Ras promotes p21Waf1/Cip1 protein stability via a cyclin D1-imposed block in proteasome-mediated degradation

EMBO Journal

Volumn 22, Issue 9, 2003, Pages 2036-2046

  Coleman, Mathew L ^a,b   Marshall, Christopher J ^a   Olson, Michael F ^a,b  

^a INSTITUTE OF CANCER RESEARCH   (United Kingdom)

^b UNIVERSITY OF PENNSYLVANIA   (United States)

Author keywords

Cyclin; Degradation; p21Waf1 Cip1; Proteasome; Ras

Indexed keywords

CYCLIN D1; MITOGEN ACTIVATED PROTEIN KINASE; PROTEASOME; PROTEIN P21; PROTEIN SUBUNIT; RAS PROTEIN;

ANIMAL CELL; ARTICLE; COMPLEX FORMATION; CONTROLLED STUDY; ENZYME ACTIVATION; FIBROBLAST; FIBROBLAST CULTURE; IN VITRO STUDY; MOUSE; NONHUMAN; NORTHERN BLOTTING; PRIORITY JOURNAL; PROTEIN BINDING; PROTEIN DEGRADATION; PROTEIN FUNCTION; PROTEIN PROTEIN INTERACTION; PROTEIN PURIFICATION; PROTEIN STABILITY; SIGNAL TRANSDUCTION; TRANSCRIPTION REGULATION;

3T3 CELLS; ANIMALS; BASE SEQUENCE; BINDING SITES; CELL LINE, TRANSFORMED; CYCLIN D1; CYCLIN-DEPENDENT KINASE INHIBITOR P21; CYCLINS; CYSTEINE ENDOPEPTIDASES; DNA PRIMERS; HYDROLYSIS; MICE; MULTIENZYME COMPLEXES; PROTEASOME ENDOPEPTIDASE COMPLEX; RAS PROTEINS; RNA PROCESSING, POST-TRANSCRIPTIONAL;

ANIMALIA; MURINAE;

EID: 0038219632     PISSN: 02614189     EISSN: None     Source Type: Journal    
DOI: 10.1093/emboj/cdg189     Document Type: Article

References (46)

1. Adams, P.D., Sellers, W.R., Sharma, S.K., Wu, A.D., Nalin, C.M. and Kaelin, W.G., Jr (1996) Identification of a cyclin-cdk2 recognition motif present in substrates and p21-like cyclin-dependent kinase inhibitors. Mol. Cell. Biol., 16, 6623-6633.
2. WAF1/CIP1 is upregulated by the geranylgeranyltransferase I inhibitor GGTI-298 through a transforming growth factor β- and Sp1-responsive element: involvement of the small GTPase rhoA. Mol. Cell. Biol., 18, 6962-6970.
3. Alessandrini, A., Chiaur, D.S. and Pagano, M. (1997) Regulation of the cyclin-dependent kinase inhibitor p27 by degradation and phosphorylation. Leukemia, 11, 342-345.
4. Cip1 promotes cyclin D1 nuclear accumulation via direct inhibition of nuclear export. J. Biol. Chem., 277, 8517-8523.
5. WAF1. Curr. Biol., 7, 71-80.
6. Bates, S., Parry, D., Bonetta, L., Vousden, K., Dickson, C. and Peters, G. (1994) Absence of cyclin D1/cdk complexes in cells lacking functional retinoblastoma protein. Oncogene, 9, 1633-1640.
7. WAF1/CIP1 expression. Biochem. Biophys. Res. Commun., 227, 564-569.
8. Bos, J.L. (1989) ras oncogenes in human cancer: a review. Cancer Res., 49, 4682-4689.
9. 1 phase. J. Cell Biol., 146, 1255-1264.
10. Brummelkamp, T.R., Bernards, R. and Agami, R. (2002) A system for stable expression of short interfering RNAs in mammalian cells. Science, 296, 550-553
11. Cayrol, C. and Ducommun, B. (1998) Interaction with cyclin-dependent kinases and PCNA modulates proteasome-dependent degradation of p21. Oncogene, 17, 2437-2444.
12. Cesarman, E., Nador, R.G., Bai, F., Bohenzky, R.A., Russo, J.J., Moore, P.S., Chang, Y. and Knowles, D.M. (1996) Kaposi's sarcoma-associated herpesvirus contains G protein-coupled receptor and cyclin D homologs which are expressed in Kaposi's sarcoma and malignant lymphoma. J. Virol., 70, 8218-8223.
13. CIP1. Mol. Cell. Biol., 16, 4673-4682.
14. Kip1 regulated by mitogen-activated protein kinase kinase (MEK1). Proc. Natl Acad. Sci. USA, 95, 1091-1096.
15. Kip1 CDK 'inhibitors' are essential activators of cyclin D-dependent kinases in murine fibroblasts. EMBO J., 18, 1571-1583.
16. Coleman, M.L., Sahai, E.A., Yeo, M., Bosch, M., Dewar, A. and Olson, M.F. (2001) Membrane blebbing during apoptosis results from caspase-mediated activation of ROCK I. Nat. Cell Biol., 3, 339-345.
17. Diehl, J.A., Cheng, M., Roussel, M.F. and Sherr, C.J. (1998) Glycogen synthase kinase-3β regulates cyclin D1 proteolysis and subcellular localization. Genes Dev., 12, 3499-3511.
18. WAF1/CIP1 gene. Exp. Cell Res., 246, 280-289.
19. Hershko, A. and Ciechanover, A. (1998) The ubiquitin system. Annu. Rev. Biochem., 67, 425-479.
20. Kerkhoff, E. and Rapp, U.R. (1998) Cell cycle targets of Ras/Raf signalling. Oncogene, 17, 1457-1462.
21. LaBaer, J., Garrett, M.D., Stevenson, L.F., Slingerland, J.M., Sandhu, C., Chou, H.S., Fattaey, A. and Harlow, E. (1997) New functional activities for the p21 family of CDK inhibitors. Genes Dev., 11, 847-862.
22. ras oncoprotein. EMBO J., 11, 569-574.
23. Cip1/WAF1 and promotes cell survival. J. Biol. Chem., 276, 52.
24. WAF1/CIP1 expression through mitogen-activated protein kinase signaling pathway. Cancer Res., 56, 31-35.
25. Lloyd, A.C., Obermuller, F., Staddon, S., Barth, C.F., McMahon, M. and Land, H. (1997) Cooperating oncogenes converge to regulate cyclin/cdk complexes. Genes Dev., 11, 663-677.
26. Waf1/Cip1. Nature, 394, 295-299.
27. Parry, D., Mahony, D., Wills, K. and Lees, E. (1999) Cyclin D-CDK subunit arrangement is dependent on the availability of competing INK4 and p21 class inhibitors. Mol. Cell. Biol., 19, 1775-1783.
28. Ravi, R.K., McMahon, M., Yangang, Z., Williams, J.R., Dillehay, L.E., Nelkin, B.D. and Mabry, M. (1999) Raf-1-induced cell cycle arrest in LNCaP human prostate cancer cells. J. Cell. Biochem., 72, 458-469.
29. WAF1/Cip1 is associated with cyclin D1CCND1 expression and tubular differentiation but is independent of p53 overexpression in human breast carcinoma. J. Pathol., 184, 265-271.
30. Cip1/Sdi1: association with cell senescence and tumour-promoting activities of stromal fibroblasts. Cancer Lett., 179, 1-14.
31. Cip1 degradation. J. Biol. Chem., 277, 9684-9689.
32. Russell, A., Hendley, J. and Germain, D. (1999) Inhibitory effect of p21 in MCF-7 cells is overcome by its coordinated stabilization with D-type cyclins. Oncogene, 18, 6454-6459.
33. Sahai, E., Olson, M.F. and Marshall, C.J. (2001) Cross-talk between Ras and Rho signalling pathways in transformation favours proliferation and increased motility. EMBO J., 20, 755-766.
34. Schulze, A., Lehmann, K., Jefferies, H.B.J, McMahon, M. and Downward, J. (2001) Analysis of the transcriptional program induced by Raf in epithelial cells. Genes Dev., 15, 981-994.
35. Sears, R., Leone, G., DeGregori, J. and Nevins, J.R. (1999) Ras enhances Myc protein stability. Mol. Cell, 3, 169-179.
36. INK4a. Cell, 88, 593-602.
37. Cip1. Mol. Cell. Biol., 17, 5588-5597.
38. Cip1 ubiquitination. Mol. Cell, 5, 403-410.
39. Swanton, C., Mann, D.J., Fleckenstein, B., Neipel, F., Peters, G. and Jones, N. (1997) Herpes viral cyclin/Cdk6 complexes evade inhibition by CDK inhibitor proteins. Nature, 390, 184-187.
40. Timchenko, N.A., Harris, T.E., Wilde, M., Bilyeu, T.A., Burgess-Beusse, B.L., Finegold, M.J. and Darlington, G.J. (1997) CCAAT/enhancer binding protein α regulates p21 protein and hepatocyte proliferation in newborn mice. Mol. Cell. Biol., 17, 7353-7361.
41. WAF1/CIP1 is a binding site for the C8 α-subunit of the 20S proteasome. EMBO J., 20, 2367-2375.
42. Vojtek, A.B. and Der, C.J. (1998) Increasing complexity of the Ras signaling pathway. J. Biol. Chem., 273, 19925-19928.
43. Cip1. Mol. Cell. Biol., 17, 5598-5611.
44. 1- and S-phase regulators. J. Cell Physiol., 187, 1-10.
45. Zuber, J., Tchernitsa, O.I., Hinzmann, B., Schmitz, A.C., Grips, M., Hellriegel, M., Sers, C., Rosenthal, A. and Schafer, R. (2000) A genome-wide survey of RAS transformation targets. Nat. Genet., 24, 144-152.
46. Zwijsen, R.M., Wientjens, E., Klompmaker, R., van der Sman, J., Bernards, R. and Michalides, R.J. (1997) CDK-independent activation of estrogen receptor by cyclin D1. Cell, 88, 405-415.