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Volumn 64, Issue 7, 2004, Pages 2449-2460

Transdominant ΔTAp73 Isoforms Are Frequently Up-regulated in Ovarian Cancer. Evidence for Their Role as Epigenetic p53 Inhibitors in Vivo

Author keywords

[No Author keywords available]

Indexed keywords

MOLECULAR MARKER; PROTEIN INHIBITOR; PROTEIN P53; PROTEIN P53 INHIBITOR; PROTEIN P73; TRANSCRIPTION FACTOR E2F1; UNCLASSIFIED DRUG; DNA BINDING PROTEIN; ISOPROTEIN; MESSENGER RNA; NUCLEAR PROTEIN; TUMOR SUPPRESSOR PROTEIN; TUMOR SUPPRESSOR PROTEIN P73;

EID: 11144357549     PISSN: 00085472     EISSN: None     Source Type: Journal    
DOI: 10.1158/0008-5472.CAN-03-1060     Document Type: Article
Times cited : (133)

References (38)
  • 1
    • 0031564954 scopus 로고    scopus 로고
    • p73 is a simian [correction of human] p53-related protein that can induce apoptosis
    • Jost CA, Marin MC, and Kaelin WG Jr. p73 is a simian [correction of human] p53-related protein that can induce apoptosis. Nature (Lond) 1997;389:191-4.
    • (1997) Nature (Lond) , vol.389 , pp. 191-194
    • Jost, C.A.1    Marin, M.C.2    Kaelin Jr., W.G.3
  • 2
    • 0036674617 scopus 로고    scopus 로고
    • Live or let die: The cell's response to p53
    • Vousden KH, Lu X. Live or let die: the cell's response to p53. Nat Rev Cancer 2002;2:594-604.
    • (2002) Nat Rev Cancer , vol.2 , pp. 594-604
    • Vousden, K.H.1    Lu, X.2
  • 3
    • 0032533514 scopus 로고    scopus 로고
    • The potential tumor suppressor p73 differentially regulates cellular p53 target genes
    • Zhu J, Jiang J, Zhou W, Chen X. The potential tumor suppressor p73 differentially regulates cellular p53 target genes. Cancer Res 1998;58:5061-5.
    • (1998) Cancer Res , vol.58 , pp. 5061-5065
    • Zhu, J.1    Jiang, J.2    Zhou, W.3    Chen, X.4
  • 4
    • 0033600240 scopus 로고    scopus 로고
    • Interaction of c-Abl and p73α and their collaboration to induce apoptosis
    • Agami R, Blandino G, Oren M, Shaul Y. Interaction of c-Abl and p73α and their collaboration to induce apoptosis. Nature (Lond) 1999;399:809-13.
    • (1999) Nature (Lond) , vol.399 , pp. 809-813
    • Agami, R.1    Blandino, G.2    Oren, M.3    Shaul, Y.4
  • 5
    • 0033600234 scopus 로고    scopus 로고
    • The tyrosine kinase c-Abl regulates p73 in apoptotic response to cisplatin-induced DNA damage
    • Gong JG, Costanzo A, Yang HQ, et al. The tyrosine kinase c-Abl regulates p73 in apoptotic response to cisplatin-induced DNA damage. Nature (Lond) 1999;399: 806-9.
    • (1999) Nature (Lond) , vol.399 , pp. 806-809
    • Gong, J.G.1    Costanzo, A.2    Yang, H.Q.3
  • 6
    • 10744230945 scopus 로고    scopus 로고
    • p53 polymorphism influences response in cancer chemotherapy via modulation of p73-dependent apoptosis
    • Bergamaschi D, Gasco M, Hiller L, et al. p53 polymorphism influences response in cancer chemotherapy via modulation of p73-dependent apoptosis. Cancer Cell 2003;3:387-402.
    • (2003) Cancer Cell , vol.3 , pp. 387-402
    • Bergamaschi, D.1    Gasco, M.2    Hiller, L.3
  • 7
    • 0034609798 scopus 로고    scopus 로고
    • Role for the p53 homologue p73 in E2F-1-induced apoptosis
    • Irwin M, Marin MC, Phillips AC, et al. Role for the p53 homologue p73 in E2F-1-induced apoptosis. Nature (Lond) 2000;407:645-8.
    • (2000) Nature (Lond) , vol.407 , pp. 645-648
    • Irwin, M.1    Marin, M.C.2    Phillips, A.C.3
  • 8
    • 0034609864 scopus 로고    scopus 로고
    • A common E2F-1 and p73 pathway mediates cell death induced by TCR activation
    • Lissy NA, Davis PK, Irwin M, et al. A common E2F-1 and p73 pathway mediates cell death induced by TCR activation. Nature (Lond) 2000;407:642-5.
    • (2000) Nature (Lond) , vol.407 , pp. 642-645
    • Lissy, N.A.1    Davis, P.K.2    Irwin, M.3
  • 9
    • 0033666776 scopus 로고    scopus 로고
    • Role of the p53-homologue p73 in E2F1-induced apoptosis
    • Stiewe T, Putzer BM. Role of the p53-homologue p73 in E2F1-induced apoptosis. Nat Genet 2000;26:464-9.
    • (2000) Nat Genet , vol.26 , pp. 464-469
    • Stiewe, T.1    Putzer, B.M.2
  • 10
    • 0035815677 scopus 로고    scopus 로고
    • Oncogenes induce and activate endogenous p73 protein
    • Zaika A, Irwin M, Sansome C, Moll UM. Oncogenes induce and activate endogenous p73 protein. J Biol Chem 2001;276:11310-6.
    • (2001) J Biol Chem , vol.276 , pp. 11310-11316
    • Zaika, A.1    Irwin, M.2    Sansome, C.3    Moll, U.M.4
  • 12
    • 17544363909 scopus 로고    scopus 로고
    • p73-deficient mice have neurological, pheromonal and inflammatory defects but lack spontaneous tumours
    • Yang A, Walker N, Bronson R, et al. p73-deficient mice have neurological, pheromonal and inflammatory defects but lack spontaneous tumours. Nature (Lond) 2000;404:99-103.
    • (2000) Nature (Lond) , vol.404 , pp. 99-103
    • Yang, A.1    Walker, N.2    Bronson, R.3
  • 13
    • 0035966345 scopus 로고    scopus 로고
    • p53, p63 and p73-solos, alliances and feuds among family members
    • Moll UM, Erster S, Zaika A. p53, p63 and p73-solos, alliances and feuds among family members. Biochim Biophys Acta 2001;1552:47-59.
    • (2001) Biochim Biophys Acta , vol.1552 , pp. 47-59
    • Moll, U.M.1    Erster, S.2    Zaika, A.3
  • 15
    • 0036468249 scopus 로고    scopus 로고
    • Possible oncogenic potential of DeltaNp73: A newly identified isoform of human p73
    • Ishimoto O, Kawahara C, Enjo K, Obinata M, Nukiwa T, Ikawa S. Possible oncogenic potential of DeltaNp73: a newly identified isoform of human p73. Cancer Res 2002;62:636-41.
    • (2002) Cancer Res , vol.62 , pp. 636-641
    • Ishimoto, O.1    Kawahara, C.2    Enjo, K.3    Obinata, M.4    Nukiwa, T.5    Ikawa, S.6
  • 16
    • 0030812331 scopus 로고    scopus 로고
    • Monoallelically expressed gene related to p53 at 1p36, a region frequently deleted in neuroblastoma and other human cancers
    • Kaghad M, Bonnet H, Yang A, Creancier L, Biscan JC, Valent A, et al. Monoallelically expressed gene related to p53 at 1p36, a region frequently deleted in neuroblastoma and other human cancers. Cell 1997;90:809-19.
    • (1997) Cell , vol.90 , pp. 809-819
    • Kaghad, M.1    Bonnet, H.2    Yang, A.3    Creancier, L.4    Biscan, J.C.5    Valent, A.6
  • 17
    • 0036203514 scopus 로고    scopus 로고
    • Autoinhibitory regulation of p73 by Delta Np73 to modulate cell survival and death through a p73-specific target element within the Delta Np73 promoter
    • Nakagawa T, Takahashi M, Ozaki T, et al. Autoinhibitory regulation of p73 by Delta Np73 to modulate cell survival and death through a p73-specific target element within the Delta Np73 promoter. Mol Cell Biol 2002;22:2575-85.
    • (2002) Mol Cell Biol , vol.22 , pp. 2575-2585
    • Nakagawa, T.1    Takahashi, M.2    Ozaki, T.3
  • 19
    • 0037119631 scopus 로고    scopus 로고
    • ΔNp73, a dominant-negative inhibitor of wild-type p53 and TAp73, is up-regulated in human tumors
    • Zaika AI, Slade N, Erster SH, et al. ΔNp73, a dominant-negative inhibitor of wild-type p53 and TAp73, is up-regulated in human tumors. J Exp Med 2002;196: 765-80.
    • (2002) J Exp Med , vol.196 , pp. 765-780
    • Zaika, A.I.1    Slade, N.2    Erster, S.H.3
  • 20
    • 17744386129 scopus 로고    scopus 로고
    • Transactivation-deficient p73alpha (p73Deltaexon2) inhibits apoptosis and competes with p53
    • Fillippovich I, Sorokina N, Gatei M, et al. Transactivation-deficient p73alpha (p73Deltaexon2) inhibits apoptosis and competes with p53. Oncogene 2001;20: 514-22.
    • (2001) Oncogene , vol.20 , pp. 514-522
    • Fillippovich, I.1    Sorokina, N.2    Gatei, M.3
  • 21
    • 0037134475 scopus 로고    scopus 로고
    • Transactivation-deficient Delta TA-p73 inhibits p53 by direct competition for DNA binding: Implications for tumorigenesis
    • Stiewe T, Theseling CC, Putzer BM. Transactivation-deficient Delta TA-p73 inhibits p53 by direct competition for DNA binding: implications for tumorigenesis. J Biol Chem 2002;277:14177-85.
    • (2002) J Biol Chem , vol.277 , pp. 14177-14185
    • Stiewe, T.1    Theseling, C.C.2    Putzer, B.M.3
  • 22
    • 18244402691 scopus 로고    scopus 로고
    • Human delta Np73 regulates a dominant negative feedback loop for TAp73 and p53
    • Grob TJ, Novak U, Maisse C, et al. Human delta Np73 regulates a dominant negative feedback loop for TAp73 and p53. Cell Death Differ 2001;8:1213-23.
    • (2001) Cell Death Differ , vol.8 , pp. 1213-1223
    • Grob, T.J.1    Novak, U.2    Maisse, C.3
  • 23
    • 0042977668 scopus 로고    scopus 로고
    • ΔNp73 facilitates cell immortalization and cooperates with oncogenic Ras in cellular transformation in vivo
    • Petrenko O, Zaika A, Moll UM. ΔNp73 facilitates cell immortalization and cooperates with oncogenic Ras in cellular transformation in vivo. Mol Cell Biol 2003;23: 5540-55.
    • (2003) Mol Cell Biol , vol.23 , pp. 5540-5555
    • Petrenko, O.1    Zaika, A.2    Moll, U.M.3
  • 24
  • 25
    • 0036005908 scopus 로고    scopus 로고
    • Expression of ΔNp73 is a molecular marker for adverse outcome in neuroblastoma patients
    • Casciano I, Mazzocco K, Boni L, et al. Expression of ΔNp73 is a molecular marker for adverse outcome in neuroblastoma patients. Cell Death Differ 2002;9:246-51.
    • (2002) Cell Death Differ , vol.9 , pp. 246-251
    • Casciano, I.1    Mazzocco, K.2    Boni, L.3
  • 26
    • 0024830707 scopus 로고
    • Quantitative comparison of mRNA levels in mammalian tissues: 28S ribosomal RNA level as an accurate internal control
    • de Leeuw WJ, Slagboom PE, Vijg J. Quantitative comparison of mRNA levels in mammalian tissues: 28S ribosomal RNA level as an accurate internal control. Nucleic Acids Res 1989;17:10137-8.
    • (1989) Nucleic Acids Res , vol.17 , pp. 10137-10138
    • De Leeuw, W.J.1    Slagboom, P.E.2    Vijg, J.3
  • 27
    • 0029043805 scopus 로고
    • A simple p53 functional assay for screening cell lines, blood, and tumors
    • Flaman JM, Frebourg T, Moreau V, et al. A simple p53 functional assay for screening cell lines, blood, and tumors. Proc Natl Acad Sci USA 1995;92:3963-7.
    • (1995) Proc Natl Acad Sci USA , vol.92 , pp. 3963-3967
    • Flaman, J.M.1    Frebourg, T.2    Moreau, V.3
  • 28
    • 0031766420 scopus 로고    scopus 로고
    • Expression level, allelic origin, and mutation analysis of the p73 gene in neuroblastoma tumors and cell lines
    • Kovalev S, Marchenko N, Swendeman S, LaQuaglia M, Moll UM. Expression level, allelic origin, and mutation analysis of the p73 gene in neuroblastoma tumors and cell lines. Cell Growth Differ 1998;9:897-903.
    • (1998) Cell Growth Differ , vol.9 , pp. 897-903
    • Kovalev, S.1    Marchenko, N.2    Swendeman, S.3    LaQuaglia, M.4    Moll, U.M.5
  • 29
    • 0037130279 scopus 로고    scopus 로고
    • Control of alternative splicing by antisense oligonucleotides as a potential chemotherapy: Effects on gene expression
    • Mercatante, DR, and Kole R. Control of alternative splicing by antisense oligonucleotides as a potential chemotherapy: effects on gene expression. Biochim Biophys Acta 2002;1587:126-32.
    • (2002) Biochim Biophys Acta , vol.1587 , pp. 126-132
    • Mercatante, D.R.1    Kole, R.2
  • 30
    • 0037130473 scopus 로고    scopus 로고
    • p53 induces the expression of its antagonist p73 AN, establishing an autoregulatory feedback loop
    • Kartasheva NN, Contente A, Lenz-Stoppler C, Roth J, Dobbelstein M. p53 induces the expression of its antagonist p73 AN, establishing an autoregulatory feedback loop. Oncogene 2002;21:4715-27.
    • (2002) Oncogene , vol.21 , pp. 4715-4727
    • Kartasheva, N.N.1    Contente, A.2    Lenz-Stoppler, C.3    Roth, J.4    Dobbelstein, M.5
  • 31
    • 0037161921 scopus 로고    scopus 로고
    • DN-p73 is activated after DNA damage in a p53-dependent manner to regulate p53-induced cell cycle arrest
    • Vossio S, Palescandolo E, Pediconi N, et al. DN-p73 is activated after DNA damage in a p53-dependent manner to regulate p53-induced cell cycle arrest. Oncogene 2002;21:3796-803.
    • (2002) Oncogene , vol.21 , pp. 3796-3803
    • Vossio, S.1    Palescandolo, E.2    Pediconi, N.3
  • 32
    • 1542359564 scopus 로고    scopus 로고
    • ΔNp73 stabilises TAp73 proteins but compromises their function due to inhibitory hetero-oligomer formation
    • Dec 12 [Epub ahead of print]. 2003;doi:10.1038/sj.cdd 4401335
    • Slade N, Zaika AI, Erster S, Moll UM. ΔNp73 stabilises TAp73 proteins but compromises their function due to inhibitory hetero-oligomer formation. Cell Death Differ [serial on the Internet]. 2003 Dec 12 [Epub ahead of print]. 2003;doi:10.1038/sj.cdd. 4401335.
    • (2003) Cell Death Differ [Serial on the Internet]
    • Slade, N.1    Zaika, A.I.2    Erster, S.3    Moll, U.M.4
  • 33
    • 0029049828 scopus 로고
    • Wild-type p53 protein undergoes cytoplasmic sequestration in undifferentiated neuroblastomas but not in differentiated tumors
    • Moll UM, LaQuaglia M, Benard J, Riou G. Wild-type p53 protein undergoes cytoplasmic sequestration in undifferentiated neuroblastomas but not in differentiated tumors. Proc Natl Acad Sci USA 1995;92:4407-11.
    • (1995) Proc Natl Acad Sci USA , vol.92 , pp. 4407-4411
    • Moll, U.M.1    LaQuaglia, M.2    Benard, J.3    Riou, G.4
  • 35
    • 0035131701 scopus 로고    scopus 로고
    • A subset of tumor-derived mutant forms of p53 down-regulate p63 and p73 through a direct interaction with the p53 core domain
    • Gaiddon C, Lokshin M, Ahn J, Zhang T, Prives C. A subset of tumor-derived mutant forms of p53 down-regulate p63 and p73 through a direct interaction with the p53 core domain. Mol Cell Biol 2001;21:1874-87.
    • (2001) Mol Cell Biol , vol.21 , pp. 1874-1887
    • Gaiddon, C.1    Lokshin, M.2    Ahn, J.3    Zhang, T.4    Prives, C.5


* 이 정보는 Elsevier사의 SCOPUS DB에서 KISTI가 분석하여 추출한 것입니다.