Plaque-associated overexpression of insulin-degrading enzyme in the cerebral cortex of aged transgenic Tg2576 mice with Alzheimer pathology

Journal of Neuropathology and Experimental Neurology

Volumn 65, Issue 10, 2006, Pages 976-987

  Leal, María C ^a   Dorfman, Verónica B ^a   Gamba, Agata Fernández ^a   Frangione, Blas ^b   Wisniewski, Thomas ^b   Castaño, Eduardo M ^a   Sigurdsson, Einar M ^b   Morelli, Laura ^a  

^a FUNDACIÓN INSTITUTO LELOIR   (Argentina)

^b NEW YORK UNIVERSITY SCHOOL OF MEDICINE   (United States)

Author keywords

Alzheimer disease; Amyloid A; Astrocytes; Inflammation; Insulin degrading enzyme; MAPK cascades; Microglia; Transgenic mice

Indexed keywords

1,4 DIAMINO 1,4 BIS(2 AMINOPHENYLTHIO) 2,3 DICYANOBUTADIENE; AMYLOID; AMYLOID BETA PROTEIN; AMYLOID PRECURSOR PROTEIN; DODECYL SULFATE SODIUM; GLIAL FIBRILLARY ACIDIC PROTEIN; INSULINASE; MITOGEN ACTIVATED PROTEIN KINASE 1; MITOGEN ACTIVATED PROTEIN KINASE 3;

AGING; ALZHEIMER DISEASE; ANIMAL CELL; ANIMAL EXPERIMENT; ANIMAL MODEL; ANIMAL TISSUE; ARTICLE; ASTROCYTE; BRAIN CORTEX; CONTROLLED STUDY; DISEASE COURSE; ENZYME ACTIVITY; ENZYME LOCALIZATION; GENE MUTATION; GENE OVEREXPRESSION; IN VITRO STUDY; INFLAMMATION; LONGITUDINAL STUDY; MICROGLIA; MOUSE; NEWBORN; NONHUMAN; PRIORITY JOURNAL; PROTEIN DEGRADATION; RAT; SENILE PLAQUE; SIGNAL TRANSDUCTION; SOLUBILITY; TRANSGENIC MOUSE;

AGE FACTORS; ALZHEIMER DISEASE; AMYLOID BETA-PROTEIN; ANIMALS; ASTROCYTES; BLOTTING, WESTERN; CEREBRAL CORTEX; DISEASE MODELS, ANIMAL; ENZYME-LINKED IMMUNOSORBENT ASSAY; IMAGE PROCESSING, COMPUTER-ASSISTED; IMMUNOHISTOCHEMISTRY; INSULYSIN; MICE; MICE, TRANSGENIC; RATS; RATS, SPRAGUE-DAWLEY; REVERSE TRANSCRIPTASE POLYMERASE CHAIN REACTION; RNA, MESSENGER; SENILE PLAQUES;

EID: 33749495463     PISSN: 00223069     EISSN: None     Source Type: Journal    
DOI: 10.1097/01.jnen.0000235853.70092.ba     Document Type: Article

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