-
1
-
-
0029849620
-
Cancer cell cycles
-
Sherr CJ. Cancer cell cycles. Science 1996; 274: 1672-1677.
-
(1996)
Science
, vol.274
, pp. 1672-1677
-
-
Sherr, C.J.1
-
3
-
-
0038052805
-
The cell cycle: A review of regulation, deregulation and therapeutic targets in cancer
-
Vermeulen K, Van Bockstaele DR, Berneman ZN. The cell cycle: a review of regulation, deregulation and therapeutic targets in cancer. Cell Prolif 2003; 36: 131-149.
-
(2003)
Cell Prolif
, vol.36
, pp. 131-149
-
-
Vermeulen, K.1
Van Bockstaele, D.R.2
Berneman, Z.N.3
-
4
-
-
0041847171
-
Cell cycle control and cancer
-
Garrett MD. Cell cycle control and cancer. Current Science 2001; 81: 515-522.
-
(2001)
Current Science
, vol.81
, pp. 515-522
-
-
Garrett, M.D.1
-
5
-
-
0033564697
-
CDK inhibitors: Positive and negative regulators of G1-phase progression
-
Sherr CJ, Roberts JM. CDK inhibitors: positive and negative regulators of G1-phase progression. Genes Dev 1999; 13: 1501-1512.
-
(1999)
Genes Dev
, vol.13
, pp. 1501-1512
-
-
Sherr, C.J.1
Roberts, J.M.2
-
6
-
-
84871963013
-
El-Deiry WS. P21WAF1 and tumourigenesis: 20 years after
-
Warfel NA, el-Deiry WS. P21WAF1 and tumourigenesis: 20 years after. Curr Opin Oncol 2013; 25: 52-58.
-
(2013)
Curr Opin Oncol
, vol.25
, pp. 52-58
-
-
Warfel, N.A.1
-
7
-
-
67649295460
-
Cip/Kip cyclin-dependent protein kinase inhibitors and the road to polyploidy
-
Ullah Z, Lee CY, Depamphilis ML. Cip/Kip cyclin-dependent protein kinase inhibitors and the road to polyploidy. Cell Div 2009; 4: 10.
-
(2009)
Cell Div
, vol.4
, pp. 10
-
-
Ullah, Z.1
Lee, C.Y.2
Depamphilis, M.L.3
-
8
-
-
0034682037
-
Cell-cycle inhibitors: Three families united by a common cause
-
Vidal A, Koff A. Cell-cycle inhibitors: three families united by a common cause. Gene 2000; 247: 1-15.
-
(2000)
Gene
, vol.247
, pp. 1-15
-
-
Vidal, A.1
Koff, A.2
-
9
-
-
0030955563
-
Ablation of the CDK inhibitor p57Kip2 results in increased apoptosis and delayed differentiation during mouse development
-
Yan Y, Frisen J, Lee MH, Massague J, Barbacid M. Ablation of the CDK inhibitor p57Kip2 results in increased apoptosis and delayed differentiation during mouse development. Genes Dev 1997; 11: 973-983.
-
(1997)
Genes Dev
, vol.11
, pp. 973-983
-
-
Yan, Y.1
Frisen, J.2
Lee, M.H.3
Massague, J.4
Barbacid, M.5
-
10
-
-
0029993450
-
Role of the INK4a locus in tumor suppression and cell mortality
-
Serrano M, Lee H, Chin L, Cordon-Cardo C, Beach D, DePinho RA. Role of the INK4a locus in tumor suppression and cell mortality. Cell 1996; 85: 27-37.
-
(1996)
Cell
, vol.85
, pp. 27-37
-
-
Serrano, M.1
Lee, H.2
Chin, L.3
Cordon-Cardo, C.4
Beach, D.5
Depinho, R.A.6
-
11
-
-
0035817688
-
Loss of p16Ink4a with retention of p19Arf predisposes mice to tumorigenesis
-
Sharpless NE, Bardeesy N, Lee KH, Carrasco D, Castrillon DH, Aguirre AJ et al. Loss of p16Ink4a with retention of p19Arf predisposes mice to tumorigenesis. Nature 2001; 413: 86-91.
-
(2001)
Nature
, vol.413
, pp. 86-91
-
-
Sharpless, N.E.1
Bardeesy, N.2
Lee, K.H.3
Carrasco, D.4
Castrillon, D.H.5
Aguirre, A.J.6
-
12
-
-
0028978183
-
Mice lacking p21CIP1/WAF1 undergo normal development, but are defective in G1 checkpoint control
-
Deng C, Zhang P, Harper JW, Elledge SJ, Leder P. Mice lacking p21CIP1/WAF1 undergo normal development, but are defective in G1 checkpoint control. Cell 1995; 82: 675-684.
-
(1995)
Cell
, vol.82
, pp. 675-684
-
-
Deng, C.1
Zhang, P.2
Harper, J.W.3
Elledge, S.J.4
Leder, P.5
-
14
-
-
80155151895
-
Combined loss of p21(waf1/cip1) and p27(kip1) enhances tumorigenesis in mice
-
Garcia-Fernandez RA, Garcia-Palencia P, Sanchez MA, Gil-Gomez G, Sanchez B, Rollan E et al. Combined loss of p21(waf1/cip1) and p27(kip1) enhances tumorigenesis in mice. Lab Invest 2011; 91: 1634-1642.
-
(2011)
Lab Invest
, vol.91
, pp. 1634-1642
-
-
Garcia-Fernandez, R.A.1
Garcia-Palencia, P.2
Ma, S.3
Gil-Gomez, G.4
Sanchez, B.5
Rollan, E.6
-
15
-
-
0026459047
-
D type cyclins associate with multiple protein kinases and the DNA replication and repair factor PCNA
-
Xiong Y, Zhang H, Beach D. D type cyclins associate with multiple protein kinases and the DNA replication and repair factor PCNA. Cell 1992; 71: 505-514.
-
(1992)
Cell
, vol.71
, pp. 505-514
-
-
Xiong, Y.1
Zhang, H.2
Beach, D.3
-
16
-
-
0027717617
-
Beach D. P21 is a universal inhibitor of cyclin kinases
-
Xiong Y, Hannon GJ, Zhang H, Casso D, Kobayashi R, Beach D. P21 is a universal inhibitor of cyclin kinases. Nature 1993; 366: 701-704.
-
(1993)
Nature
, vol.366
, pp. 701-704
-
-
Xiong, Y.1
Hannon, G.J.2
Zhang, H.3
Casso, D.4
Kobayashi, R.5
-
17
-
-
0027359827
-
WAF1, a potential mediator of p53 tumor suppression
-
el-Deiry WS, Tokino T, Velculescu VE, Levy DB, Parsons R, Trent JM et al. WAF1, a potential mediator of p53 tumor suppression. Cell 1993; 75: 817-825.
-
(1993)
Cell
, vol.75
, pp. 817-825
-
-
El-Deiry, W.S.1
Tokino, T.2
Velculescu, V.E.3
Levy, D.B.4
Parsons, R.5
Trent, J.M.6
-
18
-
-
0027496935
-
The p21 Cdk-interacting protein Cip1 is a potent inhibitor of G1 cyclin-dependent kinases
-
Harper JW, Adami GR, Wei N, Keyomarsi K, Elledge SJ. The p21 Cdk-interacting protein Cip1 is a potent inhibitor of G1 cyclin-dependent kinases. Cell 1993; 75: 805-816.
-
(1993)
Cell
, vol.75
, pp. 805-816
-
-
Harper, J.W.1
Adami, G.R.2
Wei, N.3
Keyomarsi, K.4
Elledge, S.J.5
-
19
-
-
0028342664
-
Cloning of senescent cell-derived inhibitors of DNA synthesis using an expression screen
-
Noda A, Ning Y, Venable SF, Pereira-Smith OM, Smith JR. Cloning of senescent cell-derived inhibitors of DNA synthesis using an expression screen. Exp Cell Res 1994; 211: 90-98.
-
(1994)
Exp Cell Res
, vol.211
, pp. 90-98
-
-
Noda, A.1
Ning, Y.2
Venable, S.F.3
Pereira-Smith, O.M.4
Smith, J.R.5
-
20
-
-
0029031949
-
The melanoma differentiation-associated gene mda-6, which encodes the cyclin-dependent kinase inhibitor p21, is differentially expressed during growth, differentiation and progression in human melanoma cells
-
Jiang H, Lin J, Su ZZ, Herlyn M, Kerbel RS, Weissman BE et al. The melanoma differentiation-associated gene mda-6, which encodes the cyclin-dependent kinase inhibitor p21, is differentially expressed during growth, differentiation and progression in human melanoma cells. Oncogene 1995; 10: 1855-1864.
-
(1995)
Oncogene
, vol.10
, pp. 1855-1864
-
-
Jiang, H.1
Lin, J.2
Su, Z.Z.3
Herlyn, M.4
Kerbel, R.S.5
Weissman, B.E.6
-
21
-
-
0027731971
-
Inhibition of CDK2 activity in vivo by an associated 20K regulatory subunit
-
Gu Y, Turck CW, Morgan DO. Inhibition of CDK2 activity in vivo by an associated 20K regulatory subunit. Nature 1993; 366: 707-710.
-
(1993)
Nature
, vol.366
, pp. 707-710
-
-
Gu, Y.1
Turck, C.W.2
Morgan, D.O.3
-
22
-
-
0033991755
-
An overview of the cell cycle arrest protein p21(WAF1)
-
Harada K, Ogden GR. An overview of the cell cycle arrest protein, p21(WAF1). Oral Oncol 2000; 36: 3-7.
-
(2000)
Oral Oncol
, vol.36
, pp. 3-7
-
-
Harada, K.1
Ogden, G.R.2
-
23
-
-
0029662315
-
Structural studies of p21Waf1/Cip1/Sdi1 in the free and Cdk2-bound state: Conformational disorder mediates binding diversity
-
Kriwacki RW, Hengst L, Tennant L, Reed SI, Wright PE. Structural studies of p21Waf1/Cip1/Sdi1 in the free and Cdk2-bound state: conformational disorder mediates binding diversity. Proc Natl Acad Sci USA 1996; 93: 11504-11509.
-
(1996)
Proc Natl Acad Sci USA
, vol.93
, pp. 11504-11509
-
-
Kriwacki, R.W.1
Hengst, L.2
Tennant, L.3
Reed, S.I.4
Wright, P.E.5
-
24
-
-
1842473094
-
P27 binds cyclin-CDK complexes through a sequential mechanism involving binding-induced protein folding
-
Lacy ER, Filippov I, Lewis WS, Otieno S, Xiao L, Weiss S et al. P27 binds cyclin-CDK complexes through a sequential mechanism involving binding-induced protein folding. Nat Struct Mol Biol 2004; 11: 358-364.
-
(2004)
Nat Struct Mol Biol
, vol.11
, pp. 358-364
-
-
Lacy, E.R.1
Filippov, I.2
Lewis, W.S.3
Otieno, S.4
Xiao, L.5
Weiss, S.6
-
25
-
-
84859517054
-
Intrinsic protein flexibility in regulation of cell proliferation: Advantages for signaling and opportunities for novel therapeutics
-
Follis AV, Galea CA, Kriwacki RW. Intrinsic protein flexibility in regulation of cell proliferation: advantages for signaling and opportunities for novel therapeutics. Adv Exp Med Biol 2012; 725: 27-49.
-
(2012)
Adv Exp Med Biol
, vol.725
, pp. 27-49
-
-
Follis, A.V.1
Galea, C.A.2
Kriwacki, R.W.3
-
26
-
-
47649102449
-
Regulation of cell division by intrinsically unstructured proteins: Intrinsic flexibility, modularity, and signaling conduits
-
Galea CA, Wang Y, Sivakolundu SG, Kriwacki RW. Regulation of cell division by intrinsically unstructured proteins: intrinsic flexibility, modularity, and signaling conduits. Biochemistry 2008; 47: 7598-7609.
-
(2008)
Biochemistry
, vol.47
, pp. 7598-7609
-
-
Galea, C.A.1
Wang, Y.2
Sivakolundu, S.G.3
Kriwacki, R.W.4
-
27
-
-
0029784513
-
Cyclin-binding motifs are essential for the function of p21CIP1
-
Chen J, Saha P, Kornbluth S, Dynlacht BD, Dutta A. Cyclin-binding motifs are essential for the function of p21CIP1. Mol Cell Biol 1996; 16: 4673-4682.
-
(1996)
Mol Cell Biol
, vol.16
, pp. 4673-4682
-
-
Chen, J.1
Saha, P.2
Kornbluth, S.3
Dynlacht, B.D.4
Dutta, A.5
-
28
-
-
0029665852
-
Crystal structure of the p27Kip1 cyclin-dependent-kinase inhibitor bound to the cyclin A-Cdk2 complex
-
Russo AA, Jeffrey PD, Patten AK, Massague J, Pavletich NP. Crystal structure of the p27Kip1 cyclin-dependent-kinase inhibitor bound to the cyclin A-Cdk2 complex. Nature 1996; 382: 325-331.
-
(1996)
Nature
, vol.382
, pp. 325-331
-
-
Russo, A.A.1
Jeffrey, P.D.2
Patten, A.K.3
Massague, J.4
Pavletich, N.P.5
-
29
-
-
33745150087
-
The intricacies of p21 phosphorylation: Protein/protein interactions, subcellular localization and stability
-
Child ES, Mann DJ. The intricacies of p21 phosphorylation: protein/protein interactions, subcellular localization and stability. Cell Cycle 2006; 5: 1313-1319.
-
(2006)
Cell Cycle
, vol.5
, pp. 1313-1319
-
-
Child, E.S.1
Mann, D.J.2
-
30
-
-
79952959945
-
Intrinsic disorder mediates the diverse regulatory functions of the Cdk inhibitor p21
-
Wang Y, Fisher JC, Mathew R, Ou L, Otieno S, Sublet J et al. Intrinsic disorder mediates the diverse regulatory functions of the Cdk inhibitor p21. Nat Chem Biol 2011; 7: 214-221.
-
(2011)
Nat Chem Biol
, vol.7
, pp. 214-221
-
-
Wang, Y.1
Fisher, J.C.2
Mathew, R.3
Ou, L.4
Otieno, S.5
Sublet, J.6
-
31
-
-
79959639498
-
The role of the LH subdomain in the function of the Cip/Kip cyclin-dependent kinase regulators
-
Otieno S, Grace CR, Kriwacki RW. The role of the LH subdomain in the function of the Cip/Kip cyclin-dependent kinase regulators. Biophys J 2011; 100: 2486-2494.
-
(2011)
Biophys J
, vol.100
, pp. 2486-2494
-
-
Otieno, S.1
Grace, C.R.2
Kriwacki, R.W.3
-
32
-
-
0028352434
-
The p21 inhibitor of cyclin-dependent kinases controls DNA replication by interaction with PCNA
-
Waga S, Hannon GJ, Beach D, Stillman B. The p21 inhibitor of cyclin-dependent kinases controls DNA replication by interaction with PCNA. Nature 1994; 369: 574-578.
-
(1994)
Nature
, vol.369
, pp. 574-578
-
-
Waga, S.1
Hannon, G.J.2
Beach, D.3
Stillman, B.4
-
33
-
-
34248161671
-
Cytoplasmic localization and ubiquitination of p21 (Cip1) by reactive oxygen species
-
Hwang CY, Kim IY, Kwon KS. Cytoplasmic localization and ubiquitination of p21 (Cip1) by reactive oxygen species. Biochem Biophys Res Commun 2007; 358: 219-225.
-
(2007)
Biochem Biophys Res Commun
, vol.358
, pp. 219-225
-
-
Hwang, C.Y.1
Kim, I.Y.2
Kwon, K.S.3
-
34
-
-
0037032462
-
Identification of the nuclear localization signal of p21(cip1) and consequences of its mutation on cell proliferation
-
Rodriguez-Vilarrupla A, Diaz C, Canela N, Rahn HP, Bachs O, Agell N. Identification of the nuclear localization signal of p21(cip1) and consequences of its mutation on cell proliferation. FEBS Lett 2002; 531: 319-323.
-
(2002)
FEBS Lett
, vol.531
, pp. 319-323
-
-
Rodriguez-Vilarrupla, A.1
Diaz, C.2
Canela, N.3
Rahn, H.P.4
Bachs, O.5
Agell, N.6
-
35
-
-
18144434084
-
Calmodulin binds to p21(Cip1) and is involved in the regulation of its nuclear localization
-
Taules M, Rodriguez-Vilarrupla A, Rius E, Estanyol JM, Casanovas O, Sacks DB et al. Calmodulin binds to p21(Cip1) and is involved in the regulation of its nuclear localization. J Biol Chem 1999; 274: 24445-24448.
-
(1999)
J Biol Chem
, vol.274
, pp. 24445-24448
-
-
Taules, M.1
Rodriguez-Vilarrupla, A.2
Rius, E.3
Estanyol, J.M.4
Casanovas, O.5
Sacks, D.B.6
-
36
-
-
33645285047
-
The diverging roles of calmodulin and PKC in the regulation of p21 intracellular localization
-
Agell N, Jaumot M, Rodriguez-Vilarrupla A, Brun S, Abella N, Canela N et al. The diverging roles of calmodulin and PKC in the regulation of p21 intracellular localization. Cell Cycle 2006; 5: 3-6.
-
(2006)
Cell Cycle
, vol.5
, pp. 3-6
-
-
Agell, N.1
Jaumot, M.2
Rodriguez-Vilarrupla, A.3
Brun, S.4
Abella, N.5
Canela, N.6
-
37
-
-
9744227998
-
N-acetylation and ubiquitin-independent proteasomal degradation of p21(Cip1)
-
Chen X, Chi Y, Bloecher A, Aebersold R, Clurman BE, Roberts JM. N-acetylation and ubiquitin-independent proteasomal degradation of p21(Cip1). Mol Cell 2004; 16: 839-847.
-
(2004)
Mol Cell
, vol.16
, pp. 839-847
-
-
Chen, X.1
Chi, Y.2
Bloecher, A.3
Aebersold, R.4
Clurman, B.E.5
Roberts, J.M.6
-
38
-
-
77951985216
-
Examination of the expanding pathways for the regulation of p21 expression and activity
-
Jung YS, Qian Y, Chen X. Examination of the expanding pathways for the regulation of p21 expression and activity. Cell Signal 2010; 22: 1003-1012.
-
(2010)
Cell Signal
, vol.22
, pp. 1003-1012
-
-
Jung, Y.S.1
Qian, Y.2
Chen, X.3
-
39
-
-
16244389645
-
Phosphorylation of p21 in G2/M promotes cyclin B-Cdc2 kinase activity
-
Dash BC, el-Deiry WS. Phosphorylation of p21 in G2/M promotes cyclin B-Cdc2 kinase activity. Mol Cell Biol 2005; 25: 3364-3387.
-
(2005)
Mol Cell Biol
, vol.25
, pp. 3364-3387
-
-
Dash, B.C.1
El-Deiry, W.S.2
-
40
-
-
33644747700
-
Phosphorylation of the cyclin-dependent kinase inhibitor p21Cip1 on serine 130 is essential for viral cyclin-mediated bypass of a p21Cip1-imposed G1 arrest
-
Jarviluoma A, Child ES, Sarek G, Sirimongkolkasem P, Peters G, Ojala PM et al. Phosphorylation of the cyclin-dependent kinase inhibitor p21Cip1 on serine 130 is essential for viral cyclin-mediated bypass of a p21Cip1-imposed G1 arrest. Mol Cell Biol 2006; 26: 2430-2440.
-
(2006)
Mol Cell Biol
, vol.26
, pp. 2430-2440
-
-
Jarviluoma, A.1
Child, E.S.2
Sarek, G.3
Sirimongkolkasem, P.4
Peters, G.5
Ojala, P.M.6
-
41
-
-
0034941567
-
Akt-dependent phosphorylation of p21(Cip1) regulates PCNA binding and proliferation of endothelial cells
-
Rossig L, Jadidi AS, Urbich C, Badorff C, Zeiher AM, Dimmeler S. Akt-dependent phosphorylation of p21(Cip1) regulates PCNA binding and proliferation of endothelial cells. Mol Cell Biol 2001; 21: 5644-5657.
-
(2001)
Mol Cell Biol
, vol.21
, pp. 5644-5657
-
-
Rossig, L.1
Jadidi, A.S.2
Urbich, C.3
Badorff, C.4
Zeiher, A.M.5
Dimmeler, S.6
-
42
-
-
77953806550
-
Pim-2 phosphorylation of p21(Cip1/WAF1) enhances its stability and inhibits cell proliferation in HCT116 cells
-
Wang Z, Zhang Y, Gu JJ, Davitt C, Reeves R, Magnuson NS. Pim-2 phosphorylation of p21(Cip1/WAF1) enhances its stability and inhibits cell proliferation in HCT116 cells. Int J Biochem Cell Biol 2010; 42: 1030-1038.
-
(2010)
Int J Biochem Cell Biol
, vol.42
, pp. 1030-1038
-
-
Wang, Z.1
Zhang, Y.2
Gu, J.J.3
Davitt, C.4
Reeves, R.5
Magnuson, N.S.6
-
43
-
-
79953799132
-
Human NDR kinases control G (1)/S cell cycle transition by directly regulating p21 stability
-
Cornils H, Kohler RS, Hergovich A, Hemmings BA. Human NDR kinases control G (1)/S cell cycle transition by directly regulating p21 stability. Mol Cell Biol 2011; 31: 1382-1395.
-
(2011)
Mol Cell Biol
, vol.31
, pp. 1382-1395
-
-
Cornils, H.1
Kohler, R.S.2
Hergovich, A.3
Hemmings, B.A.4
-
44
-
-
67649205804
-
Extracellular signal-regulated kinase 2-dependent phosphorylation induces cytoplasmic localization and degradation of p21Cip1
-
Hwang CY, Lee C, Kwon KS. Extracellular signal-regulated kinase 2-dependent phosphorylation induces cytoplasmic localization and degradation of p21Cip1. Mol Cell Biol 2009; 29: 3379-3389.
-
(2009)
Mol Cell Biol
, vol.29
, pp. 3379-3389
-
-
Hwang, C.Y.1
Lee, C.2
Kwon, K.S.3
-
45
-
-
0034745353
-
Cytoplasmic localization of p21Cip1/WAF1 by Akt-induced phosphorylation in HER-2/neu-overexpressing cells
-
Zhou BP, Liao Y, Xia W, Spohn B, Lee MH, Hung MC. Cytoplasmic localization of p21Cip1/WAF1 by Akt-induced phosphorylation in HER-2/neu-overexpressing cells. Nat Cell Biol 2001; 3: 245-252.
-
(2001)
Nat Cell Biol
, vol.3
, pp. 245-252
-
-
Zhou, B.P.1
Liao, Y.2
Xia, W.3
Spohn, B.4
Lee, M.H.5
Hung, M.C.6
-
46
-
-
34548670994
-
Pim-1 kinase-dependent phosphorylation of p21Cip1/WAF1 regulates its stability and cellular localization in H1299 cells
-
Zhang Y, Wang Z, Magnuson NS. Pim-1 kinase-dependent phosphorylation of p21Cip1/WAF1 regulates its stability and cellular localization in H1299 cells. Mol Cancer Res 2007; 5: 909-922.
-
(2007)
Mol Cancer Res
, vol.5
, pp. 909-922
-
-
Zhang, Y.1
Wang, Z.2
Magnuson, N.S.3
-
47
-
-
21844468764
-
Mirk/Dyrk1B mediates survival during the differentiation of C2C12 myoblasts
-
Mercer SE, Ewton DZ, Deng X, Lim S, Mazur TR, Friedman E. Mirk/Dyrk1B mediates survival during the differentiation of C2C12 myoblasts. J Biol Chem 2005; 280: 25788-25801.
-
(2005)
J Biol Chem
, vol.280
, pp. 25788-25801
-
-
Mercer, S.E.1
Ewton, D.Z.2
Deng, X.3
Lim, S.4
Mazur, T.R.5
Friedman, E.6
-
48
-
-
23344441826
-
Binding of calmodulin to the carboxy-terminal region of p21 induces nuclear accumulation via inhibition of protein kinase C-mediated phosphorylation of Ser153
-
Rodriguez-Vilarrupla A, Jaumot M, Abella N, Canela N, Brun S, Diaz C et al. Binding of calmodulin to the carboxy-terminal region of p21 induces nuclear accumulation via inhibition of protein kinase C-mediated phosphorylation of Ser153. Mol Cell Biol 2005; 25: 7364-7374.
-
(2005)
Mol Cell Biol
, vol.25
, pp. 7364-7374
-
-
Rodriguez-Vilarrupla, A.1
Jaumot, M.2
Abella, N.3
Canela, N.4
Brun, S.5
Diaz, C.6
-
49
-
-
0037121534
-
Phosphorylation of the cell cycle inhibitor p21Cip1/WAF1 by Pim-1 kinase
-
Wang Z, Bhattacharya N, Mixter PF, Wei W, Sedivy J, Magnuson NS. Phosphorylation of the cell cycle inhibitor p21Cip1/WAF1 by Pim-1 kinase. Biochim Biophys Acta 2002; 1593: 45-55.
-
(2002)
Biochim Biophys Acta
, vol.1593
, pp. 45-55
-
-
Wang, Z.1
Bhattacharya, N.2
Mixter, P.F.3
Wei, W.4
Sedivy, J.5
Magnuson, N.S.6
-
50
-
-
0034646679
-
Reversible phosphorylation at the C-terminal regulatory domain of p21(Waf1/Cip1) modulates proliferating cell nuclear antigen binding
-
Scott MT, Morrice N, Ball KL. Reversible phosphorylation at the C-terminal regulatory domain of p21(Waf1/Cip1) modulates proliferating cell nuclear antigen binding. J Biol Chem 2000; 275: 11529-11537.
-
(2000)
J Biol Chem
, vol.275
, pp. 11529-11537
-
-
Scott, M.T.1
Morrice, N.2
Ball, K.L.3
-
51
-
-
34247577963
-
Negative regulation of ASK1 by p21Cip1 involves a small domain that includes Serine 98 that is phosphorylated by ASK1 in vivo
-
Zhan J, Easton JB, Huang S, Mishra A, Xiao L, Lacy ER et al. Negative regulation of ASK1 by p21Cip1 involves a small domain that includes Serine 98 that is phosphorylated by ASK1 in vivo. Mol Cell Biol 2007; 27: 3530-3541.
-
(2007)
Mol Cell Biol
, vol.27
, pp. 3530-3541
-
-
Zhan, J.1
Easton, J.B.2
Huang, S.3
Mishra, A.4
Xiao, L.5
Lacy, E.R.6
-
52
-
-
0033623850
-
Proteasomal turnover of p21Cip1 does not require p21Cip1 ubiquitination
-
Sheaff RJ, Singer JD, Swanger J, Smitherman M, Roberts JM, Clurman BE. Proteasomal turnover of p21Cip1 does not require p21Cip1 ubiquitination. Mol Cell 2000; 5: 403-410.
-
(2000)
Mol Cell
, vol.5
, pp. 403-410
-
-
Sheaff, R.J.1
Singer, J.D.2
Swanger, J.3
Smitherman, M.4
Roberts, J.M.5
Clurman, B.E.6
-
53
-
-
84855321395
-
Multiple degradation pathways regulate versatile CIP/KIP CDK inhibitors
-
Starostina NG, Kipreos ET. Multiple degradation pathways regulate versatile CIP/KIP CDK inhibitors. Trends Cell Biol 2012; 22: 33-41.
-
(2012)
Trends Cell Biol
, vol.22
, pp. 33-41
-
-
Starostina, N.G.1
Kipreos, E.T.2
-
54
-
-
65349151239
-
Nucleophosmin/B23 interacts with p21WAF1/CIP1 and contributes to its stability
-
Xiao J, Zhang Z, Chen GG, Zhang M, Ding Y, Fu J et al. Nucleophosmin/B23 interacts with p21WAF1/CIP1 and contributes to its stability. Cell Cycle 2009; 8: 889-895.
-
(2009)
Cell Cycle
, vol.8
, pp. 889-895
-
-
Xiao, J.1
Zhang, Z.2
Chen, G.G.3
Zhang, M.4
Ding, Y.5
Fu, J.6
-
55
-
-
12344249855
-
Regulation of p21(WAF1/CIP1) stability by WISp39, a Hsp90 binding TPR protein
-
Jascur T, Brickner H, Salles-Passador I, Barbier V, El KA, Smith B et al. Regulation of p21(WAF1/CIP1) stability by WISp39, a Hsp90 binding TPR protein. Mol Cell 2005; 17: 237-249.
-
(2005)
Mol Cell
, vol.17
, pp. 237-249
-
-
Jascur, T.1
Brickner, H.2
Salles-Passador, I.3
Barbier, V.4
El, K.A.5
Smith, B.6
-
56
-
-
0038219632
-
Ras promotes p21(Waf1/Cip1) protein stability via a cyclin D1-imposed block in proteasome-mediated degradation
-
Coleman ML, Marshall CJ, Olson MF. Ras promotes p21(Waf1/Cip1) protein stability via a cyclin D1-imposed block in proteasome-mediated degradation. EMBO J 2003; 22: 2036-2046.
-
(2003)
EMBO J
, vol.22
, pp. 2036-2046
-
-
Coleman, M.L.1
Marshall, C.J.2
Olson, M.F.3
-
57
-
-
77954152739
-
Ubiquitylation and proteasomal degradation of the p21(Cip1), p27(Kip1) and p57(Kip2) CDK inhibitors
-
Lu Z, Hunter T. Ubiquitylation and proteasomal degradation of the p21(Cip1), p27(Kip1) and p57(Kip2) CDK inhibitors. Cell Cycle 2010; 9: 2342-2352.
-
(2010)
Cell Cycle
, vol.9
, pp. 2342-2352
-
-
Lu, Z.1
Hunter, T.2
-
58
-
-
78149475460
-
Targeting p21 degradation locally
-
Xiong Y. Targeting p21 degradation locally. Dev Cell 2010; 19: 641-643.
-
(2010)
Dev Cell
, vol.19
, pp. 641-643
-
-
Xiong, Y.1
-
59
-
-
0032530151
-
Human CUL-1 associates with the SKP1/SKP2 complex and regulates p21(CIP1/WAF1) and cyclin D proteins
-
Yu ZK, Gervais JL, Zhang H. Human CUL-1 associates with the SKP1/SKP2 complex and regulates p21(CIP1/WAF1) and cyclin D proteins. Proc Natl Acad Sci USA 1998; 95: 11324-11329.
-
(1998)
Proc Natl Acad Sci USA
, vol.95
, pp. 11324-11329
-
-
Yu, Z.K.1
Gervais, J.L.2
Zhang, H.3
-
60
-
-
0038152755
-
Role of the SCFSkp2 ubiquitin ligase in the degradation of p21Cip1 in S phase
-
Bornstein G, Bloom J, Sitry-Shevah D, Nakayama K, Pagano M, Hershko A. Role of the SCFSkp2 ubiquitin ligase in the degradation of p21Cip1 in S phase. J Biol Chem 2003; 278: 25752-25757.
-
(2003)
J Biol Chem
, vol.278
, pp. 25752-25757
-
-
Bornstein, G.1
Bloom, J.2
Sitry-Shevah, D.3
Nakayama, K.4
Pagano, M.5
Hershko, A.6
-
61
-
-
27644451320
-
Ubiquitination of p21Cip1/WAF1 by SCFSkp2: Substrate requirement and ubiquitination site selection
-
Wang W, Nacusi L, Sheaff RJ, Liu X. Ubiquitination of p21Cip1/WAF1 by SCFSkp2: substrate requirement and ubiquitination site selection. Biochemistry 2005; 44: 14553-14564.
-
(2005)
Biochemistry
, vol.44
, pp. 14553-14564
-
-
Wang, W.1
Nacusi, L.2
Sheaff, R.J.3
Liu, X.4
-
62
-
-
51949098691
-
PCNA-dependent regulation of p21 ubiquitylation and degradation via the CRL4Cdt2 ubiquitin ligase complex
-
Abbas T, Sivaprasad U, Terai K, Amador V, Pagano M, Dutta A. PCNA-dependent regulation of p21 ubiquitylation and degradation via the CRL4Cdt2 ubiquitin ligase complex. Genes Dev 2008; 22: 2496-2506.
-
(2008)
Genes Dev
, vol.22
, pp. 2496-2506
-
-
Abbas, T.1
Sivaprasad, U.2
Terai, K.3
Amador, V.4
Pagano, M.5
Dutta, A.6
-
63
-
-
51949112601
-
The CRL4Cdt2 ubiquitin ligase targets the degradation of p21Cip1 to control replication licensing
-
Kim Y, Starostina NG, Kipreos ET. The CRL4Cdt2 ubiquitin ligase targets the degradation of p21Cip1 to control replication licensing. Genes Dev 2008; 22: 2507-2519.
-
(2008)
Genes Dev
, vol.22
, pp. 2507-2519
-
-
Kim, Y.1
Starostina, N.G.2
Kipreos, E.T.3
-
64
-
-
57049133181
-
CDK inhibitor p21 is degraded by a proliferating cell nuclear antigen-coupled Cul4-DDB1Cdt2 pathway during S phase and after UV irradiation
-
Nishitani H, Shiomi Y, Iida H, Michishita M, Takami T, Tsurimoto T. CDK inhibitor p21 is degraded by a proliferating cell nuclear antigen-coupled Cul4-DDB1Cdt2 pathway during S phase and after UV irradiation. J Biol Chem 2008; 283: 29045-29052.
-
(2008)
J Biol Chem
, vol.283
, pp. 29045-29052
-
-
Nishitani, H.1
Shiomi, Y.2
Iida, H.3
Michishita, M.4
Takami, T.5
Tsurimoto, T.6
-
65
-
-
34547174700
-
APC/C(Cdc20) controls the ubiquitin-mediated degradation of p21 in prometaphase
-
Amador V, Ge S, Santamaria PG, Guardavaccaro D, Pagano M. APC/C(Cdc20) controls the ubiquitin-mediated degradation of p21 in prometaphase. Mol Cell 2007; 27: 462-473.
-
(2007)
Mol Cell
, vol.27
, pp. 462-473
-
-
Amador, V.1
Ge, S.2
Santamaria, P.G.3
Guardavaccaro, D.4
Pagano, M.5
-
66
-
-
28544449224
-
Forkhead box M1 regulates the transcriptional network of genes essential for mitotic progression and genes encoding the SCF (Skp2-Cks1) ubiquitin ligase
-
Wang IC, Chen YJ, Hughes D, Petrovic V, Major ML, Park HJ et al. Forkhead box M1 regulates the transcriptional network of genes essential for mitotic progression and genes encoding the SCF (Skp2-Cks1) ubiquitin ligase. Mol Cell Biol 2005; 25: 10875-10894.
-
(2005)
Mol Cell Biol
, vol.25
, pp. 10875-10894
-
-
Wang, I.C.1
Chen, Y.J.2
Hughes, D.3
Petrovic, V.4
Major, M.L.5
Park, H.J.6
-
67
-
-
83755168800
-
Degradation of p21Cip1 through anaphase-promoting complex/cyclosome and its activator Cdc20 (APC/CCdc20) ubiquitin ligase complex-mediated ubiquitylation is inhibited by cyclin-dependent kinase 2 in cardiomyocytes
-
Yamada K, Tamamori-Adachi M, Goto I, Iizuka M, Yasukawa T, Aso T et al. Degradation of p21Cip1 through anaphase-promoting complex/cyclosome and its activator Cdc20 (APC/CCdc20) ubiquitin ligase complex-mediated ubiquitylation is inhibited by cyclin-dependent kinase 2 in cardiomyocytes. J Biol Chem 2011; 286: 44057-44066.
-
(2011)
J Biol Chem
, vol.286
, pp. 44057-44066
-
-
Yamada, K.1
Tamamori-Adachi, M.2
Goto, I.3
Iizuka, M.4
Yasukawa, T.5
Aso, T.6
-
68
-
-
78149486374
-
CRL2(LRR-1) targets a CDK inhibitor for cell cycle control in C. Elegans and actin-based motility regulation in human cells
-
Starostina NG, Simpliciano JM, McGuirk MA, Kipreos ET. CRL2(LRR-1) targets a CDK inhibitor for cell cycle control in C. elegans and actin-based motility regulation in human cells. Dev Cell 2010; 19: 753-764.
-
(2010)
Dev Cell
, vol.19
, pp. 753-764
-
-
Starostina, N.G.1
Simpliciano, J.M.2
Ma, M.3
Kipreos, E.T.4
-
69
-
-
0035872863
-
A degradation signal located in the C-terminus of p21WAF1/CIP1 is a binding site for the C8 alpha-subunit of the 20S proteasome
-
Touitou R, Richardson J, Bose S, Nakanishi M, Rivett J, Allday MJ. A degradation signal located in the C-terminus of p21WAF1/CIP1 is a binding site for the C8 alpha-subunit of the 20S proteasome. EMBO J 2001; 20: 2367-2375.
-
(2001)
EMBO J
, vol.20
, pp. 2367-2375
-
-
Touitou, R.1
Richardson, J.2
Bose, S.3
Nakanishi, M.4
Rivett, J.5
Allday, M.J.6
-
71
-
-
34250342888
-
Ubiquitin-independent degradation of cell-cycle inhibitors by the REGgamma proteasome
-
Chen X, Barton LF, Chi Y, Clurman BE, Roberts JM. Ubiquitin-independent degradation of cell-cycle inhibitors by the REGgamma proteasome. Mol Cell 2007; 26: 843-852.
-
(2007)
Mol Cell
, vol.26
, pp. 843-852
-
-
Chen, X.1
Barton, L.F.2
Chi, Y.3
Clurman, B.E.4
Roberts, J.M.5
-
72
-
-
34250339984
-
Ubiquitin-and ATP-independent proteolytic turnover of p21 by the REGgamma-proteasome pathway
-
Li X, Amazit L, Long W, Lonard DM, Monaco JJ, O'Malley BW. Ubiquitin-and ATP-independent proteolytic turnover of p21 by the REGgamma-proteasome pathway. Mol Cell 2007; 26: 831-842.
-
(2007)
Mol Cell
, vol.26
, pp. 831-842
-
-
Li, X.1
Amazit, L.2
Long, W.3
Lonard, D.M.4
Monaco, J.J.5
O'Malley, B.W.6
-
73
-
-
0346243936
-
MDM2 promotes p21waf1/cip1 proteasomal turnover independently of ubiquitylation
-
Jin Y, Lee H, Zeng SX, Dai MS, Lu H. MDM2 promotes p21waf1/cip1 proteasomal turnover independently of ubiquitylation. EMBO J 2003; 22: 6365-6377.
-
(2003)
EMBO J
, vol.22
, pp. 6365-6377
-
-
Jin, Y.1
Lee, H.2
Zeng, S.X.3
Dai, M.S.4
Lu, H.5
-
74
-
-
38949093780
-
MDMX promotes proteasomal turnover of p21 at G1 and early S phases independently of, but in cooperation with, MDM2
-
Jin Y, Zeng SX, Sun XX, Lee H, Blattner C, Xiao Z et al. MDMX promotes proteasomal turnover of p21 at G1 and early S phases independently of, but in cooperation with, MDM2. Mol Cell Biol 2008; 28: 1218-1229.
-
(2008)
Mol Cell Biol
, vol.28
, pp. 1218-1229
-
-
Jin, Y.1
Zeng, S.X.2
Sun, X.X.3
Lee, H.4
Blattner, C.5
Xiao, Z.6
-
75
-
-
0037119470
-
The stress-activated protein kinases p38 alpha and JNK1 stabilize p21(Cip1) by phosphorylation
-
Kim GY, Mercer SE, Ewton DZ, Yan Z, Jin K, Friedman E. The stress-activated protein kinases p38 alpha and JNK1 stabilize p21(Cip1) by phosphorylation. J Biol Chem 2002; 277: 29792-29802.
-
(2002)
J Biol Chem
, vol.277
, pp. 29792-29802
-
-
Kim, G.Y.1
Mercer, S.E.2
Ewton, D.Z.3
Yan, Z.4
Jin, K.5
Friedman, E.6
-
76
-
-
71949111129
-
MST kinases monitor actin cytoskeletal integrity and signal via c-Jun N-terminal kinase stressactivated kinase to regulate p21Waf1/Cip1 stability
-
Densham RM, O'Neill E, Munro J, Konig I, Anderson K, Kolch W et al. MST kinases monitor actin cytoskeletal integrity and signal via c-Jun N-terminal kinase stressactivated kinase to regulate p21Waf1/Cip1 stability. Mol Cell Biol 2009; 29: 6380-6390.
-
(2009)
Mol Cell Biol
, vol.29
, pp. 6380-6390
-
-
Densham, R.M.1
O'Neill, E.2
Munro, J.3
Konig, I.4
Anderson, K.5
Kolch, W.6
-
77
-
-
1442277686
-
Phage-peptide display identifies the interferon-responsive, death-activated protein kinase family as a novel modifier of MDM2 and p21WAF1
-
Burch LR, Scott M, Pohler E, Meek D, Hupp T. Phage-peptide display identifies the interferon-responsive, death-activated protein kinase family as a novel modifier of MDM2 and p21WAF1. J Mol Biol 2004; 337: 115-128.
-
(2004)
J Mol Biol
, vol.337
, pp. 115-128
-
-
Burch, L.R.1
Scott, M.2
Pohler, E.3
Meek, D.4
Hupp, T.5
-
78
-
-
34250022553
-
Regulation of cyclin-dependent kinase inhibitor p21WAF1/CIP1 by protein kinase Cdelta-mediated phosphorylation
-
Oh YT, Chun KH, Park BD, Choi JS, Lee SK. Regulation of cyclin-dependent kinase inhibitor p21WAF1/CIP1 by protein kinase Cdelta-mediated phosphorylation. Apoptosis 2007; 12: 1339-1347.
-
(2007)
Apoptosis
, vol.12
, pp. 1339-1347
-
-
Oh, Y.T.1
Chun, K.H.2
Park, B.D.3
Choi, J.S.4
Lee, S.K.5
-
79
-
-
0037192852
-
AKT/PKB phosphorylation of p21Cip/WAF1 enhances protein stability of p21Cip/WAF1 and promotes cell survival
-
Li Y, Dowbenko D, Lasky LA. AKT/PKB phosphorylation of p21Cip/WAF1 enhances protein stability of p21Cip/WAF1 and promotes cell survival. J Biol Chem 2002; 277: 11352-11361.
-
(2002)
J Biol Chem
, vol.277
, pp. 11352-11361
-
-
Li, Y.1
Dowbenko, D.2
Lasky, L.A.3
-
80
-
-
0037155824
-
Glycogen synthase kinase-3 couples AKT-dependent signaling to the regulation of p21Cip1 degradation
-
Rossig L, Badorff C, Holzmann Y, Zeiher AM, Dimmeler S. Glycogen synthase kinase-3 couples AKT-dependent signaling to the regulation of p21Cip1 degradation. J Biol Chem 2002; 277: 9684-9689.
-
(2002)
J Biol Chem
, vol.277
, pp. 9684-9689
-
-
Rossig, L.1
Badorff, C.2
Holzmann, Y.3
Zeiher, A.M.4
Dimmeler, S.5
-
81
-
-
34147221926
-
Glycogen synthase kinase 3beta phosphorylates p21WAF1/CIP1 for proteasomal degradation after UV irradiation
-
Lee JY, Yu SJ, Park YG, Kim J, Sohn J. Glycogen synthase kinase 3beta phosphorylates p21WAF1/CIP1 for proteasomal degradation after UV irradiation. Mol Cell Biol 2007; 27: 3187-3198.
-
(2007)
Mol Cell Biol
, vol.27
, pp. 3187-3198
-
-
Lee, J.Y.1
Yu, S.J.2
Park, Y.G.3
Kim, J.4
Sohn, J.5
-
82
-
-
84885466962
-
Lats2 phosphorylates p21/CDKN1A after UV irradiation and regulates apoptosis
-
Suzuki H, Yabuta N, Okada N, Torigata K, Aylon Y, Oren M et al. Lats2 phosphorylates p21/CDKN1A after UV irradiation and regulates apoptosis. J Cell Sci 2013; 126: 4358-4368.
-
(2013)
J Cell Sci
, vol.126
, pp. 4358-4368
-
-
Suzuki, H.1
Yabuta, N.2
Okada, N.3
Torigata, K.4
Aylon, Y.5
Oren, M.6
-
83
-
-
0037121923
-
PDK1-dependent activation of atypical PKC leads to degradation of the p21 tumour modifier protein
-
Scott MT, Ingram A, Ball KL. PDK1-dependent activation of atypical PKC leads to degradation of the p21 tumour modifier protein. EMBO J 2002; 21: 6771-6780.
-
(2002)
EMBO J
, vol.21
, pp. 6771-6780
-
-
Scott, M.T.1
Ingram, A.2
Ball, K.L.3
-
84
-
-
38849187293
-
CDK inhibitors: Cell cycle regulators and beyond
-
Besson A, Dowdy SF, Roberts JM. CDK inhibitors: cell cycle regulators and beyond. Dev Cell 2008; 14: 159-169.
-
(2008)
Dev Cell
, vol.14
, pp. 159-169
-
-
Besson, A.1
Dowdy, S.F.2
Roberts, J.M.3
-
85
-
-
69349100455
-
Linking the p53 tumour suppressor pathway to somatic cell reprogramming
-
Kawamura T, Suzuki J, Wang YV, Menendez S, Morera LB, Raya A et al. Linking the p53 tumour suppressor pathway to somatic cell reprogramming. Nature 2009; 460: 1140-1144.
-
(2009)
Nature
, vol.460
, pp. 1140-1144
-
-
Kawamura, T.1
Suzuki, J.2
Wang, Y.V.3
Menendez, S.4
Morera, L.B.5
Raya, A.6
-
86
-
-
69349100179
-
Suppression of induced pluripotent stem cell generation by the p53-p21 pathway
-
Hong H, Takahashi K, Ichisaka T, Aoi T, Kanagawa O, Nakagawa M et al. Suppression of induced pluripotent stem cell generation by the p53-p21 pathway. Nature 2009; 460: 1132-1135.
-
(2009)
Nature
, vol.460
, pp. 1132-1135
-
-
Hong, H.1
Takahashi, K.2
Ichisaka, T.3
Aoi, T.4
Kanagawa, O.5
Nakagawa, M.6
-
87
-
-
67649424560
-
Dutta A. P21 in cancer: Intricate networks and multiple activities
-
Abbas T, Dutta A. P21 in cancer: intricate networks and multiple activities. Nat Rev Cancer 2009; 9: 400-414.
-
(2009)
Nat Rev Cancer
, vol.9
, pp. 400-414
-
-
Abbas, T.1
-
88
-
-
77951978240
-
Multiple roles of the cell cycle inhibitor p21(CDKN1A) in the DNA damage response
-
Cazzalini O, Scovassi AI, Savio M, Stivala LA, Prosperi E. Multiple roles of the cell cycle inhibitor p21(CDKN1A) in the DNA damage response. Mutat Res 2010; 704: 12-20.
-
(2010)
Mutat Res
, vol.704
, pp. 12-20
-
-
Cazzalini, O.1
Scovassi, A.I.2
Savio, M.3
Stivala, L.A.4
Prosperi, E.5
-
89
-
-
0037042177
-
Oncogenic functions of tumour suppressor p21(Waf1/Cip1/Sdi1): Association with cell senescence and tumour-promoting activities of stromal fibroblasts
-
Roninson IB. Oncogenic functions of tumour suppressor p21(Waf1/Cip1/Sdi1): association with cell senescence and tumour-promoting activities of stromal fibroblasts. Cancer Lett 2002; 179: 1-14.
-
(2002)
Cancer Lett
, vol.179
, pp. 1-14
-
-
Roninson, I.B.1
-
90
-
-
84874887926
-
A novel p21 attenuator which is structurally related to sorafenib
-
Wettersten HI, Hee HS, Li C, Shiu EY, Wecksler AT, Hammock BD et al. A novel p21 attenuator which is structurally related to sorafenib. Cancer Biol Ther 2013; 14: 278-285.
-
(2013)
Cancer Biol Ther
, vol.14
, pp. 278-285
-
-
Wettersten, H.I.1
Hee, H.S.2
Li, C.3
Shiu, E.Y.4
Wecksler, A.T.5
Hammock, B.D.6
-
91
-
-
68949104261
-
Enhanced susceptibility of cyclin kinase inhibitor p21 knockout mice to high fat diet induced atherosclerosis
-
Khanna AK. Enhanced susceptibility of cyclin kinase inhibitor p21 knockout mice to high fat diet induced atherosclerosis. J Biomed Sci 2009; 16: 66.
-
(2009)
J Biomed Sci
, vol.16
, pp. 66
-
-
Khanna, A.K.1
-
92
-
-
80053455768
-
Elite control of HIV: P21 (waf-1/cip-1) at its best
-
Yu XG, Lichterfeld M. Elite control of HIV: p21 (waf-1/cip-1) at its best. Cell Cycle 2011; 10: 3213-3214.
-
(2011)
Cell Cycle
, vol.10
, pp. 3213-3214
-
-
Yu, X.G.1
Lichterfeld, M.2
-
93
-
-
0033080402
-
Transcriptional regulation of the p21((WAF1/CIP1)) gene
-
Gartel AL, Tyner AL. Transcriptional regulation of the p21((WAF1/CIP1)) gene. Exp Cell Res 1999; 246: 280-289.
-
(1999)
Exp Cell Res
, vol.246
, pp. 280-289
-
-
Gartel, A.L.1
Tyner, A.L.2
-
94
-
-
20144384882
-
Lost in transcription: P21 repression, mechanisms, and consequences
-
Gartel AL, Radhakrishnan SK. Lost in transcription: p21 repression, mechanisms, and consequences. Cancer Res 2005; 65: 3980-3985.
-
(2005)
Cancer Res
, vol.65
, pp. 3980-3985
-
-
Gartel, A.L.1
Radhakrishnan, S.K.2
-
95
-
-
0028981086
-
Topological control of p21WAF1/CIP1 expression in normal and neoplastic tissues
-
el-Deiry WS, Tokino T, Waldman T, Oliner JD, Velculescu VE, Burrell M et al. Topological control of p21WAF1/CIP1 expression in normal and neoplastic tissues. Cancer Res 1995; 55: 2910-2919.
-
(1995)
Cancer Res
, vol.55
, pp. 2910-2919
-
-
El-Deiry, W.S.1
Tokino, T.2
Waldman, T.3
Oliner, J.D.4
Velculescu, V.E.5
Burrell, M.6
-
96
-
-
0036594890
-
The role of the cyclin-dependent kinase inhibitor p21 in apoptosis
-
Gartel AL, Tyner AL. The role of the cyclin-dependent kinase inhibitor p21 in apoptosis. Mol Cancer Ther 2002; 1: 639-649.
-
(2002)
Mol Cancer Ther
, vol.1
, pp. 639-649
-
-
Gartel, A.L.1
Tyner, A.L.2
-
97
-
-
0030973878
-
New functional activities for the p21 family of CDK inhibitors
-
LaBaer J, Garrett MD, Stevenson LF, Slingerland JM, Sandhu C, Chou HS et al. New functional activities for the p21 family of CDK inhibitors. Genes Dev 1997; 11: 847-862.
-
(1997)
Genes Dev
, vol.11
, pp. 847-862
-
-
Labaer, J.1
Garrett, M.D.2
Stevenson, L.F.3
Slingerland, J.M.4
Sandhu, C.5
Chou, H.S.6
-
98
-
-
0033559264
-
The p21(Cip1) and p27(Kip1) CDK 'inhibitors' are essential activators of cyclin D-dependent kinases in murine fibroblasts
-
Cheng M, Olivier P, Diehl JA, Fero M, Roussel MF, Roberts JM et al. The p21(Cip1) and p27(Kip1) CDK 'inhibitors' are essential activators of cyclin D-dependent kinases in murine fibroblasts. EMBO J 1999; 18: 1571-1583.
-
(1999)
EMBO J
, vol.18
, pp. 1571-1583
-
-
Cheng, M.1
Olivier, P.2
Diehl, J.A.3
Fero, M.4
Roussel, M.F.5
Roberts, J.M.6
-
99
-
-
0347628818
-
P21Waf1/Cip1 as a therapeutic target in breast and other cancers
-
Weiss RH. P21Waf1/Cip1 as a therapeutic target in breast and other cancers. Cancer Cell 2003; 4: 425-429.
-
(2003)
Cancer Cell
, vol.4
, pp. 425-429
-
-
Weiss, R.H.1
-
100
-
-
0037304898
-
New roles for p21 and p27 cell-cycle inhibitors: A function for each cell compartment?
-
Coqueret O. New roles for p21 and p27 cell-cycle inhibitors: a function for each cell compartment? Trends Cell Biol 2003; 13: 65-70.
-
(2003)
Trends Cell Biol
, vol.13
, pp. 65-70
-
-
Coqueret, O.1
-
101
-
-
84869186918
-
Postmitotic neurons develop a p21-dependent senescence-like phenotype driven by a DNA damage response
-
Jurk D, Wang C, Miwa S, Maddick M, Korolchuk V, Tsolou A et al. Postmitotic neurons develop a p21-dependent senescence-like phenotype driven by a DNA damage response. Aging Cell 2012; 11: 996-1004.
-
(2012)
Aging Cell
, vol.11
, pp. 996-1004
-
-
Jurk, D.1
Wang, C.2
Miwa, S.3
Maddick, M.4
Korolchuk, V.5
Tsolou, A.6
-
102
-
-
84885614963
-
The proliferation-quiescence decision is controlled by a bifurcation in CDK2 activity at mitotic exit
-
Spencer SL, Cappell SD, Tsai FC, Overton KW, Wang CL, Meyer T. The proliferation-quiescence decision is controlled by a bifurcation in CDK2 activity at mitotic exit. Cell 2013; 155: 369-383.
-
(2013)
Cell
, vol.155
, pp. 369-383
-
-
Spencer, S.L.1
Cappell, S.D.2
Tsai, F.C.3
Overton, K.W.4
Wang, C.L.5
Meyer, T.6
-
103
-
-
0034635914
-
Effects of p21Waf1/Cip1/Sdi1 on cellular gene expression: Implications for carcinogenesis, senescence, and age-related diseases
-
Chang BD, Watanabe K, Broude EV, Fang J, Poole JC, Kalinichenko TV et al. Effects of p21Waf1/Cip1/Sdi1 on cellular gene expression: implications for carcinogenesis, senescence, and age-related diseases. Proc Natl Acad Sci USA 2000; 97: 4291-4296.
-
(2000)
Proc Natl Acad Sci USA
, vol.97
, pp. 4291-4296
-
-
Chang, B.D.1
Watanabe, K.2
Broude, E.V.3
Fang, J.4
Poole, J.C.5
Kalinichenko, T.V.6
-
104
-
-
84861477671
-
P21 as a transcriptional co-repressor of S-phase and mitotic control genes
-
Ferrandiz N, Caraballo JM, Garcia-Gutierrez L, Devgan V, Rodriguez-Paredes M, Lafita MC et al. P21 as a transcriptional co-repressor of S-phase and mitotic control genes. PLoS ONE 2012; 7: e37759.
-
(2012)
PLoS ONE
, vol.7
, pp. e37759
-
-
Ferrandiz, N.1
Caraballo, J.M.2
Garcia-Gutierrez, L.3
Devgan, V.4
Rodriguez-Paredes, M.5
Lafita, M.C.6
-
105
-
-
0028365708
-
Cell cycle expression and p53 regulation of the cyclin-dependent kinase inhibitor p21
-
Li Y, Jenkins CW, Nichols MA, Xiong Y. Cell cycle expression and p53 regulation of the cyclin-dependent kinase inhibitor p21. Oncogene 1994; 9: 2261-2268.
-
(1994)
Oncogene
, vol.9
, pp. 2261-2268
-
-
Li, Y.1
Jenkins, C.W.2
Ma, N.3
Xiong, Y.4
-
106
-
-
0031594705
-
Nuclear accumulation of p21Cip1 at the onset of mitosis: A role at the G2/M-phase transition
-
Dulic V, Stein GH, Far DF, Reed SI. Nuclear accumulation of p21Cip1 at the onset of mitosis: a role at the G2/M-phase transition. Mol Cell Biol 1998; 18: 546-557.
-
(1998)
Mol Cell Biol
, vol.18
, pp. 546-557
-
-
Dulic, V.1
Stein, G.H.2
Far, D.F.3
Reed, S.I.4
-
107
-
-
0032553485
-
Requirement for p53 and p21 to sustain G2 arrest after DNA damage
-
Bunz F, Dutriaux A, Lengauer C, Waldman T, Zhou S, Brown JP et al. Requirement for p53 and p21 to sustain G2 arrest after DNA damage. Science 1998; 282: 1497-1501.
-
(1998)
Science
, vol.282
, pp. 1497-1501
-
-
Bunz, F.1
Dutriaux, A.2
Lengauer, C.3
Waldman, T.4
Zhou, S.5
Brown, J.P.6
-
108
-
-
0343569823
-
Pietenpol JA. P53 regulation of G(2) checkpoint is retinoblastoma protein dependent
-
Flatt PM, Tang LJ, Scatena CD, Szak ST, Pietenpol JA. P53 regulation of G(2) checkpoint is retinoblastoma protein dependent. Mol Cell Biol 2000; 20: 4210-4223.
-
(2000)
Mol Cell Biol
, vol.20
, pp. 4210-4223
-
-
Flatt, P.M.1
Tang, L.J.2
Scatena, C.D.3
Szak, S.T.4
-
109
-
-
0031931414
-
Characterization of the p53-dependent postmitotic checkpoint following spindle disruption
-
Lanni JS, Jacks T. Characterization of the p53-dependent postmitotic checkpoint following spindle disruption. Mol Cell Biol 1998; 18: 1055-1064.
-
(1998)
Mol Cell Biol
, vol.18
, pp. 1055-1064
-
-
Lanni, J.S.1
Jacks, T.2
-
110
-
-
65249099623
-
DNA damage triggers p21WAF1-dependent Emi1 down-regulation that maintains G2 arrest
-
Lee J, Kim JA, Barbier V, Fotedar A, Fotedar R. DNA damage triggers p21WAF1-dependent Emi1 down-regulation that maintains G2 arrest. Mol Biol Cell 2009; 20: 1891-1902.
-
(2009)
Mol Biol Cell
, vol.20
, pp. 1891-1902
-
-
Lee, J.1
Kim, J.A.2
Barbier, V.3
Fotedar, A.4
Fotedar, R.5
-
111
-
-
0031961995
-
Effects of p21 (Cip1/Waf1) at both the G1/S and the G2/M cell cycle transitions: PRb is a critical determinant in blocking DNA replication and in preventing endoreduplication
-
Niculescu ABIII, Chen X, Smeets M, Hengst L, Prives C, Reed SI. Effects of p21 (Cip1/Waf1) at both the G1/S and the G2/M cell cycle transitions: pRb is a critical determinant in blocking DNA replication and in preventing endoreduplication. Mol Cell Biol 1998; 18: 629-643.
-
(1998)
Mol Cell Biol
, vol.18
, pp. 629-643
-
-
Abiii, N.1
Chen, X.2
Smeets, M.3
Hengst, L.4
Prives, C.5
Reed, S.I.6
-
112
-
-
0035900769
-
Involvement of the interaction between p21 and proliferating cell nuclear antigen for the maintenance of G2/M arrest after DNA damage
-
Ando T, Kawabe T, Ohara H, Ducommun B, Itoh M, Okamoto T. Involvement of the interaction between p21 and proliferating cell nuclear antigen for the maintenance of G2/M arrest after DNA damage. J Biol Chem 2001; 276: 42971-42977.
-
(2001)
J Biol Chem
, vol.276
, pp. 42971-42977
-
-
Ando, T.1
Kawabe, T.2
Ohara, H.3
Ducommun, B.4
Itoh, M.5
Okamoto, T.6
-
113
-
-
0032190833
-
Cell cycle arrest and DNA endoreduplication following p21Waf1/Cip1 expression
-
Bates S, Ryan KM, Phillips AC, Vousden KH. Cell cycle arrest and DNA endoreduplication following p21Waf1/Cip1 expression. Oncogene 1998; 17: 1691-1703.
-
(1998)
Oncogene
, vol.17
, pp. 1691-1703
-
-
Bates, S.1
Ryan, K.M.2
Phillips, A.C.3
Vousden, K.H.4
-
114
-
-
0042025008
-
Permanent cell cycle exit in G2 phase after DNA damage in normal human fibroblasts
-
Baus F, Gire V, Fisher D, Piette J, Dulic V. Permanent cell cycle exit in G2 phase after DNA damage in normal human fibroblasts. EMBO J 2003; 22: 3992-4002.
-
(2003)
EMBO J
, vol.22
, pp. 3992-4002
-
-
Baus, F.1
Gire, V.2
Fisher, D.3
Piette, J.4
Dulic, V.5
-
115
-
-
4344574113
-
P21-Mediated nuclear retention of cyclin B1-Cdk1 in response to genotoxic stress
-
Charrier-Savournin FB, Chateau MT, Gire V, Sedivy J, Piette J, Dulic V. P21-Mediated nuclear retention of cyclin B1-Cdk1 in response to genotoxic stress. Mol Biol Cell 2004; 15: 3965-3976.
-
(2004)
Mol Biol Cell
, vol.15
, pp. 3965-3976
-
-
Charrier-Savournin, F.B.1
Chateau, M.T.2
Gire, V.3
Sedivy, J.4
Piette, J.5
Dulic, V.6
-
116
-
-
58549085408
-
P21Cip1/WAF1 mediates cyclin B1 degradation in response to DNA damage
-
Gillis LD, Leidal AM, Hill R, Lee PW. P21Cip1/WAF1 mediates cyclin B1 degradation in response to DNA damage. Cell Cycle 2009; 8: 253-256.
-
(2009)
Cell Cycle
, vol.8
, pp. 253-256
-
-
Gillis, L.D.1
Leidal, A.M.2
Hill, R.3
Lee, P.W.4
-
117
-
-
0032576632
-
P21waf1 can block cells at two points in the cell cycle, but does not interfere with processive DNA-replication or stress-activated kinases
-
Medema RH, Klompmaker R, Smits VA, Rijksen G. P21waf1 can block cells at two points in the cell cycle, but does not interfere with processive DNA-replication or stress-activated kinases. Oncogene 1998; 16: 431-441.
-
(1998)
Oncogene
, vol.16
, pp. 431-441
-
-
Medema, R.H.1
Klompmaker, R.2
Smits, V.A.3
Rijksen, G.4
-
118
-
-
0034730246
-
P21 inhibits Thr161 phosphorylation of Cdc2 to enforce the G2 DNA damage checkpoint
-
Smits VA, Klompmaker R, Vallenius T, Rijksen G, Makela TP, Medema RH. P21 inhibits Thr161 phosphorylation of Cdc2 to enforce the G2 DNA damage checkpoint. J Biol Chem 2000; 275: 30638-30643.
-
(2000)
J Biol Chem
, vol.275
, pp. 30638-30643
-
-
Smits, V.A.1
Klompmaker, R.2
Vallenius, T.3
Rijksen, G.4
Makela, T.P.5
Medema, R.H.6
-
119
-
-
33845674925
-
P21(Waf1/Cip1) deficiency stimulates centriole overduplication
-
Duensing A, Ghanem L, Steinman RA, Liu Y, Duensing S. P21(Waf1/Cip1) deficiency stimulates centriole overduplication. Cell Cycle 2006; 5: 2899-2902.
-
(2006)
Cell Cycle
, vol.5
, pp. 2899-2902
-
-
Duensing, A.1
Ghanem, L.2
Steinman, R.A.3
Liu, Y.4
Duensing, S.5
-
120
-
-
0033557572
-
P21(cip-1/waf-1) deficiency causes deformed nuclear architecture, centriole overduplication, polyploidy, and relaxed microtubule damage checkpoints in human hematopoietic cells
-
Mantel C, Braun SE, Reid S, Henegariu O, Liu L, Hangoc G et al. P21(cip-1/waf-1) deficiency causes deformed nuclear architecture, centriole overduplication, polyploidy, and relaxed microtubule damage checkpoints in human hematopoietic cells. Blood 1999; 93: 1390-1398.
-
(1999)
Blood
, vol.93
, pp. 1390-1398
-
-
Mantel, C.1
Braun, S.E.2
Reid, S.3
Henegariu, O.4
Liu, L.5
Hangoc, G.6
-
121
-
-
39749087580
-
P21(WAF1/CIP1) may be a tumor suppressor after all
-
Gartel AL. P21(WAF1/CIP1) may be a tumor suppressor after all. Cancer Biol Ther 2007; 6: 1171-1172.
-
(2007)
Cancer Biol Ther
, vol.6
, pp. 1171-1172
-
-
Gartel, A.L.1
-
122
-
-
33845922655
-
P21 delays tumor onset by preservation of chromosomal stability
-
Barboza JA, Liu G, Ju Z, El-Naggar AK, Lozano G. P21 delays tumor onset by preservation of chromosomal stability. Proc Natl Acad Sci USA 2006; 103: 19842-19847.
-
(2006)
Proc Natl Acad Sci USA
, vol.103
, pp. 19842-19847
-
-
Barboza, J.A.1
Liu, G.2
Ju, Z.3
El-Naggar, A.K.4
Lozano, G.5
-
123
-
-
34250315824
-
DNA damage-induced cellular senescence is sufficient to suppress tumorigenesis: A mouse model
-
Van NT, Puebla-Osorio N, Pang H, Dujka ME, Zhu C. DNA damage-induced cellular senescence is sufficient to suppress tumorigenesis: a mouse model. J Exp Med 2007; 204: 1453-1461.
-
(2007)
J Exp Med
, vol.204
, pp. 1453-1461
-
-
Van Nt Puebla-Osorio, N.1
Pang, H.2
Dujka, M.E.3
Zhu, C.4
-
124
-
-
0029058587
-
Inhibition of cyclin-dependent kinases by p21
-
Harper JW, Elledge SJ, Keyomarsi K, Dynlacht B, Tsai LH, Zhang P et al. Inhibition of cyclin-dependent kinases by p21. Mol Biol Cell 1995; 6: 387-400.
-
(1995)
Mol Biol Cell
, vol.6
, pp. 387-400
-
-
Harper, J.W.1
Elledge, S.J.2
Keyomarsi, K.3
Dynlacht, B.4
Tsai, L.H.5
Zhang, P.6
-
125
-
-
0032514752
-
Activity and nature of p21(WAF1) complexes during the cell cycle
-
Cai K, Dynlacht BD. Activity and nature of p21(WAF1) complexes during the cell cycle. Proc Natl Acad Sci USA 1998; 95: 12254-12259.
-
(1998)
Proc Natl Acad Sci USA
, vol.95
, pp. 12254-12259
-
-
Cai, K.1
Dynlacht, B.D.2
-
126
-
-
59449101448
-
Long-term downregulation of Polo-like kinase 1 increases the cyclin-dependent kinase inhibitor p21(WAF1/CIP1)
-
Kreis NN, Sommer K, Sanhaji M, Kramer A, Matthess Y, Kaufmann M et al. Long-term downregulation of Polo-like kinase 1 increases the cyclin-dependent kinase inhibitor p21(WAF1/CIP1). Cell Cycle 2009; 8: 460-472.
-
(2009)
Cell Cycle
, vol.8
, pp. 460-472
-
-
Kreis, N.N.1
Sommer, K.2
Sanhaji, M.3
Kramer, A.4
Matthess, Y.5
Kaufmann, M.6
-
127
-
-
0030011128
-
Uncoupling of S phase and mitosis induced by anticancer agents in cells lacking p21
-
Waldman T, Lengauer C, Kinzler KW, Vogelstein B. Uncoupling of S phase and mitosis induced by anticancer agents in cells lacking p21. Nature 1996; 381: 713-716.
-
(1996)
Nature
, vol.381
, pp. 713-716
-
-
Waldman, T.1
Lengauer, C.2
Kinzler, K.W.3
Vogelstein, B.4
-
128
-
-
0032952584
-
P21(Waf1/Cip1) inhibition of cyclin E/Cdk2 activity prevents endoreduplication after mitotic spindle disruption
-
Stewart ZA, Leach SD, Pietenpol JA. P21(Waf1/Cip1) inhibition of cyclin E/Cdk2 activity prevents endoreduplication after mitotic spindle disruption. Mol Cell Biol 1999; 19: 205-215.
-
(1999)
Mol Cell Biol
, vol.19
, pp. 205-215
-
-
Stewart, Z.A.1
Leach, S.D.2
Pietenpol, J.A.3
-
129
-
-
20444410393
-
Cdk2 is dispensable for cell cycle inhibition and tumor suppression mediated by p27 (Kip1) and p21(Cip1)
-
Martin A, Odajima J, Hunt SL, Dubus P, Ortega S, Malumbres M et al. Cdk2 is dispensable for cell cycle inhibition and tumor suppression mediated by p27 (Kip1) and p21(Cip1). Cancer Cell 2005; 7: 591-598.
-
(2005)
Cancer Cell
, vol.7
, pp. 591-598
-
-
Martin, A.1
Odajima, J.2
Hunt, S.L.3
Dubus, P.4
Ortega, S.5
Malumbres, M.6
-
130
-
-
84889001029
-
P21Waf1/Cip1 deficiency causes multiple mitotic defects in tumor cells
-
epub ahead of print 9 December 2013
-
Kreis NN, Sanhaji M, Rieger MA, Louwen F, Yuan J. P21Waf1/Cip1 deficiency causes multiple mitotic defects in tumor cells. Oncogene 2013; epub ahead of print 9 December 2013; doi:10.1038/onc.2013.518.
-
(2013)
Oncogene
-
-
Kreis, N.N.1
Sanhaji, M.2
Ma, R.3
Louwen, F.4
Yuan, J.5
-
131
-
-
60749109846
-
Cell cycle CDKs and cancer: A changing paradigm
-
Malumbres M, Barbacid M. Cell cycle, CDKs and cancer: a changing paradigm. Nat Rev Cancer 2009; 9: 153-166.
-
(2009)
Nat Rev Cancer
, vol.9
, pp. 153-166
-
-
Malumbres, M.1
Barbacid, M.2
-
132
-
-
0033145508
-
Temporal and spatial control of cyclin B1 destruction in metaphase
-
Clute P, Pines J. Temporal and spatial control of cyclin B1 destruction in metaphase. Nat Cell Biol 1999; 1: 82-87.
-
(1999)
Nat Cell Biol
, vol.1
, pp. 82-87
-
-
Clute, P.1
Pines, J.2
-
133
-
-
0026089183
-
Cyclin is degraded by the ubiquitin pathway
-
Glotzer M, Murray AW, Kirschner MW. Cyclin is degraded by the ubiquitin pathway. Nature 1991; 349: 132-138.
-
(1991)
Nature
, vol.349
, pp. 132-138
-
-
Glotzer, M.1
Murray, A.W.2
Kirschner, M.W.3
-
134
-
-
0024978338
-
Cyclin synthesis drives the early embryonic cell cycle
-
Murray AW, Kirschner MW. Cyclin synthesis drives the early embryonic cell cycle. Nature 1989; 339: 275-280.
-
(1989)
Nature
, vol.339
, pp. 275-280
-
-
Murray, A.W.1
Kirschner, M.W.2
-
135
-
-
0035339232
-
The schedule of destruction of three mitotic cyclins can dictate the timing of events during exit from mitosis
-
Parry DH, O'Farrell PH. The schedule of destruction of three mitotic cyclins can dictate the timing of events during exit from mitosis. Curr Biol 2001; 11: 671-683.
-
(2001)
Curr Biol
, vol.11
, pp. 671-683
-
-
Parry, D.H.1
O'Farrell, P.H.2
-
136
-
-
54249138783
-
Rapid cycling and precocious termination of G1 phase in cells expressing CDK1AF
-
Pomerening JR, Ubersax JA, Ferrell JE Jr. Rapid cycling and precocious termination of G1 phase in cells expressing CDK1AF. Mol Biol Cell 2008; 19: 3426-3441.
-
(2008)
Mol Biol Cell
, vol.19
, pp. 3426-3441
-
-
Pomerening, J.R.1
Ubersax, J.A.2
Ferrell, J.E.3
-
137
-
-
33745522462
-
Dose-dependent effects of stable cyclin B1 on progression through mitosis in human cells
-
Wolf F, Wandke C, Isenberg N, Geley S. Dose-dependent effects of stable cyclin B1 on progression through mitosis in human cells. EMBO J 2006; 25: 2802-2813.
-
(2006)
EMBO J
, vol.25
, pp. 2802-2813
-
-
Wolf, F.1
Wandke, C.2
Isenberg, N.3
Geley, S.4
-
138
-
-
38349133609
-
The end of the beginning: Cdk1 thresholds and exit from mitosis
-
Wolf F, Sigl R, Geley S. '. The end of the beginning': cdk1 thresholds and exit from mitosis. Cell Cycle 2007; 6: 1408-1411.
-
(2007)
Cell Cycle
, vol.6
, pp. 1408-1411
-
-
Wolf, F.1
Sigl, R.2
Geley, S.3
-
139
-
-
33645865537
-
The reversibility of mitotic exit in vertebrate cells
-
Potapova TA, Daum JR, Pittman BD, Hudson JR, Jones TN, Satinover DL et al. The reversibility of mitotic exit in vertebrate cells. Nature 2006; 440: 954-958.
-
(2006)
Nature
, vol.440
, pp. 954-958
-
-
Potapova, T.A.1
Daum, J.R.2
Pittman, B.D.3
Hudson, J.R.4
Jones, T.N.5
Satinover, D.L.6
-
140
-
-
0036223382
-
Probing the dynamics and functions of aurora B kinase in living cells during mitosis and cytokinesis
-
Murata-Hori M, Tatsuka M, Wang YL. Probing the dynamics and functions of aurora B kinase in living cells during mitosis and cytokinesis. Mol Biol Cell 2002; 13: 1099-1108.
-
(2002)
Mol Biol Cell
, vol.13
, pp. 1099-1108
-
-
Murata-Hori, M.1
Tatsuka, M.2
Wang, Y.L.3
-
141
-
-
4344640384
-
Cell cycle regulation of central spindle assembly
-
Mishima M, Pavicic V, Gruneberg U, Nigg EA, Glotzer M. Cell cycle regulation of central spindle assembly. Nature 2004; 430: 908-913.
-
(2004)
Nature
, vol.430
, pp. 908-913
-
-
Mishima, M.1
Pavicic, V.2
Gruneberg, U.3
Nigg, E.A.4
Glotzer, M.5
-
142
-
-
84875895893
-
Aurora B prevents delayed DNA replication and premature mitotic exit by repressing p21 (Cip1)
-
Trakala M, Fernandez-Miranda G, Perez dC I, Heeschen C, Malumbres M. Aurora B prevents delayed DNA replication and premature mitotic exit by repressing p21 (Cip1). Cell Cycle 2013; 12: 1030-1041.
-
(2013)
Cell Cycle
, vol.12
, pp. 1030-1041
-
-
Trakala, M.1
Fernandez-Miranda, G.2
Perez Dc, I.3
Heeschen, C.4
Malumbres, M.5
-
143
-
-
77955167321
-
Multifaceted polo-like kinases: Drug targets and antitargets for cancer therapy
-
Strebhardt K. Multifaceted polo-like kinases: drug targets and antitargets for cancer therapy. Nat Rev Drug Discov 2010; 9: 643-660.
-
(2010)
Nat Rev Drug Discov
, vol.9
, pp. 643-660
-
-
Strebhardt, K.1
-
144
-
-
84870527677
-
Mitosis-targeted anti-cancer therapies: Where they stand
-
Chan KS, Koh CG, Li HY. Mitosis-targeted anti-cancer therapies: where they stand. Cell Death Dis 2012; 3: e411.
-
(2012)
Cell Death Dis
, vol.3
, pp. e411
-
-
Chan, K.S.1
Koh, C.G.2
Li, H.Y.3
-
145
-
-
84884228131
-
Battle of the eternal rivals: Restoring functional p53 and inhibiting Polo-like kinase 1 as cancer therapy
-
Louwen F, Yuan J. Battle of the eternal rivals: restoring functional p53 and inhibiting Polo-like kinase 1 as cancer therapy. Oncotarget 2013; 4: 958-971.
-
(2013)
Oncotarget
, vol.4
, pp. 958-971
-
-
Louwen, F.1
Yuan, J.2
-
146
-
-
47149085982
-
P21 and p27: Roles in carcinogenesis and drug resistance
-
Abukhdeir AM, Park BH. P21 and p27: roles in carcinogenesis and drug resistance. Expert Rev Mol Med 2008; 10: e19.
-
(2008)
Expert Rev Mol Med
, vol.10
, pp. e19
-
-
Abukhdeir, A.M.1
Park, B.H.2
-
147
-
-
0028220204
-
P53-dependent inhibition of cyclin-dependent kinase activities in human fibroblasts during radiation-induced G1 arrest
-
Dulic V, Kaufmann WK, Wilson SJ, Tlsty TD, Lees E, Harper JW et al. P53-dependent inhibition of cyclin-dependent kinase activities in human fibroblasts during radiation-induced G1 arrest. Cell 1994; 76: 1013-1023.
-
(1994)
Cell
, vol.76
, pp. 1013-1023
-
-
Dulic, V.1
Kaufmann, W.K.2
Wilson, S.J.3
Tlsty, T.D.4
Lees, E.5
Harper, J.W.6
-
148
-
-
0032920581
-
Overexpression of c-Myc inhibits p21WAF1/CIP1 expression and induces S-phase entry in 12-O-tetradecanoylphorbol-13-acetate (TPA)-sensitive human cancer cells
-
Mitchell KO, el-Deiry WS. Overexpression of c-Myc inhibits p21WAF1/CIP1 expression and induces S-phase entry in 12-O-tetradecanoylphorbol-13-acetate (TPA)-sensitive human cancer cells. Cell Growth Differ 1999; 10: 223-230.
-
(1999)
Cell Growth Differ
, vol.10
, pp. 223-230
-
-
Mitchell, K.O.1
El-Deiry, W.S.2
-
149
-
-
0042197268
-
Are p27 and p21 cytoplasmic oncoproteins?
-
Blagosklonny MV. Are p27 and p21 cytoplasmic oncoproteins? Cell Cycle 2002; 1: 391-393.
-
(2002)
Cell Cycle
, vol.1
, pp. 391-393
-
-
Blagosklonny, M.V.1
-
150
-
-
0028849274
-
P21 is necessary for the p53-mediated G1 arrest in human cancer cells
-
Waldman T, Kinzler KW, Vogelstein B. P21 is necessary for the p53-mediated G1 arrest in human cancer cells. Cancer Res 1995; 55: 5187-5190.
-
(1995)
Cancer Res
, vol.55
, pp. 5187-5190
-
-
Waldman, T.1
Kinzler, K.W.2
Vogelstein, B.3
-
151
-
-
0037732510
-
P21Cip1 nullizygosity increases tumor metastasis in irradiated mice
-
Jackson RJ, Engelman RW, Coppola D, Cantor AB, Wharton W, Pledger WJ. P21Cip1 nullizygosity increases tumor metastasis in irradiated mice. Cancer Res 2003; 63: 3021-3025.
-
(2003)
Cancer Res
, vol.63
, pp. 3021-3025
-
-
Jackson, R.J.1
Engelman, R.W.2
Coppola, D.3
Cantor, A.B.4
Wharton, W.5
Pledger, W.J.6
-
152
-
-
0029805005
-
Cyclin kinase inhibitor p21WAF1/CIP1 in malignant melanoma: Reduced expression in metastatic lesions
-
Maelandsmo GM, Holm R, Fodstad O, Kerbel RS, Florenes VA. Cyclin kinase inhibitor p21WAF1/CIP1 in malignant melanoma: reduced expression in metastatic lesions. Am J Pathol 1996; 149: 1813-1822.
-
(1996)
Am J Pathol
, vol.149
, pp. 1813-1822
-
-
Maelandsmo, G.M.1
Holm, R.2
Fodstad, O.3
Kerbel, R.S.4
Florenes, V.A.5
-
153
-
-
84856446634
-
The cyclin-dependent kinase inhibitor p21CDKN1A as a target of anti-cancer drugs
-
Stivala LA, Cazzalini O, Prosperi E. The cyclin-dependent kinase inhibitor p21CDKN1A as a target of anti-cancer drugs. Curr Cancer Drug Targets 2012; 12: 85-96.
-
(2012)
Curr Cancer Drug Targets
, vol.12
, pp. 85-96
-
-
Stivala, L.A.1
Cazzalini, O.2
Prosperi, E.3
-
154
-
-
0347717882
-
Cytoplasmic p21Cip1 is involved in Ras-induced inhibition of the ROCK/LIMK/cofilin pathway
-
Lee S, Helfman DM. Cytoplasmic p21Cip1 is involved in Ras-induced inhibition of the ROCK/LIMK/cofilin pathway. J Biol Chem 2004; 279: 1885-1891.
-
(2004)
J Biol Chem
, vol.279
, pp. 1885-1891
-
-
Lee, S.1
Helfman, D.M.2
-
155
-
-
1942434712
-
Cip/Kip proteins: More than just CDKs inhibitors
-
Denicourt C, Dowdy SF. Cip/Kip proteins: more than just CDKs inhibitors. Genes Dev 2004; 18: 851-855.
-
(2004)
Genes Dev
, vol.18
, pp. 851-855
-
-
Denicourt, C.1
Dowdy, S.F.2
-
156
-
-
0034629129
-
Hematopoietic stem cell quiescence maintained by p21cip1/waf1
-
Cheng T, Rodrigues N, Shen H, Yang Y, Dombkowski D, Sykes M et al. Hematopoietic stem cell quiescence maintained by p21cip1/waf1. Science 2000; 287: 1804-1808.
-
(2000)
Science
, vol.287
, pp. 1804-1808
-
-
Cheng, T.1
Rodrigues, N.2
Shen, H.3
Yang, Y.4
Dombkowski, D.5
Sykes, M.6
-
157
-
-
58149236959
-
Cell-cycle restriction limits DNA damage and maintains self-renewal of leukaemia stem cells
-
Viale A, De FF, Orleth A, Cambiaghi V, Giuliani V, Bossi D et al. Cell-cycle restriction limits DNA damage and maintains self-renewal of leukaemia stem cells. Nature 2009; 457: 51-56.
-
(2009)
Nature
, vol.457
, pp. 51-56
-
-
Viale, A.1
De Ff Orleth, A.2
Cambiaghi, V.3
Giuliani, V.4
Bossi, D.5
-
158
-
-
84876489727
-
Cancer stem cells: The challenges ahead
-
Medema JP. Cancer stem cells: the challenges ahead. Nat Cell Biol 2013; 15: 338-344.
-
(2013)
Nat Cell Biol
, vol.15
, pp. 338-344
-
-
Medema, J.P.1
-
159
-
-
73149086829
-
P21CIP1 attenuates Ras-and c-Myc-dependent breast tumor epithelial mesenchymal transition and cancer stem cell-like gene expression in vivo
-
Liu M, Casimiro MC, Wang C, Shirley LA, Jiao X, Katiyar S et al. P21CIP1 attenuates Ras-and c-Myc-dependent breast tumor epithelial mesenchymal transition and cancer stem cell-like gene expression in vivo. Proc Natl Acad Sci USA 2009; 106: 19035-19039.
-
(2009)
Proc Natl Acad Sci USA
, vol.106
, pp. 19035-19039
-
-
Liu, M.1
Casimiro, M.C.2
Wang, C.3
Shirley, L.A.4
Jiao, X.5
Katiyar, S.6
-
160
-
-
50549218525
-
The limited in vitro lifetime of human diploid cell strains
-
Hayflick L. THE LIMITED IN VITRO LIFETIME OF HUMAN DIPLOID CELL STRAINS. Exp Cell Res 1965; 37: 614-636.
-
(1965)
Exp Cell Res
, vol.37
, pp. 614-636
-
-
Hayflick, L.1
-
161
-
-
79951912532
-
Four faces of cellular senescence
-
Rodier F, Campisi J. Four faces of cellular senescence. J Cell Biol 2011; 192: 547-556.
-
(2011)
J Cell Biol
, vol.192
, pp. 547-556
-
-
Rodier, F.1
Campisi, J.2
-
162
-
-
84860650725
-
Cellular senescence and cancer chemotherapy resistance
-
Gordon RR, Nelson PS. Cellular senescence and cancer chemotherapy resistance. Drug Resist Updat 2012; 15: 123-131.
-
(2012)
Drug Resist Updat
, vol.15
, pp. 123-131
-
-
Gordon, R.R.1
Nelson, P.S.2
-
163
-
-
84878726714
-
Small-molecule inhibitors of p21 as novel therapeutics for chemotherapy-resistant kidney cancer
-
Liu R, Wettersten HI, Park SH, Weiss RH. Small-molecule inhibitors of p21 as novel therapeutics for chemotherapy-resistant kidney cancer. Future Med Chem 2013; 5: 991-994.
-
(2013)
Future Med Chem
, vol.5
, pp. 991-994
-
-
Liu, R.1
Wettersten, H.I.2
Park, S.H.3
Weiss, R.H.4
-
164
-
-
0037945210
-
Paclitaxel increases p21 synthesis and accumulation of its AKT-phosphorylated form in the cytoplasm of cancer cells
-
Heliez C, Baricault L, Barboule N, Valette A. Paclitaxel increases p21 synthesis and accumulation of its AKT-phosphorylated form in the cytoplasm of cancer cells. Oncogene 2003; 22: 3260-3268.
-
(2003)
Oncogene
, vol.22
, pp. 3260-3268
-
-
Heliez, C.1
Baricault, L.2
Barboule, N.3
Valette, A.4
-
165
-
-
33646844478
-
Cytoplasmic p21WAF1/CIP1 correlates with Akt activation and poor response to tamoxifen in breast cancer
-
Perez-Tenorio G, Berglund F, Esguerra MA, Nordenskjold B, Rutqvist LE, Skoog L et al. Cytoplasmic p21WAF1/CIP1 correlates with Akt activation and poor response to tamoxifen in breast cancer. Int J Oncol 2006; 28: 1031-1042.
-
(2006)
Int J Oncol
, vol.28
, pp. 1031-1042
-
-
Perez-Tenorio, G.1
Berglund, F.2
Ma, E.3
Nordenskjold, B.4
Rutqvist, L.E.5
Skoog, L.6
-
166
-
-
0033621560
-
Jorgensen TJ. P21WAF1/CIP1 antisense therapy radiosensitizes human colon cancer by converting growth arrest to apoptosis
-
Tian H, Wittmack EK, Jorgensen TJ. P21WAF1/CIP1 antisense therapy radiosensitizes human colon cancer by converting growth arrest to apoptosis. Cancer Res 2000; 60: 679-684.
-
(2000)
Cancer Res
, vol.60
, pp. 679-684
-
-
Tian, H.1
Wittmack, E.K.2
-
167
-
-
84866619153
-
Cytoplasmic translocation of p21 mediates NUPR1-induced chemoresistance: NUPR1 and p21 in chemoresistance
-
Vincent AJ, Ren S, Harris LG, Devine DJ, Samant RS, Fodstad O et al. Cytoplasmic translocation of p21 mediates NUPR1-induced chemoresistance: NUPR1 and p21 in chemoresistance. FEBS Lett 2012; 586: 3429-3434.
-
(2012)
FEBS Lett
, vol.586
, pp. 3429-3434
-
-
Vincent, A.J.1
Ren, S.2
Harris, L.G.3
Devine, D.J.4
Samant, R.S.5
Fodstad, O.6
-
168
-
-
34447343401
-
Cytoplasmic expression of p21CIP1/WAF1 is correlated with IKKbeta overexpression in human breast cancers
-
Ping B, He X, Xia W, Lee DF, Wei Y, Yu D et al. Cytoplasmic expression of p21CIP1/WAF1 is correlated with IKKbeta overexpression in human breast cancers. Int J Oncol 2006; 29: 1103-1110.
-
(2006)
Int J Oncol
, vol.29
, pp. 1103-1110
-
-
Ping, B.1
He, X.2
Xia, W.3
Lee, D.F.4
Wei, Y.5
Yu, D.6
-
169
-
-
0035192637
-
Subcellular localisation of cyclin B, Cdc2 and p21(WAF1/CIP1) in breast cancer. Association with prognosis
-
Winters ZE, Hunt NC, Bradburn MJ, Royds JA, Turley H, Harris AL et al. Subcellular localisation of cyclin B, Cdc2 and p21(WAF1/CIP1) in breast cancer. association with prognosis. Eur J Cancer 2001; 37: 2405-2412.
-
(2001)
Eur J Cancer
, vol.37
, pp. 2405-2412
-
-
Winters, Z.E.1
Hunt, N.C.2
Bradburn, M.J.3
Royds, J.A.4
Turley, H.5
Harris, A.L.6
-
170
-
-
0346485798
-
Cytoplasmic p21WAF1/CIP1 expression is correlated with HER-2/neu in breast cancer and is an independent predictor of prognosis
-
Winters ZE, Leek RD, Bradburn MJ, Norbury CJ, Harris AL. Cytoplasmic p21WAF1/CIP1 expression is correlated with HER-2/neu in breast cancer and is an independent predictor of prognosis. Breast Cancer Res 2003; 5: R242-R249.
-
(2003)
Breast Cancer Res
, vol.5
, pp. R242-R249
-
-
Winters, Z.E.1
Leek, R.D.2
Bradburn, M.J.3
Norbury, C.J.4
Harris, A.L.5
-
171
-
-
2542640227
-
Phosphorylation/cytoplasmic localization of p21Cip1/WAF1 is associated with HER2/neu overexpression and provides a novel combination predictor for poor prognosis in breast cancer patients
-
Xia W, Chen JS, Zhou X, Sun PR, Lee DF, Liao Y et al. Phosphorylation/cytoplasmic localization of p21Cip1/WAF1 is associated with HER2/neu overexpression and provides a novel combination predictor for poor prognosis in breast cancer patients. Clin Cancer Res 2004; 10: 3815-3824.
-
(2004)
Clin Cancer Res
, vol.10
, pp. 3815-3824
-
-
Xia, W.1
Chen, J.S.2
Zhou, X.3
Sun, P.R.4
Lee, D.F.5
Liao, Y.6
-
172
-
-
77957832584
-
Cytoplasmic p21 expression levels determine cisplatin resistance in human testicular cancer
-
Koster R, di PA, Timmer-Bosscha H, Gibcus JH, van den Berg A, Suurmeijer AJ et al. Cytoplasmic p21 expression levels determine cisplatin resistance in human testicular cancer. J Clin Invest 2010; 120: 3594-3605.
-
(2010)
J Clin Invest
, vol.120
, pp. 3594-3605
-
-
Koster, R.1
Di, P.A.2
Timmer-Bosscha, H.3
Gibcus, J.H.4
Van Den Berg, A.5
Suurmeijer, A.J.6
-
173
-
-
80053173452
-
Cytoplasmic p21 is a potential predictor for cisplatin sensitivity in ovarian cancer
-
Xia X, Ma Q, Li X, Ji T, Chen P, Xu H et al. Cytoplasmic p21 is a potential predictor for cisplatin sensitivity in ovarian cancer. BMC Cancer 2011; 11: 399.
-
(2011)
BMC Cancer
, vol.11
, pp. 399
-
-
Xia, X.1
Ma, Q.2
Li, X.3
Ji, T.4
Chen, P.5
Xu, H.6
-
174
-
-
0036044835
-
The cyclin-dependent kinase inhibitor butyrolactone is a potent inhibitor of p21 (WAF1/CIP1 expression)
-
Sax JK, Dash BC, Hong R, Dicker DT, el-Deiry WS. The cyclin-dependent kinase inhibitor butyrolactone is a potent inhibitor of p21 (WAF1/CIP1 expression). Cell Cycle 2002; 1: 90-96.
-
(2002)
Cell Cycle
, vol.1
, pp. 90-96
-
-
Sax, J.K.1
Dash, B.C.2
Hong, R.3
Dicker, D.T.4
El-Deiry, W.S.5
-
175
-
-
58149119381
-
High throughput screening of a small molecule one-bead-one-compound combinatorial library to identify attenuators of p21 as chemotherapy sensitizers
-
Park SH, Wang X, Liu R, Lam KS, Weiss RH. High throughput screening of a small molecule one-bead-one-compound combinatorial library to identify attenuators of p21 as chemotherapy sensitizers. Cancer Biol Ther 2008; 7: 2015-2022.
-
(2008)
Cancer Biol Ther
, vol.7
, pp. 2015-2022
-
-
Park, S.H.1
Wang, X.2
Liu, R.3
Lam, K.S.4
Weiss, R.H.5
-
176
-
-
80655129639
-
Sorafenib attenuates p21 in kidney cancer cells and augments cell death in combination with DNA-damaging chemotherapy
-
Inoue H, Hwang SH, Wecksler AT, Hammock BD, Weiss RH. Sorafenib attenuates p21 in kidney cancer cells and augments cell death in combination with DNA-damaging chemotherapy. Cancer Biol Ther 2011; 12: 827-836.
-
(2011)
Cancer Biol Ther
, vol.12
, pp. 827-836
-
-
Inoue, H.1
Hwang, S.H.2
Wecksler, A.T.3
Hammock, B.D.4
Weiss, R.H.5
-
177
-
-
81355154522
-
Mutant p53 gain of function is interwoven into the hallmarks of cancer
-
Solomon H, Madar S, Rotter V. Mutant p53 gain of function is interwoven into the hallmarks of cancer. J Pathol 2011; 225: 475-478.
-
(2011)
J Pathol
, vol.225
, pp. 475-478
-
-
Solomon, H.1
Madar, S.2
Rotter, V.3
-
178
-
-
84884192068
-
The mutant p53 mouse as a pre-clinical model
-
Jackson JG, Lozano G. The mutant p53 mouse as a pre-clinical model. Oncogene 2013; 32: 4325-4330.
-
(2013)
Oncogene
, vol.32
, pp. 4325-4330
-
-
Jackson, J.G.1
Lozano, G.2
-
179
-
-
79952284127
-
Hallmarks of cancer: The next generation
-
Hanahan D, Weinberg RA. Hallmarks of cancer: the next generation. Cell 2011; 144: 646-674.
-
(2011)
Cell
, vol.144
, pp. 646-674
-
-
Hanahan, D.1
Weinberg, R.A.2
|