High throughput screening of a small molecule one-bead-one-compound combinatorial library to identify attenuators of p21 as chemotherapy sensitizers

Cancer Biology and Therapy

Volumn 7, Issue 12, 2008, Pages 2015-2022

  Park, See Hyoung ^a   Wang, Xiaobing ^a,b   Liu, Ruiwu ^a,b   Lam, Kit S ^a,b   Weiss, Robert H ^a,b,c  

^a UNIVERSITY OF CALIFORNIA   (United States)

^b UNIVERSITY OF CALIFORNIA   (United States)

^c VETERANS AFFAIRS MEDICAL CENTER   (United States)

Author keywords

Apoptosis; Chemotherapy sensitization; Combinatorial chemistry; Kidney cancer; P21

Indexed keywords

ANTINEOPLASTIC AGENT; DOXORUBICIN; PROTEASOME; SMALL P21 BINDING MOLECULE; UBIQUITIN; UNCLASSIFIED DRUG;

ANTINEOPLASTIC ACTIVITY; APOPTOSIS; ARTICLE; BINDING AFFINITY; CANCER CELL CULTURE; CANCER RESISTANCE; CELL KILLING; CELL VIABILITY; COMBINATORIAL LIBRARY; CONCENTRATION RESPONSE; CONTROLLED STUDY; CYTOTOXICITY; DNA DAMAGE; DRUG IDENTIFICATION; DRUG POTENTIATION; DRUG PROTEIN BINDING; DRUG SYNTHESIS; HIGH THROUGHPUT SCREENING; HUMAN; HUMAN CELL; KIDNEY CARCINOMA; PROTEIN DEGRADATION; SENSITIZATION;

EID: 58149119381     PISSN: 15384047     EISSN: 15558576     Source Type: Journal    
DOI: 10.4161/cbt.7.12.7069     Document Type: Article

References (38)

1. Weiss RH, Lin P-Y. Kidney Cancer: Identification of Novel Targets for Therapy. Kidney Int 2006; 69:224-32.
2. Stadler WM, Huo D, George C, Yang X, Ryan CW, Karrison T, et al. Prognostic factors for survival with gemcitabine plus 5-fluorouracil based regimens for metastatic renal cancer. J Urol 2003; 170:1141-5.
3. De Mulder PH, van Herpen CM, Mulders PA. Current treatment of renal cell carcinoma. Ann Oncol 2004; 15:319-28.
4. Tuma RS. Three molecularly targeted drugs tested in kidney cancer clinical trials. J Natl Cancer Inst 2004; 96:1270-1.
5. Matsushita H, Morishita R, Kida I, Aoki M, Hayashi S, Tomita N, et al. Inhibition of growth of human vascular smooth muscle cells by overexpression of p21 gene through induction of apoptosis. Hypertension 1998; 31:493-8.
6. Asada M, Yamada T, Ichijo H, Delia D, Miyazono K, Fukumuro K, et al. Apoptosis inhibitory activity of cytoplasmic p21(Cip1/WAF1) in monocytic differentiation. EMBO J 1999; 18:1223-34.
7. WAF1/CIP1 antisense therapy radiosensitizes human colon cancer by converting growth arrest to apoptosis. Cancer Res 2000; 60:679-84.
8. Fan Y, Borowsky AD, Weiss RH. An antisense oligodeoxynucleotide to p21(Waf1/Cip1) causes apoptosis in human breast cancer cells. Mol Cancer Ther 2003; 2:773-82.
9. Waf1/Cip1 is an assembly factor required for PDGF-induced vascular smooth muscle cell proliferation. J Biol Chem 2000; 275:10285-90.
10. WAF1/Cip1 complex formation. J Biol Chem 2003; 278:32537-43.
11. Waf1/Cip1 increases cell cycle transit in vascular smooth muscle cells. Cell Signal 2003; 16:263-9.
12. el-Deiry WS, Tokino T, Velculescu VE, Levy DB, Parsons R, Trent JM, et al. WAF1, a potential mediator of p53 tumor suppression. Cell 1993; 75:817-25.
13. Xiong Y, Hannon GJ, Zhang H, Casso D, Kobayashi R, Beach D. p21 is a universal inhibitor of cyclin kinases. Nature 1993; 366:701-4.
14. 1 cyclin-dependent kinases. Cell 1993; 75:805-16.
15. 1-phase progression. Genes and Dev 1999; 13:1501-12.
16. Fan YP, Weiss RH. Exogenous attenuation of p21(Waf1/Cip1) decreases mesangial cell hypertrophy as a result of hyperglycemia and IGF-1. J Am Soc Nephrol 2004; 15:575-84.
17. Liu XF, Xia YF, Li MZ, Wang HM, He YX, Zheng ML, et al. The effect of p21 antisense oligodeoxynucleotides on the radiosensitivity of nasopharyngeal carcinoma cells with normal p53 function. Cell Biol Int 2006; 30:283-7.
18. Sohn D, Essmann F, Schulze-Osthoff K, Janicke RU. p21 blocks irradiation-induced apoptosis downstream of mitochondria by inhibition of cyclin-dependent kinase-mediated caspase-9 activation. Cancer Res 2006; 66:11254-62.
19. Park SH, Park JY, Weiss RH. Antisense attenuation of p21 sensitizes kidney cancer to apoptosis in response to conventional DNA damaging chemotherapy associated with enhancement of phospho-p53. J Urol 2008; 180:352-60.
20. Waf1/Cip1 expression is correlated with HER-2/neu in breast cancer and is an independent predictor of prognosis. Breast Cancer Res 2003; 5:242-9.
21. Weiss RH, Borowsky AD, Seligson D, Lin PY, Dillard-Telm L, Belldegrun AS, et al. p21 is a prognostic marker for renal cell carcinoma: implications for novel therapeutic approaches. J Urol 2007; 177:63-8.
22. Lam KS, Salmon SE, Hersh EM, Hruby VJ, Kazmierski WM, Knapp RJ. A new type of synthetic peptide library for identifying ligand-binding activity. Nature 1991; 354:82-4.
23. Lam KS, Lebl M, Krchnak V. The "One-Bead-One-Compound" Combinatorial Library Method. Chem Rev 1997; 97:411-48.
24. Lam KS, Liu R, Miyamoto S, Lehman AL, Tuscano JM. Applications of one-bead one-compound combinatorial libraries and chemical microarrays in signal transduction research. Acc Chem Res 2003; 36:370-7.
25. Waf1/Cip1 as a therapeutic target in breast and other cancers. Cancer Cell 2003; 4:425-9.
26. Shim J, Lee H, Park J, Kim H, Choi EJ. A non-enzymatic p21 protein inhibitor of stress-activated protein kinases. Nature 1996; 381:804-6.
27. Gartel AL, Tyner AL. The role of the cyclin-dependent kinase inhibitor p21 in apoptosis. Mol Cancer Ther 2002; 1:639-49.
28. WAF1/CIP1 is a binding site for the C8 alpha-subunit of the 20S proteasome. EMBO J 2001; 20:2367-75.
29. CIP1/WAF1 by iron depletion. Blood 2007; 110:752-61.
30. waf1/cip1 proteasomal turnover independently of ubiquitylation. EMBO J 2003; 22:6365-77.
31. Liu S, Bishop WR, Liu M. Differential effects of cell cycle regulatory protein p21(WAF1/Cip1) on apoptosis and sensitivity to cancer chemotherapy. Drug Resist Updat 2003; 6:183-95.
32. Brown JM, Attardi LD. The role of apoptosis in cancer development and treatment response. Nat Rev Cancer 2005; 5:231-7.
33. Evan GI, Vousden KH. Proliferation, cell cycle and apoptosis in cancer. Nature 2001; 411:342-8.
34. Gjertsen BT, Bredholt T, Anensen N, Vintermyr OK. Bcl-2 antisense in the treatment of human malignancies: a delusion in targeted therapy. Curr Pharm Biotechnol 2007; 8:373-81.
35. Maki CG, Howley PM. Ubiquitination of p53 and p21 is differentially affected by ionizing and UV radiation. Mol Cell Biol 1997; 17:355-63.
36. Liu R, Marik J, Lam KS. A novel peptide-based encoding system for "one-bead one-compound" peptidomimetic and small molecule combinatorial libraries. J Am Chem Soc 2002; 124:7678-80.
37. Liu R, Wang X, Song A, Bao T, Lam KS. Development and applications of topologically segregated bilayer beads in one-bead one-compound combinatorial libraries. QSAR & Combinatorial Science 2005; 24:1127-40.
38. Wang X, Zhang J, Song A, Lebrilla CB, Lam KS. Encoding method for OBOC small molecule libraries using a biphasic approach for ladder-synthesis of coding tags. J Am Chem Soc 2004; 126:5740-9.