IRF6 is a mediator of Notch pro-differentiation and tumour suppressive function in keratinocytes

EMBO Journal

Volumn 30, Issue 22, 2011, Pages 4571-4585

  Restivo, Gaetana ^a   Nguyen, Bach Cuc ^b   Dziunycz, Piotr ^c   Ristorcelli, Elodie ^a   Ryan, Russell J H ^b   Özuysal, Özden Yalçin ^d   Di Piazza, Matteo ^d   Radtke, Freddy ^d   Dixon, Michael J ^e   Hofbauer, Günther F L ^c   Lefort, Karine ^a   Dotto, G Paolo ^a,b  

^a UNIVERSITY OF LAUSANNE   (Switzerland)

^b MASSACHUSETTS GENERAL HOSPITAL   (United States)

^c UNIVERSITY HOSPITAL ZURICH   (Switzerland)

^d EPFL   (Switzerland)

^e UNIVERSITY OF MANCHESTER   (United Kingdom)

Author keywords

keratinocytes; Notch; p63; squamous cell carcinoma; tumour suppression

Indexed keywords

CYCLIN DEPENDENT KINASE INHIBITOR 1; EPIDERMAL GROWTH FACTOR RECEPTOR; INTERFERON REGULATORY FACTOR 6; NOTCH RECEPTOR; PROTEIN HEY1; TRANSCRIPTION FACTOR HES 1; TUMOR SUPPRESSOR PROTEIN; UNCLASSIFIED DRUG;

ANIMAL EXPERIMENT; ANIMAL MODEL; ANIMAL TISSUE; ARTICLE; CANCER INHIBITION; CELL DIFFERENTIATION; CELL GROWTH; CONTROLLED STUDY; DOWN REGULATION; EPIDERMIS; GENE ACTIVATION; GENE INDUCTION; HUMAN; HUMAN TISSUE; KERATINOCYTE; MOUSE; NONHUMAN; PRIORITY JOURNAL; PROTEIN EXPRESSION; PROTEIN FUNCTION; SIGNAL TRANSDUCTION; SQUAMOUS CELL CARCINOMA;

ANIMALS; BASIC HELIX-LOOP-HELIX TRANSCRIPTION FACTORS; CELL CYCLE PROTEINS; CELL DIFFERENTIATION; CELL PROLIFERATION; CYCLIN-DEPENDENT KINASE INHIBITOR P21; DNA-BINDING PROTEINS; GENES, TUMOR SUPPRESSOR; HOMEODOMAIN PROTEINS; HUMANS; INTERFERON REGULATORY FACTORS; KERATINOCYTES; MICE; MICE, INBRED NOD; MICE, SCID; ONCOGENE PROTEIN P21(RAS); PROMOTER REGIONS, GENETIC; RECEPTOR, EPIDERMAL GROWTH FACTOR; RECEPTOR, NOTCH1; RNA INTERFERENCE; RNA, SMALL INTERFERING; SIGNAL TRANSDUCTION; SKIN NEOPLASMS;

EID: 81255210846     PISSN: 02614189     EISSN: 14602075     Source Type: Journal    
DOI: 10.1038/emboj.2011.325     Document Type: Article

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