Autoinhibitory regulation of p73 by ΔNp73 to modulate cell survival and death through a p73-specific target element within the ΔNp73 promoter

Molecular and Cellular Biology

Volumn 22, Issue 8, 2002, Pages 2575-2585

  Nakagawa, Takahito ^a   Takahashi, Masato ^a   Ozaki, Toshinori ^a   Watanabe, Ken Ichi ^a   Todo, Satoru ^a   Mizuguchi, Hiroyuki ^a   Hayakawa, Takao ^a   Nakagawara, Akira ^a  

^a CHIBA CANCER CENTER   (Japan)

Author keywords

[No Author keywords available]

Indexed keywords

CISPLATIN; PROTEIN P53; PROTEIN P63; PROTEIN P73;

APOPTOSIS; ARTICLE; CELL DEATH; CELL DIFFERENTIATION; CELL GROWTH; CELL SURVIVAL; CONTROLLED STUDY; FEEDBACK SYSTEM; GENETIC VARIABILITY; HUMAN; HUMAN CELL; IMMUNOBLOTTING; IMMUNOPRECIPITATION; MODULATION; PRIORITY JOURNAL; PROMOTER REGION; PROTEIN BINDING; REGULATORY MECHANISM; REPORTER GENE; REVERSE TRANSCRIPTION POLYMERASE CHAIN REACTION; TRANSACTIVATION; TRANSCRIPTION INITIATION;

ANIMALS; APOPTOSIS; BASE SEQUENCE; BINDING SITES; CELL LINE; CELL SURVIVAL; CISPLATIN; COS CELLS; DNA; DNA-BINDING PROTEINS; FEEDBACK, BIOCHEMICAL; GENE EXPRESSION; GENES, TUMOR SUPPRESSOR; HUMANS; MODELS, BIOLOGICAL; MOLECULAR SEQUENCE DATA; NUCLEAR PROTEINS; ONCOGENES; PROMOTER REGIONS (GENETICS); TUMOR CELLS, CULTURED; TUMOR SUPPRESSOR PROTEINS; VARIATION (GENETICS);

EID: 0036203514     PISSN: 02707306     EISSN: None     Source Type: Journal    
DOI: 10.1128/MCB.22.8.2575-2585.2002     Document Type: Article

References (62)

1. ZBP-89 promotes growth arrest through stabilization of p53
2. p14ARF links the tumour suppressors RB and p53
3. p73 gene expression in ovarian cancer tissues and cell lines
4. p73 and p63 are homotetramers capable of weak heterotypic interactions with each other but not with p53
5. The new p73 splice variants, γ and δ, with different transcriptional activity
6. Additional complexity in p73: p71 induction by mitogens in lymphoid cells and identification of two new splicing variants ε and ζ
7. Induction of neuronal differentiation by p73 in a neuroblastoma cell line
8. p73 function is inhibited by tumor-derived p53 mutants in mammalian cells
9. Inactivation of the p53-homologue p73 by the mdm2-oncoprotein
10. Duplexes of 21-nucleotide RNAs mediate RNA interference in cultured mammalian cells
11. Definition of a consensus binding site for p53
12. Human ARF binds E2F1 and inhibits its transcriptional activity
13. Comparative analysis of p73 and p53 regulation and effector functions
14. Transactivation-deficient p73α (p73Δexon2) inhibits apoptosis and competes with p53
15. Induction of nuclear accumulation of the tumor-suppressor protein p53 by DNA-damaging agents
16. The tyrosine kinase c-Abl regulates p73 in apoptotic response to cisplatin-induced DNA damage
17. MDM2 promotes the rapid degradation of p53
18. 2/M progression
19. Adenovirus E4orf6 oncoprotein modulates the function of the p53-related protein, p73
20. Oncoprotein MDM2 is a ubiquitin ligase E3 for tumor suppressor p53
21. p53 family genes: Structural comparison, expression and mutation
22. Role for the p53 homologue p73 in E217-1-induced apoptosis
23. p73 is a human p53-related protein that can induce apoptosis
24. Monoallelically expressed gene related to p53 at 1p36, a region frequently deleted in neuroblastoma and other human cancers
25. Identification of p53 as a sequence-specific DNA-binding protein
26. Regulation of p53 stability by mdm2
27. A novel allosterically trans-activated ribozyme, the maxizyme, with exceptional specificity in vitro and in vivo
28. Cleavage of structural proteins during the assembly of the head of bacteriophage T4
29. Promoter specificity and stability control of the p53-related protein p73
30. p53, the cellular gatekeeper for growth and division
31. A common E2F-1 and p73 pathway mediates cell death induced by TCR activation
32. Viral oncoproteins discriminate between p53 and the p53 homolog p73
33. A common polymorphism acts as an intragenic modifier of mutant p53 behaviour
34. Efficient construction of a recombinant adenovirus vector by an improved in vitro ligation method
35. A simple method for constructing E1 and E1/E4-deleted recombinant adenoviral vectors
36. E2F-1 induces the stabilization of p53 but blocks p53-mediated transactivation
37. Physical and functional interactions between p53 and cell cycle co-operating transcription factors, E2F- and DP1
38. Cloning and functional analysis of human p5l, which structurally and functionally resembles p53
39. Deletion of the COOH-terminal region of p73α enhances both its transactivation function and DNA-binding activity but inhibits induction of apoptosis in mammalian cells
40. Arf p19, interacts with MDM2 and neutralizes MDM2's inhibition of p53
41. An anti-apoptotic role for the p53 family member, p73, during developmental neuron death
42. Signaling to p53: Breaking the MDM2-p53 circuit
43. Inactivation of p53 but not p73 by adenovirus type 5 E1B 55-kilodalton and E4 34-kilodalton oncoproteins
44. Identification of BTG2, an antiproliferative p53-dependent component of the DNA damage cellular response pathway
45. Genomic instability in 1p and human malignancies
46. Tumor surveillance via the ARF-p53 pathway
47. Distinct regulation of p53 and p73 activity by adenovirus E1A, E1B and E4orf6 proteins
48. Role of the p53-homologue p73 in E2F-1-induced apoptosis
49. The alternative product from the human CDKN2A locus, p14(ARF), participates in a regulatory feedback loop with p53 and MDM2
50. Physical and functional interaction between p53 mutants and different isoforms of p73
51. New p73 variants with altered C-terminal structures have varied transcriptional activities
52. Differential regulation of E2F transcription factors by p53 tumor suppressor protein
53. The ins and outs of p53
54. A region of consistent deletion in neuroblastoma maps within 1p36.2-3
55. Specific interference with gene function by double-stranded RNA in early mouse development
56. p63, a p53 homolog at 3q27-29, encodes multiple products with transactivating, death-inducing, and dominant-negative activities
57. p73-deficient mice have neurological, pheromonal and inflammatory defects but lack spontaneous tumours
58. Overexpression of the wild type p73 gene in breast cancer tissues and cell lines
59. Oncogenes induce and activate endogenous p73 protein
60. MDM2 suppresses p73 function without promoting p73 degradation
61. COOH-terminal domain of p53 modulates p53-mediated transcriptional transactivation, cell growth, and apoptosis
62. The potential tumor suppressor p73 differentially regulates cellular p53 target genes