Possible oncogenic potential of ΔNp73: A newly identified isoform of human p73

Cancer Research

Volumn 62, Issue 3, 2002, Pages 636-641

  Ishimoto, Osamu ^a   Kawahara, Chikashi ^a   Enjo, Kentaro ^a   Obinata, Masuo ^a   Nukiwa, Toshihiro ^a   Ikawa, Shuntaro ^a  

^a TOHOKU UNIVERSITY   (Japan)

Author keywords

[No Author keywords available]

Indexed keywords

PROTEIN DERIVATIVE; PROTEIN P73;

AMINO TERMINAL SEQUENCE; ARTICLE; CANCER GENETICS; CARBOXY TERMINAL SEQUENCE; CARCINOGENESIS; GENE; GENE EXPRESSION; HUMAN; HUMAN CELL; P73 GENE; PRIORITY JOURNAL; PROTEIN DNA BINDING; TRANSACTIVATION;

AMINO ACID SEQUENCE; ANIMALS; CELL DIVISION; COS CELLS; DNA-BINDING PROTEINS; GENES, TUMOR SUPPRESSOR; HUMANS; MOLECULAR SEQUENCE DATA; NUCLEAR PROTEINS; PROTEIN ISOFORMS; TRANS-ACTIVATION (GENETICS); TRANSFECTION; TUMOR CELLS, CULTURED; TUMOR SUPPRESSOR PROTEIN P53; TUMOR SUPPRESSOR PROTEINS;

EID: 0036468249     PISSN: 00085472     EISSN: None     Source Type: Journal    
DOI: None     Document Type: Article

References (20)

1. p53: Puzzle and paradigm
2. p53 family update p73 and p63 develop their own identities
3. Monoallelically expressed gene related to p53 at 1p36, a region frequently deleted in neuroblastoma and other human cancers
4. Cloning and functional analysis of human p51, which structurally and functionally resembles p53
5. p63, a p53 homolog at 3q27-29, encodes multiple products with transactivating, death-inducing, and dominant-negative activities
6. p73 is a simian [correction of human] p53-related protein that can induce apoptosis
7. Two new p73 splice variants, γ and δ, with different transcriptional activity
8. p73-deficient mice have neurological, pheromonal and inflammatory defects but lack spontaneous tumours
9. An anti-apoptotic role for the p53 family member, p73, during developmental neuron death
10. Physical and functional interaction between wild-type p53 and mdm2 proteins
11. Generation and identification of recombinant adenovirus by liposome-mediated transfection and PCR analysis
12. Genomic organization and mutation analysis of p73 in oligodendrogliomas with chromosome 1 p-arm deletions
13. Inhibition of viral and cellular promoters by human wild-type p53
14. p53 associates with and targets ΔNp63 into a protein degradation pathway
15. p73 function is inhibited by tumorderived p53 mutants in mammalian cells
16. A subset of tumorderived mutant forms of p53 down-regulate p63 and p73 through a direct interaction with the p53 core domain
17. A common polymorphism acts as an intragenic modifier of mutant p53 behaviour
18. p53 family genes: Structural comparison, expression and mutation
19. Infrequent somatic mutations of the p73 gene in various human cancers
20. AIS is an oncogene amplified in squamous cell carcinoma