The tyrosine kinase c-Abl regulates p73 in apoptotic response to cisplatin-induced DNA damage

Nature

Volumn 399, Issue 6738, 1999, Pages 806-809

  Gong, JianGen ^a   Costanzo, Antonio ^b   Yang, Hong Qlong ^a   Mellno, Gerry ^c   Kaelin Jr , William G ^d   Levrero, Massimo ^b   Wang, Jean Y J ^a  

^a UNIVERSITY OF CALIFORNIA   (United States)

^b SAPIENZA UNIVERSITY OF ROME   (Italy)

^c UNIVERSITY OF ROME TOR VERGATA   (Italy)

^d HOWARD HUGHES MEDICAL INSTITUTE   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

CISPLATIN; DNA; ONCOPROTEIN; PROTEIN P53; PROTEIN TYROSINE KINASE;

ANIMAL CELL; APOPTOSIS; ARTICLE; CANCER CELL; CONTROLLED STUDY; CYTOTOXICITY; DNA DAMAGE; EMBRYO; ENZYME ACTIVITY; ENZYME REGULATION; GENE; HALF LIFE TIME; HUMAN; HUMAN CELL; IMMUNOBLOTTING; MOUSE; NONHUMAN; PRIORITY JOURNAL;

3T3 CELLS; ANIMALS; APOPTOSIS; BASE PAIR MISMATCH; CISPLATIN; DNA; DNA DAMAGE; DNA REPAIR; DNA-BINDING PROTEINS; GENES, TUMOR SUPPRESSOR; HUMANS; MICE; NUCLEAR PROTEINS; PROTO-ONCOGENE PROTEINS C-ABL; TUMOR CELLS, CULTURED; TUMOR SUPPRESSOR PROTEINS;

ANIMALIA;

EID: 0033600234     PISSN: 00280836     EISSN: None     Source Type: Journal    
DOI: 10.1038/21690     Document Type: Article

References (22)

1. Kaghad, M. et al. Monoallelically expressed gene related to p53 at 1-36, a region frequently deleted in neuroblastoma and other human cancers. Cell 90, 809-819 (1997).
2. De Laurenzi, V. et al. Two new p73 splice variants, gamma and delta, with different transcriptional activity. J. Exp. Med. 188, 1-6 (1998).
3. Jost, C., Marin, M. & Kaelin, W. p73 is a human p53-related protein that can induce apoptosis. Nature 389, 191-194 (1997).
4. Drummond, J., Anthoney, A., Brown, R. & Modrich, P. Cisplatin and Adriamycin resistance are associated with MutL-alpha and mismatch repair deficiency in an ovarian cancer cell line. J. Biol. Chem. 271, 19645-19648 (1996).
5. Fink, D. et al. In vitro and in vivo resistane to cisplatin in cells that have lost DNA mismatch repair. Cancer Res. 57, 1841-1845 (1995).
6. Buermeyer, A. B., Patten, C. W., Bakez, S. M. & Liskay, R. M. The human MLH1 cDNA complements DNA mismatch repair defects in Mlh1-deficient mouse embryonic fibroblasts. Cancer Res. 59, 538-541 (1999).
7. Toft, N. J. et al. Meh? status modulates both apoptosis and mutation frequency in the murine small intestine. Proc. Natl Acad. Sci. USA 96, 3911-3915 (1999).
8. Boyer, J. et al. Microssatellite instability, mismatch repair-deficiency, and genetic defects in human cancer all lines. Cancer Res. 55, 6063-6070 (1998).
9. Liu, Z. et al. Three distinct signalling sequences by murine fibroblasts to genotoxic stress. Nature 384, 273-276 (1996).
10. Kharbanda, S. et al. Activating of the kinase in the stress response to DNA-damaging agents. Nature 376, 785-788 (1993).
11. Nehme, A. et al. Differential Induction of c-Jun NH2-terminal kinase and c-Abl kinase in DNA mismatch repair-proficient and deficient cells exposed to cisplatin. Cancer Res. 57, 3253-3257 (1997).
12. Lowe, S. W., Schmitt, E. M., Smith, S. W., Osborne, B. A. & Jacks, T. p53 is required for radiation-induced apoptosis in mouse thymocytes. Nature 362, 847-849 (1993).
13. Tybulewics, V. L. J., Crawford, C. E., Jackson, P. K., Bronson, R. T. & Mulligan, R. C. Neonatal lethality and lymphopenia in mice with a homozygous disruption of the c-abl proto-oncogene. Cell 65, 1153-1163 (1991).
14. Edelmann, W. et al. Meiotic pachytene arrest in MLH1-deficient mice. Cell 85, 1125-1134 (1996).
15. Nelson, W. G. & Kastan, M. B. DNA breaks the DNA template alterations that trigger p53-dependent DNA damage response pathways. Mol. Cell. Biol. 14, 1815-1823 (1994).
16. Zamble, D., Jacks, T. & Lippord, S. p53-dependent and -independent responses to cisplatin in mouse testicular neurocarcinoma cells. Proc. Natl Acad. Sci. USA 95, 6163-6168 (1998).
17. Pear, W. S., Nolan, G. P., Scott, M. L. & Baltimore, D. Production of higher-titer helper-free retrovirus by transient . Proc. Natl Acad. Sci USA 90, 8392-8396 (1993).
18. Chen, C. & Oksyama, H. efficiency transformation of mammalian cells by plasmid DNA. Mol. Cell. Biol. 7, 2745-2752 (1987).
19. Marin, M. et al. Viral oncoproteins discriminate between p53 and the p53 homolog p73. Mol. Cell. Biol. 18, 6316-6324 (1998).
20. Baskaran, R. et al. Ataxia telangiectasia mutant protein activates c-Abl tyrosine kinase in response to ionizing radiation. Nature 387, 516-519 (1997).
21. Kalejta, R., Shenk, T. & Beavis, A. Use of a membrane-localized green fluorescent protein allows simultaneous identification of transfected cells and cell cycle analysis by flow cytometry. Cytometry 29, 286-291 (1997).
22. Nicoletti, I., Migliorati, G., Pagliacci, M. C., Grignani, F. & Riccardi, C. A rapid and simple method for measuring thymocyte apoptosis by propidium iodide staining and flow cytometry. J. Immunol. Meth. 139, 271-279 (1991).