Endoproteolytic activity of the proteasome

Science

Volumn 299, Issue 5605, 2003, Pages 408-411

  Liu, Chang Wei ^a   Corboy, Michael J ^a   DeMartino, George N ^a   Thomas, Philip J ^a  

^a UNIVERSITY OF TEXAS SOUTHWESTERN MEDICAL CENTER   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

DEGRADATION; PROTEINS; SUBSTRATES;

PROTEASOMES;

MOLECULAR BIOLOGY;

PROTEASOME;

PEPTIDE; PROTEIN;

ARTICLE; CHANNEL GATING; ENZYME ACTIVE SITE; ENZYME ACTIVITY; ENZYME SUBSTRATE; MODEL; MOLECULAR MECHANICS; NONHUMAN; PRIORITY JOURNAL; PROTEIN BINDING; PROTEIN DEGRADATION; PROTEIN DOMAIN; PROTEIN FOLDING;

AMINO ACID SEQUENCE; CYCLIN-DEPENDENT KINASE INHIBITOR P21; CYCLINS; CYCLIZATION; CYSTEINE ENDOPEPTIDASES; CYSTEINE PROTEINASE INHIBITORS; GREEN FLUORESCENT PROTEINS; LEUPEPTINS; LUMINESCENT PROTEINS; MULTIENZYME COMPLEXES; NERVE TISSUE PROTEINS; PEPTIDE HYDROLASES; PROTEASOME ENDOPEPTIDASE COMPLEX; PROTEIN CONFORMATION; PROTEIN FOLDING; PROTEIN SPLICING; PROTEIN STRUCTURE, TERTIARY; RECOMBINANT FUSION PROTEINS; SYNUCLEINS;

EID: 0037449572     PISSN: 00368075     EISSN: None     Source Type: Journal    
DOI: 10.1126/science.1079293     Document Type: Article

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34. We thank S. J. Elledge (Baylor College of Medicine) for his generous gift of p21cDNA; R. Nussbaum (National Human Genome Research Institute) for α-syn cDNA; C. Wigley, R. 5tidham, and 5. Muallem for critical suggestions; and members of our laboratories for helpful comments. This work was supported by grants from the Welch Foundation (P.J.T.), Muscular Dystrophy Association (G.N.D.), and NIH [grants DK46818 (G.N.D.) and DK49835 (PJ.T.)].