메뉴 건너뛰기




Volumn 20, Issue 10, 2013, Pages 1415-1424

P73 regulates autophagy and hepatocellular lipid metabolism through a transcriptional activation of the ATG5 gene

Author keywords

ATG5; autophagy; lipid droplets; lipophagy; liver; metabolism; p73; starvation; transcription

Indexed keywords

AMINO ACID; AUTOPHAGY PROTEIN 5; FAT DROPLET; FATTY ACID; PROTEIN P73; TRIACYLGLYCEROL;

EID: 84883776970     PISSN: 13509047     EISSN: 14765403     Source Type: Journal    
DOI: 10.1038/cdd.2013.104     Document Type: Article
Times cited : (75)

References (53)
  • 1
    • 34047223196 scopus 로고    scopus 로고
    • Are interactions with p63 and p73 involved in mutant p53 gain of oncogenic function?
    • DOI 10.1038/sj.onc.1210311, PII 1210311
    • Li Y, Prives C. Are interactions with p63 and p73 involved in mutant p53 gain of oncogenic function? Oncogene 2007; 26: 2220-2225. (Pubitemid 46536648)
    • (2007) Oncogene , vol.26 , Issue.15 , pp. 2220-2225
    • Li, Y.1    Prives, C.2
  • 2
    • 70449562133 scopus 로고    scopus 로고
    • One billion years of p53/p63/p73 evolution
    • Belyi VA, Levine AJ. One billion years of p53/p63/p73 evolution. Proc Natl Acad Sci USA 2009; 106: 17609-17610.
    • (2009) Proc Natl Acad Sci USA , vol.106 , pp. 17609-17610
    • Belyi, V.A.1    Levine, A.J.2
  • 4
    • 42749084082 scopus 로고    scopus 로고
    • The impact of p53 and p73 on aneuploidy and cancer
    • Tomasini R, Mak TW, Melino G. The impact of p53 and p73 on aneuploidy and cancer. Trends Cell Biol 2008; 18: 244-252.
    • (2008) Trends Cell Biol , vol.18 , pp. 244-252
    • Tomasini, R.1    Mak, T.W.2    Melino, G.3
  • 7
    • 78349237716 scopus 로고    scopus 로고
    • P73 is an essential regulator of neural stem cell maintenance in embryonal and adult CNS neurogenesis
    • Talos F, Abraham A, Vaseva AV, Holembowski L, Tsirka SE, Scheel A et al. p73 is an essential regulator of neural stem cell maintenance in embryonal and adult CNS neurogenesis. Cell Death Differ 2010; 17: 1816-1829.
    • (2010) Cell Death Differ , vol.17 , pp. 1816-1829
    • Talos, F.1    Abraham, A.2    Vaseva, A.V.3    Holembowski, L.4    Tsirka, S.E.5    Scheel, A.6
  • 8
    • 84855490109 scopus 로고    scopus 로고
    • Neuronal differentiation by TAp73 is mediated by microRNA-34a regulation of synaptic protein targets
    • Agostini M, Tucci P, Killick R, Candi E, Sayan BS, Rivetti di Val Cervo P et al. Neuronal differentiation by TAp73 is mediated by microRNA-34a regulation of synaptic protein targets. Proc Natl Acad Sci USA 2011 108: 21093-21098.
    • (2011) Proc Natl Acad Sci USA , vol.108 , pp. 21093-21098
    • Agostini, M.1    Tucci, P.2    Killick, R.3    Candi, E.4    Sayan, B.S.5    Di Val Cervo, R.P.6
  • 11
    • 84859565270 scopus 로고    scopus 로고
    • Diverse p63 and p73 isoforms regulate D133p53 expression through modulation of the internal TP53 promoter activity
    • Marcel V, Petit I, Murray-Zmijewski F, Goullet de Rugy T, Fernandes K, Meuray V et al. Diverse p63 and p73 isoforms regulate D133p53 expression through modulation of the internal TP53 promoter activity. Cell Death Differ 2012; 19: 816-826.
    • (2012) Cell Death Differ , vol.19 , pp. 816-826
    • Marcel, V.1    Petit, I.2    Murray-Zmijewski, F.3    Goullet De Rugy, T.4    Fernandes, K.5    Meuray, V.6
  • 12
    • 53549134949 scopus 로고    scopus 로고
    • TAp73 knockout shows genomic instability with infertility and tumor suppressor functions
    • Tomasini R, Tsuchihara K, Wilhelm M, Fujitani M, Rufini A, Cheung CC et al. TAp73 knockout shows genomic instability with infertility and tumor suppressor functions. Genes Dev 2008; 22: 2677-2691.
    • (2008) Genes Dev , vol.22 , pp. 2677-2691
    • Tomasini, R.1    Tsuchihara, K.2    Wilhelm, M.3    Fujitani, M.4    Rufini, A.5    Cheung, C.C.6
  • 13
    • 81155139688 scopus 로고    scopus 로고
    • Biological functions of p53 isoforms through evolution: Lessons from animal and cellular models
    • Marcel V, Dichtel-Danjoy ML, Sagne C, Hafsi H, Ma D, Ortiz-Cuaran S et al. Biological functions of p53 isoforms through evolution: lessons from animal and cellular models. Cell Death Differ 2011; 18: 1815-1824.
    • (2011) Cell Death Differ , vol.18 , pp. 1815-1824
    • Marcel, V.1    Dichtel-Danjoy, M.L.2    Sagne, C.3    Hafsi, H.4    Ma, D.5    Ortiz-Cuaran, S.6
  • 14
    • 84870573905 scopus 로고    scopus 로고
    • P53 is a major component of the transcriptional and apoptotic program regulated by PI 3-kinase/Akt/GSK3 signaling
    • Nayak G, Cooper GM. p53 is a major component of the transcriptional and apoptotic program regulated by PI 3-kinase/Akt/GSK3 signaling. Cell Death Dis 2012; 3: e400.
    • (2012) Cell Death Dis , vol.3
    • Nayak, G.1    Cooper, G.M.2
  • 15
    • 84863458436 scopus 로고    scopus 로고
    • Functional interplay between p63 and p53 controls RUNX1 function in the transition from proliferation to differentiation in human keratinocytes
    • Masse I, Barbollat-Boutrand L, Molina M, Berthier-Vergnes O, Joly-Tonetti N, Martin MT et al. Functional interplay between p63 and p53 controls RUNX1 function in the transition from proliferation to differentiation in human keratinocytes. Cell Death Dis 2012; 3: e318.
    • (2012) Cell Death Dis , vol.3
    • Masse, I.1    Barbollat-Boutrand, L.2    Molina, M.3    Berthier-Vergnes, O.4    Joly-Tonetti, N.5    Martin, M.T.6
  • 16
    • 78649338141 scopus 로고    scopus 로고
    • Autophagy and the integrated stress response
    • Kroemer G, Marino G, Levine B. Autophagy and the integrated stress response. Mol Cell 2010; 40: 280-293.
    • (2010) Mol Cell , vol.40 , pp. 280-293
    • Kroemer, G.1    Marino, G.2    Levine, B.3
  • 17
    • 81055144784 scopus 로고    scopus 로고
    • Autophagy: Renovation of cells and tissues
    • Mizushima N, Komatsu M. Autophagy: renovation of cells and tissues. Cell 2011; 147: 728-741.
    • (2011) Cell , vol.147 , pp. 728-741
    • Mizushima, N.1    Komatsu, M.2
  • 18
    • 84874945405 scopus 로고    scopus 로고
    • Sestrin2 integrates Akt and mTOR signaling to protect cells against energetic stress-induced death
    • Ben-Sahra I, Dirat B, Laurent K, Puissant A, Auberger P, Budanov A et al. Sestrin2 integrates Akt and mTOR signaling to protect cells against energetic stress-induced death. Cell Death Differ 2013; 20: 611-619.
    • (2013) Cell Death Differ , vol.20 , pp. 611-619
    • Ben-Sahra, I.1    Dirat, B.2    Laurent, K.3    Puissant, A.4    Auberger, P.5    Budanov, A.6
  • 23
    • 0024206476 scopus 로고    scopus 로고
    • Lipid quantitation in formalin-fixed liver sections
    • Mourelle M, Perez VM, Rojkind M. Lipid quantitation in formalin-fixed liver sections. J Histochem Cytochem 1998; 36: 1471-1474.
    • (1998) J Histochem Cytochem , vol.36 , pp. 1471-1474
    • Mourelle, M.1    Perez, V.M.2    Rojkind, M.3
  • 24
    • 0018416092 scopus 로고
    • Peroperative fat staining of frozen sections in primary hyperparathyroidism
    • Ljungberg O, Tibblin S. Peroperative fat staining of frozen sections in primary hyperparathyroidism. Am J Pathol 1979; 95: 633-641. (Pubitemid 9182860)
    • (1979) American Journal of Pathology , vol.95 , Issue.3 , pp. 633-641
    • Ljungberg, O.1    Tibblin, S.2
  • 25
    • 0021704709 scopus 로고
    • Changes in the sensitivity of lipogenesis in rat hepatocytes to hormones and precursors over the diurnal cycle and during longer-term starvation of donor animals
    • Gibbons GF, Pullinger CR, Bjo?rnsson OG. Changes in the sensitivity of lipogenesis in rat hepatocytes to hormones and precursors over the diurnal cycle and during longer-term starvation of donor animals. J Lipid Res 1984; 25: 1358-1367. (Pubitemid 15150646)
    • (1984) Journal of Lipid Research , vol.25 , Issue.12 , pp. 1358-1367
    • Gibbons, G.F.1    Pullinger, C.R.2    Bjornsson, O.G.3
  • 27
    • 77953122645 scopus 로고    scopus 로고
    • LC3 and GATE-16/GABARAP subfamilies are both essential yet act differently in autophagosome biogenesis
    • Weidberg H, Shvets E, Shpilka T, Shimron F, Shinder V, Elazar Z. LC3 and GATE-16/GABARAP subfamilies are both essential yet act differently in autophagosome biogenesis. EMBO J 2010; 29: 1792-1802.
    • (2010) EMBO J , vol.29 , pp. 1792-1802
    • Weidberg, H.1    Shvets, E.2    Shpilka, T.3    Shimron, F.4    Shinder, V.5    Elazar, Z.6
  • 28
    • 27944504351 scopus 로고    scopus 로고
    • P62/SQSTM1 forms protein aggregates degraded by autophagy and has a protective effect on huntingtin-induced cell death
    • DOI 10.1083/jcb.200507002
    • Bjørkøy G, Lamark T, Brech A, Outzen H, Perander M, Overvatn A et al. p62/SQSTM1 forms protein aggregates degraded by autophagy and has protective effect on huntingtininduced cell death. J Cell Biol 2005; 171: 603-614. (Pubitemid 41668720)
    • (2005) Journal of Cell Biology , vol.171 , Issue.4 , pp. 603-614
    • Bjorkoy, G.1    Lamark, T.2    Brech, A.3    Outzen, H.4    Perander, M.5    Overvatn, A.6    Stenmark, H.7    Johansen, T.8
  • 30
    • 0034757896 scopus 로고    scopus 로고
    • A novel assay to study autophagy: Regulation of autophagosome vacuole size by amino acid deprivation
    • Munafó DB, Colombo MI. A novel assay to study autophagy: regulation of autophagosome vacuole size by amino acid deprivation. J Cell Sci 2001; 114: 3619-3629. (Pubitemid 33041044)
    • (2001) Journal of Cell Science , vol.114 , Issue.20 , pp. 3619-3629
    • Munafo, D.B.1    Colombo, M.I.2
  • 32
    • 5044251753 scopus 로고    scopus 로고
    • P53 and its family members - Reporter genes may not see the difference [2]
    • DOI 10.1038/sj.cdd.4401477
    • Wischhusen J, Melino G, Weller M. p53 and its family members-reporter genes may not see the difference. Cell Death Differ 2004; 11: 1150-1152. (Pubitemid 39341641)
    • (2004) Cell Death and Differentiation , vol.11 , Issue.10 , pp. 1150-1152
    • Wischhusen, J.1    Melino, G.2    Weller, M.3
  • 33
    • 0035911162 scopus 로고    scopus 로고
    • Dissection of autophagosome formation using Apg5-deficient mouse embryonic stem cells
    • Mizushima N, Yamamoto A, Hatano M, Kobayashi Y, Kabeya Y, Suzuki K et al. Dissection of autophagosome formation using Apg5-deficient mouse embryonic stem cells. J Cell Biol 2001; 152: 657-668.
    • (2001) J Cell Biol , vol.152 , pp. 657-668
    • Mizushima, N.1    Yamamoto, A.2    Hatano, M.3    Kobayashi, Y.4    Kabeya, Y.5    Suzuki, K.6
  • 37
    • 84874192375 scopus 로고    scopus 로고
    • FOXO3A directs a protective autophagy program in haematopoietic stem cells
    • Warr MR, Binnewies M, Flach J, Reynaud D, Garg T, Malhotra R et al. FOXO3A directs a protective autophagy program in haematopoietic stem cells. Nature 2013; 494: 323-327.
    • (2013) Nature , vol.494 , pp. 323-327
    • Warr, M.R.1    Binnewies, M.2    Flach, J.3    Reynaud, D.4    Garg, T.5    Malhotra, R.6
  • 38
    • 34249056243 scopus 로고    scopus 로고
    • P73 regulates DRAM-independent autophagy that does not contribute to programmed cell death
    • DOI 10.1038/sj.cdd.4402108, PII 4402108
    • Crighton D, O?Prey J, Bell HS, Ryan KM. p73 regulates DRAM-independent autophagy that does not contribute to programmed cell death. Cell Death Differ 2007; 14: 1071-1079. (Pubitemid 46785098)
    • (2007) Cell Death and Differentiation , vol.14 , Issue.6 , pp. 1071-1079
    • Crighton, D.1    O'Prey, J.2    Bell, H.S.3    Ryan, K.M.4
  • 39
    • 58149478492 scopus 로고    scopus 로고
    • MTOR regulates autophagy-associated genes downstream of p73
    • Rosenbluth JM, Pietenpol JA. mTOR regulates autophagy-associated genes downstream of p73. Autophagy 2009; 5: 114-116.
    • (2009) Autophagy , vol.5 , pp. 114-116
    • Rosenbluth, J.M.1    Pietenpol, J.A.2
  • 40
    • 77956416339 scopus 로고    scopus 로고
    • Autophagy in mammalian development and differentiation
    • Mizushima N, Levine B. Autophagy in mammalian development and differentiation. Nat Cell Biol 2010; 12: 823-830.
    • (2010) Nat Cell Biol , vol.12 , pp. 823-830
    • Mizushima, N.1    Levine, B.2
  • 41
    • 79955555098 scopus 로고    scopus 로고
    • Autophagy, microbial sensing, endoplasmic reticulum stress, and epithelial function in inflammatory bowel disease
    • Kaser A, Blumberg RS. Autophagy, microbial sensing, endoplasmic reticulum stress, and epithelial function in inflammatory bowel disease. Gastroenterology 2011; 140: 1738-1747.
    • (2011) Gastroenterology , vol.140 , pp. 1738-1747
    • Kaser, A.1    Blumberg, R.S.2
  • 42
    • 84255210700 scopus 로고    scopus 로고
    • Molecular definitions of cell death subroutines: Recommendations of the Nomenclature Committee on Cell Death 2012
    • Galluzzi L, Vitale I, Abrams JM, Alnemri ES, Baehrecke EH, Blagosklonny MV et al. Molecular definitions of cell death subroutines: recommendations of the Nomenclature Committee on Cell Death 2012. Cell Death Differ 2012 19: 107-120.
    • (2012) Cell Death Differ , vol.19 , pp. 107-120
    • Galluzzi, L.1    Vitale, I.2    Abrams, J.M.3    Alnemri, E.S.4    Baehrecke, E.H.5    Blagosklonny, M.V.6
  • 43
    • 84870560047 scopus 로고    scopus 로고
    • Proliferation and tissue remodeling in cancer: The hallmarks revisited
    • Markert EK, Levine AJ, Vazquez A. Proliferation and tissue remodeling in cancer: the hallmarks revisited. Cell Death Dis 2012; 3: e397.
    • (2012) Cell Death Dis , vol.3
    • Markert, E.K.1    Levine, A.J.2    Vazquez, A.3
  • 45
    • 79951910694 scopus 로고    scopus 로고
    • Autophagy in immunity and cell-autonomous defense against intracellular microbes
    • Deretic V. Autophagy in immunity and cell-autonomous defense against intracellular microbes. Immunol Rev 2011; 240: 92-104.
    • (2011) Immunol Rev , vol.240 , pp. 92-104
    • Deretic, V.1
  • 46
    • 79953155924 scopus 로고    scopus 로고
    • MHC presentation via autophagy and how viruses escape from it
    • Cannage M, Mu?nz C. MHC presentation via autophagy and how viruses escape from it. Semin Immunopathol 2010; 32: 373-381.
    • (2010) Semin Immunopathol , vol.32 , pp. 373-381
    • Cannage, M.1    Munz, C.2
  • 47
    • 52149099867 scopus 로고    scopus 로고
    • Autophagy in thymic epithelium shapes the T-cell repertoire and is essential for tolerance
    • Nedjic J, Aichinger M, Emmerich J, Mizushima N, Klein L. Autophagy in thymic epithelium shapes the T-cell repertoire and is essential for tolerance. Nature 2008; 455: 396-400.
    • (2008) Nature , vol.455 , pp. 396-400
    • Nedjic, J.1    Aichinger, M.2    Emmerich, J.3    Mizushima, N.4    Klein, L.5
  • 49
    • 79959354999 scopus 로고    scopus 로고
    • Mitochondria and the autophagy-inflammation-cell death axis in organismal aging
    • Green DR, Galluzzi L, Kroemer G. Mitochondria and the autophagy-inflammation-cell death axis in organismal aging. Science 2011; 333: 1109-1112.
    • (2011) Science , vol.333 , pp. 1109-1112
    • Green, D.R.1    Galluzzi, L.2    Kroemer, G.3
  • 52
    • 67349267332 scopus 로고    scopus 로고
    • StAR overexpression decreases serum and tissue lipids in apolipoprotein E-deficient mice
    • Ning Y, Xu L, Ren S, Pandak WM, Chen S, Yin L. StAR overexpression decreases serum and tissue lipids in apolipoprotein E-deficient mice. Lipids 2009; 44: 511-519.
    • (2009) Lipids , vol.44 , pp. 511-519
    • Ning, Y.1    Xu, L.2    Ren, S.3    Pandak, W.M.4    Chen, S.5    Yin, L.6
  • 53
    • 35848970056 scopus 로고    scopus 로고
    • Theaflavins attenuate hepatic lipid accumulation through activating AMPK in human HepG2 cells
    • Lin CL, Huang HC, Lin JK. Theaflavins attenuate hepatic lipid accumulation through activating AMPK in human HepG2 cells. J Lipid Res 2007; 48: 2334-2343.
    • (2007) J Lipid Res , vol.48 , pp. 2334-2343
    • Lin, C.L.1    Huang, H.C.2    Lin, J.K.3


* 이 정보는 Elsevier사의 SCOPUS DB에서 KISTI가 분석하여 추출한 것입니다.