Uncoupling protein 3 content is decreased in skeletal muscle of patients with type 2 diabetes

Diabetes

Volumn 50, Issue 12, 2001, Pages 2870-2873

  Schrauwen, Patrick ^a,b   Hesselink, Matthijs K C ^a   Blaak, Ellen E ^a   Borghouts, Lars B ^a   Schaart, Gert ^a   Saris, Wim H M ^a   Keizer, Hans A ^a  

^a MAASTRICHT UNIVERSITY   (Netherlands)

^b MAASTRICHT UNIVERSITY   (Netherlands)

Author keywords

[No Author keywords available]

Indexed keywords

CARRIER PROTEIN; INSULIN; MESSENGER RNA; MITOCHONDRIAL UNCOUPLING PROTEIN 3; THIAZOLE DERIVATIVE;

ADULT; ARTICLE; BLOOD; BODY MASS; CHEMISTRY; FLUORESCENT ANTIBODY TECHNIQUE; GENETICS; GLUCOSE BLOOD LEVEL; HOMEOSTASIS; HUMAN; MALE; METABOLISM; NON INSULIN DEPENDENT DIABETES MELLITUS; PHYSIOLOGY; SKELETAL MUSCLE;

BLOOD GLUCOSE; BODY MASS INDEX; CARRIER PROTEINS; DIABETES MELLITUS, NON-INSULIN-DEPENDENT; FLUORESCENT ANTIBODY TECHNIQUE; HOMEOSTASIS; HUMAN; INSULIN; MALE; MIDDLE AGE; MUSCLE, SKELETAL; RNA, MESSENGER; SUPPORT, NON-U.S. GOV'T; THIAZOLES;

EID: 0035654002     PISSN: 00121797     EISSN: None     Source Type: Journal    
DOI: 10.2337/diabetes.50.12.2870     Document Type: Article

References (20)

1. Schrauwen P, Walder K, Ravussin E: Human uncoupling proteins and obesity. Obes Res 7:97-105, 1999
2. Clapham JC, Arch JR, Chapman H, Haynes A, Lister C, Moore GB, Piercy V, Carter SA, Lehner I, Smith SA, Beeley LJ, Godden RJ, Herrity N, Skehel M, Changani KK, Hockings PD, Reid DG, Squires SM, Hatcher J, Trail B, Latcham J, Rastan S, Harper AJ, Cadenas S, Buckingham JA, Brand MD, Abuin A: Mice overexpressing human uncoupling protein-3 in skeletal muscle are hyperphagic and lean. Nature 406:415-418, 2000
3. Bashan N, Burdett E, Guma A, Sargeant R, Tumiati L, Liu Z, Klip A: Mechanisms of adaptation of glucose transporters to changes in the oxidative chain of muscle and fat cells. Am J Physiol 264:C430-C440, 1993
4. Tsuboyama-Kasaoka N, Tsunoda N, Maruyama K, Takahashi M, Kim H, Cooke DW, Lane MD, Ezaki O: Overexpression of GLUT4 in mice causes up-regulation of UCP3 mRNA in skeletal muscle. Biochem Biophys Res Commun 258:187-193, 1999
5. Lin B, Coughlin S, Pilch PF: Bidirectional regulation of uncoupling protein-3 and GLUT-4 mRNA in skeletal muscle by cold. Am J Physiol 275:E386-E391, 1998
6. Tsuboyama-Kasaoka N, Tsunoda N, Maruyama K, Takahashi M, Kim H, Ikemoto S, Ezaki O: Up-regulation of uncoupling protein 3 (UCP3) mRNA by exercise training and down-regulation of UCP3 by denervation in skeletal muscles. Biochem Biophys Res Commun 247:498-503, 1998
7. Li B, Nolte LA, Ju JS, Ho Han D, Coleman T, Holloszy JO, Semenkovich CF: Skeletal muscle respiratory uncoupling prevents diet-induced obesity and insulin resistance in mice. Nat Med 6:1115-1120, 2000
8. Krook A, Digby J, O'Rahilly S, Zierath JR, Wallberg-Henriksson H: Uncoupling protein 3 is reduced in skeletal muscle of NIDDM patients. Diabetes 47:1528-1531, 1998
9. Bao S, Kennedy A, Wojciechowski B, Wallace P, Ganaway E, Garvey WT: Expression of mRNAs encoding uncoupling proteins in human skeletal muscle: effects of obesity and diabetes. Diabetes 47:1935-1940, 1998
10. Vidal H, Langin D, Andreelli F, Millet L, Larrouy D, Laville M: Lack of skeletal muscle uncoupling protein 2 and 3 mRNA induction during fasting in type-2 diabetic subjects. Am J Physiol 277:E830-E837, 1999
11. Hesselink MKC, Keizer HA, Borghouts LB, Schaart G, Kornips CFP, Slieker LJ, Sloop KW, Saris WHM, Schrauwen P: Protein expression of UCP3 differs between human type 1, type 2a and type 2b fibers. FASEB J 15:1071-1073, 2001
12. Schrauwen P, Schaart G, Saris WHM, Slieker LJ, Glatz JFC, Vidai H, Blaak EE: The effect of weight reduction on skeletal muscle UCP2 and UCP3 mRNA expression and UCP3 protein content in type II diabetic subjects. Diabetologia 43:1408-1416, 2000
13. Schrauwen P, Xia J, Walder K, Snitker S, Ravussin E: A novel polymorphism in the proximal UCP3 promoter region: effect on skeletal muscle UCP3 mRNA expression and obesity in male non-diabetic Pima Indians. Int J Obes Relat Metab Disord 23:1242-1245, 1999
14. Meirhaeghe A, Amouyel P, Helbecque N, Cottel D, Otabe S, Froguel P, Vasseur F: An uncoupling protein 3 gene polymorphism associated with a lower risk of developing type II diabetes and with atherogenic lipid profile in a French cohort. Diabetologia 43:1424-1428, 2000
15. Huppertz C, Fischer BM, Kim YB, Kotani K, Vidal-Puig A, Slieker LJ, Sloop KW, Lowell BB, Kahn BB: Uncoupling protein 3 (UCP3) stimulates glucose uptake in muscle cells through a phosphoinositide 3-kinase-dependent mechanism. J Biol Chem 276:12520-12529, 2001
16. Marin P, Andersson B, Krotkiewski M, Bjorntorp P: Muscle fiber composition and capillary density in women and men with NIDDM. Diabetes Care 17:382-386, 1994
17. Day C: Thiazolidinediones: a new class of antidiabetic drugs. Diabet Med 16:179-192, 1999
18. Emilsson V, O'Dowd J, Wang S, Liu YL, Sennitt M, Heyman R, Cawthorne MA: The effects of rexinoids and rosiglitazone on body weight and uncoupling protein isoform expression in the Zucker fa/fa rat. Metabolism 49:1610-1615, 2000
19. Oberkofler H, Neschen S, Esterbauer H, Waldhausl W, Patsch W, Furnsinn C: UCP3 gene expression does not correlate with muscle oxidation rates in troglitazone-treated Zucker fatty rats. Biochim Biophys Acta 1517:113-118, 2000
20. Bergström J, Hermansen L, Hultman E, Saltin B: Diet, muscle glycogen and physical performance. Acta Physiol Scand 71:140-150, 1967