M. Levrero, and G. Blandino. 2005. The transcriptional coactivator Yes-associated protein drives p73 gene-target specificity in response to DNA damage. Mol. Cell 18:447-459.
28. Vaziri, H., S. K. Dessain, E. N. Eaton, S. I. Imai, R. A. Frye, T. K. Pandita, L. Guarente, and R. A. Weinberg. 2001. hSIR2 (SIRT1) functions as an NAD-dependent p53 deacetylase. Cell 107:149-159.
29. Veech, R. L., L. V. Eggleston, and H. A. Krebs. 1969. The redox state of free nicotinamide-adenine dinucleotide phosphate in the cytoplasm of rat liver. Biochem. J. 115:609-619.
30. Wang, C., L. Chen, X. Hou, Z. Li, N. Kabra, Y. Ma, S. Nemoto, T. Finkel, W. Gu, W. D. Cress, and J. Chen. 2006. Interactions between E2F1 and SirTl regulate apoptotic response to DNA damage. Nat. Cell Biol. 8:1025-1031.
31. Yeung, F., J. E. Hoberg, C. S. Ramsey, M. D. Keller, D. R. Jones, R. A. Frye, and M. W. Mayo. 2004. Modulation of NF-kappa-B-dependent transcription and cell survival by the SIRT1 deacetylase. EMBO J. 23:2369-2380.
32. Yuan, Z., X. Zhang, N. Sengupta, W. S. Lane, and E. Seto. 2007. SIRT1 regulates the function of the Nijmegen breakage syndrome protein. Mol. Cell 27:149-162.
33. Zhang, Q., D. W. Piston, and R. H. Goodman. 2002. Regulation of repressor function by nuclear NADH. Science 295:1895-1897.
34. Zhao, W., J. P. Kruse, Y. Tang, S. Y. Jung, J. Qin, and W. Gu. 2008. Negative regulation of the deacetylase SIRT1 by DBC1. Nature 451:587-590.
35. Zhao, Y., J. Tan, L. Zhuang, X. Jiang, E. T. Liu, and Q. Yu. 2005. Inhibitors of histone deacetylases target the Rb-E2F1 pathway for apoptosis induction through activation of proapoptotic protein Bim. Proc. Natl. Acad. Sci. USA 102:16090-16095.