Mitochondrial DNA mutations induce mitochondrial dysfunction, apoptosis and sarcopenia in skeletal muscle of mitochondrial DNA mutator mice

PLoS ONE

Volumn 5, Issue 7, 2010, Pages

  Hiona, Asimina ^a   Sanz, Alberto ^b   Kujoth, Gregory C ^c   Pamplona, Reinald ^d   Seo, Arnold Y ^a   Hofer, Tim ^a   Someya, Shinichi ^c,e   Miyakawa, Takuya ^e   Nakayama, Chie ^e   Samhan Arias, Alejandro K ^f   Servais, Stephane ^a   Barger, Jamie L ^g   Portero Otín, Manuel ^d   Tanokura, Masaru ^e   Prolla, Tomas A ^c   Leeuwenburgh, Christiaan ^a  

^a UNIVERSITY OF FLORIDA COLLEGE OF MEDICINE   (United States)

^b UNIVERSITY OF TAMPERE   (Finland)

^c UNIVERSITY OF WISCONSIN MADISON   (United States)

^d UNIVERSITY OF LLEIDA   (Spain)

^e UNIVERSITY OF TOKYO   (Japan)

^f UNIVERSITY OF EXTREMADURA   (Spain)

^g LifeGen Technologies LLC   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

ADENOSINE TRIPHOSPHATE; CASPASE 3; CASPASE 9; DNA DIRECTED DNA POLYMERASE GAMMA; MITOCHONDRIAL DNA; REACTIVE OXYGEN METABOLITE;

AGING; ANIMAL TISSUE; APOPTOSIS; ARTICLE; BIOENERGY; CELL FUNCTION; CONTROLLED STUDY; DOWN REGULATION; ENZYME ACTIVITY; FEMALE; GENE EXPRESSION; GENE EXPRESSION PROFILING; GENE MUTATION; GENETIC ANALYSIS; MALE; MITOCHONDRIAL MEMBRANE POTENTIAL; MITOCHONDRION; MOUSE; MUSCLE ATROPHY; NONHUMAN; OXIDATIVE PHOSPHORYLATION; OXIDATIVE STRESS; PROTEIN CONTENT; SKELETAL MUSCLE; ANIMAL; DNA MICROARRAY; GENETICS; METABOLISM; MUTATION; PATHOLOGY; PHYSIOLOGY; REVERSE TRANSCRIPTION POLYMERASE CHAIN REACTION; TRANSGENIC MOUSE;

MUS;

ANIMALS; APOPTOSIS; CASPASE 3; CASPASE 9; DNA, MITOCHONDRIAL; FEMALE; MALE; MEMBRANE POTENTIAL, MITOCHONDRIAL; MICE; MICE, TRANSGENIC; MITOCHONDRIA; MUSCLE, SKELETAL; MUTATION; OLIGONUCLEOTIDE ARRAY SEQUENCE ANALYSIS; REACTIVE OXYGEN SPECIES; REVERSE TRANSCRIPTASE POLYMERASE CHAIN REACTION; SARCOPENIA;

EID: 77955380974     PISSN: None     EISSN: 19326203     Source Type: Journal    
DOI: 10.1371/journal.pone.0011468     Document Type: Article

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