A regulatory feedback loop involving p63 and IRF6 links the pathogenesis of 2 genetically different human ectodermal dysplasias

Journal of Clinical Investigation

Volumn 120, Issue 5, 2010, Pages 1570-1577

  Moretti, Francesca ^a   Marinari, Barbara ^a   Iacono, Nadia Lo ^b   Botti, Elisabetta ^a   Giunta, Alessandro ^a   Spallone, Giulia ^a   Garaffo, Giulia ^c   Vernersson Lindahl, Emma ^d   Merlo, Giorgio ^c   Mills, Alea A ^d   Ballarò, Costanza ^e   Alemà, Stefano ^e   Chimenti, Sergio ^a   Guerrini, Luisa ^b   Costanzo, Antonio ^a,f  

^a UNIVERSITY OF ROME TOR VERGATA   (Italy)

^b UNIVERSITY OF MILAN   (Italy)

^c UNIVERSITY OF TURIN   (Italy)

^d Howard Hughes Medical Institute Cold Spring Harbor Laboratory Cold Spring Harbor   (United States)

^e CNR   (Italy)

^f Rome Oncogenomic Center   (Italy)

Author keywords

[No Author keywords available]

Indexed keywords

INTERFERON REGULATORY FACTOR 6; PROTEASOME; PROTEIN P63;

ANIMAL CELL; ARTICLE; CELL CYCLE; CELL DIFFERENTIATION; CELL PROLIFERATION; CONTROLLED STUDY; ECTODERM; ECTODERMAL DYSPLASIA; FEEDBACK SYSTEM; GENE EXPRESSION; GENE MUTATION; GENETIC TRANSCRIPTION; HUMAN; HUMAN CELL; HUMAN TISSUE; KERATINOCYTE; MOLECULAR DYNAMICS; MOUSE; NONHUMAN; PALATE; PATHOGENESIS; PRIORITY JOURNAL; PROTEIN DEGRADATION; PROTEIN FUNCTION;

ANIMALS; CELL DIFFERENTIATION; CELL PROLIFERATION; ECTODERMAL DYSPLASIA; GENE EXPRESSION REGULATION; HUMANS; INTERFERON REGULATORY FACTORS; KERATINOCYTES; MICE; MICE, TRANSGENIC; MODELS, BIOLOGICAL; MUTATION; PHENOTYPE; PHOSPHOPROTEINS; SKIN; TRANS-ACTIVATORS; TUMOR SUPPRESSOR PROTEINS;

EID: 77951865156     PISSN: 00219738     EISSN: 15588238     Source Type: Journal    
DOI: 10.1172/JCI40267     Document Type: Article

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