The role of the LH subdomain in the function of the Cip/Kip cyclin-dependent kinase regulators

Biophysical Journal

Volumn 100, Issue 10, 2011, Pages 2486-2494

  Otieno, Steve ^a   Grace, Christy R ^a   Kriwacki, Richard W ^a,b  

^a ST JUDE CHILDREN S RESEARCH HOSPITAL   (United States)

^b UNIVERSITY OF TENNESSEE HEALTH SCIENCE CENTER   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

EID: 79959639498     PISSN: 00063495     EISSN: 15420086     Source Type: Journal    
DOI: 10.1016/j.bpj.2011.04.014     Document Type: Article

References (43)

1. Morgan, D. O. 1995. Principles of CDK regulation. Nature. 374:131-134.
2. Solomon, M. J. 1994. The function (s) of CAK, the p34cdc2-activating kinase. Trends Biochem. Sci. 19:496-500.
3. Harper, J. W., and S. J. Elledge. 1998. The role of Cdk7 in CAK function, a retro-retrospective. Genes Dev. 12:285-289. (Pubitemid 28084258)
4. Watanabe, N., M. Broome, and T. Hunter. 1995. Regulation of the human WEE1Hu CDK tyrosine 15-kinase during the cell cycle. EMBO J. 14:1878-1891.
5. Booher, R. N., P. S. Holman, and A. Fattaey. 1997. Human Myt1 is a cell cycle-regulated kinase that inhibits Cdc2 but not Cdk2 activity. J. Biol. Chem. 272:22300-22306. (Pubitemid 27382865)
6. Millar, J., C. McGowan, ..., P. Russell. 1991. cdc25 M-phase inducer. Cold Spring Harb. Symp. Quant. Biol. 56:577-584.
7. Cheng, M., P. Olivier, ..., C. J. Sherr. 1999. The p21 (Cip1) and p27 (Kip1) CDK 'inhibitors' are essential activators of cyclin D-dependent kinases in murine fibroblasts. EMBO J. 18:1571-1583. (Pubitemid 29127070)
8. Sherr, C. J., and J. M. Roberts. 1999. CDK inhibitors: positive and negative regulators of G1-phase progression. Genes Dev. 13:1501-1512. (Pubitemid 29297917)
9. Hannon, G. J., and D. Beach. 1994. p15INK4B is a potential effector of TGF-beta-induced cell cycle arrest. Nature. 371:257-261.
10. Serrano, M., G. J. Hannon, and D. Beach. 1993. A new regulatory motif in cell-cycle control causing specific inhibition of cyclin D/CDK4. Nature. 366:704-707. (Pubitemid 24036021)
11. Hirai, H., M. F. Roussel, ..., C. J. Sherr. 1995. Novel INK4 proteins, p19 and p18, are specific inhibitors of the cyclin D-dependent kinases CDK4 and CDK6. Mol. Cell. Biol. 15:2672-2681.
12. Harper, J. W., G. R. Adami, ..., S. J. Elledge. 1993. The p21 Cdk-interacting protein Cip1 is a potent inhibitor of G1 cyclin-dependent kinases. Cell. 75:805-816. (Pubitemid 23346377)
13. Harper, J. W., S. J. Elledge, ..., N. Wei. 1995. Inhibition of cyclindependent kinases by p21. Mol. Biol. Cell. 6:387-400.
14. el-Deiry, W. S., J. W. Harper, ..., B. Vogelstein. 1994. WAF1/CIP1 is induced in p53-mediated G1 arrest and apoptosis. Cancer Res. 54:1169-1174. (Pubitemid 24108052)
15. Polyak, K., J. Y. Kato, ..., A. Koff. 1994. p27Kip1, a cyclin-Cdk inhibitor, links transforming growth factor-beta and contact inhibition to cell cycle arrest. Genes Dev. 8:9-22.
16. Polyak, K., M. H. Lee, ..., J. Massagué. 1994. Cloning of p27Kip1, a cyclin-dependent kinase inhibitor and a potential mediator of extracellular antimitogenic signals. Cell. 78:59-66.
17. Toyoshima, H., and T. Hunter. 1994. p27, a novel inhibitor of G1 cyclin-Cdk protein kinase activity, is related to p21. Cell. 78:67-74. (Pubitemid 24228301)
18. Matsuoka, S., M. C. Edwards, ..., S. J. Elledge. 1995. p57KIP2, a structurally distinct member of the p21CIP1 Cdk inhibitor family, is a candidate tumor suppressor gene. Genes Dev. 9:650-662.
19. Adkins, J. N., and K. J. Lumb. 2002. Intrinsic structural disorder and sequence features of the cell cycle inhibitor p57Kip2. Proteins. 46:1-7. (Pubitemid 34033571)
20. Russo, A. A., L. Tong, ..., N. P. Pavletich. 1998. Structural basis for inhibition of the cyclin-dependent kinase Cdk6 by the tumour suppressor p16INK4a. Nature. 395:237-243. (Pubitemid 28447541)
21. Dyson, H. J., and P. E. Wright. 2005. Intrinsically unstructured proteins and their functions. Nat. Rev. Mol. Cell Biol. 6:197-208. (Pubitemid 40314921)
22. Wright, P. E., and H. J. Dyson. 1999. Intrinsically unstructured proteins: re-assessing the protein structure-function paradigm. J. Mol. Biol. 293:321-331. (Pubitemid 29516173)
23. Uversky, V. N. 2002. What does it mean to be natively unfolded? Eur. J. Biochem. 269:2-12. (Pubitemid 34107333)
24. Wright, P. E., and H. J. Dyson. 2009. Linking folding and binding. Curr. Opin. Struct. Biol. 19:31-38.
25. Lacy, E. R., I. Filippov, ..., R. W. Kriwacki. 2004. p27 binds cyclin-CDK complexes through a sequential mechanism involving bindinginduced protein folding. Nat. Struct. Mol. Biol. 11:358-364. (Pubitemid 38436801)
26. Reference deleted in proof.
27. Kriwacki, R. W., L. Hengst, ..., P. E. Wright. 1996. Structural studies of p21Waf1/Cip1/Sdi1 in the free and Cdk2-bound state: conformational disorder mediates binding diversity. Proc. Natl. Acad. Sci. USA. 93:11504-11509.
28. Sivakolundu, S. G., D. Bashford, and R. W. Kriwacki. 2005. Disordered p27 (Kip1) exhibits intrinsic structure resembling the Cdk2/Cyclin A-bound conformation. J. Mol. Biol. 353:1118-1128. (Pubitemid 41503276)
29. Galea, C. A., Y. Wang, ..., R. W. Kriwacki. 2008. Regulation of cell division by intrinsically unstructured proteins: intrinsic flexibility, modularity, and signaling conduits. Biochemistry. 47:7598-7609. (Pubitemid 352019491)
30. Russo, A. A., P. D. Jeffrey, ..., N. P. Pavletich. 1996. Crystal structure of the p27Kip1 cyclin-dependent-kinase inhibitor bound to the cyclin A-Cdk2 complex. Nature. 382:325-331. (Pubitemid 26260452)
31. Pervushin, K., R. Riek, ..., K. Wüthrich. 1997. Attenuated T2 relaxation by mutual cancellation of dipole-dipole coupling and chemical shift anisotropy indicates an avenue to NMR structures of very large biological macromolecules in solution. Proc. Natl. Acad. Sci. USA. 94:12366-12371.
32. Muller, L. 1979. Sensitivity enhanced detection of weak nuclei using heteronuclear multiple quantum coherence. J. Am. Chem. Soc. 101:4481-4484.
33. Bienkiewicz, E. A., J. N. Adkins, and K. J. Lumb. 2002. Functional consequences of preorganized helical structure in the intrinsically disordered cell-cycle inhibitor p27 (Kip1). Biochemistry. 41:752-759. (Pubitemid 34061975)
34. McWherter, C. A., E. Haas, ..., H. A. Scheraga. 1986. Conformational unfolding in the N-terminal region of ribonuclease A detected by nonradiative energy transfer. Biochemistry. 25:1951-1963. (Pubitemid 16036007)
35. Grimmler, M., Y. Wang, ..., L. Hengst. 2007. Cdk-inhibitory activity and stability of p27Kip1 are directly regulated by oncogenic tyrosine kinases. Cell. 128:269-280. (Pubitemid 46123508)
36. Pace, C. N., and J. M. Scholtz. 1989. Measuring the conformational stability of a protein. In Protein Structure: A Practical Approach. T. E. Creighton, editor. IRL Press, New York. 299-321.
37. Bowman, P., C. A. Galea, ..., R. W. Kriwacki. 2011. 2006. Thermodynamic characterization of interactions between p27 (Kip1) and activated and non-activated Cdk2: intrinsically unstructured proteins as thermodynamic tethers. Biochim. Biophys. Acta. 1764:182-189.
38. Fischer, E. 1894. Influence of the configuration on the action of enzymes.[Einfluss der configuration auf die wirkung der enzyme]. Ber. Dt. Chem. Ges. 27:2985-2993.
39. Tompa, P., Z. Dosztanyi, and I. Simon. 2006. Prevalent structural disorder in E. coli and S. cerevisiae proteomes. J. Proteome Res. 5:1996-2000. (Pubitemid 44232712)
40. Dunker, A. K., Z. Obradovic, ..., C. J. Brown. 2000. Intrinsic protein disorder in complete genomes. Genome Inform. Ser. Workshop Genome Inform. 11:161-171.
41. Ward, J. J., J. S. Sodhi, ..., D. T. Jones. 2004. Prediction and functional analysis of native disorder in proteins from the three kingdoms of life. J. Mol. Biol. 337:635-645. (Pubitemid 38326883)
42. Tompa, P. 2005. The interplay between structure and function in intrinsically unstructured proteins. FEBS Lett. 579:3346-3354. (Pubitemid 40804685)
43. Spolar, R. S., and M. T. Record, Jr. 1994. Coupling of local folding to site-specific binding of proteins to DNA. Science. 263:777-784. (Pubitemid 24093205)