TAp73 is required for macrophage-mediated innate immunity and the resolution of inflammatory responses

Cell Death and Differentiation

Volumn 20, Issue 2, 2013, Pages 293-301

  Tomasini, R ^a,b   Secq, V ^a   Pouyet, L ^a   Thakur, A K ^a   Wilhelm, M ^b,c   Nigri, J ^a   Vasseur, S ^a   Berthezene, P ^a   Calvo, E ^d   Melino, G ^e   Mak, T W ^b   Iovanna, J L ^a  

^a AIX MARSEILLE UNIVERSITY   (France)

^b PRINCESS MARGARET HOSPITAL   (Canada)

^c KAROLINSKA INSTITUTE   (Sweden)

^d LAVAL UNIVERSITY   (Canada)

^e UNIVERSITY OF ROME TOR VERGATA   (Italy)

Author keywords

apoptosis; inflammation; M1 M2 polarization; macrophage; p73

Indexed keywords

BETA INTERFERON; HLA ANTIGEN CLASS 2; INTERLEUKIN 6; LIPOPOLYSACCHARIDE; MACROPHAGE INFLAMMATORY PROTEIN 2; PROTEIN P73; TUMOR NECROSIS FACTOR ALPHA;

ANIMAL CELL; ANIMAL EXPERIMENT; ANIMAL MODEL; APOPTOSIS; ARTICLE; CELL POLARITY; CONTROLLED STUDY; GENE EXPRESSION; IMMUNE RESPONSE; INNATE IMMUNITY; MACROPHAGE; MALE; MOUSE; NONHUMAN; PHAGOCYTOSIS; PHENOTYPE; PRIORITY JOURNAL; SEPTIC SHOCK;

ANIMALS; CELLS, CULTURED; CHEMOKINE CXCL2; DNA-BINDING PROTEINS; GENE EXPRESSION REGULATION; IMMUNITY, INNATE; INTERFERON-BETA; INTERLEUKIN-6; LIPOPOLYSACCHARIDES; MACROPHAGES; MALE; MICE; MICE, INBRED BALB C; MICE, KNOCKOUT; NUCLEAR PROTEINS; PHENOTYPE; PROTEIN ISOFORMS; TUMOR NECROSIS FACTOR-ALPHA; TUMOR SUPPRESSOR PROTEINS;

MUS;

EID: 84872295543     PISSN: 13509047     EISSN: 14765403     Source Type: Journal    
DOI: 10.1038/cdd.2012.123     Document Type: Article

References (40)

1. Yang A, Kaghad M, Caput D, McKeon F. On the shoulders of giants: p63, p73 and the raise of p53. Trends genet 2002; 18: 90-95.
2. Melino G, Lu X, Gasco M, Crook T, Knight RA. Functional regulation of p73 and p63: development and cancer. Trends Biochem Sci 2003; 28: 663-670.
3. Tomasini R, Tsushihara K, Wilhelm M, Fujitani M, Rufini A, Cheung CC et al. TAp73 knockout shows genomic instability with infertility and tumor suppressor functions. Genes Dev 2008; 19: 2677-2691.
4. Flores ER, Sengupta S, Miller JB, Newman JJ, Bronson R, Crowley D et al. Tumor predisposition in mice mutant for p63 and p73: evidence for broader tumor suppressor functions for the p53 family. Cancer Cell 2005; 4: 363-373.
5. Pietsch MC, Sykes SM, McMahon SB, Murphy ME. The p53 family and programmed cell death. Oncogene 2008; 27: 6505-6521.
6. Talos F, Nemajerova A, Flores ER, Petrenko O, Moll UM. p73 suppresses polyploidy and aneuploidy in the absence of functional p53. Mol Cell 2007; 4: 647-659.
7. Tomasini R, Mak TW, Melino G. The impact of p53 and p73 on aneuploidy and cancer. Trends Cell Biol 2008; 5: 244-252.
8. Tomasini R, Tsuchihara K, Tsuda C, Lau SK, Wilhelm M, Rufini A et al. TAp73 regulates the spindle assembly checkpoint by modulating BubR1 activity. Proc Natl Acad Sci USA 2009; 3: 797-802.
9. Wilhelm MT, Rufini A, Wetzel MK, Tsuchihara K, Inoue S, Tomasini R et al. Isoform-specific p73 knockout mice reveal a novel role for deltaNp73 in the DNA damage response pathway. Genes Dev 2010; 24: 549-560.
10. Yang A, Walker N, Bronson R, Kaghad M, Oosterwegel M, Bonnin J et al. p73-deficient mice have neurological, pheromonal and inflammatory defects but lack spontaneous tumours. Nature 2000; 404: 99-103.
11. Levine AJ, Tomasini R, McKeon FD, Mak TW, Melino G. The p53 family: guardians of maternal reproduction. Nat Rev Mol Cell Biol 2011; 12: 259-265.
12. Takeda K, Akira S. Toll-like receptors in innate immunity. Int Immunol 2005; 1: 1-14.
13. Lin WJ, Yeh WC. Implication of Toll-like receptor and tumor necrosis factor alpha signaling in septic shock. Shock 2005; 3: 206-209.
14. Kawai T, Akira S. TLR signaling. Cell Death Differ 2005; 13: 816-825.
15. Kong XN, Yan HX, Chen L, Dong LW, Yang W, Liu Q et al. LPS-induced down-regulation of signal regulatory protein {alpha}22. contributes to innate immune activation in macrophages. J Exp Med 2007; 11: 2719-2731.
16. Martinez FO, Sica A, Mantovani A, Locati M. Macrophage activation and polarization. Front Biosci 2008; 13: 453-461.
17. Leidi M, Gotti E, Bologna L, Miranda E, Rimoldi M, Sica A et al. M2 macrophages phagocytose rituximab-opsonized leukemic targets more efficiently than m1 cells in vitro. J Immunol 2009; 182: 4415-4422.
18. Sakamori R, Takehara T, Ohnishi C, Tatsumi T, Ohkawa K, Takeda K et al. Signal transducer and activator of transcription 3 signaling within hepatocytes attenuates systemic inflammatory response and lethality in septic mice. Hepatology 2007; 46: 1564-1573.
19. Komarova EA, Krivokrysenko V, Wang K, Neznanov N, Chernov MV, Komarov PG et al. p53 is a suppressor of inflammatory response in mice. FASEB J 2005; 19: 1030-1032.
20. Sekine H, Mimura J, Oshima M, Okawa H, Kanno J, Igarashi K et al. Hypersensitivity of aryl hydrocarbon receptor-deficient mice to lipopolysaccharide-induced septic shock. Mol Cell Biol 2009; 29: 6391-6400.
21. Mehta A, Brewington R, Chatterji M, Zoubine M, Kinasewitz GT, Peer GT et al. Infection-induced modulation of m1 and m2 phenotypes in circulating monocytes: role in immune monitoring and early prognosis of sepsis. Shock 2004; 22: 423-430.
22. Schroder K, Hertzog PJ, Ravasi T, Hume DA. Interferon-gamma: an overview of signals, mechanisms and functions. J Leukoc Biol 2004; 75: 163-189.
23. Yang CP, Hayashida T, Forster N, Li C, Shen D, Maheswaran S et al. The integrin {alpha}v{beta}3-5 ligand MFG-E8 is a p63/p73 target gene in triple negative breast cancers but exhibits suppressive functions in ER and erbB2 breast cancers. Cancer Res 2011; 71: 937-945.
24. Desvergne B. PPArdelta/beta:the lobbyist switching macrophage allegiance in favor of metabolism. Cell Metab 2008; 7: 467-469.
25. Sbisa E, Catalano D, Grillo G, Licciulli F, Turi A, Liuni S et al. p53FamTaG: a database resource of human p53, p63 and p73 direct target genes combining in silico prediction and microarray data. BMC Bioinform 2007; 8(Suppl 1): S20.
26. Toshchakov V, Jones BW, Perera PY, Thomas K, Cody MJ, Zhang S et al. TLR4, but not TLR2, mediates IFN-beta-induced STAT1alpha/beta-dependent gene expression in macrophages. Nat Immunol 2002; 3: 392-398.
27. Coelho LF, Magno de Freitas Almeida G, Mennechet FJ, Blangy A, Interferon-alpha Uzé G. and-beta differentially regulate osteoclastogenesis: role of differential induction of chemokine CXCL11 expression. Proc Natl Acad Sci USA 2005; 102: 11917-11922.
28. Wong SC, Puaux AL, Chittezhath M, Shalova I, Kajiji TS, Wang X et al. Macrophage polarization to a unique phenotype driven by B cells. Eur J Immunol 2010; 40: 2296-2307.
29. Park JM, Greten FR, Wong A, Westrick RJ, Arthur JS, Otsu K et al. Signaling pathways and genes that inhibit pathogen-induced macrophage apoptosis-CREB and NF-kappaB as key regulators. Immunity 2005; 23: 319-329.
30. Medzhitov R. Origin and physiological roles of inflammation. Nature 2008; 454: 428-435.
31. De las Heras B, Hortelano S, Giron N, Bermejo P, Rodriguez B, Bosca L. Kaurane diterpenes protect against apoptosis and inhibition of phagocytosis in activated macrophages. Br J Pharmacol 2007; 2: 249-255.
32. Seitz SJ, Schleithoff ES, Koch A, Schuster A, Teufel A, Staib F et al. Chemotherapy-induced apoptosis in hepatocellular carcinoma involves the p53 family and is mediated via the extrinsic and the intrinsic pathway. Int J Cancer 2010; 26: 2049-2066.
33. Fuhrman LE, Goel AK, Smith J, Shianna KV, Aballay A. Nucleolar proteins suppress Caenorhabditis elegans innate immunity by inhibiting p53/CEP-1. PLoS Genet 2009; 5: e1000657.
34. Donehower LA, Harvey M, Slagle BL, McArthur MJ, Montgomery CA Jr, Butel JS et al. Mice deficient for p53 are developmentally normal but susceptible to spontaneous tumours. Nature 1992; 356: 215-221.
35. Rye MS, Bhutta MF, Cheeseman MT, Burgner D, Blackwell JM, Brown SD et al. Unraveling the genetics of otitis media: from mouse to human and back again. Mamm Genome 2010; 22: 66-82.
36. Carrasco G, Diaz J, Valbuena JR, Ibanez P, Rodriguez P, Araya G et al. Overexpression of p73 as a tissue marker for high-risk gastritis. Clin Cancer Res 2010; 16: 3253-3259.
37. Murray PJ, Wynn TA. Obstacles and opportunities for understanding macrophage polarization. J Leukoc Biol 2001; 89: 557-563.
38. Belikoff BG, Hatfield S, Georgiev P, Ohta A, Lukashev D, Buras JA et al. A2B adenosine receptor blockade enhances macrophage-mediated bacterial phagocytosis and improves polymicrobial sepsis survival in mice. J Immunol 2011; 186: 2444-2453.
39. Tabas I. Macrophage death and defective inflammation resolution in atherosclerosis. Nat Rev Immunol 2010; 10: 36-46.
40. Terenzi F, Díaz-Guerra MJ, Casado M, Hortelano S, Leoni S, Boscá L. Bacterial lipopeptides induce nitric oxide synthase and promote apoptosis through nitric oxide-independent pathways in rat macrophages. J Biol Chem 1995; 270: 6017-6021.