p21(waf1) can block cells at two points in the cell cycle, but does not interfere with processive DNA-replication or stress-activated kinases

Oncogene

Volumn 16, Issue 4, 1998, Pages 431-441

  Medema, René H ^a   Klompmaker, Rob ^a   Smits, Veronique A J ^a   Rijksen, Gert ^a  

^a UNIVERSITY MEDICAL CENTER UTRECHT   (Netherlands)

Author keywords

Cyclin B; Growth inhibition; p21; PCNA; Tetracycline

Indexed keywords

CYCLIN B; CYCLIN DEPENDENT KINASE; CYCLIN DEPENDENT KINASE INHIBITOR; CYCLINE; DNA; MITOGEN ACTIVATED PROTEIN KINASE; PROTEIN P21; TETRACYCLINE; ANTINEOPLASTIC AGENT; CAMPTOTHECIN; CDK2 PROTEIN, HUMAN; CDKN1A PROTEIN, HUMAN; CYCLIN DEPENDENT KINASE 2; CYCLIN DEPENDENT KINASE INHIBITOR 1A; PROTEIN KINASE; PROTEIN P16INK4A; PROTEIN SERINE THREONINE KINASE; PROTEIN SYNTHESIS INHIBITOR;

ARTICLE; CELL CYCLE; CELL CYCLE G1 PHASE; CELL CYCLE G2 PHASE; CONTROLLED STUDY; DNA CONTENT; DNA REPLICATION; ENZYME INHIBITION; HUMAN; HUMAN CELL; MITOSIS INHIBITION; PRIORITY JOURNAL; PROTEIN INDUCTION; CELL CULTURE; CELL CYCLE S PHASE; CELL DIVISION; DNA DAMAGE; DRUG EFFECT; FLOW CYTOMETRY; GENETIC TRANSFECTION; GENETICS; METABOLISM; MITOSIS; PHYSIOLOGY; PLOIDY; RADIATION EXPOSURE; TRANSACTIVATION;

ANTINEOPLASTIC AGENTS, PHYTOGENIC; CAMPTOTHECIN; CDC2-CDC28 KINASES; CELL DIVISION; CYCLIN B; CYCLIN-DEPENDENT KINASE 2; CYCLIN-DEPENDENT KINASE INHIBITOR P16; CYCLIN-DEPENDENT KINASE INHIBITOR P21; CYCLIN-DEPENDENT KINASES; CYCLINS; DNA DAMAGE; DNA REPLICATION; DNA, NEOPLASM; FLOW CYTOMETRY; G1 PHASE; G2 PHASE; HUMANS; MITOSIS; PLOIDIES; PROLIFERATING CELL NUCLEAR ANTIGEN; PROTEIN KINASES; PROTEIN SYNTHESIS INHIBITORS; PROTEIN-SERINE-THREONINE KINASES; S PHASE; TETRACYCLINE; TRANS-ACTIVATION (GENETICS); TRANSFECTION; TUMOR CELLS, CULTURED;

EID: 0032576632     PISSN: 09509232     EISSN: None     Source Type: Journal    
DOI: 10.1038/sj.onc.1201558     Document Type: Article

References (57)

1. Brugarolas J, Chandrasekaran C, Gordon JI, Beach D, Jacks T and Hannon GJ. (1995). Nature, 377, 552-557.
2. Chen J, Jackson PK, Kirschner MW and Dutta A. (1995). Nature, 374, 386-388.
3. Clarke AR, Purdie CA, Harrison DJ, Morris RG, Bird CC, Hooper ML and Wylie AH. (1993). Nature, 362, 849-852.
4. Cox LS and Lane DP. (1995). Bioessays, 17, 501-508.
5. Cross SM, Sanchez CA, Morgan CA, Schimke MK, Ramel S, Idzerda RL, Raskind WH and Reid BJ. (1995). Science, 267, 1353-1356.
6. Danos O and Mulligan RC. (1988). Proc. Natl. Acad. Sci. USA, 85, 6460-6464.
7. Datto MB, Li Y, Panus JF, Howe DJ, Xiong Y and Wang XF. (1995). Proc. Natl. Acad. Sci. USA, 92, 5545-5549.
8. Deng C, Zhang P, Harper JW, Elledge SJ and Leder P. (1995). Cell, 82, 675-684.
9. Diller L, Kassel J, Nelson CE, Gryka MA, Litwak G, Gebhardt M, Bressac B, Ozturk M, Baker SJ, Vogelstein B and Friend SH. (1990). Mol. Cell Biol., 10, 5772-5781.
10. Draetta G. (1993). Trends Cell Biol., 3, 287-289.
11. Dulic V, Kaufmann WK, Wilson SJ, Tisty TD, Lees E, Harper JW, Elledge SJ and Reed SI. (1994). Cell, 76, 1013-1123.
12. Dynlacht BD, Flores O, Lees JA and Harlow E. (1994). Genes Dev., 8, 1772-1786.
13. El-Deiry WS, Harper JW, O'Connor PM, Velculescu VE, Canman CE, Jackman J, Pientenpol JA, Burrell M, Hill DE, Wang Y, Wiman KG, Mercer WE, Kastan MB, Kohn KW, Elledge SJ, Kinzler KW and Vogelstein B. (1994). Cancer Res., 54, 1169-1174.
14. El-Deiry WS, Tokino T, Velculescu VE, Levy DB, Parsons R, Trent JM, Lin D, Mercer WE, Kinzler KW and Vogelstein B. (1993). Cell, 75, 817-825.
15. Englert C, Hou X, Maheswaran S, Bennett P, Ngwu C, Re GG, Garvin AJ, Rosner MR and Haber DA. (1995). EMBO J., 14, 4662-4675.
16. Flores-Rozas H, Kelman Z, Dean F, Pan Z, Harper JW, Elledge SJ, O'Donnell M and Hurwitz J. (1994). Proc. Natl. Acad. Sci. USA, 91, 8655-8659.
17. Gossen M and Bujard H. (1992). Proc. Natl. Acad. Sci. USA, 89, 5547-5551.
18. Gu Y, Turck CW and Morgan DO. (1993). Nature, 366, 707-710.
19. Guan KL, Jenkins CW, Li Y, Nichols MA, Wu X, O'Keefe CL, Matera AG and Xiong Y. (1994). Genes Dev., 8, 2939-2952.
20. Guo K, Wang J, Andres V, Smith RC and Walsh K. (1995). Mol. Cell Biol., 15, 3823-3829.
21. Halevy O, Novitch BG, Spicer DB, Skapek SX, Rhee J, Hannon GJ, Beach D and Lassar AB. (1995). Science, 267, 1018-1021.
22. Harper JW, Adami GR, Wei N, Keyomarsi K and Elledge SJ. (1993). Cell, 75, 805-816.
23. Harper JW, Elledge SJ, Keyomarsi K, Dynlacht B, Tsai LH, Zhang P, Dobrowolski S, Bai C, Connell-Crowley L, Swindell E, Fox MP and Wei N. (1995). Mol. Biol. Cell, 6, 387-400.
24. Hinds PW, Mittnacht S, Dulic V, Arnold A, Reed SI and Weinberg RA. (1992). Cell, 70, 993-1006.
25. Hinds PW and Weinberg RA. (1994). Curr. Opin. Genet. Dev., 4, 135-141.
26. Hollenstein M, Sidransky D, Vogelstein B and Harris CC. (1991). Science, 253, 49-53.
27. Hunter T and Pines J. (1994). Cell, 79, 573-582.
28. Jiang H, Su ZZ, Collart F, Huberman E and Fisher P. (1994). Oncogene, 9, 3397-3406.
29. Kastan MB, Onyekwere O, Sidransky D, Vogelstein B and Craig RW. (1991). Cancer Res., 51, 6304-6311.
30. Kastan MB, Zhan Q, El-Deiry WS, Carrier F, Jacks T, Walsh WV, Plunkett BS, Vogelstein B and Fornace AJ. (1992). Cell, 71, 587-597.
31. Kelman Z. (1997). Oncogene, 14, 629-640.
32. Krek W, Ewen ME, Shirodkar S, Arany Z, Kaelin WG and Livingston DM. (1994). Cell, 78, 161-172.
33. Krek W, Xu G and Livingston DM. (1995). Cell, 83, 1149-1158.
34. Kyriakis JM, Banerjee P, Nikolakaki E, Dal T, Ruble EA, Ahmed MF, Avruch J and Woodgett JR. (1994). Nature, 369, 156-160.
35. Li R, Waga S, Hannon GJ, Beach D and Stillman B. (1994). Nature, 371, 534-537.
36. Livingston LR, White A, Sprouse J, Livanos E, Jacks T and Tisty T. (1992). Cell, 70, 923-935.
37. Lowe SW, Schmitt SW, Smith BA, Osborne BA and Jacks T. (1993). Nature, 362, 847-849.
38. Luo Y, Hurwitz J and Massague J. (1995). Nature, 375, 159-161.
39. Macleod KF, Sherry N, Hannon GJ, Beach D, Tokino T, Kinzler K, Vogelstein B and Jacks T. (1995). Genes Dev., 9, 935-944.
40. Medema RH, Herrera RE, Lam F and Weinberg RA. (1995). Proc. Natl. Acad. Sci. USA, 92, 6289-6293.
41. Michieli P, Chedid M, Lin D, Pierce JH, Mercer WE and Givol D. (1994). Cancer Res., 54, 3391-3395.
42. Missero C, Calautti E, Eckner R, Chin J, Tsai LH, Livingston DM and Dotto GP. (1995). Proc. Natl. Acad. Sci. USA, 92, 5451-5455.
43. Morgan DO. (1995). Nature, 374, 131-134.
44. Noda A, Ning Y, Venable SF, Pereira-Smith OM and Smith JR. (1994). Exp. Cell Res., 211, 90-98.
45. Parker SB, Eichele G, Zhang P, Rawls A, Sands AT, Bradley A, Olsen EN, Harper JW and Elledge SJ. (1995). Science, 267, 1024-1027.
46. Reynisdottir I, Polyak K, Iavarone A and Massague J. (1995). Genes Dev., 9, 1831-1845.
47. Savio M, Stivala LA, Scovassi AI, Bianchi L and Prosperi E. (1996). Oncogene, 13, 1591-1598.
48. Sherr CJ. (1994). Cell, 79, 551-555.
49. Sherr CJ and Roberts JM. (1995). Genes Dev., 9, 1149-1163.
50. Shim J, Lee H, Park J, Kim H and Choi EJ. (1996). Nature, 381, 804-807.
51. Solomon M. (1994). Trends Biochem. Sci., 19, 496-500.
52. Steinman RA, Hoffman B, Iro A, Guillouf C, Liebermann DA and el-Houseini ME. (1994). Oncogene, 9, 3389-3396.
53. Waga S, Hannon GJ, Beach D and Stillman B. (1994). Nature, 369, 574-578.
54. Wyllie FS, Haughton MF, Bond JA, Rowson JM, Jones CJ and Wynford-Thomas D. (1996). Oncogene, 12, 1077-1082.
55. Xiong Y, Hannon GJ, Zhang H, Casso D, Kobayashi R and Beach D. (1993). Nature, 366, 701-704.
56. Xiong Y, Zhang H and Beach D. (1992). Cell, 71, 505-514.
57. Yin Y, Tainsky MA, Bischoff FZ, Strong LC and Wahl GM. (1992). Cell, 70, 937-948.