p21CIP1 attenuates Ras- and c-Myc-dependent breast tumor epithelial mesenchymal transition and cancer stem cell-like gene expression in vivo

Proceedings of the National Academy of Sciences of the United States of America

Volumn 106, Issue 45, 2009, Pages 19035-19039

  Liu, Manran ^a,b,c   Casimiro, Mathew C ^a,b   Wang, Chenguang ^a,b   Shirley, L Andrew ^a,b   Jiao, Xuanmao ^a,b   Katiyar, Sanjay ^a,b   Ju, Xiaoming ^a,b   Li, Zhiping ^a,b   Yu, Zuoren ^a,b   Zhou, Jie ^a,b   Johnson, Michael ^d   Fortina, Paolo ^a,b   Hyslop, Terry ^a   Windle, Jolene J ^e   Pestell, Richard G ^a,b  

^a THOMAS JEFFERSON UNIVERSITY   (United States)

^b THOMAS JEFFERSON UNIVERSITY   (United States)

^c CHONGQING MEDICAL UNIVERSITY   (China)

^d GEORGETOWN UNIVERSITY   (United States)

^e VIRGINIA COMMONWEALTH UNIVERSITY   (United States)

Author keywords

Cancer stem cells; EMT; Oncogene

Indexed keywords

CYCLIN DEPENDENT KINASE INHIBITOR 1; EPITOPE; CDKN1A PROTEIN, MOUSE; CYCLIN DEPENDENT KINASE INHIBITOR 1A; MYC PROTEIN; MYC PROTEIN, MOUSE; PROTEIN P21;

ANIMAL EXPERIMENT; ANIMAL MODEL; ARTICLE; BREAST CARCINOGENESIS; BREAST TUMOR; CANCER CELL CULTURE; CANCER STEM CELL; CONTROLLED STUDY; EMBRYONIC STEM CELL; GENE DELETION; GENE EXPRESSION; GENE EXPRESSION PROFILING; GENE REPRESSION; GENE SILENCING; HEMATOPOIETIC STEM CELL; HUMAN; HUMAN CELL; IMMUNOHISTOCHEMISTRY; IN VIVO STUDY; MESENCHYME; MOUSE; NONHUMAN; ONCOGENE C MYC; ONCOGENE H RAS; ONCOGENE RAS; PRIORITY JOURNAL; PROTEIN FUNCTION; ANIMAL; CELL TRANSFORMATION; CYTOLOGY; DNA MICROARRAY; EPITHELIUM CELL; GENE EXPRESSION REGULATION; METABOLISM; PATHOLOGY; REVERSE TRANSCRIPTION POLYMERASE CHAIN REACTION; TRANSGENIC MOUSE; TUMOR CELL LINE;

MUS MUSCULUS;

ANIMALS; BREAST NEOPLASMS; CELL LINE, TUMOR; CELL TRANSFORMATION, NEOPLASTIC; CYCLIN-DEPENDENT KINASE INHIBITOR P21; EPITHELIAL CELLS; GENE EXPRESSION REGULATION, NEOPLASTIC; HUMANS; IMMUNOHISTOCHEMISTRY; MICE; MICE, TRANSGENIC; NEOPLASTIC STEM CELLS; OLIGONUCLEOTIDE ARRAY SEQUENCE ANALYSIS; PROTO-ONCOGENE PROTEINS C-MYC; PROTO-ONCOGENE PROTEINS P21(RAS); REVERSE TRANSCRIPTASE POLYMERASE CHAIN REACTION;

EID: 73149086829     PISSN: 00278424     EISSN: 10916490     Source Type: Journal    
DOI: 10.1073/pnas.0910009106     Document Type: Article

References (34)

1. Hanahan D, Weinberg R (2000) The Hallmarks of Cancer. Cell 100:57-70.
2. Zucchi I, et al. (2007) The properties of a mammary gland cancer stem cell. Proc Natl Acad Sci USA 104:10476-10481.
3. el-Deiry WS, et al. (1993) WAF1, a potential mediator of p53 tumor suppression. Cell 75:817-825.
4. Cheng T, et al. (2000) Hematopoietic stem cell quiescence maintained by p21cip1/waf1. Science 287:1804-1808.
5. Cip1/WAF1 alters keratinocyte growth and differentiation and promotes ras-tumor progression. Genes Dev 10:3065-3075.
6. Liu Y, et al. (2007) Somatic cell type specific gene transfer reveals a tumor-promoting function for p21(Waf1/Cip1). EMBO J 26:4683-4693.
7. Besson A, Dowdy SF, Roberts JM (2008) CDK inhibitors: Cell cycle regulators and beyond. Dev Cell 14:159-169.
8. Bearss DJ, Lee RJ, Troyer DA, Pestell RG, Windle JJ (2002) Differential effects of p21(WAF1/CIP1) deficiency on MMTV-ras and MMTV-myc mammary tumor properties. Cancer Res 62:2077-2084.
9. O'Brien CA, Pollett A, Gallinger S, Dick JE (2007) A human colon cancer cell capable of initiating tumor growth in immunodeficient mice. Nature 445:106-110.
10. Singh SK, et al. (2004) Identification of human brain tumor initiating cells. Nature 432:396-401.
11. Al-Hajj M, Wicha MS, Benito-Hernandez A, Morrison SJ, Clarke MF (2003) Prospective identification of tumorigenic breast cancer cells. Proc Natl Acad Sci USA 100:3983-3988.
12. Mani SA, et al. (2008) The epithelial-mesenchymal transition generates cells with properties of stem cells. Cell 133:704-715.
13. Jechlinger M, et al. (2003) Expression profiling of epithelial plasticity in tumor progression. Oncogene 22:7155-7169.
14. Edelman E, et al. (2006) Analysis of sample set enrichment scores: Assaying the enrichment of sets of genes for individual samples in genome-wide expression profiles. Bioinformatics 22:e108-116.
15. Hinata K, Gervin AM, Jennifer Zhang Y, Khavari PA (2003) Divergent gene regulation and growth effects by NF-kappa B in epithelial and mesenchymal cells of human skin. Oncogene 22:1955-1964.
16. Verrecchia F, Chu ML, Mauviel A (2001) Identification of novel TGF-beta/Smad gene targets in dermal fibroblasts using a combined cDNA microarray/promoter transactivation approach. J Biol Chem 276:17058-17062.
17. Peinado H, Olmeda D, Cano A (2007) Snail, Zeb and bHLH factors in tumor progression: An alliance against the epithelial phenotype? Nat Rev Cancer 7:415-428.
18. Rodriguez-Viciana P, et al. (1997) Role of phosphoinositide 3-OH kinase in cell transformation and control of the actin cytoskeleton by ras. Cell 89:457-467.
19. Ben-Porath I, et al. (2008) An embryonic stem cell-like gene expression signature in poorly differentiated aggressive human tumors. Nat Genet 40:499-507.
20. Takahashi K, Yamanaka S (2006) Induction of pluripotent stem cells from mouse embryonic and adult fibroblast cultures by defined factors. Cell 126:663-676.
21. Al-Hajj M, Clarke MF (2004) Self-renewal and solid tumor stem cells. Oncogene 23:7274-7282.
22. Dontu G, et al. (2003) In vitro propagation and transcriptional profiling of human mammary stem/progenitor cells. Genes Dev 17:1253-1270.
23. Ponti D, et al. (2005) Isolation and in vitro propagation of tumorigenic breast cancer cells with stem/progenitor cell properties. Cancer Res 65:5506-5511.
24. Trimboli AJ, et al. (2008) Direct evidence for epithelial-mesenchymal transitions in breast cancer. Cancer Res 68:937-945.
25. Li, et al. (2009) Twist1-mediated adriamycin-induced epithelial- mesenchymal transition relates to multidrug resistance and invasive potential in breast cancer cells. Clin Cancer Res 15:2657-2665.
26. Lobo NA, Shimono Y, Qian D, Clarke MF (2007) The biology of cancer stem cells. Annu Rev Cell Dev Biol 23:675-699.
27. Boyer LA, et al. (2005) Core transcriptional regulatory circuitry in human embryonic stem cells. Cell 122:947-956.
28. Gidekel S, Pizov G, Bergman Y, Pikarsky E (2003) Oct-3/4 is a dose-dependent oncogenic fate determinant. Cancer Cell 4:361-370.
29. Rodriguez-Pinilla SM, et al. (2007) Sox2: A possible driver of the basal-like phenotype in sporadic breast cancer. Mod Pathol 20:474-481.
30. Li Z, et al. (2008) Alternate Cyclin D1 mRNA splicing modulates p27KIP1 binding and cell migration. J Biol Chem 283:7007-7015.
31. Chen Y, et al. (2002) Ratio statistics of gene expression levels and applications to microarray data analysis. Bioinformatics 18:1207-1215.
32. Smyth GK (2004) Linear models and empirical bayes methods for assessing differential expression in microarray experiments. Stat Appl Genet Mol Biol 3:Article 3.
33. Lindsay J, et al. (2008) ErbB2 induces Notch1 activity and function in breast cancer cells. Clin Transl Sci 1:107-115.
34. Shackleton M, et al. (2006) Generation of a functional mammary gland from a single stem cell. Nature 439:84-88.