TAp73 is required for spermatogenesis and the maintenance of male fertility

Proceedings of the National Academy of Sciences of the United States of America

Volumn 111, Issue 5, 2014, Pages 1843-1848

  Inoue, Satoshi ^a   Tomasini, Richard ^a,b   Rufini, Alessandro ^c   Elia, Andrew J ^a   Agostini, Massimiliano ^c   Amelio, Ivano ^c   Cescon, Dave ^a   Dinsdale, David ^c   Zhou, Lily ^a   Harris, Isaac S ^a   Lac, Sophie ^b   Silvester, Jennifer ^a   Li, Wanda Y ^a   Sasaki, Masato ^a   Haight, Jillian ^a   Brüstle, Anne ^a   Wakeham, Andrew ^a   McKerlie, Colin ^d   Jurisicova, Andrea ^e   Melino, Gerry ^c,f   Mak, Tak W ^a   more..

^a PRINCESS MARGARET HOSPITAL   (Canada)

^b CNRS   (France)

^c UNIVERSITY OF LEICESTER   (United Kingdom)

^d HOSPITAL FOR SICK CHILDREN RESEARCH INSTITUTE   (Canada)

^e MOUNT SINAI HOSPITAL   (Canada)

^f UNIVERSITY OF ROME TOR VERGATA   (Italy)

Author keywords

ADAM17; MMP13; Serpin; Timp

Indexed keywords

COLLAGENASE 3; MESSENGER RNA; PROTEIN P53; TRANSCRIPTION FACTOR; TRANSCRIPTION FACTOR TAP73; TUMOR NECROSIS FACTOR ALPHA CONVERTING ENZYME; UNCLASSIFIED DRUG;

ANIMAL EXPERIMENT; ANIMAL MODEL; APOPTOSIS; ARTICLE; CELL DEATH; CELL PROLIFERATION; DNA DAMAGE; GENE EXPRESSION; GERM CELL; HISTOLOGY; MALE; MALE FERTILITY; MITOSIS; MOUSE; NONHUMAN; OXIDATIVE STRESS; PRIORITY JOURNAL; PROGESTERONE BLOOD LEVEL; REGULATORY MECHANISM; SPERMATID; SPERMATOGENESIS; SPERMATOGONIUM; SPERMATOZOON MATURATION; STEM CELL; STEROIDOGENESIS;

ADAM17; MMP13; SERPIN; TIMP;

ADAM PROTEINS; AGING; ANIMALS; APOPTOSIS; CELL COUNT; CELL PROLIFERATION; DNA DAMAGE; DNA-BINDING PROTEINS; FEMALE; FERTILITY; GENE EXPRESSION REGULATION; HUMANS; INFERTILITY, MALE; MALE; MATRIX METALLOPROTEINASE 13; MICE; MICE, KNOCKOUT; NUCLEAR PROTEINS; OXIDATIVE STRESS; PROGESTERONE; RNA, MESSENGER; SPERMATOGENESIS; SPERMATOZOA; TESTIS; TUMOR SUPPRESSOR PROTEINS;

EID: 84893467658     PISSN: 00278424     EISSN: 10916490     Source Type: Journal    
DOI: 10.1073/pnas.1323416111     Document Type: Article

References (29)

1. Hess RA, Renato de Franca L (2008) Spermatogenesis and cycle of the seminiferous epithelium. Adv Exp Med Biol 636:1-15.
2. Cheng CY, Mruk DD (2010) A local autocrine axis in the testes that regulates spermatogenesis. Nat Rev Endocrinol 6(7):380-395.
3. Verhoeven G, Willems A, Denolet E, Swinnen JV, De Gendt K (2010) Androgens and spermatogenesis: Lessons from transgenic mouse models. Philos Trans R Soc Lond B Biol Sci 365(1546):1537-1556.
4. Melino G, De Laurenzi V, Vousden KH (2002) p73: Friend or foe in tumorigenesis. Nat Rev Cancer 2(8):605-615.
5. Tomasini R, et al. (2008) TAp73 knockout shows genomic instability with infertility and tumor suppressor functions. Genes Dev 22(19):2677-2691.
6. Tomasini R, et al. (2009) TAp73 regulates the spindle assembly checkpoint by modulating BubR1 activity. Proc Natl Acad Sci USA 106(3):797-802.
7. Wilhelm MT, et al. (2010) Isoform-specific p73 knockout mice reveal a novel role for delta Np73 in the DNA damage response pathway. Genes Dev 24(6):549-560.
8. Agostini M, et al. (2010) p73 regulates maintenance of neural stem cell. Biochem Biophys Res Commun 403(1):13-17.
9. Fujitani M, et al. (2010) TAp73 acts via the bHLH Hey2 to promote long-term maintenance of neural precursors. Curr Biol 20(22):2058-2065.
10. Rufini A, et al. (2012) TAp73 depletion accelerates aging through metabolic dysregulation. Genes Dev 26(18):2009-2014.
11. Levine AJ, Tomasini R, McKeon FD, Mak TW, Melino G (2011) The p53 family: Guardians of maternal reproduction. Nat Rev Mol Cell Biol 12(4):259-265.
12. Hu W, Feng Z, Teresky AK, Levine AJ (2007) p53 regulates maternal reproduction through LIF. Nature 450(7170):721-724.
13. Yang A, et al. (2000) p73-deficient mice have neurological, pheromonal and inflammatory defects but lack spontaneous tumours. Nature 404(6773):99-103.
14. Rockett JC, Patrizio P, Schmid JE, Hecht NB, Dix DJ (2004) Gene expression patterns associated with infertility in humans and rodent models. Mutat Res 549(1-2):225-240.
15. Moreno RD, Urriola-Muñoz P, Lagos-Cabré R (2011) The emerging role of matrix metalloproteases of the ADAM family in male germ cell apoptosis. Spermatogenesis 1(3):195-208.
16. Xiao X, Mruk DD, Cheng CY (2013) Intercellular adhesion molecules (ICAMs) and spermatogenesis. Hum Reprod Update 19(2):167-186.
17. Donehower LA, et al. (1992) Mice deficient for p53 are developmentally normal but susceptible to spontaneous tumours. Nature 356(6366):215-221.
18. Beumer TL, et al. (1998) The role of the tumor suppressor p53 in spermatogenesis. Cell Death Differ 5(8):669-677.
19. Hamer G, Gademan IS, Kal HB, de Rooij DG (2001) Role for c-Abl and p73 in the radiation response of male germ cells. Oncogene 20(32):4298-4304.
20. Codelia VA, Cisterna M, Alvarez AR, Moreno RD (2010) p73 participates in male germ cells apoptosis induced by etoposide. Mol Hum Reprod 16(10):734-742.
21. Walker WH (2011) Testosterone signaling and the regulation of spermatogenesis. Spermatogenesis 1(2):116-120.
22. Flück CE, Pandey AV (2011) Clinical and biochemical consequences of p450 oxidoreductase deficiency. Endocr Dev 20:63-79.
23. Lue Y, et al. (2013) Functional role of progestin and the progesterone receptor in the suppression of spermatogenesis in rodents. Andrology 1(2):308-317.
24. Uhrin P, et al. (2000) Disruption of the protein C inhibitor gene results in impaired spermatogenesis and male infertility. J Clin Invest 106(12):1531-1539.
25. Lee B, et al. (2011) Impaired spermatogenesis and fertility in mice carrying a mutation in the Spink2 gene expressed predominantly in testes. J Biol Chem 286(33): 29108-29117.
26. Lane DP (1992) Cancer. p53, guardian of the genome. Nature 358(6381):15-16.
27. Suh EK, et al. (2006) p63 protects the female germ line during meiotic arrest. Nature 444(7119):624-628.
28. Jacks T, et al. (1994) Tumor spectrum analysis in p53-mutant mice. Curr Biol 4(1):1-7.
29. Inoue S, et al. (2013) Mule/Huwe1/Arf-BP1 suppresses Ras-driven tumorigenesis by preventing c-Myc/Miz1-mediated down-regulation of p21 and p15. Genes Dev 27(10): 1101-1114.