Developmental factor IRF6 exhibits tumor suppressor activity in squamous cell carcinomas

Proceedings of the National Academy of Sciences of the United States of America

Volumn 108, Issue 33, 2011, Pages 13710-13715

  Botti, Elisabetta ^a   Spallone, Giulia ^a   Moretti, Francesca ^a   Marinari, Barbara ^a   Pinetti, Valentina ^a   Galanti, Sergio ^b   De Meo, Paolo D'Onorio ^c   De Nicola, Francesca ^b   Ganci, Federica ^b   Castrignanò, Tiziana ^c   Pesole, Graziano ^d   Chimenti, Sergio ^a   Guerrini, Luisa ^e   Fanciulli, Maurizio ^b   Blandino, Giovanni ^b   Karin, Michael ^f   Costanzo, Antonio ^a,b  

^a UNIVERSITY OF ROME TOR VERGATA   (Italy)

^b REGINA ELENA NATIONAL CANCER INSTITUTE   (Italy)

^c CASPUR   (Italy)

^d UNIVERSITY OF BARI   (Italy)

^e UNIVERSITY OF MILAN   (Italy)

^f UNIVERSITY OF CALIFORNIA   (United States)

Author keywords

HRas; Oncogene induced senescence; Ovo like 1(drosophila); Skin cancer; Transforming growth factor

Indexed keywords

INTERFERON REGULATORY FACTOR 6; SMALL INTERFERING RNA;

ARTICLE; CANCER INHIBITION; CELL ADHESION; CELL DIFFERENTIATION; CONTROLLED STUDY; DOWN REGULATION; GENE EXPRESSION PROFILING; GENOME ANALYSIS; HUMAN; HUMAN CELL; HUMAN TISSUE; KERATINOCYTE; PRIORITY JOURNAL; PROTEIN EXPRESSION; SQUAMOUS CELL CARCINOMA;

CARCINOMA, SQUAMOUS CELL; CELL PHYSIOLOGICAL PROCESSES; CELL PROLIFERATION; DNA METHYLATION; GENE EXPRESSION REGULATION, NEOPLASTIC; HUMANS; INTERFERON REGULATORY FACTORS; KERATINOCYTES; NEOPLASM INVASIVENESS; SKIN NEOPLASMS; TUMOR CELLS, CULTURED; TUMOR SUPPRESSOR PROTEINS;

SPONDIAS PURPUREA;

EID: 80051983047     PISSN: 00278424     EISSN: 10916490     Source Type: Journal    
DOI: 10.1073/pnas.1110931108     Document Type: Article

References (32)

1. Hanahan D., Weinberg R.A. (2000) The hallmarks of cancer. Cell 100:57-70. (Pubitemid 30046295)
2. Akhurst R.J., Balmain A. (1999) Genetic events and the role of TGF beta in epithelial tumour progression. J Pathol 187:82-90. (Pubitemid 29009837)
3. Mangan P.R., et al. (2006) Transforming growth factor-β induces development of the T (H)17 lineage. Nature 441:231-234.
4. Descargues P., Sil A.K., Karin M. (2008) IKKalpha, a critical regulator of epidermal differentiation and a suppressor of skin cancer. EMBO J 27:2639-2647.
5. Descargues P., et al. (2008) IKKalpha is a critical coregulator of a Smad4-independent TGFbeta-Smad2/3 signaling pathway that controls keratinocyte differentiation. Proc Natl Acad Sci USA 105:2487-2492. (Pubitemid 351520540)
6. Marinari B., et al. (2008) The tumor suppressor activity of IKKalpha in stratified epithelia is exerted in part via the TGF-beta antiproliferative pathway. Proc Natl Acad Sci USA 105:17091-17096.
7. Liu B., et al. (2006) A critical role for I kappaB kinase alpha in the development of human and mouse squamous cell carcinomas. Proc Natl Acad Sci USA 103:17202-17207. (Pubitemid 44788947)
8. Savitsky D., Tamura T., Yanai H., Taniguchi T. (2010) Regulation of immunity and oncogenesis by the IRF transcription factor family. Cancer Immunol Immunother 59:489-510.
9. Ingraham C.R., et al. (2006) Abnormal skin, limb and craniofacial morphogenesis in mice deficient for interferon regulatory factor 6 (Irf6). Nat Genet 38:1335-1340. (Pubitemid 44646298)
10. Kondo S., et al. (2002) Mutations in IRF6 cause Van der Woude and popliteal pterygium syndromes. Nat Genet 32:285-289.
11. Richardson R.J., et al. (2006) Irf6 is a key determinant of the keratinocyte proliferation-differentiation switch. Nat Genet 38:1329-1334. (Pubitemid 44646297)
12. Moretti F., et al. (2010) A regulatory feedback loop involving p63 and IRF6 links the pathogenesis of 2 genetically different human ectodermal dysplasias. J Clin Invest 120:1570-1577.
13. Thomason H.A., et al. (2010) Cooperation between the transcription factors p63 and IRF6 is essential to prevent cleft palate in mice. J Clin Invest 120:1561-1569.
14. Hu Y., et al. (1999) Abnormal morphogenesis but intact IKK activation in mice lacking the IKKalpha subunit of IkappaB kinase. Science 284:316-320.
15. Hu Y., et al. (2001) IKKalpha controls formation of the epidermis independently of NF-kappaB. Nature 410:710-714. (Pubitemid 32290360)
16. Jones P.A., Laird P.W. (1999) Cancer epigenetics comes of age. Nat Genet 21:163-167. (Pubitemid 29070360)
17. Fujita P.A., et al. (2010) The UCSC Genome Browser database: Update 2011. Nucleic Acids Res 39:D876-D882.
18. Li L.C., Dahiya R. (2002) MethPrimer: Designing primers for methylation PCRs. Bioinformatics 18:1427-1431.
19. Zhang Y., et al. (2008) Model-based analysis of ChIP-Seq (MACS). Genome Biol 9:R137. 1-9.
20. Ji H., et al. (2008) An integrated software system for analyzing ChIP-chip and ChIP-seq data. Nat Biotechnol 26:1293-1300.
21. Little H.J., et al. (2009) Missense mutations that cause Van der Woude syndrome and popliteal pterygium syndrome affect the DNA-binding and transcriptional activation functions of IRF6. Hum Mol Genet 18:535-545.
22. Iwata J., et al. (2010) Transforming growth factor-beta regulates basal transcriptional regulatory machinery to control cell proliferation and differentiation in cranial neural crest-derived osteoprogenitor cells. J Biol Chem 285:4975-4982.
23. Nair M., et al. (2006) Ovol1 regulates the growth arrest of embryonic epidermal progenitor cells and represses c-myc transcription. J Cell Biol 173:253-264.
24. Teng A., Nair M., Wells J., Segre J.A., Dai X. (2007) Strain-dependent perinatal lethality of Ovol1-deficient mice and identification of Ovol2 as a downstream target of Ovol1 in skin epidermis. Biochim Biophys Acta 1772:89-95. (Pubitemid 44960722)
25. Huang da W, Sherman BT, Lempicki RA (2009) Systematic and integrative analysis of large gene lists using DAVID bioinformatics resources. Nat Protoc 4:44-57.
26. Keyes W.M., et al. (2011) ΔNp63α is an oncogene that targets chromatin remodeler Lsh to drive skin stem cell proliferation and tumorigenesis. Cell Stem Cell 8:164-176.
27. Michelson S., Leith J.T. (1996) Host response in tumor growth and progression. Invasion Metastasis 16:235-246. (Pubitemid 27399789)
28. Kemperman H., Driessens M., La Rivière G., Meijne A.M., Roos E. (1994-1995) The role of integrins and integrin activation in liver metastasis. Invasion Metastasis 14:98-108.
29. BussemakersM.J., Schalken J.A. (1996) The role of cell adhesion molecules and proteases in tumor invasion and metastasis. World J Urol 14:151-156. (Pubitemid 126775156)
30. Behrens J. (1993) The role of cell adhesion molecules in cancer invasion and metastasis. Breast Cancer Res Treat 24:175-184.
31. Kulis M., Esteller M. (2010) DNA methylation and cancer. Adv Genet 70:27-56.
32. Repesh L.A. (1989) A new in vitro assay for quantitating tumor cell invasion. Invasion Metastasis 9:192-208.