Mitochondrial DNA polymerase editing mutation, PolgD257A, reduces the diabetic phenotype of Akita male mice by suppressing appetite

Proceedings of the National Academy of Sciences of the United States of America

Volumn 108, Issue 21, 2011, Pages 8779-8784

  Fox, Raymond ^a,b   Kim, Hyung Suk ^b   Reddick, Robert L ^c   Kujoth, Gregory C ^d,e   Prolla, Tomas A ^d   Tsutsumi, Shuichi ^f   Wada, Youichiro ^f   Smithies, Oliver ^a,b   Maeda, Nobuyo ^a,b  

^a UNIVERSITY OF NORTH CAROLINA   (United States)

^b UNIVERSITY OF NORTH CAROLINA SCHOOL OF MEDICINE   (United States)

^c Mays Cancer Center at UT Health San Antonio   (United States)

^d UNIVERSITY OF WISCONSIN MADISON   (United States)

^e UNIVERSITY OF WISCONSIN SCHOOL OF MEDICINE AND PUBLIC HEALTH   (United States)

^f UNIVERSITY OF TOKYO   (Japan)

Author keywords

[No Author keywords available]

Indexed keywords

CYTOCHROME B; DNA DIRECTED DNA POLYMERASE GAMMA; GHRELIN; GLUCOSE; INSULIN; LEPTIN; MITOCHONDRIAL DNA; MITOCHONDRIAL TRANSCRIPTION FACTOR A; NEUROPEPTIDE Y; OREXIN; PROOPIOMELANOCORTIN; TESTOSTERONE;

AGING; ANIMAL EXPERIMENT; ANIMAL MODEL; ANIMAL TISSUE; ARTICLE; BODY WEIGHT; CONTROLLED STUDY; DIABETES MELLITUS; FEMALE; FLUID INTAKE; FOOD INTAKE; GENE EXPRESSION; GENE MUTATION; GENE SEQUENCE; GLUCOSE BLOOD LEVEL; HETEROZYGOSITY; HOMOZYGOSITY; HYPERGLYCEMIA; HYPERPHAGIA; HYPOTHALAMUS; INSULIN BLOOD LEVEL; INSULIN SENSITIVITY; INTESTINE FUNCTION; KIDNEY DISTAL TUBULE; KIDNEY FUNCTION; KIDNEY INJURY; MALE; MOUSE; NONHUMAN; PHENOTYPE; PRIORITY JOURNAL; SMALL INTESTINE; TESTIS; TESTOSTERONE BLOOD LEVEL; URINE VOLUME;

AGING; ANIMALS; APPETITE; DIABETES MELLITUS; DNA, MITOCHONDRIAL; DNA-DIRECTED DNA POLYMERASE; FEMALE; HYPERGLYCEMIA; LEYDIG CELLS; MALE; MICE; MICE, INBRED STRAINS; MUTATION; PHENOTYPE; RNA EDITING; TESTIS; TESTOSTERONE;

MUS;

EID: 79957690363     PISSN: 00278424     EISSN: 10916490     Source Type: Journal    
DOI: 10.1073/pnas.1106344108     Document Type: Article

References (36)

1. de Andrade PB, et al. (2006) Diabetes-associated mitochondrial DNA mutation A3243G impairs cellular metabolic pathways necessary for beta cell function. Diabetologia 49:1816-1826.
2. Patti ME, Corvera S (2010) The role of mitochondria in the pathogenesis of type 2 diabetes. Endocr Rev 31:364-395.
3. Simmons RA, Suponitsky-Kroyter I, Selak MA (2005) Progressive accumulation of mitochondrial DNA mutations and decline in mitochondrial function lead to beta-cell failure. J Biol Chem 280:28785-28791. (Pubitemid 41105780)
4. Someya S, et al. (2008) The role of mtDNA mutations in the pathogenesis of age-related hearing loss in mice carrying a mutator DNA polymerase gamma. Neurobiol Aging 29:1080-1092. (Pubitemid 351697986)
5. Trifunovic A, Larsson NG (2008) Mitochondrial dysfunction as a cause of ageing. J Intern Med 263:167-178.
6. Wang J, Markesbery WR, Lovell MA (2006) Increased oxidative damage in nuclear and mitochondrial DNA in mild cognitive impairment. J Neurochem 96:825-832.
7. Zhang D, et al. (2003) Mitochondrial DNA mutations activate the mitochondrial apoptotic pathway and cause dilated cardiomyopathy. Cardiovasc Res 57:147-157. (Pubitemid 36009446)
8. Kakoki M, et al. (2006) Senescence-associated phenotypes in Akita diabetic mice are enhanced by absence of bradykinin B2 receptors. J Clin Invest 116:1302-1309.
9. Kakoki M, Takahashi N, Jennette JC, Smithies O (2004) Diabetic nephropathy is markedly enhanced in mice lacking the bradykinin B2 receptor. Proc Natl Acad Sci USA 101:13302-13305. (Pubitemid 39209660)
10. Hance N, Ekstrand MI, Trifunovic A (2005) Mitochondrial DNA polymerase gamma is essential for mammalian embryogenesis. Hum Mol Genet 14:1775-1783. (Pubitemid 41418049)
11. Kujoth GC, et al. (2005) Mitochondrial DNA mutations, oxidative stress, and apoptosis in mammalian aging. Science 309:481-484.
12. Trifunovic A, et al. (2004) Premature ageing in mice expressing defective mitochondrial DNA polymerase. Nature 429:417-423. (Pubitemid 38715133)
13. Wang J, et al. (1999) A mutation in the insulin 2 gene induces diabetes with severe pancreatic beta-cell dysfunction in the Mody mouse. J Clin Invest 103:27-37. (Pubitemid 29031160)
14. Vermulst M, et al. (2008) DNA deletions and clonal mutations drive premature aging in mitochondrial mutator mice. Nat Genet 40:392-394. (Pubitemid 351450885)
15. Vermulst M, et al. (2007) Mitochondrial point mutations do not limit the natural lifespan of mice. Nat Genet 39:540-543. (Pubitemid 46514771)
16. Yoshioka M, Kayo T, Ikeda T, Koizumi A (1997) A novel locus, Mody4, distal to D7Mit189 on chromosome 7 determines early-onset NIDDM in nonobese C57BL/6 (Akita) mutant mice. Diabetes 46:887-894. (Pubitemid 27188269)
17. Ekstrand MI, et al. (2004) Mitochondrial transcription factor A regulates mtDNA copy number in mammals. Hum Mol Genet 13:935-944. (Pubitemid 38628429)
18. Foury F (1989) Cloning and sequencing of the nuclear gene MIP1 encoding the catalytic subunit of the yeast mitochondrial DNA polymerase. J Biol Chem 264: 20552-20560.
19. Blakely EL, et al. (2005) A mitochondrial cytochrome b mutation causing severe respiratory chain enzyme deficiency in humans and yeast. FEBS J 272:3583-3592. (Pubitemid 41021171)
20. Toyoshima M, et al. (2007) Dimorphic gene expression patterns of anorexigenic and orexigenic peptides in hypothalamus account male and female hyperphagia in Akita type 1 diabetic mice. Biochem Biophys Res Commun 352:703-708. (Pubitemid 44880311)
21. Nathan L, et al. (2001) Testosterone inhibits early atherogenesis by conversion to estradiol: Critical role of aromatase. Proc Natl Acad Sci USA 98:3589-3593. (Pubitemid 32220889)
22. Moore CX, Cooper GJ (1991) Co-secretion of amylin and insulin from cultured islet beta-cells: Modulation by nutrient secretagogues, islet hormones and hypoglycemic agents. Biochem Biophys Res Commun 179:1-9.
23. Morris MJ, Nguyen T (2001) Does neuropeptide Y contribute to the anorectic action of amylin? Peptides 22:541-546.
24. Mayer CM, Belsham DD (2009) Insulin directly regulates NPY and AgRP gene expression via the MAPK MEK/ERK signal transduction pathway in mHypoE-46 hypothalamic neurons. Mol Cell Endocrinol 307:99-108.
25. Westman EC, Yancy WS, Jr., Humphreys M (2006) Dietary treatment of diabetes mellitus in the pre-insulin era (1914-1922). Perspect Biol Med 49:77-83.
26. Morley JE (2001) Decreased food intake with aging. J Gerontol A Biol Sci Med Sci 56: 81-88.
27. Baumgartner RN, et al. (1999) Serum leptin in elderly people: Associations with sex hormones, insulin, and adipose tissue volumes. Obes Res 7:141-149.
28. Sih R, et al. (1997) Testosterone replacement in older hypogonadal men: A 12-month randomized controlled trial. J Clin Endocrinol Metab 82:1661-1667. (Pubitemid 127495166)
29. Kapoor D, Clarke S, Stanworth R, Channer KS, Jones TH (2007) The effect of testosterone replacement therapy on adipocytokines and C-reactive protein in hypogonadal men with type 2 diabetes. Eur J Endocrinol 156:595-602. (Pubitemid 46796527)
30. Gupta V, et al. (2008) Effects of dihydrotestosterone on differentiation and proliferation of human mesenchymal stem cells and preadipocytes. Mol Cell Endocrinol 296:32-40.
31. Friedman JM, Halaas JL (1998) Leptin and the regulation of body weight in mammals. Nature 395:763-770. (Pubitemid 28485436)
32. Gentry RT, Wade GN (1976) Androgenic control of food intake and body weight in male rats. J Comp Physiol Psychol 90:18-25.
33. Gurley SB, et al. (2006) Impact of genetic background on nephropathy in diabetic mice. Am J Physiol Renal Physiol 290:F214-F222.
34. Qi Z, et al. (2005) Characterization of susceptibility of inbred mouse strains to diabetic nephropathy. Diabetes 54:2628-2637. (Pubitemid 41233584)
35. Graham JM (2001) Isolation of mitochondria from tissues and cells by differential centrifugation. Curr Protoc Cell Biol, Chapter 3:Unit 3.3.
36. Chomczynski P, Sacchi N (1987) Single-step method of RNA isolation by acid guanidinium thiocyanate-phenol-chloroform extraction. Anal Biochem 162:156-159. (Pubitemid 17064313)