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Volumn 19, Issue 5, 1999, Pages 3257-3266

MDM2 suppresses p73 function without promoting p73 degradation

Author keywords

[No Author keywords available]

Indexed keywords

PROTEIN MDM2; PROTEIN P53;

EID: 0032961828     PISSN: 02707306     EISSN: None     Source Type: Journal    
DOI: 10.1128/MCB.19.5.3257     Document Type: Article
Times cited : (307)

References (66)
  • 2
    • 0027459198 scopus 로고
    • mdm2 expression is induced by wild type p53 activity
    • Barak, Y., T. Juven, R. Haffner, and M. Oren. 1993. mdm2 expression is induced by wild type p53 activity. EMBO J. 12:461-468.
    • (1993) EMBO J. , vol.12 , pp. 461-468
    • Barak, Y.1    Juven, T.2    Haffner, R.3    Oren, M.4
  • 3
    • 0028049474 scopus 로고
    • Regulation of mdm2 expression by p53: Alternative promoters produce transcripts with nonidentical translation potential
    • Barak, Y., E. Gottlieb, T. Juven-Gershon, and M. Oren. 1994. Regulation of mdm2 expression by p53: alternative promoters produce transcripts with nonidentical translation potential. Genes Dev. 8:1739-1749.
    • (1994) Genes Dev. , vol.8 , pp. 1739-1749
    • Barak, Y.1    Gottlieb, E.2    Juven-Gershon, T.3    Oren, M.4
  • 4
    • 0031464286 scopus 로고    scopus 로고
    • P53CP, a putative p53 competing protein, that specifically binds to the consensus p53 DNA binding sites: A third member of the p53 family?
    • Bian, J., and Y. Sun. 1997. P53CP, a putative p53 competing protein, that specifically binds to the consensus p53 DNA binding sites: a third member of the p53 family? Proc. Natl. Acad. Sci. USA. 94:14753-14758.
    • (1997) Proc. Natl. Acad. Sci. USA , vol.94 , pp. 14753-14758
    • Bian, J.1    Sun, Y.2
  • 5
    • 0031282325 scopus 로고    scopus 로고
    • Design of a synthetic Mdm2-binding mini protein that activates the p53 response in vivo
    • Bottger, A., V. Bottger, A. Sparks, W. L. Liu, S. F. Howard, and D. P. Lane. 1997. Design of a synthetic Mdm2-binding mini protein that activates the p53 response in vivo. Curr. Biol. 7:860-869.
    • (1997) Curr. Biol. , vol.7 , pp. 860-869
    • Bottger, A.1    Bottger, V.2    Sparks, A.3    Liu, W.L.4    Howard, S.F.5    Lane, D.P.6
  • 6
    • 0023339504 scopus 로고
    • Molecular analysis and chromosomal mapping of amplified genes isolated from a transformed mouse 3T3 cell line
    • Cahilly-Snyder, L., T. Yang-Feng, U. Francke, and D. L. George. 1987. Molecular analysis and chromosomal mapping of amplified genes isolated from a transformed mouse 3T3 cell line. Somatic Cell Mol. Genet. 13:235-244.
    • (1987) Somatic Cell Mol. Genet. , vol.13 , pp. 235-244
    • Cahilly-Snyder, L.1    Yang-Feng, T.2    Francke, U.3    George, D.L.4
  • 7
    • 0027222956 scopus 로고
    • Mapping of the p53 and mdm-2 interaction domains
    • Chen, J., V. Marechal, and A. J. Levine. 1993. Mapping of the p53 and mdm-2 interaction domains. Mol. Cell. Biol. 13:4107-4114.
    • (1993) Mol. Cell. Biol. , vol.13 , pp. 4107-4114
    • Chen, J.1    Marechal, V.2    Levine, A.J.3
  • 8
    • 0029171789 scopus 로고
    • Regulation of transcription functions of the p53 tumor suppressor by the mdm-2 oncogene
    • Chen, J., J. Lin, and A. J. Levine. 1995. Regulation of transcription functions of the p53 tumor suppressor by the mdm-2 oncogene. Mol. Med. 1:142-152.
    • (1995) Mol. Med. , vol.1 , pp. 142-152
    • Chen, J.1    Lin, J.2    Levine, A.J.3
  • 9
    • 0029913730 scopus 로고    scopus 로고
    • 1 arrest and apoptosis functions of the p53 tumor suppressor protein
    • 1 arrest and apoptosis functions of the p53 tumor suppressor protein. Mol. Cell. Biol. 16:2445-2452.
    • (1996) Mol. Cell. Biol. , vol.16 , pp. 2445-2452
    • Chen, J.1    Wu, X.2    Lin, J.3    Levine, A.J.4
  • 10
    • 0031939875 scopus 로고    scopus 로고
    • Synergistic activation of p53 by inhibition of mdm2 expression and DNA damage
    • Chen, L., S. Agrawal, W. Zhou, R. Zhang, and J. Chen. 1998. Synergistic activation of p53 by inhibition of mdm2 expression and DNA damage. Proc. Natl. Acad. Sci. USA 95:195-200.
    • (1998) Proc. Natl. Acad. Sci. USA , vol.95 , pp. 195-200
    • Chen, L.1    Agrawal, S.2    Zhou, W.3    Zhang, R.4    Chen, J.5
  • 12
    • 0028220204 scopus 로고
    • p53-dependent inhibition of cyclin-dependent kinase activities in human fibroblasts during radiation-induced G1 arrest
    • Dulic, V., W. K. Kaufmann, S. J. Lees, T. D. Tisty, E. Lees, J. W. Harper, S. J. Elledge, and S. I. Reed. 1994. p53-dependent inhibition of cyclin-dependent kinase activities in human fibroblasts during radiation-induced G1 arrest. Cell 76:1013-1023.
    • (1994) Cell , vol.76 , pp. 1013-1023
    • Dulic, V.1    Kaufmann, W.K.2    Lees, S.J.3    Tisty, T.D.4    Lees, E.5    Harper, J.W.6    Elledge, S.J.7    Reed, S.I.8
  • 14
    • 0029760621 scopus 로고    scopus 로고
    • The MDM2 oncoprotein binds specifically to RNA through its RING finger domain
    • Elenbaas, B., M. Dobbelstein, J. Roth, T. Shenk, and A. J. Levine. 1996. The MDM2 oncoprotein binds specifically to RNA through its RING finger domain. Mol. Med. 2:439-451.
    • (1996) Mol. Med. , vol.2 , pp. 439-451
    • Elenbaas, B.1    Dobbelstein, M.2    Roth, J.3    Shenk, T.4    Levine, A.J.5
  • 15
    • 0025853776 scopus 로고
    • Tumorigenic potential associated with enhanced expression of a gene that is amplified in a mouse tumor cell line
    • Fakharzadeh, S. S., S. P. Trusko, and D. L. George. 1991. Tumorigenic potential associated with enhanced expression of a gene that is amplified in a mouse tumor cell line. EMBO J. 10:1565-1569.
    • (1991) EMBO J. , vol.10 , pp. 1565-1569
    • Fakharzadeh, S.S.1    Trusko, S.P.2    George, D.L.3
  • 16
    • 0027498314 scopus 로고
    • The mdm-2 oncogene can overcome wild-type p53 suppression of transformed cell growth
    • Finlay, C. A. 1993. The mdm-2 oncogene can overcome wild-type p53 suppression of transformed cell growth. Mol. Cell. Biol. 13:301-306.
    • (1993) Mol. Cell. Biol. , vol.13 , pp. 301-306
    • Finlay, C.A.1
  • 17
    • 0030981049 scopus 로고    scopus 로고
    • A genetic approach to mapping the p53 binding site in the MDM2 protein
    • Freedman, D. A., C. B. Epstein, J. C. Roth, and A. J. Levine. 1997. A genetic approach to mapping the p53 binding site in the MDM2 protein. Mol. Med. 3:248-259.
    • (1997) Mol. Med. , vol.3 , pp. 248-259
    • Freedman, D.A.1    Epstein, C.B.2    Roth, J.C.3    Levine, A.J.4
  • 20
    • 0030996361 scopus 로고    scopus 로고
    • Synergistic activation of transcription by CBP and p53
    • Gu, W., X. L. Shi, and R. G. Roeder. 1997. Synergistic activation of transcription by CBP and p53. Nature 387:819-823.
    • (1997) Nature , vol.387 , pp. 819-823
    • Gu, W.1    Shi, X.L.2    Roeder, R.G.3
  • 21
    • 0029985647 scopus 로고    scopus 로고
    • Cell type-specific inhibition of p53-mediated apoptosis by mdm2
    • Haupt, Y., Y. Barak, and M. Oren. 1996. Cell type-specific inhibition of p53-mediated apoptosis by mdm2. EMBO J. 15:1596-1606.
    • (1996) EMBO J. , vol.15 , pp. 1596-1606
    • Haupt, Y.1    Barak, Y.2    Oren, M.3
  • 22
    • 0030905284 scopus 로고    scopus 로고
    • Mdm2 promotes the rapid degradation of p53
    • Haupt, Y., R. Maya, A. Kazaz, and M. Oren. 1997. Mdm2 promotes the rapid degradation of p53. Nature 387:296-299.
    • (1997) Nature , vol.387 , pp. 296-299
    • Haupt, Y.1    Maya, R.2    Kazaz, A.3    Oren, M.4
  • 24
    • 0031583962 scopus 로고    scopus 로고
    • Oncoprotein MDM2 is a ubiquitin ligase E3 for tumor suppressor p53
    • Honda, R., H. Tanaka, and H. Yasuda. 1997. Oncoprotein MDM2 is a ubiquitin ligase E3 for tumor suppressor p53. FEBS Lett. 420:25-27.
    • (1997) FEBS Lett. , vol.420 , pp. 25-27
    • Honda, R.1    Tanaka, H.2    Yasuda, H.3
  • 25
    • 0028834902 scopus 로고
    • Rescue of embryonic lethality in Mdm2-deficient mice by absence of p53
    • Jones, S. N., A. E. Roe, L. A. Donehower, and A. Bradley. 1995. Rescue of embryonic lethality in Mdm2-deficient mice by absence of p53. Nature 378: 206-208.
    • (1995) Nature , vol.378 , pp. 206-208
    • Jones, S.N.1    Roe, A.E.2    Donehower, L.A.3    Bradley, A.4
  • 26
    • 0029953586 scopus 로고    scopus 로고
    • A conserved region of unknown function participates in the recognition of E2F family members by the adenovirus E4 ORF 6/7 protein
    • Jost, C. A., D. Ginsberg, and W. J. Kaelin. 1996. A conserved region of unknown function participates in the recognition of E2F family members by the adenovirus E4 ORF 6/7 protein. Virology 220:78-90.
    • (1996) Virology , vol.220 , pp. 78-90
    • Jost, C.A.1    Ginsberg, D.2    Kaelin, W.J.3
  • 27
    • 0031564954 scopus 로고    scopus 로고
    • p73 is a human p53-related protein that can induce apoptosis
    • Jost, C. A., M. C. Marin, and W. G. Kaelin. 1997. p73 is a human p53-related protein that can induce apoptosis. Nature 389:191-194.
    • (1997) Nature , vol.389 , pp. 191-194
    • Jost, C.A.1    Marin, M.C.2    Kaelin, W.G.3
  • 30
    • 0029972806 scopus 로고    scopus 로고
    • p53: Puzzle and paradigm
    • Ko, J. L., and C. Prives. 1996. p53: puzzle and paradigm. Genes Dev. 10: 1054-1072.
    • (1996) Genes Dev. , vol.10 , pp. 1054-1072
    • Ko, J.L.1    Prives, C.2
  • 31
    • 0031766420 scopus 로고    scopus 로고
    • Expression level, allelic origin, and mutation analysis of the p73 gene in neuroblastoma tumors and cell lines
    • Kovalev, S., N. Marchenko, S. Swendeman, M. LaQuaglia, and U. M. Moll. 1998. Expression level, allelic origin, and mutation analysis of the p73 gene in neuroblastoma tumors and cell lines. Cell Growth Differ. 9:897-903.
    • (1998) Cell Growth Differ. , vol.9 , pp. 897-903
    • Kovalev, S.1    Marchenko, N.2    Swendeman, S.3    LaQuaglia, M.4    Moll, U.M.5
  • 32
    • 0030965946 scopus 로고    scopus 로고
    • Regulation of p53 stability by mdm2
    • Kubbutat, M. H. G., S. N. Jones, and K. H. Vousden. 1997. Regulation of p53 stability by mdm2. Nature 387:299-303.
    • (1997) Nature , vol.387 , pp. 299-303
    • Kubbutat, M.H.G.1    Jones, S.N.2    Vousden, K.H.3
  • 33
    • 0031702817 scopus 로고    scopus 로고
    • Regulation of Mdm2-directed degradation by the C terminus of p53
    • Kubbutat, M. H., R. L. Ludwig, M. Ashcroft, and K. H. Vousden. 1998. Regulation of Mdm2-directed degradation by the C terminus of p53. Mol. Cell. Biol. 18:5690-5698.
    • (1998) Mol. Cell. Biol. , vol.18 , pp. 5690-5698
    • Kubbutat, M.H.1    Ludwig, R.L.2    Ashcroft, M.3    Vousden, K.H.4
  • 34
    • 0030941458 scopus 로고    scopus 로고
    • p53, the cellular gatekeeper for growth and division
    • Levine, A. J. 1997. p53, the cellular gatekeeper for growth and division. Cell 88:323-331.
    • (1997) Cell , vol.88 , pp. 323-331
    • Levine, A.J.1
  • 36
    • 0028303752 scopus 로고
    • Several hydrophobic amino acids in the p53 amino-terminal domain are required for transcriptional activation, binding to MDM2 and the adenovirus 5 E1B 55-kd protein
    • Lin, J., J. Chen, B. Elenbass, and A. J. Levine. 1994. Several hydrophobic amino acids in the p53 amino-terminal domain are required for transcriptional activation, binding to MDM2 and the adenovirus 5 E1B 55-kd protein. Genes Dev. 8:1235-1246.
    • (1994) Genes Dev. , vol.8 , pp. 1235-1246
    • Lin, J.1    Chen, J.2    Elenbass, B.3    Levine, A.J.4
  • 38
    • 0028979005 scopus 로고
    • Human TAF-31 is a transcriptional coactivator of the p53 protein
    • Lu, H., and A. J. Levine. 1995. Human TAF-31 is a transcriptional coactivator of the p53 protein. Proc. Natl. Acad. Sci. USA 92:5154-5158.
    • (1995) Proc. Natl. Acad. Sci. USA , vol.92 , pp. 5154-5158
    • Lu, H.1    Levine, A.J.2
  • 39
    • 0028678543 scopus 로고    scopus 로고
    • Regulation of p53 transcriptional function: TAFs and MDM2
    • Lu, H., J. Lin, J. Chen, and A. J. Levine. 1996. Regulation of p53 transcriptional function: TAFs and MDM2. Harvey Lect. 90:81-93.
    • (1996) Harvey Lect. , vol.90 , pp. 81-93
    • Lu, H.1    Lin, J.2    Chen, J.3    Levine, A.J.4
  • 40
    • 0032568633 scopus 로고    scopus 로고
    • Phosphorylation of p53 at serine 389 is responsive uniquely to UV- But not to gamma- and etoposide-induced DNA damage
    • Lu, H., V. Taya, M. Ikeda, and A. J. Levine. 1998. Phosphorylation of p53 at serine 389 is responsive uniquely to UV- but not to gamma- and etoposide-induced DNA damage. Proc. Natl. Acad. Sci. USA 95:6399-6402.
    • (1998) Proc. Natl. Acad. Sci. USA , vol.95 , pp. 6399-6402
    • Lu, H.1    Taya, V.2    Ikeda, M.3    Levine, A.J.4
  • 42
    • 0028883179 scopus 로고
    • Tumor suppressor p53 is a direct transcriptional activator of the human bax gene
    • Miyashita, T., and J. C. Reed. 1995. Tumor suppressor p53 is a direct transcriptional activator of the human bax gene. Cell 80:293-299.
    • (1995) Cell , vol.80 , pp. 293-299
    • Miyashita, T.1    Reed, J.C.2
  • 43
    • 0026649648 scopus 로고
    • The radm-2 oncogene product forms a complex with the p53 protein and inhibits p53-mediated transactivation
    • Momand, J., G. P. Zambetti, D. C. Olson, D. George, and A. J. Levine. 1992. The radm-2 oncogene product forms a complex with the p53 protein and inhibits p53-mediated transactivation. Cell 69:1237-1245.
    • (1992) Cell , vol.69 , pp. 1237-1245
    • Momand, J.1    Zambetti, G.P.2    Olson, D.C.3    George, D.4    Levine, A.J.5
  • 44
  • 45
    • 0028823020 scopus 로고
    • Rescue of early embryonic lethality in mdm2-deficient mice by deletion of p53
    • Oca Luna, R. M., D. S. Wagner, and G. Lozano. 1995. Rescue of early embryonic lethality in mdm2-deficient mice by deletion of p53. Nature 378: 203-206.
    • (1995) Nature , vol.378 , pp. 203-206
    • Oca Luna, R.M.1    Wagner, D.S.2    Lozano, G.3
  • 46
    • 0026740449 scopus 로고
    • Amplification of a gene encoding a p53-associated protein in human sarcomas
    • Oliner, J. D., K. W. Kinzler, P. S. Meltzer, D. L. George, and B. Vogelstein. 1992. Amplification of a gene encoding a p53-associated protein in human sarcomas. Nature 358:80-83.
    • (1992) Nature , vol.358 , pp. 80-83
    • Oliner, J.D.1    Kinzler, K.W.2    Meltzer, P.S.3    George, D.L.4    Vogelstein, B.5
  • 49
    • 0030800922 scopus 로고    scopus 로고
    • Mdm2: Keeping p53 under control
    • Plette, J., H. Neel, and V. Marechal. 1997. Mdm2: keeping p53 under control. Oncogene 15:1001-1010.
    • (1997) Oncogene , vol.15 , pp. 1001-1010
    • Plette, J.1    Neel, H.2    Marechal, V.3
  • 52
    • 0031596434 scopus 로고    scopus 로고
    • p73beta, unlike p53, suppresses growth and induces apoptosis of human papillomavirus E6-expressing cancer cells
    • Prabhu, N. S., K. Somasundaram, K. Satyamoorthy, M. Herlyn, and W. S. El-Deiry. 1998. p73beta, unlike p53, suppresses growth and induces apoptosis of human papillomavirus E6-expressing cancer cells. Int. J. Oncol. 13:5-9.
    • (1998) Int. J. Oncol. , vol.13 , pp. 5-9
    • Prabhu, N.S.1    Somasundaram, K.2    Satyamoorthy, K.3    Herlyn, M.4    El-Deiry, W.S.5
  • 53
    • 0030884751 scopus 로고    scopus 로고
    • A novel protein with strong homology to the tumor suppressor p53
    • Schmale, H., and C. Bamberger. 1997. A novel protein with strong homology to the tumor suppressor p53. Oncogene 15:1363-1367.
    • (1997) Oncogene , vol.15 , pp. 1363-1367
    • Schmale, H.1    Bamberger, C.2
  • 54
    • 0343417089 scopus 로고    scopus 로고
    • The p300/CBP family: Integrating signals with transcription factors and chromatin
    • Shikama, N., L. Lyon, and N. B. La Thangue. 1997. The p300/CBP family: integrating signals with transcription factors and chromatin. Trends Cell Biol. 7:230-236.
    • (1997) Trends Cell Biol. , vol.7 , pp. 230-236
    • Shikama, N.1    Lyon, L.2    La Thangue, N.B.3
  • 55
    • 0040979100 scopus 로고
    • Immunoaffinity purification
    • V. S. Malik and E. P. Lillehoj (ed.). Academic Press, Inc., New York, N.Y.
    • Tharakan, J. 1994. Immunoaffinity purification, p. 327-340. In V. S. Malik and E. P. Lillehoj (ed.), Antibody techniques. Academic Press, Inc., New York, N.Y.
    • (1994) Antibody Techniques , pp. 327-340
    • Tharakan, J.1
  • 56
    • 0028922929 scopus 로고
    • p53 transcriptional activation mediated by coactivators TAFII40 and TAFII60
    • Thut, C. J., J. L. Chen, R. Klemin, and R. Tjian. 1995. p53 transcriptional activation mediated by coactivators TAFII40 and TAFII60. Science 267:100-104.
    • (1995) Science , vol.267 , pp. 100-104
    • Thut, C.J.1    Chen, J.L.2    Klemin, R.3    Tjian, R.4
  • 57
    • 0030860911 scopus 로고    scopus 로고
    • Repression of p53-mediated transcription by MDM2: A dual mechanism
    • Thut, C. J., J. A. Goodrich, and R. Tjian. 1997. Repression of p53-mediated transcription by MDM2: a dual mechanism. Genes Dev. 11:1974-1986.
    • (1997) Genes Dev. , vol.11 , pp. 1974-1986
    • Thut, C.J.1    Goodrich, J.A.2    Tjian, R.3
  • 59
    • 0027244853 scopus 로고
    • The p53-mdm-2 autoregulatory feedback loop
    • Wu, X., J. H. Bayle, D. Olson, and A. J. Levine. 1993. The p53-mdm-2 autoregulatory feedback loop. Genes Dev. 7:1126-1132.
    • (1993) Genes Dev. , vol.7 , pp. 1126-1132
    • Wu, X.1    Bayle, J.H.2    Olson, D.3    Levine, A.J.4
  • 62
    • 0032161624 scopus 로고    scopus 로고
    • p63, a p53 homolog at 3q27-29, encodes multiple products with transactivating, death-inducing, and dominant-negative activities
    • Yang, A., M. Kaghad, Y. Wang, E. Gillett, M. D. Fleming, V. Dotsch, N. C. Andrews, D. Caput, and F. McKeon. 1998. p63, a p53 homolog at 3q27-29, encodes multiple products with transactivating, death-inducing, and dominant-negative activities. Mol. Cell 2:305-316.
    • (1998) Mol. Cell , vol.2 , pp. 305-316
    • Yang, A.1    Kaghad, M.2    Wang, Y.3    Gillett, E.4    Fleming, M.D.5    Dotsch, V.6    Andrews, N.C.7    Caput, D.8    McKeon, F.9
  • 63
    • 0032499528 scopus 로고    scopus 로고
    • Non-p53 p53RE binding protein, a human transcription factor functionally analogous to p53
    • Zeng, X. Y., A. J. Levine, and H. Lu. 1998. Non-p53 p53RE binding protein, a human transcription factor functionally analogous to p53. Proc. Natl. Acad. Sci. USA 95:6681-6686.
    • (1998) Proc. Natl. Acad. Sci. USA , vol.95 , pp. 6681-6686
    • Zeng, X.Y.1    Levine, A.J.2    Lu, H.3
  • 66
    • 0032549711 scopus 로고    scopus 로고
    • ARF promotes MDM2 degradation and stabilizes p53: ARF-INK4a locus deletion impairs both the Rb and p53 tumor suppression pathways
    • Zhang, Y., Y. Xiong, and W. G. Yarbrough. 1998. ARF promotes MDM2 degradation and stabilizes p53: ARF-INK4a locus deletion impairs both the Rb and p53 tumor suppression pathways. Cell 92:725-734.
    • (1998) Cell , vol.92 , pp. 725-734
    • Zhang, Y.1    Xiong, Y.2    Yarbrough, W.G.3


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