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Volumn 586, Issue 19, 2012, Pages 3429-3434

Cytoplasmic translocation of p21 mediates NUPR1-induced chemoresistance: NUPR1 and p21 in chemoresistance

Author keywords

Akt; Chemoresistance; IKK ; NUPR1; P21

Indexed keywords

DOXORUBICIN; I KAPPA B KINASE BETA; NUCLEAR PROTEIN; NUCLEAR PROTEIN 1; PHOSPHATIDYLINOSITOL 3 KINASE; PROTEIN BCL XL; PROTEIN KINASE B; PROTEIN P21; PROTEIN P53; UNCLASSIFIED DRUG;

EID: 84866619153     PISSN: 00145793     EISSN: 18733468     Source Type: Journal    
DOI: 10.1016/j.febslet.2012.07.063     Document Type: Article
Times cited : (50)

References (44)
  • 1
    • 77949351429 scopus 로고    scopus 로고
    • A phase 2 study of a fixed combination of uracil and ftorafur (UFT) and leucovorin given orally in a 3-times-daily regimen to treat patients with recurrent metastatic breast cancer
    • G.N. Hortobagyi, W. Heim, L. Hutchins, E. Rivera, B. Mason, D.J. Booser, and J. Kirshner A phase 2 study of a fixed combination of uracil and ftorafur (UFT) and leucovorin given orally in a 3-times-daily regimen to treat patients with recurrent metastatic breast cancer Cancer 116 2010 1440 1445
    • (2010) Cancer , vol.116 , pp. 1440-1445
    • Hortobagyi, G.N.1    Heim, W.2    Hutchins, L.3    Rivera, E.4    Mason, B.5    Booser, D.J.6    Kirshner, J.7
  • 2
    • 0031415404 scopus 로고    scopus 로고
    • Retreating recurrent breast cancer with the same CMF-containing regimen used as adjuvant therapy
    • International Breast Cancer Study Group
    • M. Castiglione-Gertsch, and The International Breast Cancer Study Group Retreating recurrent breast cancer with the same CMF-containing regimen used as adjuvant therapy Eur. J. Cancer 33 1997 2321 2325
    • (1997) Eur. J. Cancer , vol.33 , pp. 2321-2325
    • Castiglione-Gertsch, M.1
  • 4
    • 0035119539 scopus 로고    scopus 로고
    • Expression of p8 in human pancreatic cancer
    • S.B. Su Expression of p8 in human pancreatic cancer Clin. Cancer Res. 7 2001 309 313
    • (2001) Clin. Cancer Res. , vol.7 , pp. 309-313
    • Su, S.B.1
  • 5
    • 0036336214 scopus 로고    scopus 로고
    • Clinical and cell line specific expression profiles of a human gene identified in experimental central nervous system metastases
    • A.H. Ree Clinical and cell line specific expression profiles of a human gene identified in experimental central nervous system metastases Anticancer Res. 22 2002 1949 1957
    • (2002) Anticancer Res. , vol.22 , pp. 1949-1957
    • Ree, A.H.1
  • 6
    • 0242352520 scopus 로고    scopus 로고
    • Expression and cellular localization of p8 protein in thyroid neoplasms
    • Y. Ito Expression and cellular localization of p8 protein in thyroid neoplasms Cancer Lett. 201 2003 237 244
    • (2003) Cancer Lett. , vol.201 , pp. 237-244
    • Ito, Y.1
  • 7
    • 5044234185 scopus 로고    scopus 로고
    • Reexpression of p8 contributes to tumorigenic properties of pituitary cells and appears in a subset of prolactinomas in transgenic mice that hypersecrete luteinizing hormone
    • H.P. Mohammad, D.D. Seachrist, C.C. Quirk, and J.H. Nilson Reexpression of p8 contributes to tumorigenic properties of pituitary cells and appears in a subset of prolactinomas in transgenic mice that hypersecrete luteinizing hormone Mol. Endocrinol. 18 2004 2583 2593
    • (2004) Mol. Endocrinol. , vol.18 , pp. 2583-2593
    • Mohammad, H.P.1    Seachrist, D.D.2    Quirk, C.C.3    Nilson, J.H.4
  • 8
    • 77950899469 scopus 로고    scopus 로고
    • Deficiency of the transcriptional regulator p8 results in increased autophagy and apoptosis, and causes impaired heart function
    • D.K. Kong, S.P. Georgescu, C. Cano, M.J. Aronovitz, J.L. Iovanna, R.D. Patten, J.M. Kyriakis, and S. Goruppi Deficiency of the transcriptional regulator p8 results in increased autophagy and apoptosis, and causes impaired heart function Mol. Biol. Cell 21 2010 1335 1349
    • (2010) Mol. Biol. Cell , vol.21 , pp. 1335-1349
    • Kong, D.K.1    Georgescu, S.P.2    Cano, C.3    Aronovitz, M.J.4    Iovanna, J.L.5    Patten, R.D.6    Kyriakis, J.M.7    Goruppi, S.8
  • 9
    • 48849090170 scopus 로고    scopus 로고
    • NUPR1 interacts with p53, transcriptionally regulates p21 and rescues breast epithelial cells from doxorubicin-induced genotoxic stress
    • D.W. Clark, A. Mitra, R.A. Fillmore, W.G. Jiang, R.S. Samant, O. Fodstad, and L.A. Shevde NUPR1 interacts with p53, transcriptionally regulates p21 and rescues breast epithelial cells from doxorubicin-induced genotoxic stress Curr. Cancer Drug Targets 8 2008 421 430
    • (2008) Curr. Cancer Drug Targets , vol.8 , pp. 421-430
    • Clark, D.W.1    Mitra, A.2    Fillmore, R.A.3    Jiang, W.G.4    Samant, R.S.5    Fodstad, O.6    Shevde, L.A.7
  • 10
    • 0033567927 scopus 로고    scopus 로고
    • Expression of a novel factor in human breast cancer cells with metastatic potential
    • A.H. Ree Expression of a novel factor in human breast cancer cells with metastatic potential Cancer Res. 59 1999 4675 4680
    • (1999) Cancer Res. , vol.59 , pp. 4675-4680
    • Ree, A.H.1
  • 12
    • 0033104495 scopus 로고    scopus 로고
    • Apoptosis inhibitory activity of cytoplasmic p21(Cip1/WAF1) in monocyticdifferentiation
    • M. Asada, T. Yamada, H. Ichijo, D. Delia, K. Miyazono, K. Fukumuro, and 5. Mizutani Apoptosis inhibitory activity of cytoplasmic p21(Cip1/WAF1) in monocyticdifferentiation EMBO J. 18 1999 1223 1234
    • (1999) EMBO J. , vol.18 , pp. 1223-1234
    • Asada, M.1    Yamada, T.2    Ichijo, H.3    Delia, D.4    Miyazono, K.5    Fukumuro, K.6    Mizutani, S.7
  • 13
    • 0042197268 scopus 로고    scopus 로고
    • Are p27 and p21 cytoplasmic oncoproteins?
    • M.V. Blagosklonny Are p27 and p21 cytoplasmic oncoproteins? Cell Cycle 1 2002 391 393
    • (2002) Cell Cycle , vol.1 , pp. 391-393
    • Blagosklonny, M.V.1
  • 14
    • 0029058587 scopus 로고
    • Inhibition of cyclin-dependent kinases by p21
    • J.W. Harper Inhibition of cyclin-dependent kinases by p21 Mol. Biol. Cell 6 1995 387 400
    • (1995) Mol. Biol. Cell , vol.6 , pp. 387-400
    • Harper, J.W.1
  • 15
    • 0027981476 scopus 로고
    • Cdk-interacting protein 1 directly binds with proliferating cell nuclear antigen and inhibits DNA replication catalyzed by the DNA polymerase delta holoenzyme
    • H. Flores-Rozas, Z. Kelman, F.B. Dean, Z.Q. Pan, J.W. Harper, S.J. Elledge, M. O'Donnell, and J. Hurwitz Cdk-interacting protein 1 directly binds with proliferating cell nuclear antigen and inhibits DNA replication catalyzed by the DNA polymerase delta holoenzyme Proc. Natl. Acad. Sci. USA 91 1994 8655 8659
    • (1994) Proc. Natl. Acad. Sci. USA , vol.91 , pp. 8655-8659
    • Flores-Rozas, H.1    Kelman, Z.2    Dean, F.B.3    Pan, Z.Q.4    Harper, J.W.5    Elledge, S.J.6    O'Donnell, M.7    Hurwitz, J.8
  • 16
    • 34247577963 scopus 로고    scopus 로고
    • Negative regulation of ASK1 by p21Cip1 involves a small domain that includes Serine 98 that is phosphorylated by ASK1 in vivo
    • J. Zhan, J.B. Easton, S. Huang, A. Mishra, L. Xiao, E.R. Lacy, R.W. Kriwacki, and P.J. Houghton Negative regulation of ASK1 by p21Cip1 involves a small domain that includes Serine 98 that is phosphorylated by ASK1 in vivo Mol. Cell. Biol. 27 2007 3530 3541
    • (2007) Mol. Cell. Biol. , vol.27 , pp. 3530-3541
    • Zhan, J.1    Easton, J.B.2    Huang, S.3    Mishra, A.4    Xiao, L.5    Lacy, E.R.6    Kriwacki, R.W.7    Houghton, P.J.8
  • 17
    • 0033499801 scopus 로고    scopus 로고
    • BCL-2 is phosphorylated and inactivated by an ASK1/Jun N-terminal protein kinase pathway normally activated at G(2)/M
    • K. Yamamoto, H. Ichijo, and S.J. Korsmeyer BCL-2 is phosphorylated and inactivated by an ASK1/Jun N-terminal protein kinase pathway normally activated at G(2)/M Mol. Cell. Biol. 19 1999 8469 8478
    • (1999) Mol. Cell. Biol. , vol.19 , pp. 8469-8478
    • Yamamoto, K.1    Ichijo, H.2    Korsmeyer, S.J.3
  • 22
    • 0034745353 scopus 로고    scopus 로고
    • Cytoplasmic localization of p21Cip1/WAF1 by Akt-induced phosphorylation in HER- 2/neu-overexpressing cells
    • B.P. Zhou, Y. Liao, W. Xia, B. Spohn, M.H. Lee, and M.C. Hung Cytoplasmic localization of p21Cip1/WAF1 by Akt-induced phosphorylation in HER- 2/neu-overexpressing cells Nat. Cell. Biol. 3 2001 245 252
    • (2001) Nat. Cell. Biol. , vol.3 , pp. 245-252
    • Zhou, B.P.1    Liao, Y.2    Xia, W.3    Spohn, B.4    Lee, M.H.5    Hung, M.C.6
  • 23
    • 2542640227 scopus 로고    scopus 로고
    • Phosphorylation/cytoplasmic localization of p21Cip1/WAF1 is associated with HER2/neu overexpression and provides a novel combination predictor for poor prognosis in breast cancer patients
    • W. Xia, J.S. Chen, X. Zhou, P.R. Sun, D.F. Lee, Y. Liao, B.P. Zhou, and M.C. Hung Phosphorylation/cytoplasmic localization of p21Cip1/WAF1 is associated with HER2/neu overexpression and provides a novel combination predictor for poor prognosis in breast cancer patients Clin. Cancer Res. 10 2004 3815 3824
    • (2004) Clin. Cancer Res. , vol.10 , pp. 3815-3824
    • Xia, W.1    Chen, J.S.2    Zhou, X.3    Sun, P.R.4    Lee, D.F.5    Liao, Y.6    Zhou, B.P.7    Hung, M.C.8
  • 24
    • 23044436390 scopus 로고    scopus 로고
    • Activation of ErbB2 by overexpression or by transmembrane neuregulin results in differential signaling and sensitivity to herceptin
    • L. Yuste, J.C. Montero, A. Esparis-Ogando, and A. Pandiella Activation of ErbB2 by overexpression or by transmembrane neuregulin results in differential signaling and sensitivity to herceptin Cancer Res. 65 2005 6801 6810
    • (2005) Cancer Res. , vol.65 , pp. 6801-6810
    • Yuste, L.1    Montero, J.C.2    Esparis-Ogando, A.3    Pandiella, A.4
  • 26
    • 0037945210 scopus 로고    scopus 로고
    • Paclitaxel increases p21 synthesis and accumulation of its AKT-phosphorylated form in the cytoplasm of cancer cells
    • C. Heliez, L. Baricault, N. Barboule, and A. Valette Paclitaxel increases p21 synthesis and accumulation of its AKT-phosphorylated form in the cytoplasm of cancer cells Oncogene 22 2003 3260 3268
    • (2003) Oncogene , vol.22 , pp. 3260-3268
    • Heliez, C.1    Baricault, L.2    Barboule, N.3    Valette, A.4
  • 27
    • 34447343401 scopus 로고    scopus 로고
    • Cytoplasmic expression of p21CIP1/WAF1 is correlated with IKKbeta overexpression in human breast cancers
    • B. Ping Cytoplasmic expression of p21CIP1/WAF1 is correlated with IKKbeta overexpression in human breast cancers Int. J. Oncol. 29 2006 1103 1110
    • (2006) Int. J. Oncol. , vol.29 , pp. 1103-1110
    • Ping, B.1
  • 28
    • 58149090998 scopus 로고    scopus 로고
    • Identification of the major phosphorylation site in Bcl-xL induced by microtubule inhibitors and analysis of its functional significance
    • M. Upreti, E.N. Galitovskaya, R. Chu, A.J. Tackett, D.T. Terrano, S. Granell, and T.C. Chambers Identification of the major phosphorylation site in Bcl-xL induced by microtubule inhibitors and analysis of its functional significance J. Biol. Chem. 283 2008 35517 35525
    • (2008) J. Biol. Chem. , vol.283 , pp. 35517-35525
    • Upreti, M.1    Galitovskaya, E.N.2    Chu, R.3    Tackett, A.J.4    Terrano, D.T.5    Granell, S.6    Chambers, T.C.7
  • 29
    • 64649098653 scopus 로고    scopus 로고
    • Augmentation of sodium butyrate-induced apoptosis by phosphatidylinositol 3-kinase inhibition in the human cervical cancer cell-line
    • J.K. Park, C.H. Cho, S. Ramachandran, S.J. Shin, S.H. Kwon, S.Y. Kwon, and S.D. Cha Augmentation of sodium butyrate-induced apoptosis by phosphatidylinositol 3-kinase inhibition in the human cervical cancer cell-line Cancer Res. Treat. 38 2006 112 117
    • (2006) Cancer Res. Treat. , vol.38 , pp. 112-117
    • Park, J.K.1    Cho, C.H.2    Ramachandran, S.3    Shin, S.J.4    Kwon, S.H.5    Kwon, S.Y.6    Cha, S.D.7
  • 30
    • 0037192852 scopus 로고    scopus 로고
    • AKT/PKB phosphorylation of p21Cip/WAF1 enhances protein stability of p21Cip/WAF1 and promotes cell survival
    • Y. Li, D. Dowbenko, and L.A. Lasky AKT/PKB phosphorylation of p21Cip/WAF1 enhances protein stability of p21Cip/WAF1 and promotes cell survival J. Biol. Chem. 277 2002 11352 11361
    • (2002) J. Biol. Chem. , vol.277 , pp. 11352-11361
    • Li, Y.1    Dowbenko, D.2    Lasky, L.A.3
  • 31
    • 0031465799 scopus 로고    scopus 로고
    • Cloning and expression of the rat p8 cDNA, a new gene activated in pancreas during the acute phase of pancreatitis, pancreatic development, and regeneration, and which promotes cellular growth
    • G.V. Mallo, F. Fiedler, E.L. Calvo, E.M. Ortiz, S. Vasseur, V. Keim, J. Morisset, and J.L. Iovanna Cloning and expression of the rat p8 cDNA, a new gene activated in pancreas during the acute phase of pancreatitis, pancreatic development, and regeneration, and which promotes cellular growth J. Biol. Chem. 272 1997 32360 32369
    • (1997) J. Biol. Chem. , vol.272 , pp. 32360-32369
    • Mallo, G.V.1    Fiedler, F.2    Calvo, E.L.3    Ortiz, E.M.4    Vasseur, S.5    Keim, V.6    Morisset, J.7    Iovanna, J.L.8
  • 32
    • 15444362203 scopus 로고    scopus 로고
    • Com-1/P8 in oestrogen regulated growth of breast cancer cells, the ER-beta connection
    • W.G. Jiang, G. Davies, and O. Fodstad Com-1/P8 in oestrogen regulated growth of breast cancer cells, the ER-beta connection Biochem. Biophys. Res. Commun. 330 2005 253 262
    • (2005) Biochem. Biophys. Res. Commun. , vol.330 , pp. 253-262
    • Jiang, W.G.1    Davies, G.2    Fodstad, O.3
  • 33
    • 1342304085 scopus 로고    scopus 로고
    • P8 improves pancreatic response to acute pancreatitis by enhancing the expression of the anti-inflammatory protein pancreatitis-associated protein i
    • S. Vasseur p8 improves pancreatic response to acute pancreatitis by enhancing the expression of the anti-inflammatory protein pancreatitis- associated protein I J. Biol. Chem. 279 2004 7199 7207
    • (2004) J. Biol. Chem. , vol.279 , pp. 7199-7207
    • Vasseur, S.1
  • 34
    • 0032572789 scopus 로고    scopus 로고
    • Resistance to Fas-mediated apoptosis: Activation of caspase 3 is regulated by cell cycle regulator p21WAF1 and IAP gene family ILP
    • A. Suzuki, Y. Tsutomi, K. Akahane, T. Araki, and M. Miura Resistance to Fas-mediated apoptosis: activation of caspase 3 is regulated by cell cycle regulator p21WAF1 and IAP gene family ILP Oncogene 17 1998 931 939
    • (1998) Oncogene , vol.17 , pp. 931-939
    • Suzuki, A.1    Tsutomi, Y.2    Akahane, K.3    Araki, T.4    Miura, M.5
  • 35
    • 0035192637 scopus 로고    scopus 로고
    • Subcellular localisation of cyclin B, Cdc2 and p21(WAF1/CIP1) in breast cancer association with prognosis
    • Z.E. Winters, N.C. Hunt, M.J. Bradburn, J.A. Royds, H. Turley, A.L. Harris, and C.J. Norbury Subcellular localisation of cyclin B, Cdc2 and p21(WAF1/CIP1) in breast cancer association with prognosis Eur. J. Cancer 37 2001 2405 2412
    • (2001) Eur. J. Cancer , vol.37 , pp. 2405-2412
    • Winters, Z.E.1    Hunt, N.C.2    Bradburn, M.J.3    Royds, J.A.4    Turley, H.5    Harris, A.L.6    Norbury, C.J.7
  • 36
    • 30344478587 scopus 로고    scopus 로고
    • Is Cyclin D1-CDK4 kinase a bona fide cancer target?
    • M. Malumbres, and M. Barbacid Is Cyclin D1-CDK4 kinase a bona fide cancer target? Cancer Cell 9 2006 2 4
    • (2006) Cancer Cell , vol.9 , pp. 2-4
    • Malumbres, M.1    Barbacid, M.2
  • 38
    • 77951295615 scopus 로고    scopus 로고
    • Distinct gene mutation profiles among luminal-type and basal-type breast cancer cell lines
    • A. Hollestelle Distinct gene mutation profiles among luminal-type and basal-type breast cancer cell lines Breast Cancer Res. Treat. 121 2010 53 64
    • (2010) Breast Cancer Res. Treat. , vol.121 , pp. 53-64
    • Hollestelle, A.1
  • 39
    • 0035971181 scopus 로고    scopus 로고
    • Phosphatidylinositol 3-kinase/AKT-mediated activation of estrogen receptor alpha: A new model for anti-estrogen resistance
    • R.A. Campbell, P. Bhat-Nakshatri, N.M. Patel, D. Constantinidou, S. Ali, and H. Nakshatri Phosphatidylinositol 3-kinase/AKT-mediated activation of estrogen receptor alpha: a new model for anti-estrogen resistance J. Biol. Chem. 276 2001 9817 9824
    • (2001) J. Biol. Chem. , vol.276 , pp. 9817-9824
    • Campbell, R.A.1    Bhat-Nakshatri, P.2    Patel, N.M.3    Constantinidou, D.4    Ali, S.5    Nakshatri, H.6
  • 40
    • 18244391514 scopus 로고    scopus 로고
    • Activation of AKT/PKB in breast cancer predicts a worse outcome among endocrine treated patients
    • G. Perez-Tenorio, and O. Stal Activation of AKT/PKB in breast cancer predicts a worse outcome among endocrine treated patients Br. J. Cancer 86 2002 540 545
    • (2002) Br. J. Cancer , vol.86 , pp. 540-545
    • Perez-Tenorio, G.1    Stal, O.2
  • 41
    • 20244376768 scopus 로고    scopus 로고
    • Phospho-akt expression is associated with a favorable outcome in non-small cell lung cancer
    • A. Shah Phospho-akt expression is associated with a favorable outcome in non-small cell lung cancer Clin. Cancer Res. 11 2005 2930 2936
    • (2005) Clin. Cancer Res. , vol.11 , pp. 2930-2936
    • Shah, A.1
  • 43
    • 67349103358 scopus 로고    scopus 로고
    • Inhibition of PI3K-AKT-mTOR signaling sensitizes melanoma cells to cisplatin and temozolomide
    • T. Sinnberg Inhibition of PI3K-AKT-mTOR signaling sensitizes melanoma cells to cisplatin and temozolomide J. Invest. Dermatol. 129 2009 1500 1515
    • (2009) J. Invest. Dermatol. , vol.129 , pp. 1500-1515
    • Sinnberg, T.1
  • 44
    • 27844598284 scopus 로고    scopus 로고
    • The Akt/PKB pathway: Molecular target for cancer drug discovery
    • J.Q. Cheng, C.W. Lindsley, G.Z. Cheng, H. Yang, and S.V. Nicosia The Akt/PKB pathway: molecular target for cancer drug discovery Oncogene 24 2005 7482 7492
    • (2005) Oncogene , vol.24 , pp. 7482-7492
    • Cheng, J.Q.1    Lindsley, C.W.2    Cheng, G.Z.3    Yang, H.4    Nicosia, S.V.5


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