Regulation of cyclin-dependent kinase inhibitor p21WAF1/CIP1 by protein kinase Cδ-mediated phosphorylation

Apoptosis

Volumn 12, Issue 7, 2007, Pages 1339-1347

  Oh, You Take ^a   Chun, Kwang Hoon ^a   Park, Byoung Duck ^a   Choi, Joon Seok ^a   Lee, Seung Ki ^a  

^a Seoul National University   (South Korea)

Author keywords

p21WAF1 CIP1; Phosphorylation; PKC ; PKC ; TNF

Indexed keywords

CYCLIN DEPENDENT KINASE INHIBITOR 1; PHORBOL 13 ACETATE 12 MYRISTATE; PROTEIN KINASE C DELTA; SMALL INTERFERING RNA;

AMINO ACID SEQUENCE; APOPTOSIS; ARTICLE; CARBOXY TERMINAL SEQUENCE; CARCINOGENESIS; CONTROLLED STUDY; ENZYME PHOSPHORYLATION; FEMALE; HELA CELL; HUMAN; HUMAN CELL; PRIORITY JOURNAL; PROTEIN ANALYSIS; PROTEIN FUNCTION; REGULATORY MECHANISM; SINGLE NUCLEOTIDE POLYMORPHISM;

ANIMALS; APOPTOSIS; CASPASE 3; CELL LINE; CYCLIN-DEPENDENT KINASE INHIBITOR P21; HELA CELLS; HUMANS; MICE; PHOSPHORYLATION; PROTEIN KINASE C-DELTA; TUMOR NECROSIS FACTOR-ALPHA;

MUS;

EID: 34250022553     PISSN: 13608185     EISSN: 1573675X     Source Type: Journal    
DOI: 10.1007/s10495-007-0066-8     Document Type: Article

References (44)

1. Chen J, Saha P, Kornbluth S, Dynlacht BD, Dutta A (1996) Cyclin-binding motifs are essential for the function of p21CIP1. Mol Cell Biol 16:4673-4882
2. Goubin F, Ducommun B (1995) Identification of binding domains on the p21Cip1 cyclin-dependent kinase inhibitor. Oncogene 10:2281-2287
3. Luo Y, Hurwitz J, Massague J (1995) Cell-cycle inhibition by independent CDK and PCNA binding domains in p21Cip1. Nature 375:159-161
4. Yang W, Velcich A, Lozonschi I, Liang J, Nicholas C, Zhuang M, Bancroft L, Augenlicht LH (2005) Inactivation of p21WAF1/cip1 enhances intestinal tumor formation in Muc2-/- mice. Am. J. Pathol. 166:1239-1246
5. Jackson RJ, Adnane J, Coppola D, Cantor A, Sebti SM, Pledger WJ (2002) Loss of the cell cycle inhibitors p21(Cip1) and p27(Kip1) enhances tumorigenesis in knockout mouse models. Oncogene 21:8486-8497
6. Martin-Caballero J, Flores JM, Garcia-Palencia P, Serrano M (2001) Tumor susceptibility of p21(Waf1/Cip1)-deficient mice. Cancer Res 61:6234-6238
7. Ralhan R, Agarwal S, Mathur M, Wasylyk B, Srivastava A (2000) Association between polymorphism in p21(Waf1/Cip1) cyclin-dependent kinase inhibitor gene and human oral cancer. Clin Cancer Res 6:2440-2447
8. Bahl R, Arora S, Nath N, Mathur M, Shukla NK, Ralhan R (2000) Novel polymorphism in p21(waf1/cip1) cyclin dependent kinase inhibitor gene:association with human esophageal cancer. Oncogene 19:323-328
9. Mousses S, Ozcelik H, Lee PD, Malkin D, Bull SB, Andrulis IL (1995) Two variants of the CIP1/WAF1 gene occur together and are associated with human cancer. Hum Mol Genet 4:1089-1092
10. Weinberg WC, Fernandez-Salas E, Morgan DL, Shalizi A, Mirosh E, Stanulis E, Deng C, Hennings H, Yuspa SH (1999) Genetic deletion of p21WAF1 enhances papilloma formation but not malignant conversion in experimental mouse skin carcinogenesis. Cancer Res 59:2050-2054
11. Topley GI, Okuyama R, Gonzales JG, Conti C, Dotto GP (1999) p21(WAF1/Cip1) functions as a suppressor of malignant skin tumor formation and a determinant of keratinocyte stem-cell potential. Proc Natl Acad Sci USA 96:9089-9094
12. Philipp J, Vo K, Gurley KE, Seidel K, Kemp CJ (1999) Tumor suppression by p27Kip1 and p21Cip1 during chemically induced skin carcinogenesis. Oncogene 18:4689-4698
13. Todd C, Reynolds NJ (1998) Up-regulation of p21WAF1 by phorbol ester and calcium in human keratinocytes through a protein kinase C-dependent pathway. Am J Pathol 153:39-45
14. Akashi M, Osawa Y, Koeffler HP, Hachiya M (1999) p21WAF1 expression by an activator of protein kinase C is regulated mainly at the post-transcriptional level in cells lacking p53:important role of RNA stabilization. Biochem J 337:607-616
15. Dotto GP (2000) p21(WAF1/Cip1):more than a break to the cell cycle? Biochim Biophys Acta 1471:43-56
16. Mutoh M, Lung FD, Long YQ, Roller PP, Sikorski RS, O'Connor PM (1999) A p21(Waf1/Cip1)carboxyl-terminal peptide exhibited cyclin-dependent kinase-inhibitory activity and cytotoxicity when introduced into human cells. Cancer Res 59:3480-3488
17. Zheleva DI, McInnes C, Gavine AL, Zhelev NZ, Fischer PM, Lane DP (2002) Highly potent p21(WAF1)-derived peptide inhibitors of CDK-mediated pRb phosphorylation:delineation and structural insight into their interactions with cyclin A. J Pept Res 60:257-270
18. Gulbis JM, Kelman Z, Hurwitz J, O'Donnell M, Kuriyan J (1996) Structure of the C-terminal region of p21(WAF1/CIP1) complexed with human PCNA. Cell 87:297-306
19. Russo AA, Jeffrey PD, Patten AK, Massague J, Pavletich NP (1996) Crystal structure of the p27Kip1 cyclin-dependent-kinase inhibitor bound to the cyclin A-Cdk2 complex. Nature 382:325-331
20. Touitou R, Richardson J, Bose S, Nakanishi M, Rivett J, Allday MJ (2001) A degradation signal located in the C-terminus of p21WAF1/CIP1 is a binding site for the C8 alpha-subunit of the 20S proteasome. EMBO J 20:2367-2375
21. Sheaff RJ, Singer JD, Swanger J, Smitherman M, Roberts JM, Clurman BE (2000) Proteasomal turnover of p21Cip1 does not require p21Cip1 ubiquitination. Mol Cell 5:403-410
22. Jin Y, Lee H, Zeng SX, Dai MS, Lu H (2003) MDM2 promotes p21waf1/cip1 proteasomal turnover independently of ubiquitylation. EMBO J 22:6365-6377
23. Wang W, Nacusi L, Sheaff RJ, Liu X (2005) Ubiquitination of p21Cip1/WAF1 by SCFSkp2:substrate requirement and ubiquitination site selection. Biochemistry 44:14553-14564
24. Park JA, Kim KW, Kim SI, Lee SK (1998) Caspase 3 specifically cleaves p21WAF1/CIP1 in the earlier stage of apoptosis in SK-HEP-1 human hepatoma cells. Eur J Biochem 257:242-248
25. Poole AW, Pula G, Hers I, Crosby D, Jones ML (2004) PKC-interacting proteins:from function to pharmacology. Trends Pharmacol Sci 25:528-535
26. Schechtman D, Mochly-Rosen D (2001) Adaptor proteins in protein kinase C-mediated signal transduction. Oncogene 20:6339-6347
27. Jaken S, Parker PJ (2000) Protein kinase C binding partners. Bioessays 22:245-254
28. Sando JJ, Beals JK, Hussaini IM (2003) Subcellular translocation of protein kinase C. Methods Mol Biol 233:77-85
29. Mochly-Rosen D, Gordon AS (1998) Anchoring proteins for protein kinase C:a means for isozyme selectivity. FASEB J 12:35-42
30. Black JD (2000) Protein kinase C-mediated regulation of the cell cycle. Front Biosci 5:D406-D423
31. Hofmann J (1997) The potential for isoenzyme-selective modulation of protein kinase C. FASEB J 11:649-669
32. Rowland BD, Peeper DS (2006) KLF4, p21 and context-dependent opposing forces in cancer. Nat Rev Cancer 6:11-23
33. Weiss RH (2003) p21Waf1/Cip1 as a therapeutic target in breast and other cancers. Cancer Cell 4:425-429
34. Gartel AL, Tyner AL (2002) The role of the cyclin-dependent kinase inhibitor p21 in apoptosis. Mol Cancer Ther 1:639-649
35. Bloom J, Amador V, Bartolini F, DeMartino G, Pagano M (2003) Proteasome-mediated degradation of p21 via N-terminal ubiquitinylation. Cell 115:71-82
36. Zhou BP, Liao Y, Xia W, Spohn B, Lee MH, Hung MC (2001) Cytoplasmic localization of p21Cip1/WAF1 by Akt-induced phosphorylation in HER-2/neu-overexpressing cells. Nat Cell Biol 3:245-252
37. Ruvolo PP, Deng X, Carr BK, May WS (1998) A functional role for mitochondrial protein kinase Calpha in Bcl2 phosphorylation and suppression of apoptosis. J Biol Chem 273:25436-25442
38. Li W, Zhang J, Flechner L, Hyun T, Yam A, Franke TF, Pierce JH (1999) Protein kinase C-alpha overexpression stimulates Akt activity and suppresses apoptosis induced by interleukin 3 withdrawal. Oncogene 18:6564-6572
39. Oh JI, Chun KH, Joo SH, Oh YT, Lee SK (2005) Caspase-3-dependent protein kinase C delta activity is required for the progression of Ginsenoside-Rh2- induced apoptosis in SK-HEP-1 cells. Cancer Lett 230:228-238
40. Oh YT, Chun KH, Oh JI, Park JA, Kim YU, Lee SK (2006) PKCδ-modulates p21WAF1/CIP1 ability to bind to Cdk2 during TNFα-induced apoptosis. Biochem Biophys Res Commun 339:1138-1147
41. Scott MT, Morrice N, Ball KL (2000) Reversible phosphorylation at the C-terminal regulatory domain of p21(Waf1/Cip1) modulates proliferating cell nuclear antigen binding. J Biol Chem 275:11529-11537
42. Rossig L, Jadidi AS, Urbich C, Badorff C, Zeiher AM, Dimmeler S (2001) Akt-dependent phosphorylation of p21(Cip1) regulates PCNA binding and proliferation of endothelial cells. Mol Cell Biol 21:5644-5657
43. Timchenko NA, Harris TE, Wilde M, Bilyeu TA, Burgess-Beusse BL, Finegold MJ, Darlington GJ (1997) CCAAT/enhancer binding protein alpha regulates p21 protein and hepatocyte proliferation in newborn mice. Mol Cell Biol 17:7353-7361
44. Coleman ML, Marshall CJ, Olson MF (2003) Ras promotes p21(Waf1/Cip1) protein stability via a cyclin D1-imposed block in proteasome-mediated degradation. EMBO J 22:2036-2046