p63, a p53 homolog at 3q27-29, encodes multiple products with transactivating, death-inducing, and dominant-negative activities

Molecular Cell

Volumn 2, Issue 3, 1998, Pages 305-316

  Yang, Annie ^a   Kaghad, Mourad ^b   Wang, Yunmei ^a   Gillett, Emily ^a   Fleming, Mark D ^a,c,d   Dötsch, Volker ^a   Andrews, Nancy C ^a,c   Caput, Daniel ^b   McKeon, Frank ^a  

^a HARVARD MEDICAL SCHOOL   (United States)

^b SANOFI   (France)

^c BOSTON CHILDREN S HOSPITAL   (United States)

^d BRIGHAM AND WOMEN S HOSPITAL   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

CKAP4 PROTEIN, HUMAN; DNA BINDING PROTEIN; ISOPROTEIN; MEMBRANE PROTEIN; PHOSPHOPROTEIN; PROTEIN P53; TP73L PROTEIN, HUMAN; TRANSACTIVATOR PROTEIN; TRP63 PROTEIN, MOUSE; TUMOR SUPPRESSOR PROTEIN;

AMINO ACID SEQUENCE; ANIMAL; ARTICLE; C57BL MOUSE; CHEMISTRY; CHROMOSOME 3; CHROMOSOME MAP; CROSS BREEDING; FEMALE; FLUORESCENCE IN SITU HYBRIDIZATION; GENETIC POLYMORPHISM; GENETICS; HUMAN; INTRON; MALE; MOLECULAR GENETICS; MOUSE; MOUSE MUTANT; MURIDAE; SEQUENCE ALIGNMENT; SEQUENCE HOMOLOGY; TUMOR SUPPRESSOR GENE;

AMINO ACID SEQUENCE; ANIMALS; CHROMOSOME MAPPING; CHROMOSOMES, HUMAN, PAIR 3; CROSSES, GENETIC; DNA-BINDING PROTEINS; FEMALE; GENES, P53; GENES, TUMOR SUPPRESSOR; HUMANS; IN SITU HYBRIDIZATION, FLUORESCENCE; INTRONS; MALE; MEMBRANE PROTEINS; MICE; MICE, INBRED C57BL; MICE, KNOCKOUT; MOLECULAR SEQUENCE DATA; MURIDAE; PHOSPHOPROTEINS; POLYMORPHISM, GENETIC; PROTEIN ISOFORMS; SEQUENCE ALIGNMENT; SEQUENCE HOMOLOGY, AMINO ACID; TRANS-ACTIVATORS; TUMOR SUPPRESSOR PROTEIN P53; TUMOR SUPPRESSOR PROTEINS;

EID: 0032161624     PISSN: 10972765     EISSN: None     Source Type: Journal    
DOI: 10.1016/S1097-2765(00)80275-0     Document Type: Article

References (37)

1. Bjorkqvist, A.M., Husgafvel-Pursiainen, K., Anttila, S., Karjalainen, A., Tammilehto, L., Mattson, K., Vainio, H., and Knuutila, S. (1998). DNA gains in 3q occur frequently in squamous cell carcinoma of the lung, but not in adenocarcinoma. Genes Chromosomes Cancer 22, 79-82.
2. Bockmuhl, U., Schwendel, A., Dietel, M., and Petersen, I. (1996). Distinct patterns of chromosomal alterations in high- and low-grade head and neck squamous cell carcinomas. Cancer Res. 56, 5325-5329.
3. Caron, H., Peter, M., van Sluis, P., Speleman, F., de Kraker, J., Laureys, G., Michon, J., Brugieres, L., Voute, P.A., Westerveld, A., et al. (1995). Evidence for two tumour suppressor loci on chromosomal bands 1p35-36 involved in neuroblastoma: one probably imprinted, another associated with N-myc amplification. Hum. Mol. Genet. 4, 535-539.
4. Crook, T., Wrede, D., Tidy, J.A., Mason, W.P., Evan, D.J., and Vousden, K.H. (1992). Lancet 339, 1070-1073.
5. Cross, S.M., Sanchez, C.A., Morgan, C.A., Schimke, M.K., Ramel, S., Idzerda, R.L., Raskind, W.H., and Reid, B.J. (1995). A p53-dependent mouse spindle checkpoint. Science 267, 1353-1356.
6. Deng, C., Zhang, P., Harper, J.W., Elledge, S.J., and Leder, P. (1995). Mice lacking p21CIP1/WAF1 undergo normal development, but are defective in G1 checkpoint control. Cell 82, 675-684.
7. Dietrich, W.F., Radany, E.H., Smith, J.S., Bishop, J.M., Hanahan, D., and Lander, E.S. (1994). Genome-wide search for loss of heterozygosity in transgenic mouse tumors reveals candidate tumor suppressor genes on chromosome 9 and 16. Proc. Natl. Acad. Sci. USA 91, 9451-9455.
8. Donehower, L.A., Harvey, M., Slagle, B.L., McArthur, M.J., Montgomery, C.A., Jr., Butel, J.S., and Bradley, A. (1992). Mice deficient for p53 are developmentally normal but susceptible to spontaneous tumours. Nature 356, 215-221.
9. Dracopoli, N.C., Harnett, P., Bale, S.J., Stanger, B.Z., Tucker, M.A., Housman, D.E., and Kefford, R.F. (1989). Loss of alleles from the distal short arm of chromosome 1 occurs late in melanoma tumor progression. Proc. Natl. Acad. Sci. USA 86, 4614-4618.
10. El-Deiry, W.S., Tokino, T., Velculescu, V.E., Levy, D.B., Parsons, R., Trent, J.M., Lin, D., Mercer, W.E., Kinzler, K.W., and Vogelstein, B. (1993). WAF1, a potential mediator of p53 tumor suppression. Cell 75, 817-825.
11. Genuardi, M., Tsihira, H., Anderson, D.E., and Saunders, G.F. (1989). Distal deletion of chromosome Ip in ductal carcinoma of the breast. Amer. J. Hum. Genet. 45, 73-82.
12. Graeber, T.G., Osmanian, C., Jacks, T., Housman, D.E., Koch, C.J., Lowe, S.W., and Giaccia, A.J. (1996). Hypoxia-mediated selection of cells with diminished apoptotic potential in solid tumours. Nature 379, 88-91.
13. Gualberto, A., Aldape, K., Kozakiewicz, K., and Tlsty, T.D. (1998). An oncogenic form of p53 confers a dominant, gain-of-function phenotype that disrupts spindle checkpoint control. Proc. Natl. Acad. Sci. USA 95, 5166-5171.
14. Heald, R., McLoughlin, M., and McKeon, F. (1993). Human Wee1 maintains mitotic timing by protecting the nucleus from cytoplasmically activated cdc2 kinase. Cell 74, 463-474.
15. Heselmeyer K., Schrock, E., du Manoir, S., Biegen, H., Shah, K., Steinbeck, R., Auer, G., and Ried, T. (1996). Gain of chromosome 3q defines the transition from severe dysplasia to invasive carcinoma of the uterine cervix. Proc. Natl. Acad. Sci. USA 93, 479-484.
16. Hollstein, M., Sidransky, D., Vogelstein, B., and Harris, C.C. (1991). p53 mutations in human cancers. Science 253, 49-53.
17. Jetten, A.M., and Harvat, B.L. (1997). Epidermal differentiation and squamous metaplasia: from stem cell to cell death. J. Dermatol. 24, 711-725.
18. Jost, C.A., Marin, M.C., and Kaelin, W.G. Jr. (1997). p73 is a human p53-related protein that can induceapoptosis. Nature 389, 191-194.
19. Kaghad, M., Bonnet, H., Yang, A., Creancier, L., Biscan, J.-C., Valent, A., Minty, A., Chalon, P., Lelias, J.-M., Dumont, X., et al. (1997). Monoallelically expressed gene related to p53 at 1p36, a region frequently deleted in neuroblastoma and other human cancers. Cell 90, 809-819.
20. Kern, S.E., Pietenpol, J.A., Thiagalingam, S., Seymour, A., Kinzler, K.W., and Vogelstein, B. (1992). Oncogenic forms of p53 inhibit p53-regulated gene expression. Science 256, 827-830.
21. Ko, L.J., and Prives, C. (1996). p53: puzzle and paradigm. Genes Dev. 10, 1054-1072.
22. Levine, A.J. (1997). p53, the cellular gatekeeper for growth and division. Cell 88, 323-331.
23. Li, F.P., and Fraumeni, J.F., Jr. (1969). Soft-tissue sarcomas, breast cancer, and other neoplasms. A familial syndrome? Ann. Intern. Med. 71, 747-752.
24. Linzer, D.I., and Levine, A.J. (1979). Characterization of a 54K dalton cellular SV40 tumor antigen present in SV40-transformed cells and uninfected embryonal carcinoma cells. Cell 17, 43-52.
25. Lo Coco, F., Ye, B.H., Lista, F., Corradini, P., Offit, K., Knowles, D.M., Chaganti, R.S., and Dalla-Favera, R. (1994). Rearrangements of the BCL6 gene in diffuse large cell non-Hodgkin's lymphoma. Blood 83, 1757-1759.
26. Miyashita, T., and Reed, J.C. (1995). Tumor suppressor p53 is a direct transcriptional activator of the human bax gene. Cell 80, 293-299.
27. Myers, R.B., and Grizzle, W.E. (1997). Changes in biomarker expression in the development of prostatic adenocarcinoma. Biotech. Histochem. 72, 86-95.
28. Oliner, J.D., Kinzler, K.W., Metzler, P.S., George, D.L., and Vogelstein, B. (1992). Oncoprotein MDM2 conceals the activation domain of tumour suppressor p53. Nature 358, 80-83.
29. Oren, M. (1994). Relationship of p53 to the control of apoptotic cell death. Semin. Cancer Biol. 5, 221-227.
30. Oren, M. (1997). Lonely no more: p53 finds its kin in a tumor suppressor haven. Cell 90, 829-832.
31. Polyak, K., Xia, Y., Zweier, J.L., Kinzler, K.W., and Vogelstein, B. (1997). A model for p53-induced apoptosis. Nature 389, 300-305.
32. Rowe, L.B., Nadeau, J.H., Turner, R., Frankel, W.N., Letts, V.A., Eppig, J.T., Ko, M.S., Thurston, S.J., and Birkenmeier, E.H. (1994). Maps form two interspecific backcross DNA panels available as a community genetic mapping resource. Mamm. Genome 5, 253-274.
33. Schmale, H., and Bamberger, C. (1997). A novel protein with strong homology to the tumor suppressor p53. Oncogene 15, 1363-1367.
34. Taylor, S.S., and McKeon, F. (1997). Kinetochore localization of murine Bub1 is required for normal mitotic timing and checkpoint response to spindle damage. Cell 89, 727-735.
35. Vogelstein, B., and Kinzler, K.W. (1992). p53 function and dysfunction. Cell 70, 523-526.
36. Werness, B.A., Levine, A.J., and Howley, P.M. (1990). Association of human papilloma virus types 16 and 18 E6 proteins with p53. Science 248, 76-79.
37. Zambetti, G.P., and Levine, A.J. (1993). A comparison of the biological activities of wild-type and mutant p53. FASEB J. 7, 855-865.