메뉴 건너뛰기




Volumn 18, Issue 1, 1998, Pages 629-643

Effects of p21(Cip1/Waf1) at both the G1/S and the G2/M cell cycle transitions: pRB is a critical determinant in blocking DNA replication and in preventing endoreduplication

Author keywords

[No Author keywords available]

Indexed keywords

CYCLIN DEPENDENT KINASE INHIBITOR; PROTEIN P21; RETINOBLASTOMA PROTEIN;

EID: 0031961995     PISSN: 02707306     EISSN: None     Source Type: Journal    
DOI: 10.1128/mcb.18.1.629     Document Type: Article
Times cited : (690)

References (80)
  • 1
    • 0028980494 scopus 로고
    • p53 controls both the G2/M and the G1 cell cycle checkpoints and mediates reversible growth arrest in human fibroblasts
    • Agarwal, M. L., A. Agarwal, W. R. Taylor, and G. R. Stark. 1995. p53 controls both the G2/M and the G1 cell cycle checkpoints and mediates reversible growth arrest in human fibroblasts. Proc. Natl. Acad. Sci. USA 92:8493-8497.
    • (1995) Proc. Natl. Acad. Sci. USA , vol.92 , pp. 8493-8497
    • Agarwal, M.L.1    Agarwal, A.2    Taylor, W.R.3    Stark, G.R.4
  • 2
    • 0029829249 scopus 로고    scopus 로고
    • Defect in multiple cell cycle checkpoints in ataxia-telangiectasia postirradiation
    • Beamish, H., R. Williams, P. Chen, and M. F. Lavin. 1996. Defect in multiple cell cycle checkpoints in ataxia-telangiectasia postirradiation. J. Biol. Chem. 271:20486-20493.
    • (1996) J. Biol. Chem. , vol.271 , pp. 20486-20493
    • Beamish, H.1    Williams, R.2    Chen, P.3    Lavin, M.F.4
  • 3
    • 0030921428 scopus 로고    scopus 로고
    • The role of inhibitory phosphorylation of cdc2 following DNA replication block and radiation-induced damage in human cells
    • Blasina A., E. S. Paegle, and C. H. McGowan. 1997. The role of inhibitory phosphorylation of cdc2 following DNA replication block and radiation-induced damage in human cells. Mol. Biol. Cell 8:1013-1023.
    • (1997) Mol. Biol. Cell , vol.8 , pp. 1013-1023
    • Blasina, A.1    Paegle, E.S.2    McGowan, C.H.3
  • 5
    • 0027494125 scopus 로고
    • Reversal of terminal differentiation and control of DNa replication: Cyclin a and Cdk2 specifically localize at subnuclear sites of DNa replication
    • Cardoso, M., H. Leonhardt, and B. Nadal-Ginard. 1993. Reversal of terminal differentiation and control of DNA replication: cyclin A and Cdk2 specifically localize at subnuclear sites of DNA replication. Cell 74:979-992.
    • (1993) Cell , vol.74 , pp. 979-992
    • Cardoso, M.1    Leonhardt, H.2    Nadal-Ginard, B.3
  • 6
    • 0029802591 scopus 로고    scopus 로고
    • p53 levels, functional domains, and DNA damage determine the extent of the apoptotic response of tumor cells
    • Chen, X., L. J. Ko, L. Jayaraman, and C. Prives. 1996. p53 levels, functional domains, and DNA damage determine the extent of the apoptotic response of tumor cells. Genes Dev. 10:2438-2451.
    • (1996) Genes Dev. , vol.10 , pp. 2438-2451
    • Chen, X.1    Ko, L.J.2    Jayaraman, L.3    Prives, C.4
  • 7
    • 0029923780 scopus 로고    scopus 로고
    • Cell growth arrest and induction of cyclin-dependent kinase inhibitor p21 WAF1/CIP1 mediated by STAT1
    • Chin, Y. E., M. Kitagawa, W. C. Su, Z. H. You, Y. Iwamoto, and X. Y. Fu. 1996. Cell growth arrest and induction of cyclin-dependent kinase inhibitor p21 WAF1/CIP1 mediated by STAT1. Science 272:719-722.
    • (1996) Science , vol.272 , pp. 719-722
    • Chin, Y.E.1    Kitagawa, M.2    Su, W.C.3    You, Z.H.4    Iwamoto, Y.5    Fu, X.Y.6
  • 8
    • 0029957947 scopus 로고    scopus 로고
    • Turnover of cyclin e by the ubiquitin-proteosome pathway is regulated by cdk2 binding and cyclin phosphorylation
    • Clurman, B. E., R. J. Sheaff, K. Thress, M. Groudine, and J. M. Roberts. 1996. Turnover of cyclin E by the ubiquitin-proteosome pathway is regulated by cdk2 binding and cyclin phosphorylation. Genes Dev. 10:1979-1990.
    • (1996) Genes Dev. , vol.10 , pp. 1979-1990
    • Clurman, B.E.1    Sheaff, R.J.2    Thress, K.3    Groudine, M.4    Roberts, J.M.5
  • 9
    • 0028991396 scopus 로고
    • Mutation of cell cycle regulators: Biological and clinical implications for human neoplasia
    • Cordon-Cardo, C. 1995. Mutation of cell cycle regulators: biological and clinical implications for human neoplasia. Am. J. Pathol. 147:545-560.
    • (1995) Am. J. Pathol. , vol.147 , pp. 545-560
    • Cordon-Cardo, C.1
  • 10
    • 0029073142 scopus 로고
    • Transforming growth factor beta induces the cyclin-dependent kinase inhibitor p21 through a p53-independent mechanism
    • Datto, M. B., Y. Li, J. F. Panus, D. J. Howe, Y. Xiong, and X. F. Wang. 1995. Transforming growth factor beta induces the cyclin-dependent kinase inhibitor p21 through a p53-independent mechanism. Proc. Natl. Acad. Sci. USA 92:5545-5549.
    • (1995) Proc. Natl. Acad. Sci. USA , vol.92 , pp. 5545-5549
    • Datto, M.B.1    Li, Y.2    Panus, J.F.3    Howe, D.J.4    Xiong, Y.5    Wang, X.F.6
  • 11
    • 0028978183 scopus 로고
    • Mice lacking p21CIP1/WAF1 undergo normal development, but are detective in G1 checkpoint control
    • Deng, C., P. Zhang, J. W. Harper, S. J. Elledge, and P. Leder. 1995. Mice lacking p21CIP1/WAF1 undergo normal development, but are detective in G1 checkpoint control. Cell 82:675-684.
    • (1995) Cell , vol.82 , pp. 675-684
    • Deng, C.1    Zhang, P.2    Harper, J.W.3    Elledge, S.J.4    Leder, P.5
  • 12
    • 0021192651 scopus 로고
    • Low dose rate ionizing radiation induces increased growth capacities of d-deletion retinoblastoma skin fibroblasts
    • Diatloff-Zito, C., C. Turleau, M. O. Cabanis, and J. de Grouchy. 1984. Low dose rate ionizing radiation induces increased growth capacities of d-deletion retinoblastoma skin fibroblasts. Carcinogenesis 5:1305-1310.
    • (1984) Carcinogenesis , vol.5 , pp. 1305-1310
    • Diatloff-Zito, C.1    Turleau, C.2    Cabanis, M.O.3    De Grouchy, J.4
  • 13
    • 0026698263 scopus 로고
    • Association of human cyclin e with a periodic G1-S phase protein kinase
    • Dulic, V., E. Lees, and S. I. Reed. 1992. Association of human cyclin E with a periodic G1-S phase protein kinase. Science 257:1958-1961.
    • (1992) Science , vol.257 , pp. 1958-1961
    • Dulic, V.1    Lees, E.2    Reed, S.I.3
  • 14
    • 0028220204 scopus 로고
    • p53-dependent inhibition of cyclin-dependent kinase activities in human fibroblasts during radiation-induced G1 arrest
    • Dulic, V., W. K. Kaufmann, S. J. Wilson, T. D. Tlsty, E. Lees, J. W. Harper, S. J. Elledge, and S. I. Reed. 1994. p53-dependent inhibition of cyclin-dependent kinase activities in human fibroblasts during radiation-induced G1 arrest. Cell 76:1013-23.
    • (1994) Cell , vol.76 , pp. 1013-1023
    • Dulic, V.1    Kaufmann, W.K.2    Wilson, S.J.3    Tlsty, T.D.4    Lees, E.5    Harper, J.W.6    Elledge, S.J.7    Reed, S.I.8
  • 17
    • 0029808466 scopus 로고    scopus 로고
    • Cell cycle checkpoints: Preventing an identity crisis
    • Elledge, S. J. 1996. Cell cycle checkpoints: preventing an identity crisis. Science 274:1664-1672.
    • (1996) Science , vol.274 , pp. 1664-1672
    • Elledge, S.J.1
  • 18
    • 0030027049 scopus 로고    scopus 로고
    • Dependence of cyclin E-CDK2 kinase activity on cell anchorage
    • Fang, F., G. Orend, N. Watanabe, T. Hunter, and E. Ruoslahti. 1996. Dependence of cyclin E-CDK2 kinase activity on cell anchorage. Science 271: 499-502.
    • (1996) Science , vol.271 , pp. 499-502
    • Fang, F.1    Orend, G.2    Watanabe, N.3    Hunter, T.4    Ruoslahti, E.5
  • 20
    • 0029442277 scopus 로고
    • Protein kinases in the control of mitosis: Focus on nucleocytoplasmic trafficking
    • Gallant, P., A. M. Fry, and E. A. Nigg. 1995. Protein kinases in the control of mitosis: focus on nucleocytoplasmic trafficking. J. Cell Sci. Suppl. 19:21-28.
    • (1995) J. Cell Sci. Suppl. , vol.19 , pp. 21-28
    • Gallant, P.1    Fry, A.M.2    Nigg, E.A.3
  • 21
    • 0028345392 scopus 로고
    • Retinoblastoma gene mutations in human cancer
    • Gallie, B. L. 1994. Retinoblastoma gene mutations in human cancer. N. Engl. J. Med. 330:786-787.
    • (1994) N. Engl. J. Med. , vol.330 , pp. 786-787
    • Gallie, B.L.1
  • 22
    • 0026320075 scopus 로고
    • Cyclin a is required for the onset of DNa replication in mammalian fibroblasts
    • Girard, F., U. Strausfeld, A. Fernandez, and N. J. Lamb. 1991. Cyclin A is required for the onset of DNA replication in mammalian fibroblasts. Cell 67:1169-1179.
    • (1991) Cell , vol.67 , pp. 1169-1179
    • Girard, F.1    Strausfeld, U.2    Fernandez, A.3    Lamb, N.J.4
  • 23
    • 0030061451 scopus 로고    scopus 로고
    • Cdk2 kinase is required for entry into mitosis as a positive regulator of Cdc2-cyclin B kinase activity
    • Guadagno, T. M., and J. W. Newport. 1996. Cdk2 kinase is required for entry into mitosis as a positive regulator of Cdc2-cyclin B kinase activity. Cell 84:73-82.
    • (1996) Cell , vol.84 , pp. 73-82
    • Guadagno, T.M.1    Newport, J.W.2
  • 24
    • 0028582034 scopus 로고
    • Growth suppression by p18, a p16INK4/MTS1-and p14INK4B/MTS2-related CDK6 inhibitor, correlates with wild-type pRb function
    • Guan, K. L., C. W. Jenkins, Y. Li, M. A. Nichols, X. Wu, C. L. O'Keefe, A. G. Matera, and Y. Xiong. 1994. Growth suppression by p18, a p16INK4/MTS1-and p14INK4B/MTS2-related CDK6 inhibitor, correlates with wild-type pRb function. Genes Dev. 8:2939-2952.
    • (1994) Genes Dev. , vol.8 , pp. 2939-2952
    • Guan, K.L.1    Jenkins, C.W.2    Li, Y.3    Nichols, M.A.4    Wu, X.5    O'Keefe, C.L.6    Matera, A.G.7    Xiong, Y.8
  • 26
    • 0028168242 scopus 로고
    • p15INK4B is a potential effector of TGF-beta-induced cell cycle arrest
    • Hannon, G., and D. Beach. 1994. p15INK4B is a potential effector of TGF-beta-induced cell cycle arrest. Nature 371:257-261.
    • (1994) Nature , vol.371 , pp. 257-261
    • Hannon, G.1    Beach, D.2
  • 28
  • 31
    • 0029670477 scopus 로고    scopus 로고
    • Kip1 accumulation during the cell cycle
    • Kip1 accumulation during the cell cycle. Science 271:1861-1864.
    • (1996) Science , vol.271 , pp. 1861-1864
    • Hengst, L.1    Reed, S.I.2
  • 33
    • 0028918388 scopus 로고
    • Novel INK4 proteins, p19 and p18, are specific inhibitors of the cyclin D-dependent kinases CDK4 and CDK6
    • Hirai, H., M. F. Roussel, J. Y. Kato, R. A. Ashmun, and C. J. Sherr. 1995. Novel INK4 proteins, p19 and p18, are specific inhibitors of the cyclin D-dependent kinases CDK4 and CDK6. Mol. Cell. Biol. 15:2672-2681.
    • (1995) Mol. Cell. Biol. , vol.15 , pp. 2672-2681
    • Hirai, H.1    Roussel, M.F.2    Kato, J.Y.3    Ashmun, R.A.4    Sherr, C.J.5
  • 34
    • 2642614971 scopus 로고    scopus 로고
    • Personal communication
    • Jacks, T. Personal communication.
    • Jacks, T.1
  • 36
    • 0027987170 scopus 로고
    • Induction of differentiation in human promyelocytic HL-60 leukemia cells activates p21 WAF1/CIP1 expression in the absence of p53
    • Jiang, H., J. Lin, Z. Z. Su, F. R. Collart, E. Huberman, and P. B. Fisher. 1994. Induction of differentiation in human promyelocytic HL-60 leukemia cells activates p21 WAF1/CIP1 expression in the absence of p53. Oncogene 9:3397-3406.
    • (1994) Oncogene , vol.9 , pp. 3397-3406
    • Jiang, H.1    Lin, J.2    Su, Z.Z.3    Collart, F.R.4    Huberman, E.5    Fisher, P.B.6
  • 37
    • 0029031949 scopus 로고
    • The melanoma differentiation-associated gene mda-6, which encodes the cyclin-dependent kinase inhibitor p21, is differentially expressed during growth, differentiation and progression in human melanoma cells
    • Jiang, H., J. Lin, Z. Z. Su, M. Herlyn, R. S. Kerbel, B. E. Weissman, D. R. Welch, and P. B. Fisher. 1995. The melanoma differentiation-associated gene mda-6, which encodes the cyclin-dependent kinase inhibitor p21, is differentially expressed during growth, differentiation and progression in human melanoma cells. Oncogene 10:1855-1864.
    • (1995) Oncogene , vol.10 , pp. 1855-1864
    • Jiang, H.1    Lin, J.2    Su, Z.Z.3    Herlyn, M.4    Kerbel, R.S.5    Weissman, B.E.6    Welch, D.R.7    Fisher, P.B.8
  • 39
    • 0030582716 scopus 로고    scopus 로고
    • Fibrillar collagen inhibits arterial smooth muscle proliferation through regulation of Cdk2 inhibitors
    • Koyama, H., E. W. Raines, K. E. Bornfeldt, J. M. Roberts, and R. Ross. 1996. Fibrillar collagen inhibits arterial smooth muscle proliferation through regulation of Cdk2 inhibitors. Cell 87:1069-1078.
    • (1996) Cell , vol.87 , pp. 1069-1078
    • Koyama, H.1    Raines, E.W.2    Bornfeldt, K.E.3    Roberts, J.M.4    Ross, R.5
  • 40
    • 0028988158 scopus 로고
    • KIP2, a cyclin-dependent kinase inhibitor with unique domain structure and tissue distribution
    • KIP2, a cyclin-dependent kinase inhibitor with unique domain structure and tissue distribution. Genes Dev. 9:639-649.
    • (1995) Genes Dev. , vol.9 , pp. 639-649
    • Lee, M.H.1    Reynisdottir, I.2    Massague, J.3
  • 45
    • 0030462640 scopus 로고    scopus 로고
    • The p53-independent activation of transcription of p21 WAF1/CIP1/SDI1 after acute renal failure
    • Megyesi, J., N. Udvarhelyi, R. L. Safirstein, and P. M. Price. 1996. The p53-independent activation of transcription of p21 WAF1/CIP1/SDI1 after acute renal failure. Am. J. Physiol. 271:F1211-F1216.
    • (1996) Am. J. Physiol. , vol.271
    • Megyesi, J.1    Udvarhelyi, N.2    Safirstein, R.L.3    Price, P.M.4
  • 46
    • 0029020945 scopus 로고
    • Involvement of the cell cycle inhibitor Cip1/WAF1 and the E1a-associated p300 protein in terminal differentiation
    • Missero, C., E. Calautti, R. Ekner, J. Chin, L.-H. Tsai, D. M. Livingston, and G. P. Dotto. 1995. Involvement of the cell cycle inhibitor Cip1/WAF1 and the E1a-associated p300 protein in terminal differentiation. Proc. Natl. Acad. Sci. USA 92:5451-5455.
    • (1995) Proc. Natl. Acad. Sci. USA , vol.92 , pp. 5451-5455
    • Missero, C.1    Calautti, E.2    Ekner, R.3    Chin, J.4    Tsai, L.-H.5    Livingston, D.M.6    Dotto, G.P.7
  • 47
    • 0029658030 scopus 로고    scopus 로고
    • Cip1/Waf1 alters kcratinocyte growth and differentiation and promotes ras-tumor progression
    • Cip1/Waf1 alters kcratinocyte growth and differentiation and promotes ras-tumor progression. Genes Dev. 10:3065-3075.
    • (1996) Genes Dev. , vol.10 , pp. 3065-3075
    • Missero, C.1    Di Cunto, F.2    Kiyokawa, H.3    Koff, A.4    Dotto, G.P.5
  • 48
    • 0028931265 scopus 로고
    • Principles of CDK regulation
    • Morgan, D. O. 1995. Principles of CDK regulation. Nature 374:131-134.
    • (1995) Nature , vol.374 , pp. 131-134
    • Morgan, D.O.1
  • 50
    • 0028204160 scopus 로고
    • DNA strand breaks: The DNA template alterations that trigger p53-dependent DNA damage response pathways
    • Nelson, W. G., and M. B. Kastan. 1994. DNA strand breaks: the DNA template alterations that trigger p53-dependent DNA damage response pathways. Mol. Cell. Biol. 14:1815-1823.
    • (1994) Mol. Cell. Biol. , vol.14 , pp. 1815-1823
    • Nelson, W.G.1    Kastan, M.B.2
  • 51
    • 0029317904 scopus 로고
    • Cyclin-dependent protein kinases: Key regulators of the eukaryotic cell cycle
    • Nigg, E. A. 1995. Cyclin-dependent protein kinases: key regulators of the eukaryotic cell cycle. Bioessays 17:471-480.
    • (1995) Bioessays , vol.17 , pp. 471-480
    • Nigg, E.A.1
  • 52
    • 0028342664 scopus 로고
    • Cloning of senescent cell-derived inhibitors of DNA synthesis using an expression screen
    • Noda, A., Y. Ning, S. F. Venable, O. M. Pereira-Smith, and J. R. Smith. 1994. Cloning of senescent cell-derived inhibitors of DNA synthesis using an expression screen. Exp. Cell Res. 211:90-98.
    • (1994) Exp. Cell Res. , vol.211 , pp. 90-98
    • Noda, A.1    Ning, Y.2    Venable, S.F.3    Pereira-Smith, O.M.4    Smith, J.R.5
  • 53
    • 0029960519 scopus 로고    scopus 로고
    • Skeletal muscle cells lacking the retinoblastoma protein display defects in muscle gene expression and accumulate in S and G2 phases of the cell cycle
    • Novitch, B. G., G. J. Mulligan, T. Jacks, and A. B. Lassar. 1996. Skeletal muscle cells lacking the retinoblastoma protein display defects in muscle gene expression and accumulate in S and G2 phases of the cell cycle. J. Cell Biol. 135:441-456.
    • (1996) J. Cell Biol. , vol.135 , pp. 441-456
    • Novitch, B.G.1    Mulligan, G.J.2    Jacks, T.3    Lassar, A.B.4
  • 55
    • 0026583746 scopus 로고
    • Cyclin a is required at two points in the human cell cycle
    • Pagano, M., R. Pepperkok, F. Verde, W. Ansorge, and G. Draetta. 1992. Cyclin A is required at two points in the human cell cycle. EMBO J. 11:961-971.
    • (1992) EMBO J. , vol.11 , pp. 961-971
    • Pagano, M.1    Pepperkok, R.2    Verde, F.3    Ansorge, W.4    Draetta, G.5
  • 56
    • 0028869884 scopus 로고
    • Lack of cyclin D-Cdk complexes in Rb-negative cells correlates with high levels of p16INK4/MTS1 tumor suppressor gene product
    • Parry, D., S. Bates, D. J. Mann, and G. Peters. 1995. Lack of cyclin D-Cdk complexes in Rb-negative cells correlates with high levels of p16INK4/MTS1 tumor suppressor gene product. EMBO J. 14:503-511.
    • (1995) EMBO J. , vol.14 , pp. 503-511
    • Parry, D.1    Bates, S.2    Mann, D.J.3    Peters, G.4
  • 57
    • 0029000579 scopus 로고
    • Cyclins and cyclin-dependent kinases: A biochemical view
    • Pines, J. 1995. Cyclins and cyclin-dependent kinases: a biochemical view. Biochem. J. 308:697-711.
    • (1995) Biochem. J. , vol.308 , pp. 697-711
    • Pines, J.1
  • 60
    • 0030573463 scopus 로고    scopus 로고
    • Cyclin E: In mid-cycle
    • Reed, S. I. 1996. Cyclin E: in mid-cycle. Biochim. Biophys. Acta 1287:151-153.
    • (1996) Biochim. Biophys. Acta , vol.1287 , pp. 151-153
    • Reed, S.I.1
  • 61
  • 62
    • 0030614715 scopus 로고    scopus 로고
    • The subcellular location of p15INK4b and p27Kip1 coordinate their inhibitory interactions with cdk4 and cdk2
    • Reynisdottir, I., and J. Massague. 1997. The subcellular location of p15INK4b and p27Kip1 coordinate their inhibitory interactions with cdk4 and cdk2. Genes Dev. 11:492-503.
    • (1997) Genes Dev. , vol.11 , pp. 492-503
    • Reynisdottir, I.1    Massague, J.2
  • 64
    • 0029767016 scopus 로고    scopus 로고
    • Structural basis of cyclin-dependent kinase activation by phosphorylation
    • Russo, A. A., P. D. Jeffrey, and N. P. Pavletich. 1996. Structural basis of cyclin-dependent kinase activation by phosphorylation. Nat. Struct. Biol. 3:696-700.
    • (1996) Nat. Struct. Biol. , vol.3 , pp. 696-700
    • Russo, A.A.1    Jeffrey, P.D.2    Pavletich, N.P.3
  • 68
    • 0028227197 scopus 로고
    • A novel inhibitor of cyclin-Cdk activity detected in transforming growth factor beta-arrested epithelial cells
    • Slingerland, J. M., L. Hengst, C. H. Pan, D. Alexander, M. R. Stampfer, and S. I. Reed. 1994. A novel inhibitor of cyclin-Cdk activity detected in transforming growth factor beta-arrested epithelial cells. Mol. Cell. Biol. 14:3683-3694.
    • (1994) Mol. Cell. Biol. , vol.14 , pp. 3683-3694
    • Slingerland, J.M.1    Hengst, L.2    Pan, C.H.3    Alexander, D.4    Stampfer, M.R.5    Reed, S.I.6
  • 70
    • 0029317383 scopus 로고
    • Origins of G1 arrest in senescent human fibroblasts
    • Stein, G. H., and V. Dulic. 1995. Origins of G1 arrest in senescent human fibroblasts. Bioessays 17:537-543.
    • (1995) Bioessays , vol.17 , pp. 537-543
    • Stein, G.H.1    Dulic, V.2
  • 72
    • 0030249292 scopus 로고    scopus 로고
    • A quantitative model for the cdc2 control of S phase and mitosis in fission yeast
    • Stern, B., and P. Nurse. 1996. A quantitative model for the cdc2 control of S phase and mitosis in fission yeast. Trends Genet. 12:345-350.
    • (1996) Trends Genet. , vol.12 , pp. 345-350
    • Stern, B.1    Nurse, P.2
  • 73
    • 0029810269 scopus 로고    scopus 로고
    • Cell cycle control of DNA replication
    • Stillman, B. 1996. Cell cycle control of DNA replication. Science 274:1659-1664.
    • (1996) Science , vol.274 , pp. 1659-1664
    • Stillman, B.1
  • 74
    • 0028363519 scopus 로고
    • p27, a novel inhibitor of G1 cyclin-Cdk protein kinase activity, is related to p21
    • Toyoshima, H., and T. Hunter. 1994. p27, a novel inhibitor of G1 cyclin-Cdk protein kinase activity, is related to p21. Cell 78:67-74.
    • (1994) Cell , vol.78 , pp. 67-74
    • Toyoshima, H.1    Hunter, T.2
  • 75
    • 0029822745 scopus 로고    scopus 로고
    • Growth arrest by the cyclin-dependent kinase inhibitor p27Kip1 is abbrogated by c-Myc
    • Vlach, J., S. Hennecke, K. Alevizopoulos, D. Conti, and B. Amati. 1996. Growth arrest by the cyclin-dependent kinase inhibitor p27Kip1 is abbrogated by c-Myc. EMBO J. 15:6595-6604.
    • (1996) EMBO J. , vol.15 , pp. 6595-6604
    • Vlach, J.1    Hennecke, S.2    Alevizopoulos, K.3    Conti, D.4    Amati, B.5
  • 76
    • 0030011128 scopus 로고    scopus 로고
    • Uncoupling of S phase and mitosis induced by anticancer agents in cells lacking p21
    • Waldman, T., C. Lengauer, K. W. Kinzler, and B. Vogelstein. 1996. Uncoupling of S phase and mitosis induced by anticancer agents in cells lacking p21. Nature 381:713-716.
    • (1996) Nature , vol.381 , pp. 713-716
    • Waldman, T.1    Lengauer, C.2    Kinzler, K.W.3    Vogelstein, B.4
  • 77
    • 0029737650 scopus 로고    scopus 로고
    • Activation of cyclin E/CDK2 is coupled to site-specific autophosphorylation and ubiquitin-dependent degradation of cyclin E
    • Won, K. A., and S. I. Reed. 1996. Activation of cyclin E/CDK2 is coupled to site-specific autophosphorylation and ubiquitin-dependent degradation of cyclin E. EMBO J. 15:4182-1193.
    • (1996) EMBO J. , vol.15 , pp. 4182-11193
    • Won, K.A.1    Reed, S.I.2
  • 78
    • 0030067581 scopus 로고    scopus 로고
    • Targeted in vivo expression of the cyclin-dependent kinase inhibitor p21 halts hepatocyte cell-cycle progression, postnatal liver development and regeneration
    • Wu, H., M. Wade, L. Krall, J. Grisham, V. Xiong, and T. Van Dyke. 1996. Targeted in vivo expression of the cyclin-dependent kinase inhibitor p21 halts hepatocyte cell-cycle progression, postnatal liver development and regeneration. Genes Dev. 10:245-260.
    • (1996) Genes Dev. , vol.10 , pp. 245-260
    • Wu, H.1    Wade, M.2    Krall, L.3    Grisham, J.4    Xiong, V.5    Van Dyke, T.6
  • 79
    • 0029670422 scopus 로고    scopus 로고
    • Regulation of p21 WAF1/CIP1 expression by p53-independent pathways
    • Zeng, Y. X., and W. S. el-Deiry. 1996. Regulation of p21 WAF1/CIP1 expression by p53-independent pathways. Oncogene 12:1557-1564.
    • (1996) Oncogene , vol.12 , pp. 1557-1564
    • Zeng, Y.X.1    El-Deiry, W.S.2
  • 80
    • 0029876639 scopus 로고    scopus 로고
    • Adhesion-dependent cell cycle progression linked to the expression of cyclin D1, activation of cyclin E-cdk2, and phosphorylation of the retinoblastoma protein
    • Zhu, X., M. Ohtsubo, R. M. Enhmer, J. M. Roberts, and R. K. Assoian. 1996. Adhesion-dependent cell cycle progression linked to the expression of cyclin D1, activation of cyclin E-cdk2, and phosphorylation of the retinoblastoma protein. J. Cell Biol. 133:391-403.
    • (1996) J. Cell Biol. , vol.133 , pp. 391-403
    • Zhu, X.1    Ohtsubo, M.2    Enhmer, R.M.3    Roberts, J.M.4    Assoian, R.K.5


* 이 정보는 Elsevier사의 SCOPUS DB에서 KISTI가 분석하여 추출한 것입니다.