The effect of soybean-derived phosphatidylserine on cognitive performance in elderly with subjective memory complaints: A pilot study

Clinical Interventions in Aging

Volumn 8, Issue , 2013, Pages 557-563

  Richter, Yael ^a   Herzog, Yael ^a   Lifshitz, Yael ^a   Hayun, Rami ^a   Zchut, Sigalit ^a  

^a Enzymotec Ltd   (Israel)

Author keywords

AAMI; Cognitive; Learning; Memory; Phosphatidylserine

Indexed keywords

PHOSPHATIDYLSERINE; SHARP PS; SOYBEAN DERIVED PHOSPHATIDYLSERINE; UNCLASSIFIED DRUG;

ADULT; AGED; ARTICLE; CLINICAL ARTICLE; CLINICAL EFFECTIVENESS; COMPUTER ANALYSIS; CONTROLLED CLINICAL TRIAL; CONTROLLED STUDY; DIASTOLIC BLOOD PRESSURE; DRUG SAFETY; DRUG TOLERABILITY; EXECUTIVE FUNCTION; FEMALE; GASTROINTESTINAL SYMPTOM; HEART ARRHYTHMIA; HUMAN; LEARNING; MALE; MEMORY DISORDER; MENTAL PERFORMANCE; PHYSICAL EXAMINATION; PILOT STUDY; PNEUMONIA; PSYCHOLOGIC TEST; RECALL; RECOGNITION; REY AUDITORY VERBAL LEARNING TEST; SOYBEAN; SUPPLEMENTATION; SYSTOLIC BLOOD PRESSURE; TREATMENT DURATION; UNSPECIFIED SIDE EFFECT;

AAMI; COGNITIVE; LEARNING; MEMORY; PHOSPHATIDYLSERINE;

AGED; AGED, 80 AND OVER; ANALYSIS OF VARIANCE; FEMALE; GERIATRIC ASSESSMENT; HUMANS; MALE; MEMORY DISORDERS; MIDDLE AGED; NEUROPSYCHOLOGICAL TESTS; PHOSPHATIDYLSERINES; PILOT PROJECTS; SOYBEANS; STATISTICS, NONPARAMETRIC; TREATMENT OUTCOME;

EID: 84878212615     PISSN: 11769092     EISSN: 11781998     Source Type: Journal    
DOI: 10.2147/CIA.S40348     Document Type: Article

References (34)

1. Klenk J, Rapp K, Büchele G, Keil U, Weiland SK. Increasing life expectancy in Germany: quantitative contributions from changes in age- and disease-specific mortality. Eur J Public Health. 2007;17(6): 587-592.
2. Paradise MB, Glozier NS, Naismith SL, Davenport TA, Hickie IB. Subjective memory complaints, vascular risk factors and psychological distress in the middle-aged: a cross-sectional study. BMC Psychiatry. 2011;11:108.
3. O'Brien JT. Age-associated memory impairment and related disorders. Advances in Psychiatric Treatment. 1999;5:279-287.
4. Küllenberg D, Taylor LA, Schneider M, Massing U. Health effects of dietary phospholipids. Lipids Health Dis. 2012;11(1):3.
5. Vance JE, Steenbergen R. Metabolism and functions of phosphatidylserine. Prog Lipid Res. 2005;44(4):207-234.
6. Mozzi R, Buratta S, Goracci G. Metabolism and functions of phosphatedylserine in mammalian brain. Neurochem Res. 2003;28(2):195-214.
7. [No authors listed]. Phosphatidylserine. Monograph. Altern Med Rev. 2008;13(3):245-247.
8. Amaducci L. Phosphatidylserine in the treatment of Alzheimer's disease: results of a multicenter study. Psychopharmacol Bull. 1988;24(1): 130-134.
9. Amaducci L, Crook TH, Lippi A, et al. Use of phosphatidylserine in Alzheimer's disease. Ann N Y Acad Sci. 1991;640:245-249.
10. Crook T, Petrie W, Wells C, Massari DC. Effects of phosphatidylserine in Alzheimer's disease. Psychopharmacol Bull. 1992;28(1):61-66.
11. Richter Y, Herzog Y, Cohen T, Steinhart Y. The effect of phosphatidylserine-containing omega-3 fatty acids on memory abilities in subjects with subjective memory complaints: a pilot study. Clin Interv Aging. 2010;5:313-316.
12. Allegro L, Favaretto V, Ziliotto G. Oral phosphatidylserine in elderly patients with cognitive deterioration. An open study. Clin Trials J. 1987;24(1):104-108.
13. Cenacchi T, Bertoldin T, Farina C, Fiori MG, Crepaldi G. Cognitive decline in the elderly: a double-blind, placebo-controlled multicenter study on efficacy of phosphatidylserine administration. Aging (Milano). 1993;5(2):123-133.
14. Crook TH, Tinklenberg J, Yesavage J, Petrie W, Nunzi MG, Massari DC. Effects of phosphatidylserine in age-associated memory impairment. Neurology. 1991;41(5):644-649.
15. Sinforiani E, Agostinis C, Merlo P, Gualtireri S, Mauri M, Mancuso A. Cognitive decline in ageing brain. Therapeutic approach with phosphtadylserine. Clin Trials J. 1987;24(1):115-124.
16. villardita C, Grioli S, Salmeri G, Nicoletti F, Pennisi G. Multicentre clinical trial of brain phosphatidylserine in elderly patients with intellectual deterioration. Clin Trials J. 1987;24(1):84-93.
17. Prusiner SB. Molecular biology of prion diseases. Science. 1991; 252(5012):1515-1522.
18. Jorissen BL, Brouns F, Van Boxtel MP, Riedel WJ. Safety of soyderived phosphatidylserine in elderly people. Nutr Neurosci. 2002;5(5): 337-343.
19. Blokland A, Honig W, Brouns F, Jolles J. Cognition-enhancing properties of subchronic phosphatidylserine (PS) treatment in middle-aged rats: comparison of bovine cortex PS with egg PS and soybean PS. Nutrition. 1999;15(10):778-783.
20. Suzuki S, Yamatoya H, Sakai M, Kataoka A, Furushiro M, Kudo S. Oral administration of soybean lecithin transphosphatidylated phosphatidylserine improves memory impairment in aged rats. J Nutr. 2001;131(11): 2951-2956.
21. Sakai M, Yamatoya H, Kudo S. Pharmacological effects of phosphatidylserine enzymatically synthesized from soybean lecithin on brain functions in rodents. J Nutr Sci Vitaminol (Tokyo). 1996;42(1):47-54.
22. Jorissen BL, Brouns F, Van Boxtel MP, et al. The influence of soyderived phosphatidylserine on cognition in age-associated memory impairment. Nutr Neurosci. 2001;4(2):121-134.
23. Kato-Kataoka A, Sakai M, Ebina R, Nonaka C, Asano T, Miyamori T. Soybean-derived phosphatidylserine improves memory function of the elderly Japanese subjects with memory complaints. J Clin Biochem Nutr. 2010;47(3):246-255.
24. Gindin JNM, Dedar D, Walter-Ginzburg A, Naor S, Levi S. The Effect of Plant Phosphatidylserine on Age Associated Memory Impairment and Mood in the Functioning Elderly. The Geriatric Institute for Education and Research, and Department of Geriatrics, Kaplan Hospital, Rehovot, Israel. 1993.
25. Asano TK-KA, Sakai M, Tsuji A, Ebina R, Nonaka C, Takamizawa K. The effect of soybean derived phosphatidylserine on the cognitive function of the elderly. Jpn J Nutr Ass. 2005;24:165-170.
26. Schreiber S, Kampf-Sherf O, Gorfine M, Kelly D, Oppenheim Y, Lerer B. An open trial of plant-source derived phosphatydilserine for treatment of age-related cognitive decline. Isr J Psychiatry Relat Sci. 2000;37(4):302-307.
27. Aharonson V, Korczyn AD. Human-computer interaction in the administration and analysis of neuropsychological tests. Comput Methods Programs Biomed. 2004;73(1):43-53.
28. Vakil E, Blachstein H. Rey Auditory-Verbal Learning Test: structure analysis. J Clin Psychol. 1993;49(6):883-890.
29. Wheeler KP, Whitman R. ATPase activity of the sodium pump needs of phosphatidylserine. Nature. 1970;225(5231):449-450.
30. Raese J, Patrick RL, Barchas JD. Phospholipid-induced activation of tyrosine hydroxylase from rat brain striatal synaptosomes. Biochem Pharmacol. 1976;25(20):2245-2250.
31. Nishizuka Y. Turnover of inositol phospholipids and signal transduction. Science. 1984;225(4668):1365-1370.
32. Toffano G, Leon A, Mazzari S, Savoini G, Teolato S, Orlando P. Modification of noradrenergic hypothalamic system in rat injected with phosphatidylserine liposomes. Life Sci. 1978;23(10):1093-1101.
33. Maggioni M, Picotti GB, Bondiolotti GP, etal. Effects of phosphatedylserine therapy in geriatric patients with depressive disorders. Acta Psychiatr Scand. 1990;81(3):265-270.
34. Benton D, Donohoe RT, Sillance B, Nabb S. The influence of phosphatidylserine supplementation on mood and heart rate when faced with an acute stressor. Nutr Neurosci. 2001;4(3):169-178.