DNA damage-dependent acetylation of p73 dictates the selective activation of apoptotic target genes

Molecular Cell

Volumn 9, Issue 1, 2002, Pages 175-186

  Costanzo, Antonio ^a,b   Merlo, Paola ^a   Pediconi, Natalia ^a   Fulco, Marcella ^a   Sartorelli, Vittorio ^c   Cole, Philip A ^d   Fontemaggi, Giulia ^e   Fanciulli, Maurizio ^e   Schiltz, Louis ^c   Blandino, Giovanni ^e   Balsano, Clara ^f   Levrero, Massimo ^a,g  

^a SAPIENZA UNIVERSITY OF ROME   (Italy)

^b UNIVERSITY OF ROME TOR VERGATA   (Italy)

^c NATIONAL INSTITUTE OF ARTHRITIS AND MUSCULOSKELETAL AND SKIN DISEASES   (United States)

^d JOHNS HOPKINS UNIVERSITY SCHOOL OF MEDICINE   (United States)

^e REGINA ELENA NATIONAL CANCER INSTITUTE   (Italy)

^f UNIVERSITY OF L'AQUILA   (Italy)

^g UNIVERSITY OF CAGLIARI   (Italy)

Author keywords

[No Author keywords available]

Indexed keywords

DNA; PROTEIN P21; PROTEIN P300; PROTEIN P53; PROTEIN P73;

ACETYLATION; ANIMAL CELL; APOPTOSIS; ARTICLE; CELL CYCLE; CONTROLLED STUDY; DNA DAMAGE; ENZYME ACTIVITY; ENZYME INHIBITION; GENE ACTIVATION; GENE CONTROL; GENE TARGETING; GENETIC TRANSCRIPTION; HUMAN; HUMAN CELL; MITOSIS INHIBITION; MOUSE; NONHUMAN; PROTO ONCOGENE;

ANIMALIA;

EID: 18244408596     PISSN: 10972765     EISSN: None     Source Type: Journal    
DOI: 10.1016/S1097-2765(02)00431-8     Document Type: Article

References (39)

1. Interaction of c-Abl and p73α and their collaboration to induce apoptosis
2. PERP, an apoptosis-associated target of p53, is a novel member of the PMP-22/gas3 family
3. Recruitment of p300/CBP in p53-dependent signal pathways
4. Microsatellite instability, mismatch repair deficiency, and genetic defects in human cancer cell lines
5. Regulation of activity of the transcription factor GATA-1 by acetylation
6. WAF1/CIP1 is induced in p53-mediated G1 arrest and apoptosis
7. A mutant p53 that discriminates between p53-responsive genes cannot induce apoptosis
8. Mutations truncating the EP300 acetylase in human cancers
9. The complexity of p53 modulation: Emerging patterns from divergent signals
10. The tyrosine kinase c-Abl regulates p73 in apoptotic response to cisplatin-induced DNA damage
11. Activation of p53 sequence-specific DNA binding by acetylation of the p53 C-terminal domain
12. Signaling events controlling the molecular response to genotoxic stress
13. Acetylation of general transcription factors by histone acetyltransferases
14. Monoallelically expressed gene related to p53 at 1p36, a region frequently deleted in neuroblastoma and other human cancers
15. Transcription factor-specific requirements for coactivators and their acetyltransferase functions
16. HATs off: Selective synthetic inhibitors of the histone acetyltransferases p300 and PCAF
17. Promoter specificity and stability control of the p53-related protein p73
18. The p53/p63/p73 family of transcription factors: Overlapping and distinct functions
19. p53 sites acetylated in vitro by PCAF and p300 are acetylated in vivo in response to DNA damage
20. Regulation of E2F1 activity by acetylation
21. Multisite phosphorylation and the integration of stress signals at p53
22. Tumor suppressor p53 is a direct transcriptional activator of the human bax gene
23. Noxa, a BH3-only member of the Bcl-2 family and candidate mediator of p53-induced apoptosis
24. p53AIP1, a potential mediator of p53-dependent apoptosis, and its regulation by Ser-46-phosphorylated p53
25. The transcriptional coactivators p300 and CBP are histone acetyltransferases
26. A model for p53-induced apoptosis
27. The p53 pathway
28. Defying death after DNA damage
29. Characterization of structural p53 mutants which show selective defects in apoptosis but not cell cycle arrest
30. DNA damage activates p53 through a phosphorylation-acetylation cascade
31. Increased apoptosis induction by 121F mutant p53
32. Acetylation of MyoD directed by PCAF is necessary for the execution of the muscle program
33. p53-dependent and -independent regulation of the death receptor KILLER/DR5 gene expression in response to genotoxic stress and tumor necrosis factor alpha
34. Physical and functional interaction between p53 mutants and different isoforms of p73
35. A p300/CBP-associated factor that competes with the adenoviral oncoprotein E1A
36. p73 is regulated by tyrosine kinase c-Abl in the apoptotic response to DNA damage
37. Function for p300 and not CBP in the apoptotic response to DNA damage
38. The N-terminal domain of p73 interacts with the CH1 domain of p300/CREB binding protein and mediates transcriptional activation and apoptosis
39. p300 does not require its acetylase activity to stimulate p73 function