Proteasomal turnover of p21(Cip1) does not require p21(Cip1) ubiquitination

Molecular Cell

Volumn 5, Issue 2, 2000, Pages 403-410

  Sheaff, Robert J ^a,b   Singer, Jeffrey D ^b   Swanger, Jherek ^b   Smitherman, Matthew ^b   Roberts, James M ^b,c   Clurman, Bruce E ^b  

^a UNIVERSITY OF MINNESOTA   (United States)

^b UNIVERSITY OF WASHINGTON   (United States)

^c HOWARD HUGHES MEDICAL INSTITUTE   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

ACTINOMYCIN DERIVATIVE; ALDEHYDE DERIVATIVE; CYCLIN DEPENDENT KINASE; CYCLIN E; LACTONE DERIVATIVE; LYSINE; PROTEASOME; PROTEIN P21; PROTEIN P27; UBIQUITIN; CDKN1A PROTEIN, HUMAN; CDKN1A PROTEIN, MOUSE; CYCLIN DEPENDENT KINASE INHIBITOR 1A; CYCLINE; CYSTEINE PROTEINASE; MULTIENZYME COMPLEX;

ARTICLE; CELL CYCLE; CONTROLLED STUDY; DIPLOIDY; DRUG INHIBITION; GENETIC TRANSFECTION; HALF LIFE TIME; MOUSE; NONHUMAN; PROTEIN DEGRADATION; PROTEIN METABOLISM; PROTEIN SYNTHESIS; PROTEIN SYNTHESIS INHIBITION; PROTEIN SYNTHESIS REGULATION; TURNOVER TIME; ANIMAL; CELL STRAIN 3T3; DRUG ANTAGONISM; HUMAN; METABOLISM; PROTEIN PROCESSING;

3T3 CELLS; ANIMALS; CYCLIN-DEPENDENT KINASE INHIBITOR P21; CYCLIN-DEPENDENT KINASES; CYCLINS; CYSTEINE ENDOPEPTIDASES; HUMANS; MICE; MULTIENZYME COMPLEXES; PROTEASOME ENDOPEPTIDASE COMPLEX; PROTEIN PROCESSING, POST-TRANSLATIONAL; UBIQUITINS;

EID: 0033623850     PISSN: 10972765     EISSN: None     Source Type: Journal    
DOI: 10.1016/S1097-2765(00)80435-9     Document Type: Article

References (40)

1. Critical role for lysines 21 and 22 in signal-induced, ubiquitin-mediated proteolysis of I kappa B-alpha
2. Proteasome-dependent regulation of p21WAF1/CIP1 expression
3. N-terminal processing: The methionine aminopeptidase and N alpha-acetyl transferase families
4. A novel site for ubiquitination: The N-terminal residue, and not internal lysines of MyoD, is essential for conjugation and degradation of the protein
5. A comparison of the turnover of alpha-N-acetylated and nonacetylated mouse L-cell proteins
6. Interaction with cyclin-dependent kinases and PCNA modulates proteasome-dependent degradation of p21
7. Turnover of cyclin E by the ubiquitin-proteasome pathway is regulated by cdk2 binding and cyclin phosphorylation
8. Loss of Cul1 results in early embryonic lethality and dysregulation of cyclin E
9. Ubiquitin-dependent degradation of multiple F-box proteins by an autocatalytic mechanism
10. The ubiquitin system
11. Role of the alpha-amino group of protein in ubiquitin-mediated protein breakdown
12. Ubiquitin-dependent protein degradation
13. Ubiquitinylation is not an absolute requirement for degradation of c-Jun protein by the 26 S proteasome
14. Effects of denaturation and methylation on the degradation of proteins in cultured hepatoma cells and in reticulocyte cell-free systems
15. How proteolysis drives the cell cycle
16. Mutagenic analysis of the destruction signal of mitotic cyclins and structural characterization of ubiquitinated intermediates
17. How the cyclin became a cyclin: Regulated proteolysis in the cell cycle
18. Structural studies of p21Waf1/Cip1/Sdi1 in the free and Cdk2-bound state:Conformational disorder mediates binding diversity
19. Proteolysis, matrix-assisted laser desorption/ionization mass spectrometry, high performance liquid chromatography and size-exclusion chromatography of p21Waf1/Cip1/Sdi1
20. The univector plasmid-fusion system, a method for rapid construction of recombinant DNA without restriction enzymes
21. Ubiquitination of p53 and p21 is differentially affected by ionizing and UV radiation
22. Chemical denaturation and modification of ovalbumin alters its dependence on ubiquitin conjugation for class I antigen presentation
23. Improved retroviral vectors for gene transfer and expression
24. Ornithine decarboxylase is degraded by the 26S proteasome without ubiquitination
25. SCF and APC: The Yin and Yang of cell cycle regulated proteolysis
26. Identification of lysine residues required for signal-induced ubiquitination and degradation of I kappa B-alpha in vivo
27. Growth inhibition by CDK-cyclin and PCNA binding domains of p21 occurs by distinct mechanisms and is regulated by ubiquitin-proteasome pathway
28. Signal-induced degradation of I kappa B alpha requires site-specific ubiquitination
29. Cyclin E-CDK2 is a regulator of p27Kip1
30. Inhibitors of mammalian G1 cyclin-dependent kinases
31. Cullin-3 targets cyclin E for ubiquitination and controls S phase in mammalian cells
32. Amino-terminal acetylation of proteins: An overview
33. Degradation of the cyclin-dependent-kinase inhibitor p27Kip1 is instigated by Jab1
34. Deletion of the Cul1 gene in mice causes arrest in early embryogenesis and accumulation of cyclin E
35. Thermoplasma acidophilum proteasomes degrade partially unfolded and ubiquitin-associated proteins
36. Activation of cyclin E/CDK2 is coupled to site-specific autophosphorylation and ubiquitin-dependent degradation of cyclin E
37. Regulation of cyclin A-Cdk2 by SCF component Skp1 and F-box protein Skp2
38. Cytosolic degradation of T-cell receptor alpha chains by the proteasome
39. Human CUL-1 associates with the SKP1/SKP2 complex and regulates p21(CIP1/WAF1) and cyclin D proteins
40. Ubiquitination and degradation of the substance recognition subunits of SCF ubiquitin-protein ligases