TAp73 depletion accelerates aging through metabolic dysregulation

Genes and Development

Volumn 26, Issue 18, 2012, Pages 2009-2014

  Rufini, Alessandro ^a   Niklison Chirou, Maria Victoria ^a   Inoue, Satoshi ^b   Tomasini, Richard ^c   Harris, Isaac S ^b   Marino, Arianna ^d   Federici, Massimo ^d   Dinsdale, David ^a   Knight, Richard A ^a   Melino, Gerry ^a,d   Mak, Tak Wah ^b  

^a UNIVERSITY OF LEICESTER   (United Kingdom)

^b PRINCESS MARGARET HOSPITAL   (Canada)

^c INSERM   (France)

^d UNIVERSITY OF ROME TOR VERGATA   (Italy)

Author keywords

Aging; Metabolism; Mitochondria; P53; P73; ROS; Senescence

Indexed keywords

ADENOSINE TRIPHOSPHATE; CYTOCHROME C OXIDASE SUBUNIT 4; OXIDOREDUCTASE; PROTEIN P53; PROTEIN TAP73; REACTIVE OXYGEN METABOLITE; UNCLASSIFIED DRUG;

AGING; ANIMAL CELL; ANIMAL EXPERIMENT; ANIMAL MODEL; ARTICLE; CONTROLLED STUDY; METABOLIC DISORDER; MOUSE; NONHUMAN; OXIDATIVE STRESS; OXYGEN CONSUMPTION; PRIORITY JOURNAL;

AGING; ANIMALS; CELLS, CULTURED; ELECTRON TRANSPORT COMPLEX IV; FIBROBLASTS; GENE KNOCKDOWN TECHNIQUES; HCT116 CELLS; HUMANS; MICE; MICE, KNOCKOUT; MITOCHONDRIA; OXYGEN CONSUMPTION; TRANSCRIPTION FACTORS; ZEBRAFISH PROTEINS;

MUS;

EID: 84866497949     PISSN: 08909369     EISSN: 15495477     Source Type: Journal    
DOI: 10.1101/gad.197640.112     Document Type: Article

References (31)

1. Balaban RS, Nemoto S, Finkel T. 2005. Mitochondria, oxidants, and aging. Cell 120: 483-495.
2. Belyi VA, Ak P, Markert E, Wang H, Hu W, Puzio-Kuter A, Levine AJ. 2010. The origins and evolution of the p53 family of genes. Cold Spring Harb Perspect Biol 2: a001198. doi: 10.1101/cshperspect.a001198.
3. Chen YF, Kao CH, Chen YT, Wang CH, Wu CY, Tsai CY, Liu FC, Yang CW, Wei YH, Hsu MT, et al. 2009. Cisd2 deficiency drives premature aging and causes mitochondria-mediated defects in mice. Genes Dev 23: 1183-1194.
4. Gottlieb E, Vousden KH. 2010. p53 regulation of metabolic pathways. Cold Spring Harb Perspect Biol 2: a001040. doi: 10.1101/cshperspect.a001040.
5. Kenyon CJ. 2010. The genetics of ageing. Nature 464: 504-512.
6. Keyes WM, Wu Y, Vogel H, Guo X, Lowe SW, Mills AA. 2005. p63 deficiency activates a program of cellular senescence and leads to accelerated aging. Genes Dev 19: 1986-1999.
7. Krishnamurthy J, Torrice C, Ramsey MR, Kovalev GI, Al-Regaiey K, Su L, Sharpless NE. 2004. Ink4a/Arf expression is a biomarker of aging. J Clin Invest 114: 1299-1307.
8. Lapointe J, Hekimi S. 2010. When a theory of aging ages badly. Cell Mol Life Sci 67: 1-8.
9. Laurent G, Solari F, Mateescu B, Karaca M, Castel J, Bourachot B, Magnan C, Billaud M, Mechta-Grigoriou F. 2008. Oxidative stress contributes to aging by enhancing pancreatic angiogenesis and insulin signaling. Cell Metab 7: 113-124.
10. Lee HY, Choi CS, Birkenfeld AL, Alves TC, Jornayvaz FR, Jurczak MJ, Zhang D, Woo DK, Shadel GS, Ladiges W, et al. 2010. Targeted expression of catalase to mitochondria prevents age-associated reductions in mitochondrial function and insulin resistance. Cell Metab 12: 668-674.
11. Levine AJ, Tomasini R, McKeon FD, Mak TW, Melino G. 2011. The p53 family: Guardians of maternal reproduction. Nat Rev Mol Cell Biol 12: 259-265.
12. Lin YL, Sengupta S, Gurdziel K, Bell GW, Jacks T, Flores ER. 2009. p63 and p73 transcriptionally regulate genes involved in DNA repair. PLoS Genet 5: e1000680. doi: 10.1371/journal.pgen.1000680.
13. Liu J, Cao L, Chen J, Song S, Lee IH, Quijano C, Liu H, Keyvanfar K, Chen H, Cao LY, et al. 2009. Bmi1 regulates mitochondrial function and the DNA damage response pathway. Nature 459: 387-392.
14. Loh K, Deng H, Fukushima A, Cai X, Boivin B, Galic S, Bruce C, Shields BJ, Skiba B, Ooms LM, et al. 2009. Reactive oxygen species enhance insulin sensitivity. Cell Metab 10: 260-272.
15. Matheu A, Maraver A, Serrano M. 2008. The Arf/p53 pathway in cancer and aging. Cancer Res 68: 6031-6034.
16. Matoba S, Kang JG, Patino WD, Wragg A, Boehm M, Gavrilova O, Hurley PJ, Bunz F, Hwang PM. 2006. p53 regulates mitochondrial respiration. Science 312: 1650-1653.
17. Melino G, De Laurenzi V, Vousden KH. 2002. p73: Friend or foe in tumorigenesis. Nat Rev Cancer 2: 605-615.
18. Menghini R, Menini S, Amoruso R, Fiorentino L, Casagrande V, Marzano V, Tornei F, Bertucci P, Iacobini C, Serino M et al. 2009. Tissue inhibitor of metalloproteinase 3 deficiency causes hepatic steatosis and adipose tissue inflammation in mice. Gastroenterology 136: 663-672.e4. doi: 10.1053/j.gastro.2008.10.079.
19. Minamino T, Orimo M, Shimizu I, Kunieda T, Yokoyama M, Ito T, Nojima A, Nabetani A, Oike Y, Matsubara H, et al. 2009. A crucial role for adipose tissue p53 in the regulation of insulin resistance. Nat Med 15: 1082-1087.
20. Parrinello S, Samper E, Krtolica A, Goldstein J, Melov S, Campisi J. 2003. Oxygen sensitivity severely limits the replicative lifespan of murine fibroblasts. Nat Cell Biol 5: 741-747.
21. Reilly SM, Bhargava P, Liu S, Gangl MR, Gorgun C, Nofsinger RR, Evans RM, Qi L, Hu FB, Lee CH. 2010. Nuclear receptor corepressor SMRT regulates mitochondrial oxidative metabolism and mediates agingrelated metabolic deterioration. Cell Metab 12: 643-653.
22. Sahin E, Depinho RA. 2012. Axis of ageing: Telomeres, p53 and mitochondria. Nat Rev Mol Cell Biol 13: 397-404.
23. Sahin E, Colla S, Liesa M, Moslehi J, Muller FL, Guo M, Cooper M, Kotton D, Fabian AJ, Walkey C, et al. 2011. Telomere dysfunction induces metabolic and mitochondrial compromise. Nature 470: 359-365.
24. Su X, Paris M, Gi YJ, Tsai KY, Cho MS, Lin YL, Biernaskie JA, Sinha S, Prives C, Pevny LH, et al. 2009. TAp63 prevents premature aging by promoting adult stem cell maintenance. Cell Stem Cell 5: 64-75.
25. Sung HJ, Ma W, Wang PY, Hynes J, O'Riordan TC, Combs CA, McCoy JP Jr, Bunz F, Kang JG, Hwang PM. 2010. Mitochondrial respiration protects against oxygen-associated DNA damage. Nat Commun 1: 5. doi: 10.1038/ncomms1003.
26. Tomasini R, Tsuchihara K, Wilhelm M, Fujitani M, Rufini A, Cheung CC, Khan F, Itie-Youten A, Wakeham A, Tsao MS, et al. 2008. TAp73 knockout shows genomic instability with infertility and tumor suppressor functions. Genes Dev 22: 2677-2691.
27. Trifunovic A, Wredenberg A, Falkenberg M, Spelbrink JN, Rovio AT, Bruder CE, Bohlooly YM, Gidlof S, Oldfors A, Wibom R, et al. 2004. Premature ageing in mice expressing defective mitochondrial DNA polymerase. Nature 429: 417-423.
28. Trifunovic A, Hansson A, Wredenberg A, Rovio AT, Dufour E, Khvorostov I, Spelbrink JN, Wibom R, Jacobs HT, Larsson NG. 2005. Somatic mtDNA mutations cause aging phenotypes without affecting reactive oxygen species production. Proc Natl Acad Sci 102: 17993-17998.
29. Wilhelm MT, Rufini A, Wetzel MK, Tsuchihara K, Inoue S, Tomasini R, Itie-Youten A, Wakeham A, Arsenian-Henriksson M, Melino G, et al. 2010. Isoform-specific p73 knockout mice reveal a novel role for DNp73 in the DNA damage response pathway. Genes Dev 24: 549-560.
30. Yang A, Walker N, Bronson R, Kaghad M, Oosterwegel M, Bonnin J, Vagner C, Bonnet H, Dikkes P, Sharpe A, et al. 2000. p73-deficient mice have neurological, pheromonal and inflammatory defects but lack spontaneous tumours. Nature 404: 99-103.
31. Yen TC, Chen YS, King KL, Yeh SH, Wei YH. 1989. Liver mitochondrial respiratory functions decline with age. Biochem Biophys Res Commun 165: 944-1003.