메뉴 건너뛰기




Volumn 247, Issue 1-2, 2000, Pages 1-15

Cell-cycle inhibitors: Three families united by a common cause

Author keywords

CDK; Cell cycle; CKI; Cyclin; Mouse models

Indexed keywords

CYCLIN D; CYCLIN D1; CYCLIN DEPENDENT KINASE; CYCLIN DEPENDENT KINASE 2; CYCLIN DEPENDENT KINASE INHIBITOR;

EID: 0034682037     PISSN: 03781119     EISSN: None     Source Type: Journal    
DOI: 10.1016/S0378-1119(00)00092-5     Document Type: Review
Times cited : (378)

References (153)
  • 1
    • 0030822196 scopus 로고    scopus 로고
    • Cyclin E and c-Myc promote cell proliferation in the presence of p16INK4a and of hypophosphorylated retinoblastoma family proteins
    • Alevizopoulos K., Vlach J., Hennecke S., Amati B. Cyclin E and c-Myc promote cell proliferation in the presence of p16INK4a and of hypophosphorylated retinoblastoma family proteins. EMBO J. 16:1997;5322-5333.
    • (1997) EMBO J. , vol.16 , pp. 5322-5333
    • Alevizopoulos, K.1    Vlach, J.2    Hennecke, S.3    Amati, B.4
  • 2
    • 0030845187 scopus 로고    scopus 로고
    • Differential interaction of the cyclin-dependent kinase (Cdk) inhibitor p27Kip1 with cyclin A-Cdk2 and cyclin D2-Cdk4
    • Blain S.W., Montalvo E., Massague J. Differential interaction of the cyclin-dependent kinase (Cdk) inhibitor p27Kip1 with cyclin A-Cdk2 and cyclin D2-Cdk4. J. Biol. Chem. 272:1997;25863-25872.
    • (1997) J. Biol. Chem. , vol.272 , pp. 25863-25872
    • Blain, S.W.1    Montalvo, E.2    Massague, J.3
  • 6
    • 0032550224 scopus 로고    scopus 로고
    • P21 is a critical CDK2 regulator essential for proliferation control in Rb-deficient cells
    • Brugarolas J., Bronson R.T., Jacks T. p21 is a critical CDK2 regulator essential for proliferation control in Rb-deficient cells. J. Cell Biol. 141:1998;503-514.
    • (1998) J. Cell Biol. , vol.141 , pp. 503-514
    • Brugarolas, J.1    Bronson, R.T.2    Jacks, T.3
  • 7
    • 0032546150 scopus 로고    scopus 로고
    • TGF-beta1 actions on FRTL-5 cells provide a model for the physiological regulation of thyroid growth
    • Carneiro C., Alvarez C.V., Zalvide J., Vidal A., Dominguez F. TGF-beta1 actions on FRTL-5 cells provide a model for the physiological regulation of thyroid growth. Oncogene. 16:1998;1455-1465.
    • (1998) Oncogene , vol.16 , pp. 1455-1465
    • Carneiro, C.1    Alvarez, C.V.2    Zalvide, J.3    Vidal, A.4    Dominguez, F.5
  • 8
    • 0030922936 scopus 로고    scopus 로고
    • Oligodendrocyte precursor differentiation is perturbed in the absence of the cyclin-dependent kinase inhibitor p27Kip1
    • Casaccia-Bonnefil P., Tikoo R., Kiyokawa H., Friedrich V. Jr., Chao M.V., Koff A. Oligodendrocyte precursor differentiation is perturbed in the absence of the cyclin-dependent kinase inhibitor p27Kip1. Genes Dev. 11:1997;2335-2346.
    • (1997) Genes Dev. , vol.11 , pp. 2335-2346
    • Casaccia-Bonnefil, P.1    Tikoo, R.2    Kiyokawa, H.3    Friedrich, V.4    Chao, M.V.5    Koff, A.6
  • 9
    • 0031865232 scopus 로고    scopus 로고
    • Dual cyclin-binding domains are required for p107 to function as a kinase inhibitor
    • Castano E., Kleyner Y., Dynlacht B.D. Dual cyclin-binding domains are required for p107 to function as a kinase inhibitor. Mol. Cell. Biol. 18:1998;5380-5391.
    • (1998) Mol. Cell. Biol. , vol.18 , pp. 5380-5391
    • Castano, E.1    Kleyner, Y.2    Dynlacht, B.D.3
  • 11
    • 0028911830 scopus 로고
    • Identification of human and mouse p19, a novel CDK4 and CDK6 inhibitor with homology to p16ink4
    • Chan F.K., Zhang J., Cheng L., Shapiro D.N., Winoto A. Identification of human and mouse p19, a novel CDK4 and CDK6 inhibitor with homology to p16ink4. Mol. Cell. Biol. 15:1995;2682-2688.
    • (1995) Mol. Cell. Biol. , vol.15 , pp. 2682-2688
    • Chan, F.K.1    Zhang, J.2    Cheng, L.3    Shapiro, D.N.4    Winoto, A.5
  • 12
    • 0032933174 scopus 로고    scopus 로고
    • P27(Kip1) links cell proliferation to morphogenesis in the developing organ of Corti
    • Chen P., Segil N. p27(Kip1) links cell proliferation to morphogenesis in the developing organ of Corti. Development. 126:1999;1581-1590.
    • (1999) Development , vol.126 , pp. 1581-1590
    • Chen, P.1    Segil, N.2
  • 13
    • 0033559264 scopus 로고    scopus 로고
    • The p21(Cip1) and p27(Kip1) CDK 'inhibitors' are essential activators of cyclin D-dependent kinases in murine fibroblasts
    • Cheng M., Olivier P., Diehl J.A., Fero M., Roussel M.F., Roberts J.M., Sherr C.J. The p21(Cip1) and p27(Kip1) CDK 'inhibitors' are essential activators of cyclin D-dependent kinases in murine fibroblasts. EMBO J. 18:1999;1571-1583.
    • (1999) EMBO J. , vol.18 , pp. 1571-1583
    • Cheng, M.1    Olivier, P.2    Diehl, J.A.3    Fero, M.4    Roussel, M.F.5    Roberts, J.M.6    Sherr, C.J.7
  • 15
    • 0032446246 scopus 로고    scopus 로고
    • New insights into the tumor suppression function of P27(kip1)
    • Clurman B.E., Porter P. New insights into the tumor suppression function of P27(kip1). Proc. Natl. Acad. Sci. USA. 95:1998;15158-15160.
    • (1998) Proc. Natl. Acad. Sci. USA , vol.95 , pp. 15158-15160
    • Clurman, B.E.1    Porter, P.2
  • 16
    • 0029664461 scopus 로고    scopus 로고
    • Requirement of p27Kip1 for restriction point control of the fibroblast cell cycle
    • Coats S., Flanagan W.M., Nourse J., Roberts J.M. Requirement of p27Kip1 for restriction point control of the fibroblast cell cycle. Science. 272:1996;877-880.
    • (1996) Science , vol.272 , pp. 877-880
    • Coats, S.1    Flanagan, W.M.2    Nourse, J.3    Roberts, J.M.4
  • 20
    • 0028978183 scopus 로고
    • Mice lacking p21CIP1/WAF1 undergo normal development, but are defective in G1 checkpoint control
    • Deng C., Zhang P., Harper J.W., Elledge S.J., Leder P. Mice lacking p21CIP1/WAF1 undergo normal development, but are defective in G1 checkpoint control. Cell. 82:1995;675-684.
    • (1995) Cell , vol.82 , pp. 675-684
    • Deng, C.1    Zhang, P.2    Harper, J.W.3    Elledge, S.J.4    Leder, P.5
  • 22
    • 0026698263 scopus 로고
    • Association of human cyclin E with a periodic G1-S phase protein kinase
    • Dulic V., Lees E., Reed S.I. Association of human cyclin E with a periodic G1-S phase protein kinase. Science. 257:1992;1958-1961.
    • (1992) Science , vol.257 , pp. 1958-1961
    • Dulic, V.1    Lees, E.2    Reed, S.I.3
  • 23
    • 0028220204 scopus 로고
    • P53-dependent inhibition of cyclin-dependent kinase activities in human fibroblasts during radiation-induced G1 arrest
    • Dulic V., Kaufmann W.K., Wilson S.J., Tlsty T.D., Lees E., Harper J.W., Elledge S.J., Reed S.I. p53-dependent inhibition of cyclin-dependent kinase activities in human fibroblasts during radiation-induced G1 arrest. Cell. 76:1994;1013-1023.
    • (1994) Cell , vol.76 , pp. 1013-1023
    • Dulic, V.1    Kaufmann, W.K.2    Wilson, S.J.3    Tlsty, T.D.4    Lees, E.5    Harper, J.W.6    Elledge, S.J.7    Reed, S.I.8
  • 24
    • 0032498961 scopus 로고    scopus 로고
    • P27Kip1 alters the response of cells to mitogen and is part of a cell- intrinsic timer that arrests the cell cycle and initiates differentiation
    • Durand B., Fero M.L., Roberts J.M., Raff M.C. p27Kip1 alters the response of cells to mitogen and is part of a cell- intrinsic timer that arrests the cell cycle and initiates differentiation. Curr. Biol. 8:1998;431-440.
    • (1998) Curr. Biol. , vol.8 , pp. 431-440
    • Durand, B.1    Fero, M.L.2    Roberts, J.M.3    Raff, M.C.4
  • 26
    • 0032146274 scopus 로고    scopus 로고
    • The regulation of E2F by pRB-family proteins
    • Dyson N. The regulation of E2F by pRB-family proteins. Genes Dev. 12:1998;2245-2262.
    • (1998) Genes Dev. , vol.12 , pp. 2245-2262
    • Dyson, N.1
  • 29
    • 0027374766 scopus 로고
    • TGF beta inhibition of Cdk4 synthesis is linked to cell cycle arrest
    • Ewen M.E., Sluss H.K., Whitehouse L.L., Livingston D.M. TGF beta inhibition of Cdk4 synthesis is linked to cell cycle arrest. Cell. 74:1993;1009-1020.
    • (1993) Cell , vol.74 , pp. 1009-1020
    • Ewen, M.E.1    Sluss, H.K.2    Whitehouse, L.L.3    Livingston, D.M.4
  • 30
    • 0031609235 scopus 로고    scopus 로고
    • Regulation of the cell cycle by the Rb tumor suppressor family
    • Ewen M.E. Regulation of the cell cycle by the Rb tumor suppressor family. Results Probl. Cell Differ. 22:1998;149-179.
    • (1998) Results Probl. Cell Differ. , vol.22 , pp. 149-179
    • Ewen, M.E.1
  • 31
    • 0028889751 scopus 로고
    • Mice lacking cyclin D1 are small and show defects in eye and mammary gland development
    • Fantl V., Stamp G., Andrews A., Rosewell I., Dickson C. Mice lacking cyclin D1 are small and show defects in eye and mammary gland development. Genes Dev. 9:1995;2364-2372.
    • (1995) Genes Dev. , vol.9 , pp. 2364-2372
    • Fantl, V.1    Stamp, G.2    Andrews, A.3    Rosewell, I.4    Dickson, C.5
  • 33
    • 0032511848 scopus 로고    scopus 로고
    • The murine gene p27Kip1 is haplo-insufficient for tumour suppression
    • Fero M.L., Randel E., Gurley K.E., Roberts J.M., Kemp C.J. The murine gene p27Kip1 is haplo-insufficient for tumour suppression. Nature. 396:1998;177-180.
    • (1998) Nature , vol.396 , pp. 177-180
    • Fero, M.L.1    Randel, E.2    Gurley, K.E.3    Roberts, J.M.4    Kemp, C.J.5
  • 34
    • 0032168984 scopus 로고    scopus 로고
    • The three members of the pocket proteins family share the ability to repress E2F activity through recruitment of a histone deacetylase
    • Ferreira R., Magnaghi-Jaulin L., Robin P., Harel-Bellan A., Trouche D. The three members of the pocket proteins family share the ability to repress E2F activity through recruitment of a histone deacetylase. Proc. Natl. Acad. Sci. USA. 95:1998;10493-10498.
    • (1998) Proc. Natl. Acad. Sci. USA , vol.95 , pp. 10493-10498
    • Ferreira, R.1    Magnaghi-Jaulin, L.2    Robin, P.3    Harel-Bellan, A.4    Trouche, D.5
  • 35
    • 0030457645 scopus 로고    scopus 로고
    • TGF-beta mediated G1 arrest in a human melanoma cell line lacking p15INK4B: Evidence for cooperation between p21Cip1/WAF1 and p27Kip1
    • Florenes V.A., Bhattacharya N., Bani M.R., Ben-David Y., Kerbel R.S., Slingerland J.M. TGF-beta mediated G1 arrest in a human melanoma cell line lacking p15INK4B: evidence for cooperation between p21Cip1/WAF1 and p27Kip1. Oncogene. 13:1996;2447-2457.
    • (1996) Oncogene , vol.13 , pp. 2447-2457
    • Florenes, V.A.1    Bhattacharya, N.2    Bani, M.R.3    Ben-David, Y.4    Kerbel, R.S.5    Slingerland, J.M.6
  • 36
    • 0032530112 scopus 로고    scopus 로고
    • CDK inhibitors p18(INK4c) and p27(Kip1) mediate two separate pathways to collaboratively suppress pituitary tumorigenesis
    • Franklin D.S., Godfrey V.L., Lee H., Kovalev G.I., Schoonhoven R., Chen-Kiang S., Su L., Xiong Y. CDK inhibitors p18(INK4c) and p27(Kip1) mediate two separate pathways to collaboratively suppress pituitary tumorigenesis. Genes Dev. 12:1998;2899-2911.
    • (1998) Genes Dev. , vol.12 , pp. 2899-2911
    • Franklin, D.S.1    Godfrey, V.L.2    Lee, H.3    Kovalev, G.I.4    Schoonhoven, R.5    Chen-Kiang, S.6    Su, L.7    Xiong, Y.8
  • 37
    • 0033080402 scopus 로고    scopus 로고
    • Transcriptional regulation of the p21((WAF1/CIP1)) gene
    • Gartel A.L., Tyner A.L. Transcriptional regulation of the p21((WAF1/CIP1)) gene. Exp. Cell Res. 246:1999;280-289.
    • (1999) Exp. Cell Res. , vol.246 , pp. 280-289
    • Gartel, A.L.1    Tyner, A.L.2
  • 39
    • 0032437776 scopus 로고    scopus 로고
    • Role of the retinoblastoma protein family, pRB, p107 and p130 in the negative control of cell growth
    • Grana X., Garriga J., Mayol X. Role of the retinoblastoma protein family, pRB, p107 and p130 in the negative control of cell growth. Oncogene. 17:1998;3365-3383.
    • (1998) Oncogene , vol.17 , pp. 3365-3383
    • Grana, X.1    Garriga, J.2    Mayol, X.3
  • 40
    • 0027731971 scopus 로고
    • Inhibition of CDK2 activity in vivo by an associated 20K regulatory subunit
    • Gu Y., Turck C.W., Morgan D.O. Inhibition of CDK2 activity in vivo by an associated 20K regulatory subunit. Nature. 366:1993;707-710.
    • (1993) Nature , vol.366 , pp. 707-710
    • Gu, Y.1    Turck, C.W.2    Morgan, D.O.3
  • 41
    • 0028582034 scopus 로고
    • Growth suppression by p18, a p16INK4/MTS1- And p14INK4B/MTS2-related CDK6 inhibitor, correlates with wild-type pRb function
    • Guan K.L., Jenkins C.W., Li Y., Nichols M.A., Wu X., O'Keefe C.L., Matera A.G., Xiong Y. Growth suppression by p18, a p16INK4/MTS1- and p14INK4B/MTS2-related CDK6 inhibitor, correlates with wild-type pRb function. Genes Dev. 8:1994;2939-2952.
    • (1994) Genes Dev. , vol.8 , pp. 2939-2952
    • Guan, K.L.1    Jenkins, C.W.2    Li, Y.3    Nichols, M.A.4    Wu, X.5    O'Keefe, C.L.6    Matera, A.G.7    Xiong, Y.8
  • 42
    • 0028168242 scopus 로고
    • P15INK4B is a potential effector of TGF-beta-induced cell cycle arrest
    • Hannon G.J., Beach D. p15INK4B is a potential effector of TGF-beta-induced cell cycle arrest. Nature. 371:1994;257-261.
    • (1994) Nature , vol.371 , pp. 257-261
    • Hannon, G.J.1    Beach, D.2
  • 43
    • 0033578816 scopus 로고    scopus 로고
    • Cdk phosphorylation triggers sequential intramolecular interactions that progressively block Rb functions as cells move through G1
    • Harbour J.W., Luo R.X., Dei Santi A., Postigo A.A., Dean D.C. Cdk phosphorylation triggers sequential intramolecular interactions that progressively block Rb functions as cells move through G1. Cell. 98:1999;859-869.
    • (1999) Cell , vol.98 , pp. 859-869
    • Harbour, J.W.1    Luo, R.X.2    Dei Santi, A.3    Postigo, A.A.4    Dean, D.C.5
  • 44
    • 0027496935 scopus 로고
    • The p21 Cdk-interacting protein Cip1 is a potent inhibitor of G1 cyclin-dependent kinases
    • Harper J.W., Adami G.R., Wei N., Keyomarsi K., Elledge S.J. The p21 Cdk-interacting protein Cip1 is a potent inhibitor of G1 cyclin-dependent kinases. Cell. 75:1993;805-816.
    • (1993) Cell , vol.75 , pp. 805-816
    • Harper, J.W.1    Adami, G.R.2    Wei, N.3    Keyomarsi, K.4    Elledge, S.J.5
  • 45
    • 0028988697 scopus 로고
    • Effects of heterozygosity for the Rb-1t19neo allele in the mouse
    • Harrison D.J., Hooper M.L., Armstrong J.F., Clarke A.R. Effects of heterozygosity for the Rb-1t19neo allele in the mouse. Oncogene. 10:1995;1615-1620.
    • (1995) Oncogene , vol.10 , pp. 1615-1620
    • Harrison, D.J.1    Hooper, M.L.2    Armstrong, J.F.3    Clarke, A.R.4
  • 46
    • 0028980026 scopus 로고
    • Genomic imprinting of p57KIP2, a cyclin-dependent kinase inhibitor, in mouse
    • Hatada I., Mukai T. Genomic imprinting of p57KIP2, a cyclin-dependent kinase inhibitor, in mouse. Nat. Genet. 11:1995;204-206.
    • (1995) Nat. Genet. , vol.11 , pp. 204-206
    • Hatada, I.1    Mukai, T.2
  • 48
    • 0029670477 scopus 로고    scopus 로고
    • Translational control of p27Kip1 accumulation during the cell cycle
    • Hengst L., Reed S.I. Translational control of p27Kip1 accumulation during the cell cycle. Science. 271:1996;1861-1864.
    • (1996) Science , vol.271 , pp. 1861-1864
    • Hengst, L.1    Reed, S.I.2
  • 50
    • 0028918388 scopus 로고
    • Novel INK4 proteins, p19 and p18, are specific inhibitors of the cyclin D-dependent kinases CDK4 and CDK6
    • Hirai H., Roussel M.F., Kato J.Y., Ashmun R.A., Sherr C.J. Novel INK4 proteins, p19 and p18, are specific inhibitors of the cyclin D-dependent kinases CDK4 and CDK6. Mol. Cell. Biol. 15:1995;2672-2681.
    • (1995) Mol. Cell. Biol. , vol.15 , pp. 2672-2681
    • Hirai, H.1    Roussel, M.F.2    Kato, J.Y.3    Ashmun, R.A.4    Sherr, C.J.5
  • 51
    • 0029926060 scopus 로고    scopus 로고
    • Differential effects of cdk2 and cdk3 on the control of pRb and E2F function during G1 exit
    • Hofmann F., Livingston D.M. Differential effects of cdk2 and cdk3 on the control of pRb and E2F function during G1 exit. Genes Dev. 10:1996;851-861.
    • (1996) Genes Dev. , vol.10 , pp. 851-861
    • Hofmann, F.1    Livingston, D.M.2
  • 52
    • 0028174064 scopus 로고
    • Heterozygous Rb-1 delta 20/+mice are predisposed to tumors of the pituitary gland with a nearly complete penetrance
    • Hu N., Gutsmann A., Herbert D.C., Bradley A., Lee W.H., Lee E.Y. Heterozygous Rb-1 delta 20/+mice are predisposed to tumors of the pituitary gland with a nearly complete penetrance. Oncogene. 9:1994;1021-1027.
    • (1994) Oncogene , vol.9 , pp. 1021-1027
    • Hu, N.1    Gutsmann, A.2    Herbert, D.C.3    Bradley, A.4    Lee, W.H.5    Lee, E.Y.6
  • 53
    • 15444353328 scopus 로고    scopus 로고
    • PRB and p107/p130 are required for the regulated expression of different sets of E2F responsive genes
    • Hurford R.K. Jr., Cobrinik D., Lee M.H., Dyson N. pRB and p107/p130 are required for the regulated expression of different sets of E2F responsive genes. Genes Dev. 11:1997;1447-1463.
    • (1997) Genes Dev. , vol.11 , pp. 1447-1463
    • Hurford, R.K.1    Cobrinik, D.2    Lee, M.H.3    Dyson, N.4
  • 54
    • 0030978315 scopus 로고    scopus 로고
    • Repression of the CDK activator Cdc25A and cell-cycle arrest by cytokine TGF-beta in cells lacking the CDK inhibitor p15
    • Iavarone A., Massague J. Repression of the CDK activator Cdc25A and cell-cycle arrest by cytokine TGF-beta in cells lacking the CDK inhibitor p15. Nature. 387:1997;417-422.
    • (1997) Nature , vol.387 , pp. 417-422
    • Iavarone, A.1    Massague, J.2
  • 56
    • 0032994432 scopus 로고    scopus 로고
    • Multistep regulation of DNA replication by Cdk phosphorylation of HsCdc6
    • Jiang W., Wells N.J., Hunter T. Multistep regulation of DNA replication by Cdk phosphorylation of HsCdc6. Proc. Natl. Acad. Sci. USA. 96:1999;6193-6198.
    • (1999) Proc. Natl. Acad. Sci. USA , vol.96 , pp. 6193-6198
    • Jiang, W.1    Wells, N.J.2    Hunter, T.3
  • 59
    • 0027973043 scopus 로고
    • Cyclic AMP-induced G1 phase arrest mediated by an inhibitor (p27Kip1) of cyclin-dependent kinase 4 activation
    • Kato J.Y., Matsuoka M., Polyak K., Massague J., Sherr C.J. Cyclic AMP-induced G1 phase arrest mediated by an inhibitor (p27Kip1) of cyclin-dependent kinase 4 activation. Cell. 79:1994;487-496.
    • (1994) Cell , vol.79 , pp. 487-496
    • Kato, J.Y.1    Matsuoka, M.2    Polyak, K.3    Massague, J.4    Sherr, C.J.5
  • 62
    • 0027318843 scopus 로고
    • Negative regulation of G1 in mammalian cells: Inhibition of cyclin E- dependent kinase by TGF-beta
    • Koff A., Ohtsuki M., Polyak K., Roberts J.M., Massague J. Negative regulation of G1 in mammalian cells: inhibition of cyclin E- dependent kinase by TGF-beta. Science. 260:1993;536-539.
    • (1993) Science , vol.260 , pp. 536-539
    • Koff, A.1    Ohtsuki, M.2    Polyak, K.3    Roberts, J.M.4    Massague, J.5
  • 63
    • 0029052951 scopus 로고
    • Tumour-derived p16 alleles encoding proteins defective in cell-cycle inhibition
    • Koh J., Enders G.H., Dynlacht B.D., Harlow E. Tumour-derived p16 alleles encoding proteins defective in cell-cycle inhibition. Nature. 375:1995;506-510.
    • (1995) Nature , vol.375 , pp. 506-510
    • Koh, J.1    Enders, G.H.2    Dynlacht, B.D.3    Harlow, E.4
  • 64
    • 0033166447 scopus 로고    scopus 로고
    • P27(Kip1) induction and inhibition of proliferation by the intracellular Ah receptor in developing thymus and hepatoma cells [In Process Citation]
    • Kolluri S.K., Weiss C., Koff A., Gottlicher M. p27(Kip1) induction and inhibition of proliferation by the intracellular Ah receptor in developing thymus and hepatoma cells [In Process Citation]. Genes Dev. 13:1999;1742-1753.
    • (1999) Genes Dev. , vol.13 , pp. 1742-1753
    • Kolluri, S.K.1    Weiss, C.2    Koff, A.3    Gottlicher, M.4
  • 65
    • 0031782695 scopus 로고    scopus 로고
    • Strain-dependent myeloid hyperplasia, growth deficiency, and accelerated cell cycle in mice lacking the Rb-related p107 gene
    • LeCouter J.E., Kablar B., Hardy W.R., Ying C., Megeney L.A., May L.L., Rudnicki M.A. Strain-dependent myeloid hyperplasia, growth deficiency, and accelerated cell cycle in mice lacking the Rb-related p107 gene. Mol. Cell. Biol. 18:1998;7455-7465.
    • (1998) Mol. Cell. Biol. , vol.18 , pp. 7455-7465
    • Lecouter, J.E.1    Kablar, B.2    Hardy, W.R.3    Ying, C.4    Megeney, L.A.5    May, L.L.6    Rudnicki, M.A.7
  • 66
    • 0032433267 scopus 로고    scopus 로고
    • Strain-dependent embryonic lethality in mice lacking the retinoblastoma- related p130 gene
    • LeCouter J.E., Kablar B., Whyte P.F., Ying C., Rudnicki M.A. Strain-dependent embryonic lethality in mice lacking the retinoblastoma- related p130 gene. Development. 125:1998;4669-4679.
    • (1998) Development , vol.125 , pp. 4669-4679
    • Lecouter, J.E.1    Kablar, B.2    Whyte, P.F.3    Ying, C.4    Rudnicki, M.A.5
  • 67
    • 0026744563 scopus 로고
    • Mice deficient for Rb are nonviable and show defects in neurogenesis and haematopoiesis [see comments]
    • Lee E.Y., Chang C.Y., Hu N., Wang Y.C., Lai C.C., Herrup K., Lee W.H., Bradley A. Mice deficient for Rb are nonviable and show defects in neurogenesis and haematopoiesis [see comments]. Nature. 359:1992;288-294.
    • (1992) Nature , vol.359 , pp. 288-294
    • Lee, E.Y.1    Chang, C.Y.2    Hu, N.3    Wang, Y.C.4    Lai, C.C.5    Herrup, K.6    Lee, W.H.7    Bradley, A.8
  • 68
    • 0028988158 scopus 로고
    • Cloning of p57KIP2, a cyclin-dependent kinase inhibitor with unique domain structure and tissue distribution
    • Lee M.H., Reynisdottir I., Massague J. Cloning of p57KIP2, a cyclin-dependent kinase inhibitor with unique domain structure and tissue distribution. Genes Dev. 9:1995;639-649.
    • (1995) Genes Dev. , vol.9 , pp. 639-649
    • Lee, M.H.1    Reynisdottir, I.2    Massague, J.3
  • 70
    • 0030265327 scopus 로고    scopus 로고
    • Genes in the RB pathway and their knockout in mice
    • Lin S.C., Skapek S.X., Lee E.Y. Genes in the RB pathway and their knockout in mice. Semin. Cancer Biol. 7:1996;279-289.
    • (1996) Semin. Cancer Biol. , vol.7 , pp. 279-289
    • Lin, S.C.1    Skapek, S.X.2    Lee, E.Y.3
  • 71
    • 0031048236 scopus 로고    scopus 로고
    • Increased proteasome-dependent degradation of the cyclin-dependent kinase inhibitor p27 in aggressive colorectal carcinomas [see comments]
    • Loda M., Cukor B., Tam S.W., Lavin P., Fiorentino M., Draetta G.F., Jessup J.M., Pagano M. Increased proteasome-dependent degradation of the cyclin-dependent kinase inhibitor p27 in aggressive colorectal carcinomas [see comments]. Nat. Med. 3:1997;231-234.
    • (1997) Nat. Med. , vol.3 , pp. 231-234
    • Loda, M.1    Cukor, B.2    Tam, S.W.3    Lavin, P.4    Fiorentino, M.5    Draetta, G.F.6    Jessup, J.M.7    Pagano, M.8
  • 76
    • 0031951182 scopus 로고    scopus 로고
    • Functional inactivation of the retinoblastoma protein requires sequential modification by at least two distinct cyclin-cdk complexes
    • Lundberg A.S., Weinberg R.A. Functional inactivation of the retinoblastoma protein requires sequential modification by at least two distinct cyclin-cdk complexes. Mol. Cell. Biol. 18:1998;753-761.
    • (1998) Mol. Cell. Biol. , vol.18 , pp. 753-761
    • Lundberg, A.S.1    Weinberg, R.A.2
  • 77
    • 0029063745 scopus 로고
    • Cell-cycle inhibition by independent CDK and PCNA binding domains in p21Cip1
    • Luo Y., Hurwitz J., Massague J. Cell-cycle inhibition by independent CDK and PCNA binding domains in p21Cip1. Nature. 375:1995;159-161.
    • (1995) Nature , vol.375 , pp. 159-161
    • Luo, Y.1    Hurwitz, J.2    Massague, J.3
  • 78
    • 0032549001 scopus 로고    scopus 로고
    • Rb interacts with histone deacetylase to repress transcription
    • Luo R.X., Postigo A.A., Dean D.C. Rb interacts with histone deacetylase to repress transcription. Cell. 92:1998;463-473.
    • (1998) Cell , vol.92 , pp. 463-473
    • Luo, R.X.1    Postigo, A.A.2    Dean, D.C.3
  • 82
    • 0032981481 scopus 로고    scopus 로고
    • Induced expression of p16(INK4a) inhibits both CDK4- And CDK2- associated kinase activity by reassortment of cyclin-CDK-inhibitor complexes
    • McConnell B.B., Gregory F.J., Stott F.J., Hara E., Peters G. Induced expression of p16(INK4a) inhibits both CDK4- and CDK2- associated kinase activity by reassortment of cyclin-CDK-inhibitor complexes. Mol. Cell. Biol. 19:1999;1981-1989.
    • (1999) Mol. Cell. Biol. , vol.19 , pp. 1981-1989
    • McConnell, B.B.1    Gregory, F.J.2    Stott, F.J.3    Hara, E.4    Peters, G.5
  • 83
    • 0028988159 scopus 로고
    • P57KIP2, a structurally distinct member of the p21CIP1 Cdk inhibitor family, is a candidate tumor suppressor gene
    • Matsuoka S., Edwards M.C., Bai C., Parker S., Zhang P., Baldini A., Harper J.W., Elledge S.J. p57KIP2, a structurally distinct member of the p21CIP1 Cdk inhibitor family, is a candidate tumor suppressor gene. Genes Dev. 9:1995;650-662.
    • (1995) Genes Dev. , vol.9 , pp. 650-662
    • Matsuoka, S.1    Edwards, M.C.2    Bai, C.3    Parker, S.4    Zhang, P.5    Baldini, A.6    Harper, J.W.7    Elledge, S.J.8
  • 86
  • 87
    • 15144357686 scopus 로고    scopus 로고
    • Enhanced ribosomal association of p27(Kip1) mRNA is a mechanism contributing to accumulation during growth arrest
    • Millard S.S., Yan J.S., Nguyen H., Pagano M., Kiyokawa H., Koff A. Enhanced ribosomal association of p27(Kip1) mRNA is a mechanism contributing to accumulation during growth arrest. J. Biol. Chem. 272:1997;7093-7098.
    • (1997) J. Biol. Chem. , vol.272 , pp. 7093-7098
    • Millard, S.S.1    Yan, J.S.2    Nguyen, H.3    Pagano, M.4    Kiyokawa, H.5    Koff, A.6
  • 88
    • 0029978325 scopus 로고    scopus 로고
    • E2F-4 switches from p130 to p107 and pRB in response to cell cycle reentry
    • Moberg K., Starz M.A., Lees J.A. E2F-4 switches from p130 to p107 and pRB in response to cell cycle reentry. Mol. Cell. Biol. 16:1996;1436-1449.
    • (1996) Mol. Cell. Biol. , vol.16 , pp. 1436-1449
    • Moberg, K.1    Starz, M.A.2    Lees, J.A.3
  • 89
    • 0031466305 scopus 로고    scopus 로고
    • Cyclin-dependent kinases: Engines, clocks and microprocessors
    • Morgan D.O. Cyclin-dependent kinases: engines, clocks and microprocessors. Annu. Rev. Cell Dev. Biol. 13:1997;261-291.
    • (1997) Annu. Rev. Cell Dev. Biol. , vol.13 , pp. 261-291
    • Morgan, D.O.1
  • 90
    • 0031831681 scopus 로고    scopus 로고
    • The retinoblastoma gene family: Cousins with overlapping interests
    • Mulligan G., Jacks T. The retinoblastoma gene family: cousins with overlapping interests. Trends Genet. 14:1998;223-229.
    • (1998) Trends Genet. , vol.14 , pp. 223-229
    • Mulligan, G.1    Jacks, T.2
  • 91
    • 0031983190 scopus 로고    scopus 로고
    • P130 is dispensable in peripheral T lymphocytes: Evidence for functional compensation by p107 and pRB
    • Mulligan G.J., Wong J., Jacks T. p130 is dispensable in peripheral T lymphocytes: evidence for functional compensation by p107 and pRB. Mol. Cell. Biol. 18:1998;206-220.
    • (1998) Mol. Cell. Biol. , vol.18 , pp. 206-220
    • Mulligan, G.J.1    Wong, J.2    Jacks, T.3
  • 92
    • 0030010591 scopus 로고    scopus 로고
    • Mice lacking p27(Kip1) display increased body size, multiple organ hyperplasia, retinal dysplasia and pituitary tumors
    • Nakayama K., Ishida N., Shirane M., Inomata A., Inoue T., Shishido N., Horii I., Loh D.Y. Mice lacking p27(Kip1) display increased body size, multiple organ hyperplasia, retinal dysplasia and pituitary tumors. Cell. 85:1996;707-720.
    • (1996) Cell , vol.85 , pp. 707-720
    • Nakayama, K.1    Ishida, N.2    Shirane, M.3    Inomata, A.4    Inoue, T.5    Shishido, N.6    Horii, I.7    Loh, D.Y.8
  • 93
    • 0031815596 scopus 로고    scopus 로고
    • Toward an understanding of the functional complexity of the E2F and retinoblastoma families
    • Nevins J.R. Toward an understanding of the functional complexity of the E2F and retinoblastoma families. Cell Growth Differ. 9:1998;585-593.
    • (1998) Cell Growth Differ. , vol.9 , pp. 585-593
    • Nevins, J.R.1
  • 94
    • 0032905150 scopus 로고    scopus 로고
    • Cell-free degradation of p27(kip1), a G1 cyclin-dependent kinase inhibitor, is dependent on CDK2 activity and the proteasome
    • Nguyen H., Gitig D.M., Koff A. Cell-free degradation of p27(kip1), a G1 cyclin-dependent kinase inhibitor, is dependent on CDK2 activity and the proteasome. Mol. Cell. Biol. 19:1999;1190-1201.
    • (1999) Mol. Cell. Biol. , vol.19 , pp. 1190-1201
    • Nguyen, H.1    Gitig, D.M.2    Koff, A.3
  • 95
    • 0029811983 scopus 로고    scopus 로고
    • Early loss of the retinoblastoma gene is associated with impaired growth inhibitory innervation during melanotroph carcinogenesis in Rb+/- mice
    • Nikitin A., Lee W.H. Early loss of the retinoblastoma gene is associated with impaired growth inhibitory innervation during melanotroph carcinogenesis in Rb+/- mice. Genes Dev. 10:1996;1870-1879.
    • (1996) Genes Dev. , vol.10 , pp. 1870-1879
    • Nikitin, A.1    Lee, W.H.2
  • 96
    • 0028342664 scopus 로고
    • Cloning of senescent cell-derived inhibitors of DNA synthesis using an expression screen
    • Noda A., Ning Y., Venable S.F., Pereira-Smith O.M., Smith J.R. Cloning of senescent cell-derived inhibitors of DNA synthesis using an expression screen. Exp. Cell Res. 211:1994;90-98.
    • (1994) Exp. Cell Res. , vol.211 , pp. 90-98
    • Noda, A.1    Ning, Y.2    Venable, S.F.3    Pereira-Smith, O.M.4    Smith, J.R.5
  • 97
    • 0029583648 scopus 로고
    • Regulation of the cyclin E gene by transcription factor E2F1
    • Ohtani K., DeGregori J., Nevins J.R. Regulation of the cyclin E gene by transcription factor E2F1. Proc. Natl. Acad. Sci. USA. 92:1995;12146-12150.
    • (1995) Proc. Natl. Acad. Sci. USA , vol.92 , pp. 12146-12150
    • Ohtani, K.1    Degregori, J.2    Nevins, J.R.3
  • 98
    • 0027193034 scopus 로고
    • Cyclin-dependent regulation of G1 in mammalian fibroblasts
    • Ohtsubo M., Roberts J.M. Cyclin-dependent regulation of G1 in mammalian fibroblasts. Science. 259:1993;1908-1912.
    • (1993) Science , vol.259 , pp. 1908-1912
    • Ohtsubo, M.1    Roberts, J.M.2
  • 100
    • 0029024015 scopus 로고
    • Role of the ubiquitin-proteasome pathway in regulating abundance of the cyclin-dependent kinase inhibitor p27 [see comments]
    • Pagano M., Tam S.W., Theodoras A.M., Beer-Romero P., Del Sal G., Chau V., Yew P.R., Draetta G.F., Rolfe M. Role of the ubiquitin-proteasome pathway in regulating abundance of the cyclin-dependent kinase inhibitor p27 [see comments]. Science. 269:1995;682-685.
    • (1995) Science , vol.269 , pp. 682-685
    • Pagano, M.1    Tam, S.W.2    Theodoras, A.M.3    Beer-Romero, P.4    Del Sal, G.5    Chau, V.6    Yew, P.R.7    Draetta, G.F.8    Rolfe, M.9
  • 101
    • 0024473604 scopus 로고
    • G1 events and regulation of cell proliferation
    • Pardee A.B. G1 events and regulation of cell proliferation. Science. 246:1989;603-608.
    • (1989) Science , vol.246 , pp. 603-608
    • Pardee, A.B.1
  • 103
    • 0028869884 scopus 로고
    • Lack of cyclin D-Cdk complexes in Rb-negative cells correlates with high levels of p16INK4/MTS1 tumour suppressor gene product
    • Parry D., Bates S., Mann D.J., Peters G. Lack of cyclin D-Cdk complexes in Rb-negative cells correlates with high levels of p16INK4/MTS1 tumour suppressor gene product. EMBO J. 14:1995;503-511.
    • (1995) EMBO J. , vol.14 , pp. 503-511
    • Parry, D.1    Bates, S.2    Mann, D.J.3    Peters, G.4
  • 104
    • 0032980425 scopus 로고    scopus 로고
    • Cyclin D-CDK subunit arrangement is dependent on the availability of competing INK4 and p21 class inhibitors
    • Parry D., Mahony D., Wills K., Lees E. Cyclin D-CDK subunit arrangement is dependent on the availability of competing INK4 and p21 class inhibitors. Mol. Cell. Biol. 19:1999;1775-1783.
    • (1999) Mol. Cell. Biol. , vol.19 , pp. 1775-1783
    • Parry, D.1    Mahony, D.2    Wills, K.3    Lees, E.4
  • 105
    • 0033574614 scopus 로고    scopus 로고
    • Mechanisms of cyclin-dependent kinase regulation: Structures of Cdks, their cyclin activators and Cip and INK4 inhibitors
    • Pavletich N.P. Mechanisms of cyclin-dependent kinase regulation: structures of Cdks, their cyclin activators and Cip and INK4 inhibitors. J. Mol. Biol. 287:1999;821-828.
    • (1999) J. Mol. Biol. , vol.287 , pp. 821-828
    • Pavletich, N.P.1
  • 107
    • 0028179669 scopus 로고
    • P27Kip1, a cyclin-Cdk inhibitor, links transforming growth factor-beta and contact inhibition to cell cycle arrest
    • Polyak K., Kato J.Y., Solomon M.J., Sherr C.J., Massague J., Roberts J.M., Koff A. p27Kip1, a cyclin-Cdk inhibitor, links transforming growth factor-beta and contact inhibition to cell cycle arrest. Genes Dev. 8:1994;9-22.
    • (1994) Genes Dev. , vol.8 , pp. 9-22
    • Polyak, K.1    Kato, J.Y.2    Solomon, M.J.3    Sherr, C.J.4    Massague, J.5    Roberts, J.M.6    Koff, A.7
  • 108
    • 0028176483 scopus 로고
    • Cloning of p27Kip1, a cyclin-dependent kinase inhibitor and a potential mediator of extracellular antimitogenic signals
    • Polyak K., Lee M.H., Erdjument-Bromage H., Koff A., Roberts J.M., Tempst P., Massague J. Cloning of p27Kip1, a cyclin-dependent kinase inhibitor and a potential mediator of extracellular antimitogenic signals. Cell. 78:1994;59-66.
    • (1994) Cell , vol.78 , pp. 59-66
    • Polyak, K.1    Lee, M.H.2    Erdjument-Bromage, H.3    Koff, A.4    Roberts, J.M.5    Tempst, P.6    Massague, J.7
  • 109
    • 0031048716 scopus 로고    scopus 로고
    • Expression of cell-cycle regulators p27Kip1 and cyclin E, alone and in combination, correlate with survival in young breast cancer patients [see comments]
    • Porter P.L., Malone K.E., Heagerty P.J., Alexander G.M., Gatti L.A., Firpo E.J., Daling J.R., Roberts J.M. Expression of cell-cycle regulators p27Kip1 and cyclin E, alone and in combination, correlate with survival in young breast cancer patients [see comments]. Nat. Med. 3:1997;222-225.
    • (1997) Nat. Med. , vol.3 , pp. 222-225
    • Porter, P.L.1    Malone, K.E.2    Heagerty, P.J.3    Alexander, G.M.4    Gatti, L.A.5    Firpo, E.J.6    Daling, J.R.7    Roberts, J.M.8
  • 111
    • 0032937751 scopus 로고    scopus 로고
    • Loss of Cdk4 expression causes insulin-deficient diabetes and Cdk4 activation results in beta-islet cell hyperplasia
    • Rane S.G., Dubus P., Mettus R.V., Galbreath E.J., Boden G., Reddy E.P., Barbacid M. Loss of Cdk4 expression causes insulin-deficient diabetes and Cdk4 activation results in beta-islet cell hyperplasia. Nat. Genet. 22:1999;44-52.
    • (1999) Nat. Genet. , vol.22 , pp. 44-52
    • Rane, S.G.1    Dubus, P.2    Mettus, R.V.3    Galbreath, E.J.4    Boden, G.5    Reddy, E.P.6    Barbacid, M.7
  • 112
    • 0028173667 scopus 로고
    • Acceleration of the G1/S phase transition by expression of cyclins D1 and E with an inducible system
    • Resnitzky D., Gossen M., Bujard H., Reed S.I. Acceleration of the G1/S phase transition by expression of cyclins D1 and E with an inducible system. Mol. Cell. Biol. 14:1994;1669-1679.
    • (1994) Mol. Cell. Biol. , vol.14 , pp. 1669-1679
    • Resnitzky, D.1    Gossen, M.2    Bujard, H.3    Reed, S.I.4
  • 113
    • 0029153609 scopus 로고
    • Kip/Cip and Ink4 Cdk inhibitors cooperate to induce cell cycle arrest in response to TGF-beta
    • Reynisdottir I., Polyak K., Iavarone A., Massague J. Kip/Cip and Ink4 Cdk inhibitors cooperate to induce cell cycle arrest in response to TGF-beta. Genes Dev. 9:1995;1831-1845.
    • (1995) Genes Dev. , vol.9 , pp. 1831-1845
    • Reynisdottir, I.1    Polyak, K.2    Iavarone, A.3    Massague, J.4
  • 114
    • 0029666482 scopus 로고    scopus 로고
    • Abrogation of p27Kip1 by cDNA antisense suppresses quiescence (G0 state) in fibroblasts
    • Rivard N., L'Allemain G., Bartek J., Pouyssegur J. Abrogation of p27Kip1 by cDNA antisense suppresses quiescence (G0 state) in fibroblasts. J. Biol. Chem. 271:1996;18337-18341.
    • (1996) J. Biol. Chem. , vol.271 , pp. 18337-18341
    • Rivard, N.1    L'Allemain, G.2    Bartek, J.3    Pouyssegur, J.4
  • 116
    • 0033588882 scopus 로고    scopus 로고
    • The INK4 family of cell cycle inhibitors in cancer
    • Roussel M.F. The INK4 family of cell cycle inhibitors in cancer. Oncogene. 18:1999;5311-5317.
    • (1999) Oncogene , vol.18 , pp. 5311-5317
    • Roussel, M.F.1
  • 117
    • 0032517341 scopus 로고    scopus 로고
    • The p16INK4a/CDKN2A tumor suppressor and its relatives
    • Ruas M., Peters G. The p16INK4a/CDKN2A tumor suppressor and its relatives. Biochim. Biophys. Acta. 1378:1998;F115-177.
    • (1998) Biochim. Biophys. Acta , vol.1378 , pp. 115-177
    • Ruas, M.1    Peters, G.2
  • 118
    • 0031930466 scopus 로고    scopus 로고
    • Stable binding to E2F is not required for the retinoblastoma protein to activate transcription, promote differentiation and suppress tumor cell growth
    • Sellers W.R., Novitch B.G., Miyake S., Heith A., Otterson G.A., Kaye F.J., Lassar A.B., Kaelin W.G. Jr. Stable binding to E2F is not required for the retinoblastoma protein to activate transcription, promote differentiation and suppress tumor cell growth. Genes Dev. 12:1998;95-106.
    • (1998) Genes Dev. , vol.12 , pp. 95-106
    • Sellers, W.R.1    Novitch, B.G.2    Miyake, S.3    Heith, A.4    Otterson, G.A.5    Kaye, F.J.6    Lassar, A.B.7    Kaelin, W.G.8
  • 119
    • 0027769876 scopus 로고
    • A new regulatory motif in cell-cycle control causing specific inhibition of cyclin D/CDK4
    • Serrano M., Hannon G.J., Beach D. A new regulatory motif in cell-cycle control causing specific inhibition of cyclin D/CDK4. Nature. 366:1993;704-707.
    • (1993) Nature , vol.366 , pp. 704-707
    • Serrano, M.1    Hannon, G.J.2    Beach, D.3
  • 122
    • 0027336491 scopus 로고
    • Mammalian G1 cyclins
    • Sherr C.J. Mammalian G1 cyclins. Cell. 73:1993;1059-1065.
    • (1993) Cell , vol.73 , pp. 1059-1065
    • Sherr, C.J.1
  • 123
    • 0029849620 scopus 로고    scopus 로고
    • Cancer cell cycles
    • Sherr C.J. Cancer cell cycles. Science. 274:1996;1672-1677.
    • (1996) Science , vol.274 , pp. 1672-1677
    • Sherr, C.J.1
  • 124
    • 0032191393 scopus 로고    scopus 로고
    • Tumor surveillance via the ARF-p53 pathway
    • Sherr C.J. Tumor surveillance via the ARF-p53 pathway. Genes Dev. 12:1998;2984-2991.
    • (1998) Genes Dev. , vol.12 , pp. 2984-2991
    • Sherr, C.J.1
  • 125
    • 0033564697 scopus 로고    scopus 로고
    • CDK inhibitors: Positive and negative regulators of G1-phase progression
    • Sherr C.J., Roberts J.M. CDK inhibitors: positive and negative regulators of G1-phase progression. Genes Dev. 13:1999;1501-1512.
    • (1999) Genes Dev. , vol.13 , pp. 1501-1512
    • Sherr, C.J.1    Roberts, J.M.2
  • 128
    • 0031815206 scopus 로고    scopus 로고
    • Distinct mechanisms control the accumulation of the Rb-related p107 and p130 proteins during cell growth
    • Smith E.J., Leone G., Nevins J.R. Distinct mechanisms control the accumulation of the Rb-related p107 and p130 proteins during cell growth. Cell Growth Differ. 9:1998;297-303.
    • (1998) Cell Growth Differ. , vol.9 , pp. 297-303
    • Smith, E.J.1    Leone, G.2    Nevins, J.R.3
  • 130
    • 0032430241 scopus 로고    scopus 로고
    • Inactivation of the cyclin-dependent kinase inhibitor p27 upon loss of the tuberous sclerosis complex gene-2 [see comments]
    • Soucek T., Yeung R.S., Hengstschlager M. Inactivation of the cyclin-dependent kinase inhibitor p27 upon loss of the tuberous sclerosis complex gene-2 [see comments]. Proc. Natl. Acad. Sci. USA. 95:1998;15653-15658.
    • (1998) Proc. Natl. Acad. Sci. USA , vol.95 , pp. 15653-15658
    • Soucek, T.1    Yeung, R.S.2    Hengstschlager, M.3
  • 131
    • 0029810269 scopus 로고    scopus 로고
    • Cell cycle control of DNA replication
    • Stillman B. Cell cycle control of DNA replication. Science. 274:1996;1659-1664.
    • (1996) Science , vol.274 , pp. 1659-1664
    • Stillman, B.1
  • 132
    • 0030794278 scopus 로고    scopus 로고
    • Inactivation of pRB-related proteins p130 and p107 mediated by the J domain of simian virus 40 large T antigen
    • Stubdal H., Zalvide J., Campbell K.S., Schweitzer C., Roberts T.M., DeCaprio J.A. Inactivation of pRB-related proteins p130 and p107 mediated by the J domain of simian virus 40 large T antigen. Mol. Cell. Biol. 17:1997;4979-4990.
    • (1997) Mol. Cell. Biol. , vol.17 , pp. 4979-4990
    • Stubdal, H.1    Zalvide, J.2    Campbell, K.S.3    Schweitzer, C.4    Roberts, T.M.5    Decaprio, J.A.6
  • 133
    • 0029774145 scopus 로고    scopus 로고
    • Reduced expression of the cyclin-dependent kinase inhibitor gene p57KIP2 in Wilms' tumor
    • Thompson J.S., Reese K.J., DeBaun M.R., Perlman E.J., Feinberg A.P. Reduced expression of the cyclin-dependent kinase inhibitor gene p57KIP2 in Wilms' tumor. Cancer Res. 56:1996;5723-5727.
    • (1996) Cancer Res. , vol.56 , pp. 5723-5727
    • Thompson, J.S.1    Reese, K.J.2    Debaun, M.R.3    Perlman, E.J.4    Feinberg, A.P.5
  • 134
    • 0031667133 scopus 로고    scopus 로고
    • The absence of p27Kip1, an inhibitor of G1 cyclin-dependent kinases, uncouples differentiation and growth arrest during the granulosa→luteal transition
    • Tong W., Kiyokawa H., Soos T.J., Park M.S., Soares V.C., Manova K., Pollard J.W., Koff A. The absence of p27Kip1, an inhibitor of G1 cyclin-dependent kinases, uncouples differentiation and growth arrest during the granulosa→luteal transition. Cell Growth Differ. 9:1998;787-794.
    • (1998) Cell Growth Differ. , vol.9 , pp. 787-794
    • Tong, W.1    Kiyokawa, H.2    Soos, T.J.3    Park, M.S.4    Soares, V.C.5    Manova, K.6    Pollard, J.W.7    Koff, A.8
  • 135
    • 0028363519 scopus 로고
    • P27, a novel inhibitor of G1 cyclin-Cdk protein kinase activity, is related to p21
    • Toyoshima H., Hunter T. p27, a novel inhibitor of G1 cyclin-Cdk protein kinase activity, is related to p21. Cell. 78:1994;67-74.
    • (1994) Cell , vol.78 , pp. 67-74
    • Toyoshima, H.1    Hunter, T.2
  • 136
    • 0032159103 scopus 로고    scopus 로고
    • Mutation of E2f-1 suppresses apoptosis and inappropriate S phase entry and extends survival of Rb-deficient mouse embryos
    • Tsai K.Y., Hu Y., Macleod K.F., Crowley D., Yamasaki L., Jacks T. Mutation of E2f-1 suppresses apoptosis and inappropriate S phase entry and extends survival of Rb-deficient mouse embryos. Mol. Cell. 2:1998;293-304.
    • (1998) Mol. Cell. , vol.2 , pp. 293-304
    • Tsai, K.Y.1    Hu, Y.2    Macleod, K.F.3    Crowley, D.4    Yamasaki, L.5    Jacks, T.6
  • 138
    • 0030847760 scopus 로고    scopus 로고
    • Phosphorylation-dependent degradation of the cyclin-dependent kinase inhibitor p27
    • Vlach J., Hennecke S., Amati B. Phosphorylation-dependent degradation of the cyclin-dependent kinase inhibitor p27. EMBO J. 16:1997;5334-5344.
    • (1997) EMBO J. , vol.16 , pp. 5334-5344
    • Vlach, J.1    Hennecke, S.2    Amati, B.3
  • 140
    • 0029043782 scopus 로고
    • Mechanism of active transcriptional repression by the retinoblastoma protein
    • Weintraub S.J., Chow K.N., Luo R.X., Zhang S.H., He S., Dean D.C. Mechanism of active transcriptional repression by the retinoblastoma protein. Nature. 375:1995;812-815.
    • (1995) Nature , vol.375 , pp. 812-815
    • Weintraub, S.J.1    Chow, K.N.2    Luo, R.X.3    Zhang, S.H.4    He, S.5    Dean, D.C.6
  • 141
    • 1842413645 scopus 로고    scopus 로고
    • P130 and p107 use a conserved domain to inhibit cellular cyclin- dependent kinase activity
    • Woo M.S., Sanchez I., Dynlacht B.D. p130 and p107 use a conserved domain to inhibit cellular cyclin- dependent kinase activity. Mol. Cell. Biol. 17:1997;3566-3579.
    • (1997) Mol. Cell. Biol. , vol.17 , pp. 3566-3579
    • Woo, M.S.1    Sanchez, I.2    Dynlacht, B.D.3
  • 143
    • 0031603542 scopus 로고    scopus 로고
    • Growth regulation by the E2F and DP transcription factor families
    • Yamasaki L. Growth regulation by the E2F and DP transcription factor families. Results Probl. Cell Differ. 22:1998;199-227.
    • (1998) Results Probl. Cell Differ. , vol.22 , pp. 199-227
    • Yamasaki, L.1
  • 144
    • 0030955563 scopus 로고    scopus 로고
    • Ablation of the CDK inhibitor p57Kip2 results in increased apoptosis and delayed differentiation during mouse development
    • Yan Y., Frisen J., Lee M.H., Massague J., Barbacid M. Ablation of the CDK inhibitor p57Kip2 results in increased apoptosis and delayed differentiation during mouse development. Genes Dev. 11:1997;973-983.
    • (1997) Genes Dev. , vol.11 , pp. 973-983
    • Yan, Y.1    Frisen, J.2    Lee, M.H.3    Massague, J.4    Barbacid, M.5
  • 145
    • 0029091312 scopus 로고
    • Role of pRb-related proteins in simian virus 40 large-T-antigen- mediated transformation
    • Zalvide J., DeCaprio J.A. Role of pRb-related proteins in simian virus 40 large-T-antigen- mediated transformation. Mol. Cell. Biol. 15:1995;5800-5810.
    • (1995) Mol. Cell. Biol. , vol.15 , pp. 5800-5810
    • Zalvide, J.1    Decaprio, J.A.2
  • 146
    • 0027440552 scopus 로고
    • Proliferating cell nuclear antigen and p21 are components of multiple cell cycle kinase complexes
    • Zhang H., Xiong Y., Beach D. Proliferating cell nuclear antigen and p21 are components of multiple cell cycle kinase complexes. Mol. Biol. Cell. 4:1993;897-906.
    • (1993) Mol. Biol. Cell , vol.4 , pp. 897-906
    • Zhang, H.1    Xiong, Y.2    Beach, D.3
  • 148
    • 0032532490 scopus 로고    scopus 로고
    • Cooperation between the Cdk inhibitors p27(KIP1) and p57(KIP2) in the control of tissue growth and development
    • Zhang P., Wong C., DePinho R.A., Harper J.W., Elledge S.J. Cooperation between the Cdk inhibitors p27(KIP1) and p57(KIP2) in the control of tissue growth and development. Genes Dev. 12:1998;3162-3167.
    • (1998) Genes Dev. , vol.12 , pp. 3162-3167
    • Zhang, P.1    Wong, C.2    Depinho, R.A.3    Harper, J.W.4    Elledge, S.J.5
  • 149
    • 0033556237 scopus 로고    scopus 로고
    • P21(CIP1) and p57(KIP2) control muscle differentiation at the myogenin step
    • Zhang P., Wong C., Liu D., Finegold M., Harper J.W., Elledge S.J. p21(CIP1) and p57(KIP2) control muscle differentiation at the myogenin step. Genes Dev. 13:1999;213-224.
    • (1999) Genes Dev. , vol.13 , pp. 213-224
    • Zhang, P.1    Wong, C.2    Liu, D.3    Finegold, M.4    Harper, J.W.5    Elledge, S.J.6
  • 150
    • 0032520093 scopus 로고    scopus 로고
    • Expression of NPAT, a novel substrate of cyclin E-CDK2, promotes S-phase entry
    • Zhao J., Dynlacht B., Imai T., Hori T., Harlow E. Expression of NPAT, a novel substrate of cyclin E-CDK2, promotes S-phase entry. Genes Dev. 12:1998;456-461.
    • (1998) Genes Dev. , vol.12 , pp. 456-461
    • Zhao, J.1    Dynlacht, B.2    Imai, T.3    Hori, T.4    Harlow, E.5
  • 151
    • 0028983384 scopus 로고
    • P107 uses a p21CIP1-related domain to bind cyclin/cdk2 and regulate interactions with E2F
    • Zhu L., Harlow E., Dynlacht B.D. p107 uses a p21CIP1-related domain to bind cyclin/cdk2 and regulate interactions with E2F. Genes Dev. 9:1995;1740-1752.
    • (1995) Genes Dev. , vol.9 , pp. 1740-1752
    • Zhu, L.1    Harlow, E.2    Dynlacht, B.D.3
  • 152


* 이 정보는 Elsevier사의 SCOPUS DB에서 KISTI가 분석하여 추출한 것입니다.